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Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases

, PhD & , PhD
Pages 1-18 | Published online: 20 Dec 2009

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Maroula G. Kokotou, Dimitris Limnios, Aikaterini Nikolaou, Anastasia Psarra & George Kokotos. (2017) Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016). Expert Opinion on Therapeutic Patents 27:2, pages 217-225.
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Victoria Magrioti & George Kokotos. (2013) Phospholipase A2 inhibitors for the treatment of inflammatory diseases: a patent review (2010 – present). Expert Opinion on Therapeutic Patents 23:3, pages 333-344.
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K. Roebrock, M. Wolf, S. Bovens, M. Lehr & C. Sunderkötter. (2012) Inhibition of benzalkonium chloride-induced skin inflammation in mice by an indol-1-ylpropan-2-one inhibitor of cytosolic phospholipase A2α. British Journal of Dermatology 166:2, pages 306-316.
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Cécile Fèvre, Sandrine Bellenger, Anne-Sophie Pierre, Mélaine Minville, Jérôme Bellenger, Joseph Gresti, Mickaël Rialland, Michel Narce & Christian Tessier. (2011) The metabolic cascade leading to eicosanoid precursors – desaturases, elongases, and phospholipases A2 – is altered in Zucker fatty rats. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1811:6, pages 409-417.
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Jeffrey M CraftDennis Hallahan. (2011) Towards novel radiosensitizing agents: the role of cytosolic PLA2α in combined modality cancer therapy. Future Medicinal Chemistry 3:7, pages 835-843.
Crossref
Diana Gaspar, Marlene Lúcio, Sandra Rocha, J.L.F. Costa Lima & Salette Reis. (2011) Changes in PLA2 activity after interacting with anti-inflammatory drugs and model membranes: evidence for the involvement of tryptophan residues. Chemistry and Physics of Lipids 164:4, pages 292-299.
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Stefan Zahov, Andreas Drews, Mark Hess, Alwine Schulze Elfringhoff & Matthias Lehr. (2011) 1‐(3‐Biaryloxy‐2‐oxopropyl)indole‐5‐carboxylic Acids and Related Compounds as Dual Inhibitors of Human Cytosolic Phospholipase A 2 α and Fatty Acid Amide Hydrolase . ChemMedChem 6:3, pages 544-549.
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Martina Kaptur, Alwine Schulze Elfringhoff & Matthias Lehr. (2011) Structure–activity relationship studies on 1-(5-carboxyindol-1-yl)-propan-2-one inhibitors of human cytosolic phospholipase A2α: Variation of the activated ketone moiety. Bioorganic & Medicinal Chemistry Letters 21:6, pages 1773-1776.
Crossref
Young Man Lee. (2011) A Study on the Mechanism of Immunomodulating Effects of Moxifloxacin in Oleic Acid-Induced Acute Lung Injury. Tuberculosis and Respiratory Diseases 71:2, pages 97.
Crossref
Hitoshi NakayamaYuka Morita, Hirohiko KimuraKeiichi Ishihara, Satoshi Akiba & Jun'ichi Uenishi. (2011) Synthesis of N-(Trifluoromethyl-2-pyridinyl)arenesulfonamides as an Inhibitor of Secretory Phospholipase A2. Chemical and Pharmaceutical Bulletin 59:6, pages 783-786.
Crossref
Varnavas D. Mouchlis, Victoria Magrioti, Efrosini Barbayianni, Nathan Cermak, Rob C. Oslund, Thomas M. Mavromoustakos, Michael H. Gelb & George Kokotos. (2011) Inhibition of secreted phospholipases A2 by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations. Bioorganic & Medicinal Chemistry 19:2, pages 735-743.
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Shivaprasad H. Venkatesha, Brian M. Berman & Kamal D. Moudgil. (2011) Herbal medicinal products target defined biochemical and molecular mediators of inflammatory autoimmune arthritis. Bioorganic & Medicinal Chemistry 19:1, pages 21-29.
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Stefanie Bovens, Alwine Schulze Elfringhoff, Martina Kaptur, Dirk Reinhardt, Michael Schäfers & Matthias Lehr. (2010) 1-(5-Carboxyindol-1-yl)propan-2-one Inhibitors of Human Cytosolic Phospholipase A 2 α: Effect of Substituents in Position 3 of the Indole Scaffold on Inhibitory Potency, Metabolic Stability, Solubility, and Bioavailability . Journal of Medicinal Chemistry 53:23, pages 8298-8308.
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Peter J. Barnes. (2010) New therapies for asthma: is there any progress?. Trends in Pharmacological Sciences 31:7, pages 335-343.
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Jinmei Wang & Miriam Kolko. (2010) Phospholipases A2 in ocular homeostasis and diseases. Biochimie 92:6, pages 611-619.
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