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Research Article

Glucosamine sulphate for the management of arthrosis: A controlled clinical investigation

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Pages 104-109 | Received 29 Jul 1980, Published online: 11 Aug 2008

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Yoshihiro Seto, Takuya Yoshihashi, Mari Tomonari & Hideto To. (2020) Absorption of glucosamine is improved by considering circadian rhythm and feeding time in rats. Chronobiology International 37:11, pages 1528-1537.
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Vahid Shaygannejad, Mohsen Janghorbani, Mohammad Reza Savoj & Fereshteh Ashtari. (2010) Effects of adjunct glucosamine sulfate on relapsing–remitting multiple sclerosis progression: Preliminary findings of a randomized, placebo-controlled trial. Neurological Research 32:9, pages 981-985.
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S.M. Ostojic, M. Arsic, S. Prodanovic, J. Vukovic & M. Zlatanovic. (2007) Glucosamine Administration in Athletes: Effects on Recovery of Acute Knee Injury. Research in Sports Medicine 15:2, pages 113-124.
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Carol Potera. (1997) Can supplements reduce arthritis symptoms?. The Physician and Sportsmedicine 25:12, pages 15-16.
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Michael T. Murray. 2020. Textbook of Natural Medicine. Textbook of Natural Medicine 629 633.e2 .
Abhinav Gulihar, Shalin Shaunak, Pinelopi Linardatou Novak, Parthiban Vinayakam, Baljinder Dhinsa & Grahame Taylor. (2017) Glucosamine reduces the inhibition of proteoglycan metabolism caused by local anaesthetic solution in human articular cartilage: an in vitro study. Journal of Experimental Orthopaedics 4:1.
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Stephanie Harrison-Muñoz, Valentina Rojas-Briones & Sebastián Irarrázaval. (2017) Is glucosamine effective for osteoarthritis?. Medwave 17:Suppl1, pages e6867-e6867.
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Zhanwu Yu, Yinghua Ju & Hongxu Liu. (2017) Anti-lung cancer effect of glucosamine by suppressing the phosphorylation of FOXO. Molecular Medicine Reports 16:3, pages 3395-3400.
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Mamoru Igarashi, Koji Sakamoto & Isao Nagaoka. (2017) Effect of glucosamine on expression of type II collagen, matrix metalloproteinase and sirtuin genes in a human chondrocyte cell line. International Journal of Molecular Medicine 39:2, pages 472-478.
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Atsushi Katoh, Hisashi Kai, Haruhito Harada, Hiroshi Niiyama & Hisao Ikeda. (2017) Oral Administration of Glucosamine Improves Vascular Endothelial Function by Modulating Intracellular Redox State. International Heart Journal 58:6, pages 926-932.
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Patrick Eriksen, Else M. Bartels, Roy D. Altman, Henning Bliddal, Carsten Juhl & Robin Christensen. (2014) Risk of Bias and Brand Explain the Observed Inconsistency in Trials on Glucosamine for Symptomatic Relief of Osteoarthritis: A Meta-Analysis of Placebo-Controlled Trials. Arthritis Care & Research 66:12, pages 1844-1855.
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Yuh-Lin Wu, An-Hsuan Lin, Chao-Hung Chen, Wen-Chien Huang, Hsin-Yi Wang, Meng-Han Liu, Tzong-Shyuan Lee & Yu Ru Kou. (2014) Glucosamine attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling. Free Radical Biology and Medicine 69, pages 208-218.
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Kei Kaida, Hiromi Yamashita, Kazuo Toda & Yoshihiko Hayashi. (2014) Suppressive Effects of D-Glucosamine on the 5-HT Sensitive Nociceptive Units in the Rat Tooth Pulpal Nerve. BioMed Research International 2014, pages 1-6.
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Kun-Han Chuang, Yen-Chun Peng, Han-Yun Chien, Meng-Lun Lu, Hsin-I Du & Yuh-Lin Wu. (2013) Attenuation of LPS-Induced Lung Inflammation by Glucosamine in Rats. American Journal of Respiratory Cell and Molecular Biology 49:6, pages 1110-1119.
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Yinghua Ju. (2013) Glucosamine, a naturally occurring amino monosaccharide, inhibits A549 and H446 cell proliferation by blocking G1/S transition. Molecular Medicine Reports.
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Kei Kaida, Hiromi Yamashita, Kazuo Toda & Yoshihiko Hayashi. (2013) Effects of glucosamine on tooth pulpal nociceptive responses in the rat. Journal of Dental Sciences 8:1, pages 68-73.
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Tamil Selvan, Kingston Rajiah, M. Sundara-Moorthi Nainar & Elizabeth M. Mathew. (2012) A Clinical Study on Glucosamine Sulfate versus Combination of Glucosamine Sulfate and NSAIDs in Mild to Moderate Knee Osteoarthritis. The Scientific World Journal 2012, pages 1-5.
