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Expert Opinion on Therapeutic Patents Volume 19, 2009 - Issue 12
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Reviews

TRPA1 modulators in preclinical development

Félix Viana Universidad Miguel Hernández-CSIC, Instituto de Neurociencias, Tenured Reserach Investigator CSIC, Avenida Santiago Ramón y Cajal, s/n. 03550 San Juan de Alicante, Alicante, Spain; Universidad Miguel Hernández, Instituto de Biología Molecular y Celular, Alicante, Av. de la Universidad s/n, Elche, Alicante, Spain +34 966658727; +34 966658758; [email protected]
&
Antonio Ferrer-Montiel Universidad Miguel Hernández-CSIC, Instituto de Neurociencias, Tenured Reserach Investigator CSIC, Avenida Santiago Ramón y Cajal, s/n. 03550 San Juan de Alicante, Alicante, Spain; Universidad Miguel Hernández, Instituto de Biología Molecular y Celular, Alicante, Av. de la Universidad s/n, Elche, Alicante, Spain +34 966658727; +34 966658758; [email protected]
Pages 1787-1799 | Published online: 26 Nov 2009

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Laura Vay, Chunjing Gu & Peter A McNaughton. (2010) Current perspectives on the modulation of thermo-TRP channels: new advances and therapeutic implications. Expert Review of Clinical Pharmacology 3:5, pages 687-704.
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Articles from other publishers (24)

