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Neurology: Original articles

An open-label multicenter study to assess the safety of dextromethorphan/quinidine in patients with pseudobulbar affect associated with a range of underlying neurological conditions

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Pages 2255-2265 | Accepted 26 Jun 2014, Published online: 28 Jul 2014

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Yuyao Sun, Michael Benatar, Javier Mascías Cadavid, Dave Ennist, Paul Wicks, Kim Staats, Morgan Beauchamp, Sartaj Jhooty, Gary Pattee, Andrew Brown, Tulio Bertorini, Paul Barkhaus, Mark Bromberg, Greg Carter, Richard Bedlack & Xiaoyan Li. (2023) ALSUntangled #71: Nuedexta. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 0:0, pages 1-5.
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David G Coughlin & Irene Litvan. (2022) Investigational therapeutics for the treatment of progressive supranuclear palsy. Expert Opinion on Investigational Drugs 31:8, pages 813-823.
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Marian W. Roman. (2015) NueDexta: A Treatment for Pseudobulbar Affect. Issues in Mental Health Nursing 36:12, pages 1019-1021.
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Articles from other publishers (29)

Naser-Aldin Lashgari, Maryam Shayan, Hedieh shamsnia, Nazanin Momeni Roudsari, Saeideh Momtaz & Amir Hossein Abdolghaffari. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 91 102 .
Elliot W. McClure & R. Nathan Daniels. (2023) Classics in Chemical Neuroscience: Dextromethorphan (DXM). ACS Chemical Neuroscience 14:12, pages 2256-2270.
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Emma Husbands & Kevin Talbot. (2022) Pathological laughter and crying in neurological disorders: recognition and treatment. Practical Neurology 22:6, pages 486-490.
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Michael Francis, Mira Hamame, Mariam Nasrallah, Alison Nesbitt & James P. Meza. (2021) Dextromethorphan-quinidine is helpful for pseudobulbar affect disorder in stroke patients. Clinical Research In Practice: The Journal of Team Hippocrates 7:2.
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Jesus Sancho, Santos Ferrer, Enric Burés, José Luis Díaz, Teresa Torrecilla, Jaime Signes-Costa & Emilio Servera. (2021) Effect of one-year dextromethorphan/quinidine treatment on management of respiratory impairment in amyotrophic lateral sclerosis. Respiratory Medicine 186, pages 106536.
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Hendrik Lintel, Timothy Corpuz, Saif-ur-Rahman Paracha & George T. Grossberg. (2021) Mood Disorders and Anxiety in Parkinson’s Disease: Current Concepts. Journal of Geriatric Psychiatry and Neurology 34:4, pages 280-288.
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David G. Coughlin, Dennis W. Dickson, Keith A. Josephs & Irene Litvan. 2021. Frontotemporal Dementias. Frontotemporal Dementias 151 176 .
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Michael Chez, Shawn Kile, Christopher Lepage, Carol Parise, Bobbie Benabides & Andrea Hankins. (2018) A Randomized, Placebo-Controlled, Blinded, Crossover, Pilot Study of the Effects of Dextromethorphan/Quinidine for the Treatment of Neurobehavioral Symptoms in Adults with Autism. Journal of Autism and Developmental Disorders 50:5, pages 1532-1538.
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David G. Coughlin & Irene Litvan. (2020) Progressive supranuclear palsy: Advances in diagnosis and management. Parkinsonism & Related Disorders 73, pages 105-116.
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Amelia J. Hicks, Fiona J. Clay, Jennie L. Ponsford, Luke A. Perry, Mahesh Jayaram, Rachel Batty & Malcolm Hopwood. (2020) Pharmacotherapy for the Pseudobulbar Affect in Individuals Who Have Sustained a Traumatic Brain Injury: a Systematic Review. Neuropsychology Review 30:1, pages 28-50.
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Mathew Hakimi & Carine W. Maurer. (2019) Pseudobulbar Affect in Parkinsonian Disorders: A Review. Journal of Movement Disorders 12:1, pages 14-21.
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Richard D. ZorowitzDavid N. Alexander, Andrea E. Formella, Fred Ledon, Charles Davis & Joao Siffert. (2019) Dextromethorphan/Quinidine for Pseudobulbar Affect Following Stroke: Safety and Effectiveness in the PRISM II Trial. PM&R 11:1, pages 17-24.