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Harpal S. Khanuja, Marc W. Hungerford, Stephen R. Thompson, Maria S. Goddard & Michael A. Mont. 2012. Insall &amp Scott Surgery of the Knee. Insall &amp Scott Surgery of the Knee 896 908 .
Huma Jawed, Shazia Anjum, Shahid I. Awan & Shabana U. Simjee. (2011) Anti-arthritic effect of GN1, a novel synthetic analog of glucosamine, in the collagen-induced arthritis model in rats. Inflammation Research 60:12, pages 1113-1120.
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I. Nagaoka, M. Igarashi, J. Hua, Y. Ju, S. Yomogida & K. Sakamoto. (2011) Recent aspects of the anti-inflammatory actions of glucosamine. Carbohydrate Polymers 84:2, pages 825-830.
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R. R. Simon, V. Marks, A. R. Leeds & J. W. Anderson. (2010) A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals. Diabetes/Metabolism Research and Reviews 27:1, pages 14-27.
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EC Huskisson. (2010) Modern Management of Mild-to-Moderate Joint Pain due to Osteoarthritis: A Holistic Approach. Journal of International Medical Research 38:4, pages 1175-1212.
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Kiyohito Naito, Taiji Watari, Atsushi Furuhata, Shin Yomogida, Koji Sakamoto, Hisashi Kurosawa, Kazuo Kaneko & Isao Nagaoka. (2010) Evaluation of the effect of glucosamine on an experimental rat osteoarthritis model. Life Sciences 86:13-14, pages 538-543.
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M. Udompataikul, P. Sripiroj & P. Palungwachira. (2009) An oral nutraceutical containing antioxidants, minerals and glycosaminoglycans improves skin roughness and fine wrinkles. International Journal of Cosmetic Science 31:6, pages 427-435.
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Grazyna Sobal, Johannes Menzel & Helmut Sinzinger. (2009) Optimal 99m Tc Radiolabeling and Uptake of Glucosamine Sulfate by Cartilage. A Potential Tracer for Scintigraphic Detection of Osteoarthritis . Bioconjugate Chemistry 20:8, pages 1547-1552.
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S.S. Dhaneshwar, D. Patil, S. Mengi, G. Mulay & J. Lahane. (2009) Diacerein mutual prodrug for osteoarthritis: synthesis, in vitro kinetic studies and preliminary pharmacological screening. Journal of Drug Delivery Science and Technology 19:1, pages 25-29.
Crossref
Paola de Pablo & Timothy E. McAlindon. 2009. Handbook of Clinical Nutrition and Aging. Handbook of Clinical Nutrition and Aging 439 477 .
Rianne Rozendaal, Bart Koes, Gerjo van Osch, Elian Uitterlinden, Eric Garling, Sten Willemsen, Abida Ginai, Jan Verhaar, Harrie Weinans & Sita Bierma-Zeinstra. (2008) Het effect van glucosaminesulfaat op de progressie van heupartrose. Huisarts en Wetenschap 51:11, pages 535-541.
Crossref
Paola de Pablo, Grace Lo & Timothy E. McAlindon. 2008. Nutrition and Rheumatic Disease. Nutrition and Rheumatic Disease 125 158 .
Maria Sulindro-Ma, Charise L. Ivy & Amber C. Isenhart. 2008. Integrative Pain Medicine. Integrative Pain Medicine 417 445 .
Steven C. Vlad, Michael P. LaValley, Timothy E. McAlindon & David T. Felson. (2007) Glucosamine for pain in osteoarthritis: Why do trial results differ?. Arthritis & Rheumatism 56:7, pages 2267-2277.
Crossref
Peter F. Sharkey, David L. Paskin, Thomas D. Meade & Richard H. Rothman. (2007) Diet, Nutrition, Obesity, and Their Roles in Arthritis. Seminars in Arthroplasty 18:2, pages 117-121.
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Susanne X. Wang, Sheila Laverty, Mircea Dumitriu, Anna Plaas & Marc D. Grynpas. (2007) The effects of glucosamine hydrochloride on subchondral bone changes in an animal model of osteoarthritis. Arthritis & Rheumatism 56:5, pages 1537-1548.
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Dianne Volker & Peony Lee. 2006. Handbook of Nutraceuticals and Functional Foods, Second Edition. Handbook of Nutraceuticals and Functional Foods, Second Edition 193 222 .
A. Bennett, R. Phillip, P. Scott, D. Minden, T. Jones & A. Mistlin. (2006) Rheumatology, Rehabilitation Medicine and Sports and Exercise Medicine. Journal of the Royal Army Medical Corps 152:3, pages 163-174.
