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Arthritis: Original article

Efficacy and safety of low-dose submicron diclofenac for the treatment of osteoarthritis pain: a 12 week, phase 3 study

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Pages 1883-1893 | Accepted 14 Jul 2014, Published online: 06 Aug 2014

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Kevin H. Maniar, Ian A. Jones, Rayudu Gopalakrishna & C. Thomas Vangsness$suffix/text()$suffix/text(). (2018) Lowering side effects of NSAID usage in osteoarthritis: recent attempts at minimizing dosage. Expert Opinion on Pharmacotherapy 19:2, pages 93-102.
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Roy D. Altman, Vibeke Strand, Marc C. Hochberg, Allan Gibofsky, Joseph A. Markenson, William E. Hopkins, Byron Cryer, Alan Kivitz, Jennifer Nezzer, Olaolu Imasogie & Clarence L. Young. (2015) Low-dose SoluMatrix diclofenac in the treatment of osteoarthritis: A 1-year, open-label, Phase III safety study. Postgraduate Medicine 127:5, pages 517-528.
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Allan Gibofsky, Roy Altman, Stephen Daniels, Olaolu Imasogie & Clarence Young. (2015) Low-dose SoluMatrix diclofenac: a review of safety across two Phase III studies in patients with acute and osteoarthritis pain. Expert Opinion on Drug Safety 14:8, pages 1327-1339.
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Articles from other publishers (23)