Márcia S. Martins, Isabel F. Almeida, Maria T. Cruz & Emília Sousa. (2023) Chronic pruritus: From pathophysiology to drug design. Biochemical Pharmacology 212, pages 115568.
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JinHeng Lin, Michael Taggart, Lee Borthwick, Andrew Fisher, Malcolm Brodlie, M. Flori Sassano, Robert Tarran & Michael A. Gray. (2021) Acute cigarette smoke or extract exposure rapidly activates TRPA1-mediated calcium influx in primary human airway smooth muscle cells. Scientific Reports 11:1.
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Aurélien Haustrate, Aline Hantute-Ghesquier, Natalia Prevarskaya & V’yacheslav Lehen’kyi. (2019) Monoclonal Antibodies Targeting Ion Channels and Their Therapeutic Potential. Frontiers in Pharmacology 10.
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Félix Viana. (2016) TRPA1 channels: molecular sentinels of cellular stress and tissue damage. The Journal of Physiology 594:15, pages 4151-4169.
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Tom Rouwette, Julia Sondermann, Luca Avenali, David Gomez-Varela & Manuela Schmidt. (2016) Standardized Profiling of The Membrane-Enriched Proteome of Mouse Dorsal Root Ganglia (DRG) Provides Novel Insights Into Chronic Pain. Molecular & Cellular Proteomics 15:6, pages 2152-2168.
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Nieves Fresno, Ruth Pérez-Fernández, Carlos Goicoechea, Ibon Alkorta, Asia Fernández-Carvajal, Roberto de la Torre-Martínez, Susana Quirce, Antonio Ferrer-Montiel, M. Isabel Martín, Pilar Goya & José Elguero. (2014) Adamantyl Analogues of Paracetamol as Potent Analgesic Drugs via Inhibition of TRPA1. PLoS ONE 9:12, pages e113841.
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Ki Jeong Lee, Weiya Wang, Rupa Padaki, Vivian Bi, Cherylene A. Plewa & Narender R. Gavva. (2014) Mouse Monoclonal Antibodies to Transient Receptor Potential Ankyrin 1 Act as Antagonists of Multiple Modes of Channel Activation. Journal of Pharmacology and Experimental Therapeutics 350:2, pages 223-231.
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Junhong Gui, Boyi Liu, Guan Cao, Andrew M. Lipchik, Minervo Perez, Zoltan Dekan, Mehdi Mobli, Norelle L. Daly, Paul F. Alewood, Laurie L. Parker, Glenn F. King, Yufeng Zhou, Sven-Eric Jordt & Michael N. Nitabach. (2014) A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain. Current Biology 24:5, pages 473-483.
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Peter M. Zygmunt & Edward D. Högestätt. 2014. Mammalian Transient Receptor Potential (TRP) Cation Channels. Mammalian Transient Receptor Potential (TRP) Cation Channels 583 630 .
Sharan K. BagalAlan D. BrownPeter J. CoxKiyoyuki OmotoRobert M. OwenDavid C. PrydeBenjamin SiddersSarah E. SkerrattEdward B. StevensR. Ian StorerNigel A. Swain. (2012) Ion Channels as Therapeutic Targets: A Drug Discovery Perspective. Journal of Medicinal Chemistry 56:3, pages 593-624.
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Sonali S. BharateSandip B. Bharate. (2012) Modulation of Thermoreceptor TRPM8 by Cooling Compounds. ACS Chemical Neuroscience 3:4, pages 248-267.
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Raffaele Capasso, Gabriella Aviello, Barbara Romano, Francesca Borrelli, Luciano De Petrocellis, Vincenzo Di Marzo & Angelo A Izzo. (2012) Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables ( Brassicaceae ): evidence for TRPA1-independent effects . British Journal of Pharmacology 165:6, pages 1966-1977.
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Laura Vay, Chunjing Gu & Peter A McNaughton. (2012) The thermo-TRP ion channel family: properties and therapeutic implications. British Journal of Pharmacology 165:4, pages 787-801.
Crossref
Asia Fernández-Carvajal, Gregorio Fernández-Ballester, Isabel Devesa, José Manuel González-Ros & Antonio Ferrer-Montiel. (2011) New Strategies to Develop Novel Pain Therapies: Addressing Thermoreceptors from Different Points of View. Pharmaceuticals 5:1, pages 16-48.
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Maria G. Belvisi, Eric Dubuis & Mark A. Birrell. (2011) Transient Receptor Potential A1 Channels. Chest 140:4, pages 1040-1047.
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Antti Pertovaara & Ari Koivisto. (2011) TRPA1 ion channel in the spinal dorsal horn as a therapeutic target in central pain hypersensitivity and cutaneous neurogenic inflammation. European Journal of Pharmacology 666:1-3, pages 1-4.
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Pierluigi Valente, Asia Fernández-Carvajal, María Camprubí-Robles, Ana Gomis, Susana Quirce, Félix Viana, Gregorio Fernández-Ballester, José M. González-Ros, Carlos Belmonte, Rosa Planells-Cases & Antonio Ferrer-Montiel. (2011) Membrane‐tethered peptides patterned after the TRP domain (TRPducins) selectively inhibit TRPV1 channel activity. The FASEB Journal 25:5, pages 1628-1640.
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Félix Viana. (2010) Chemosensory Properties of the Trigeminal System. ACS Chemical Neuroscience 2:1, pages 38-50.
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Irina Vetter & Richard J. Lewis. 2011. Transient Receptor Potential Channels. Transient Receptor Potential Channels 41 85 .
Harrie J. M. Gijsen, Didier Berthelot, Mirko Zaja, Bert Brône, Ivo Geuens & Marc Mercken. (2010) Analogues of Morphanthridine and the Tear Gas Dibenz[ b , f ][1,4]oxazepine (CR) as Extremely Potent Activators of the Human Transient Receptor Potential Ankyrin 1 (TRPA1) Channel . Journal of Medicinal Chemistry 53:19, pages 7011-7020.
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Pier Giovanni Baraldi, Delia Preti, Serena Materazzi & Pierangelo Geppetti. (2010) Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents. Journal of Medicinal Chemistry 53:14, pages 5085-5107.
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Jason C Rech, William A Eckert, Michael P Maher, Tue Banke, Anindya Bhattacharya & Alan D Wickenden. (2010) Recent advances in the biology and medicinal chemistry of TRPA1. Future Medicinal Chemistry 2:5, pages 843-858.
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Paul J Wrigley, Hyo-Jin Jeong & Christopher W Vaughan. (2010) Dissociation of μ- and δ-opioid Inhibition of Glutamatergic Synaptic Transmission in Superficial Dorsal Horn. Molecular Pain 6, pages 1744-8069-6-71.
Crossref
Rajagopal Bakthavatchalam & S. David Kimball. 2010. 37 53 .

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