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Shin Yomogida, Jian Hua, Yuko Tsutsumi-Ishii, Koji Sakamoto & Isao Nagaoka. (2006) Effect of glucosamine on Interleukin-8 production from human colonic epithelial cell line. Inflammation and Regeneration 26:6, pages 513-518.
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Jian Hua, Shiori Suguro, Koji Sakamoto & Isao Nagaoka. (2006) Inhibitory effect of oral glucosamine administration on platelet activation in guinea pigs. Inflammation and Regeneration 26:5, pages 446-452.
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Kenneth Blum, Brian Meshkin & B. William Downs. (2006) DNA based customized nutraceutical “gene therapy” utilizing a genoscore: A hypothesized paradigm shift of a novel approach to the diagnosis, stratification, prognosis and treatment of inflammatory processes in the human. Medical Hypotheses 66:5, pages 1008-1018.
Crossref
. (2005) Glucosamine for osteoarthritis. Evidence-based Healthcare and Public Health 9:5, pages 322-331.
Crossref
Tanveer Towheed, Lara Maxwell, Tassos P Anastassiades, Beverley Shea, JB Houpt, Vivian Welch, Marc C Hochberg & George A Wells. (2005) Glucosamine therapy for treating osteoarthritis. Cochrane Database of Systematic Reviews 2009:4.
Crossref
Timothy E. McAlindon. 2005. Preventive Nutrition. Preventive Nutrition 405 423 .
Timothy McAlindon, Margaret Formica, Michael LaValley, Melissa Lehmer & Karim Kabbara. (2004) Effectiveness of glucosamine for symptoms of knee osteoarthritis: Results from an internet-based randomized double-blind controlled trial. The American Journal of Medicine 117:9, pages 643-649.
Crossref
Jolanda Cibere, Jacek A. Kopec, Anona Thorne, Joel Singer, Janice Canvin, David B. Robinson, Janet Pope, Paul Hong, Eric Grant & John M. Esdaile. (2004) Randomized, double‐blind, placebo‐controlled glucosamine discontinuation trial in knee osteoarthritis. Arthritis Care & Research 51:5, pages 738-745.
Crossref
David M. Mello, Brian D. Nielsen, Tonia L. Peters, John P. Caron & Michael W. Orth. (2004) Comparison of inhibitory effects of glucosamine and mannosamine on bovine articular cartilage degradation in vitro. American Journal of Veterinary Research 65:10, pages 1440-1445.
Crossref
S. Fuchs. 2004. Arthrose. Arthrose 103 106 .
Marc W Hungerford & Daniel Valaik. (2003) Chondroprotective agents: glucosamine and chondroitin. Foot and Ankle Clinics 8:2, pages 201-219.
Crossref
Hitoshi Sashiwa, Shizu Fujishima, Naoko Yamano, Norioki Kawasaki, Atsuyoshi Nakayama, Einosuke Muraki, Mongkol Sukwattanasinitt, Rath Pichyangkura & Sei-ichi Aiba. (2003) Enzymatic production of N-acetyl-d-glucosamine from chitin. Degradation study of N-acetylchitooligosaccharide and the effect of mixing of crude enzymes. Carbohydrate Polymers 51:4, pages 391-395.
Crossref
M. de Mattei, A. Pellati, M. Pasello, F. de Terlizzi, L. Massari, D. Gemmati & A. Caruso. (2002) High doses of glucosamine-HCl have detrimental effects on bovine articular cartilage explants cultured in vitro. Osteoarthritis and Cartilage 10:10, pages 816-825.
Crossref
J.A. Blakeley & V Ribeiro. (2002) A survey of self-medication practices and perceived effectiveness of glucosamine products among older adults. Complementary Therapies in Medicine 10:3, pages 154-160.
Crossref
Yasunori Tamai, Katsuyuki Miyatake, Yoshiharu Okamoto, Yoshimori Takamori, Hiroshi Sakamoto & Saburo Minami. (2002) Enhanced healing of cartilaginous injuries by glucosamine hydrochloride. Carbohydrate Polymers 48:4, pages 369-378.
Crossref
Jian Hua, Koji Sakamoto & Isao Nagaoka. (2002) Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils. Journal of Leukocyte Biology 71:4, pages 632-640.
Crossref
D. Platt. (2010) The role of oral disease‐modifying agents glucosamine and chondroitin sulphate in the management of equine degenerative joint disease. Equine Veterinary Education 13:4, pages 206-215.
Crossref
I. M. WRIGHT. (2010) Oral supplements in the treatment and prevention of joint diseases: a review of their potential application to the horse. Equine Veterinary Education 13:3, pages 135-139.