Erin Nicholas, Jennifer Cheng & Peter J. Moley. (2023) Non-operative Treatment Options for Osteoarthritis in the Hip. HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery 19:4, pages 486-493.
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V.V. Stroblіa, S.M. Drogovoz & R.V. Lutsenko. (2023) Нетрадиційні методи лікування остеоартрозу колінного суглоба. TRAUMA 24:1, pages 39-45.
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Francesco Oliva, Marco Quaranta, Lucio Cipollaro, Valeria Conti, Emanuela De Bellis, Amelia Filippelli & Nicola Maffulli. (2022) Low-Dose NSAIDs Efficacy in Orthopedic Applications. Sports Medicine and Arthroscopy Review 30:3, pages 147-161.
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Chiara Delbaldo, Matilde Tschon, Lucia Martini, Milena Fini & Giorgia Codispoti. (2022) Benefits of Applying Nanotechnologies to Hydrogels in Efficacy Tests in Osteoarthritis Models—A Systematic Review of Preclinical Studies. International Journal of Molecular Sciences 23:15, pages 8236.
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Yura Kim, Gregory Levin, Nikolay P. Nikolov, Robert Abugov & Rebecca Rothwell. (2022) Concept End Points Informing Design Considerations for Confirmatory Clinical Trials in Osteoarthritis. Arthritis Care & Research 74:7, pages 1154-1162.
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Elena Rezuş, Alexandra Burlui, Anca Cardoneanu, Luana Andreea Macovei, Bogdan Ionel Tamba & Ciprian Rezuş. (2021) From Pathogenesis to Therapy in Knee Osteoarthritis: Bench-to-Bedside. International Journal of Molecular Sciences 22:5, pages 2697.
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Ziqin Cao, Jian Zhou, Zeling Long, Yihan Li, Jingjing Sun, Yingquan Luo & Wanchun Wang. (2020) Targeting nerve growth factor, a new option for treatment of osteoarthritis: a network meta-analysis of comparative efficacy and safety with traditional drugs. Aging 13:1, pages 1051-1070.
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Ziqin Cao, Yajia Li, Wanchun Wang, Shuo Jie, Xuantao Hu, Jian Zhou, Tong Wu, Dilihumaer Aili, Zeling Long, Yihan Li, Pengcheng Dou & Ren Wu. (2020) Is Lutikizumab, an Anti–Interleukin-1α/β Dual Variable Domain Immunoglobulin, efficacious for Osteoarthritis? Results from a bayesian network meta-analysis. BioMed Research International 2020, pages 1-10.
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Delaram Babadi, Simin Dadashzadeh, Mahraz Osouli, Maryam Sadat Daryabari & Azadeh Haeri. (2020) Nanoformulation strategies for improving intestinal permeability of drugs: A more precise look at permeability assessment methods and pharmacokinetic properties changes. Journal of Controlled Release 321, pages 669-709.
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Susanne Hellms, Faikah Gueler, Marcel Gutberlet, Nils Helge Schebb, Katharina Rund, Jan T Kielstein, VanDai VoChieu, Sebastian Rauhut, Robert Greite, Petros Martirosian, Hermann Haller, Frank Wacker & Katja Derlin. (2019) Single-dose diclofenac in healthy volunteers can cause decrease in renal perfusion measured by functional magnetic resonance imaging†. Journal of Pharmacy and Pharmacology 71:8, pages 1262-1270.
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Emma L Parry, Martin J Thomas & George Peat. (2018) Defining acute flares in knee osteoarthritis: a systematic review. BMJ Open 8:7, pages e019804.
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David S. Jevsevar, Peter B. Shores, Kyle Mullen, Danielle M. Schulte, Gregory A. Brown & Deborah S. Cummins. (2018) Mixed Treatment Comparisons for Nonsurgical Treatment of Knee Osteoarthritis: A Network Meta-analysis. Journal of the American Academy of Orthopaedic Surgeons 26:9, pages 325-336.
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Marita Cross, Ludovic Dubouis, Matthieu Mangin, David J. Hunter, Lyn March, Gillian Hawker & Francis Guillemin. (2017) Defining Flare in Osteoarthritis of the Hip and Knee: A Systematic Literature Review — OMERACT Virtual Special Interest Group. The Journal of Rheumatology 44:12, pages 1920-1927.
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Gabriel Calvo Mosquera, Dania Calvo Rodríguez & Amparo González Cal. (2017) Abordaje multifactorial del dolor crónico no neoplásico en Atención Primaria. FMC - Formación Médica Continuada en Atención Primaria 24, pages 1-55.
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Vibeke Strand, Martin Bergman, Jasvinder A. Singh, Allan Gibofsky, Alan Kivitz & Clarence Young. (2017) Low-dose SoluMatrix diclofenac in patients with osteoarthritis pain: impact on quality of life in a controlled trial. Clinical Rheumatology 36:6, pages 1357-1367.
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Mostafa Hossein Beyki, Mosleh Mohammadirad, Farzaneh Shemirani & Ali Akbar Saboury. (2017) Magnetic cellulose ionomer/layered double hydroxide: An efficient anion exchange platform with enhanced diclofenac adsorption property. Carbohydrate Polymers 157, pages 438-446.
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Alexios Carayannopoulos. 2017. Comprehensive Pain Management in the Rehabilitation Patient. Comprehensive Pain Management in the Rehabilitation Patient 373 402 .
Charles Argoff, Bill McCarberg, Jeff Gudin, Srinivas Nalamachu & Clarence Young. (2016) SoluMatrix ® Diclofenac: Sustained Opioid-Sparing Effects in a Phase 3 Study in Patients with Postoperative Pain . Pain Medicine 17:10, pages 1933-1941.
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Ashleigh M. Philp, Edward T. Davis & Simon W. Jones. (2016) Developing anti-inflammatory therapeutics for patients with osteoarthritis. Rheumatology, pages kew278.
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Peter Wehling, Carsten Moser & William Maixner. (2016) How does surgery compare with advanced intra-articular therapies in knee osteoarthritis: current thoughts. Therapeutic Advances in Musculoskeletal Disease 8:3, pages 72-85.
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Joseph V PergolizziJrJr, Robert B Raffa, Srinivas Nalamachu & Robert TaylorJrJr. (2016) Evolution to low-dose NSAID therapy. Pain Management 6:2, pages 175-189.
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Charles V. PollackJr.Jr., Deborah B. Diercks, Stephen H. Thomas, Nathan I. Shapiro, John Fanikos, Sharon E. Mace, Zubaid Rafique & Knox H. Todd. (2016) Patient-reported Outcomes from A National, Prospective, Observational Study of Emergency Department Acute Pain Management With an Intranasal Nonsteroidal Anti-inflammatory Drug, Opioids, or Both. Academic Emergency Medicine 23:3, pages 331-341.
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Paul J. Desjardins, Kemi Olugemo, Daniel Solorio & Clarence L. Young. (2015) Pharmacokinetic Properties and Tolerability of Low-dose SoluMatrix Diclofenac. Clinical Therapeutics 37:2, pages 448-461.
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