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Linda Nguyen & Rae R. Matsumoto. 2019. Psychopharmacology of Neurologic Disease. Psychopharmacology of Neurologic Disease 243 251 .
Flora M. Hammond, William Sauve, Fred Ledon, Charles Davis & Andrea E. Formella. (2018) Safety, Tolerability, and Effectiveness of Dextromethorphan/Quinidine for Pseudobulbar Affect Among Study Participants With Traumatic Brain Injury: Results From the PRISM-II Open Label Study. PM&R 10:10, pages 993-1003.
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Fiona J. Clay, Amelia J. Hicks, Luke A. Perry, Jennie L. Ponsford, Mahesh Jayaram & Malcolm Hopwood. (2018) Pharmacotherapy for the pseudobulbar affect in individuals who have sustained a traumatic brain injury: a systematic review protocol. JBI Database of Systematic Reviews and Implementation Reports 16:9, pages 1739-1757.
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Natalia Ospina-García, Gustavo C Román, Belén Pascual, Mary R Schwartz & Hector Alejandro Preti. (2018) Hypothalamic relapse of a cardiac large B-cell lymphoma presenting with memory loss, confabulation, alexia–agraphia, apathy, hypersomnia, appetite disturbances and diabetes insipidus. BMJ Case Reports, pages bcr-2016-217700.
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Frank A. Rodden. (2018) The neurology and psychiatry of humor, smiling and laughter: A tribute to Paul McGhee. Part I. Introduction and clinical studies. HUMOR 31:2, pages 339-371.
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Abhijit Dey & Anuradha Mukherjee. 2018. Discovery and Development of Neuroprotective Agents from Natural Products. Discovery and Development of Neuroprotective Agents from Natural Products 237 320 .
Frank Rodden. (2017) The neurology and psychiatry of humor, smiling and laughter: A tribute to Paul McGhee. Part I. Introduction and clinical studies. HUMOR 0:0.
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Richard Smith, Erik Pioro, Kathleen Myers, Michael Sirdofsky, Kimberly Goslin, Gregg Meekins, Hong Yu, James Wymer, Merit Cudkowicz, Eric A. Macklin, David Schoenfeld & Gary Pattee. (2017) Enhanced Bulbar Function in Amyotrophic Lateral Sclerosis: The Nuedexta Treatment Trial. Neurotherapeutics 14:3, pages 762-772.
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Robert G. WahlerJrJrAlfred T. ReimanJoshua V. Schrader. (2017) Use of Compounded Dextromethorphan–Quinidine Suspension for Pseudobulbar Affect in Hospice Patients. Journal of Palliative Medicine 20:3, pages 294-297.
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Ji-ye Liu & Ying-hua Chen. (2017) Influence of acupoint-injection on TXB2 and 6-keto-PGF1a in patients with pseudobulbar palsy: a randomized controlled trial穴位注射对假性延髓麻痹患者TXB2 和6-keto-PGF1a 的影响的随机对照试验. Journal of Acupuncture and Tuina Science 15:1, pages 22-26.
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M. Cataldi. 2017. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Flora M. Hammond, David N. Alexander, Andrew J. Cutler, Stephen D’Amico, Rachelle S. Doody, William Sauve, Richard D. Zorowitz, Charles S. Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E. Formella & Joao Siffert. (2016) PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury. BMC Neurology 16:1.
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Rachelle S. Doody, Stephen D’Amico, Andrew J. Cutler, Charles S. Davis, Paul Shin, Fred Ledon, Charles Yonan & João Siffert. (2015) An open-label study to assess safety, tolerability, and effectiveness of dextromethorphan/quinidine for pseudobulbar affect in dementia: PRISM II results. CNS Spectrums 21:6, pages 450-459.
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Linda Nguyen, Kelan L. Thomas, Brandon P. Lucke-Wold, John Z. Cavendish, Molly S. Crowe & Rae R. Matsumoto. (2016) Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders. Pharmacology & Therapeutics 159, pages 1-22.
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Eman Bahrani, Chloe E. Nunneley, Sylvia Hsu & Joseph S. Kass. (2016) Cutaneous Adverse Effects of Neurologic Medications. CNS Drugs 30:3, pages 245-267.
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Lily P. H. Yang & Emma D. Deeks. (2014) Dextromethorphan/Quinidine: A Review of Its Use in Adults with Pseudobulbar Affect. Drugs 75:1, pages 83-90.
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