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Expert Opinion on Therapeutic Patents Volume 19, 2009 - Issue 6
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Patent Evaluations

A new class of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitors for the treatment of Gram-negative infections: PCT application WO 2008027466

Gregory D Cuny Senior Director of Medicinal Chemistry, Assistant Professor Brigham & Women's Hospital and Harvard Medical School, Partners Center for Drug Discovery, Laboratory for Drug Discovery in Neurodegeneration, 65 Landsdowne Street, Cambridge, MA 02139, USA +1 617 768 8640; +1 617 768 8606; [email protected]
, PhD
Pages 893-899 | Published online: 08 Apr 2009

Citations (9)

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Dmitrii V. Kalinin & Ralph Holl. (2017) LpxC inhibitors: a patent review (2010-2016). Expert Opinion on Therapeutic Patents 27:11, pages 1227-1250.
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Articles from other publishers (8)

Zhendong Niu, Peng Lei, Yuxi Wang, Jiaxing Wang, Jinlin Yang & Jifa Zhang. (2023) Small molecule LpxC inhibitors against gram-negative bacteria: Advances and future perspectives. European Journal of Medicinal Chemistry 253, pages 115326.
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Sudhir Kumar Pal & Sanjit Kumar. (2023) LpxC (UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase) inhibitors: A long path explored for potent drug design. International Journal of Biological Macromolecules 234, pages 122960.
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Azza Troudi, Jean Marie Pagès & Jean Michel Brunel. (2021) Chemical Highlights Supporting the Role of Lipid A in Efficient Biological Adaptation of Gram-Negative Bacteria to External Stresses. Journal of Medicinal Chemistry 64:4, pages 1816-1834.
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Raivis Žalubovskis & Jean-Yves Winum. (2019) Inhibitors of Selected Bacterial Metalloenzymes. Current Medicinal Chemistry 26:15, pages 2690-2714.
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Chiranjeevi Pasala, Sudheer Kumar Katari, Ravina Madhulitha Nalamolu, Aparna R. Bitla & Umamaheswari Amineni. (2019) Hierarchical-Clustering, Scaffold-Mining Exercises and Dynamics Simulations for Effectual Inhibitors Against Lipid-A Biosynthesis of Helicobacter pylori. Cellular and Molecular Bioengineering 12:3, pages 255-274.
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Magdalena Galster, Marius Löppenberg, Fabian Galla, Frederik Börgel, Oriana Agoglitta, Johannes Kirchmair & Ralph Holl. (2019) Phenylethylene glycol-derived LpxC inhibitors with diverse Zn2+-binding groups. Tetrahedron 75:4, pages 486-509.
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Matthew F. Brown, Usa Reilly, Joseph A. Abramite, Joel T. Arcari, Robert Oliver, Rose A. Barham, Ye Che, Jinshan Michael Chen, Elizabeth M. Collantes, Seung Won Chung, Charlene Desbonnet, Jonathan Doty, Matthew Doroski, Juntyma J. Engtrakul, Thomas M. Harris, Michael Huband, John D. Knafels, Karen L. Leach, Shenping Liu, Anthony Marfat, Andrea Marra, Eric McElroy, Michael Melnick, Carol A. Menard, Justin I. Montgomery, Lisa Mullins, Mark. C. Noe, John O’Donnell, Joseph Penzien, Mark S. Plummer, Loren M. Price, Veerabahu Shanmugasundaram, Christy Thoma, Daniel P. Uccello, Joseph S. Warmus & Donn G. Wishka. (2012) Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections. Journal of Medicinal Chemistry 55:2, pages 914-923.
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Lynn L. Silver. (2011) Challenges of Antibacterial Discovery. Clinical Microbiology Reviews 24:1, pages 71-109.
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