Crossref
Joseph A. Buckwalter, William D. Stanish, Randy N. Rosier, Robert C. SchenckJr.Jr., Douglas A. Dennis & Richard D. Coutts. (2001) The Increasing Need for Nonoperative Treatment of Patients With Osteoarthritis. Clinical Orthopaedics and Related Research 385, pages 36-45.
Crossref
Andrew A. Brief, Stephen G. Maurer & Paul E. Di Cesare. (2001) Use of Glucosamine and Chondroitin Sulfatein the Management of Osteoarthritis. Journal of the American Academy of Orthopaedic Surgeons 9:2, pages 71-78.
Crossref
Timothy E. McAlindon. 2001. Primary and Secondary Preventive Nutrition. Primary and Secondary Preventive Nutrition 291 305 .
Louis Lippiello, John Woodward, Robert Karpman & Tarek A. Hammad. (2000) In Vivo Chondroprotection and Metabolic Synergy of Glucosamine and Chondroitin Sulfate. Clinical Orthopaedics and Related Research 381, pages 229-240.
Crossref
John J. Callaghan, Joseph A. Buckwalter & Robert C. SchenckJr.Jr.. (2000) Argument Against Use of Food Additives for Osteoarthritis of the Hip. Clinical Orthopaedics and Related Research 381, pages 88-90.
Crossref
Cynthia J. Meininger, Katherine A. Kelly, Hui Li, Tony E. Haynes & Guoyao Wu. (2000) Glucosamine Inhibits Inducible Nitric Oxide Synthesis. Biochemical and Biophysical Research Communications 279:1, pages 234-239.
Crossref
Roland W. Moskowitz. (2000) Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism 30:2, pages 87-99.
Crossref
A DasJrJr & T.A Hammad. (2000) Efficacy of a combination of FCHG49™ glucosamine hydrochloride, TRH122™ low molecular weight sodium chondroitin sulfate and manganese ascorbate* in the management of knee osteoarthritis. Osteoarthritis and Cartilage 8:5, pages 343-350.
Crossref
Ron McLaughlin. (2000) Management of Chronic Osteoarthritic Pain. Veterinary Clinics of North America: Small Animal Practice 30:4, pages 933-949.
Crossref
Jeffrey C. Delafuente. (2000) GLUCOSAMINE IN THE TREATMENT OF OSTEOARTHRITIS. Rheumatic Disease Clinics of North America 26:1, pages 1-11.
Crossref
Gerlie C. de los Reyes, Robert T. Koda & Eric J. Lien. 2000. Progress in Drug Research. Progress in Drug Research 81 103 .
M. W. Whitehouse & D. E. Butters. (1999) Non-NSAID over-the-counter (OTC) remedies for arthritis: good, bad or indifferent?. InflammoPharmacology 7:3, pages 227-247.
Crossref
Chris D. Meletis. (1999) Natural Medicine Approaches for the Treatment of Degenerative Arthritis. Alternative and Complementary Therapies 5:3, pages 136-139.
Crossref
Chad L. Deal & Roland W. Moskowitz. (1999) NUTRACEUTICALS AS THERAPEUTIC AGENTS IN OSTEOARTHRITIS. Rheumatic Disease Clinics of North America 25:2, pages 379-395.
Crossref
C. Thomas VangsnessJrJr. (1999) OVERVIEW OF TREATMENT OPTIONS FOR ARTHRITIS IN THE ACTIVE PATIENT. Clinics in Sports Medicine 18:1, pages 1-11.
Crossref
Stephen Holt. (1998) Bone and Joint Health. Alternative and Complementary Therapies 4:3, pages 195-205.
Crossref
Teresa Susanne Barclay, Candy Tsourounis & Gary M McCart. (2016) Glucosamine. Annals of Pharmacotherapy 32:5, pages 574-579.
Crossref
Carlos C da Camara & Gregory V Dowless. (2016) Glucosamine Sulfate for Osteoarthritis. Annals of Pharmacotherapy 32:5, pages 580-587.
Crossref
M.F. McCarty. (1997) Glucosamine may retard atherogenesis by promoting endothelial production of heparan sulfate proteoglycans. Medical Hypotheses 48:3, pages 245-251.
Crossref
M.F. McCarty. (1996) Glucosamine for wound healing. Medical Hypotheses 47:4, pages 273-275.
Crossref
M.F. McCarty. (1994) The neglect of glucosamine as a treatment for osteoarthritis — A personal perspective. Medical Hypotheses 42:5, pages 323-327.
Crossref
K. Miehlke. 1989. Verhandlungen der Deutschen Gesellschaft für Innere Medizin. Verhandlungen der Deutschen Gesellschaft für Innere Medizin 462 471 .
Claudia B. Caputo & Andrew Shaw. 1987. 179 189 .

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