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Novel TACE inhibitors in drug discovery: a review of patented compounds

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Pages 31-57 | Published online: 20 Dec 2009

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Prashant R. Murumkar, Rahul B. Ghuge, Monica Chauhan, Rahul R. Barot, Sharmishtha Sorathiya, Kailash M. Choudhary, Karan D. Joshi & Mange Ram Yadav. (2020) Recent developments and strategies for the discovery of TACE inhibitors. Expert Opinion on Drug Discovery 15:7, pages 779-801.
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A.P. Sarkate, P.R. Murumkar, D.K. Lokwani, A.D. Kandhare, S.L. Bodhankar, D.B. Shinde & K.G. Bothara. (2015) Design of selective TACE inhibitors using molecular docking studies: Synthesis and preliminary evaluation of anti-inflammatory and TACE inhibitory activity. SAR and QSAR in Environmental Research 26:11, pages 905-923.
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Jorge Luis Sotelo, Dominique Musselman & Charles Nemeroff. (2014) The biology of depression in cancer and the relationship between depression and cancer progression. International Review of Psychiatry 26:1, pages 16-30.
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Prashant R Murumkar, Rajani Giridhar & Mange Ram Yadav. (2013) Novel methods and strategies in the discovery of TACE inhibitors. Expert Opinion on Drug Discovery 8:2, pages 157-181.
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Fabio Penna, Valerio G Minero, Domiziana Costamagna, Gabriella Bonelli, Francesco M Baccino & Paola Costelli. (2010) Anti-cytokine strategies for the treatment of cancer-related anorexia and cachexia. Expert Opinion on Biological Therapy 10:8, pages 1241-1250.
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Prashant R. Murumkar, Mayank Kumar Sharma, Pradeep Gupta, Niyati M. Patel & Mange Ram Yadav. (2023) Selection of Suitable Protein Structure from Protein Data Bank: An Important Step in Structure-based Drug Design Studies. Mini-Reviews in Medicinal Chemistry 23:3, pages 246-264.
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Stefano Pluda, Ylenia Mazzocato & Alessandro Angelini. (2021) Peptide-Based Inhibitors of ADAM and ADAMTS Metalloproteinases. Frontiers in Molecular Biosciences 8.
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Sahin Sultana & Biswadev Bishayi. (2020) Potential anti-arthritic and anti-inflammatory effects of TNF-α processing inhibitor-1 (TAPI-1): A new approach to the treatment of S. aureus arthritis. Immunobiology 225:2, pages 151887.
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Marina Badenes, Abdulbasit Amin, Ismael González-García, Inês Félix, Emma Burbridge, Miguel Cavadas, Francisco José Ortega, Érika de Carvalho, Pedro Faísca, Stefania Carobbio, Elsa Seixas, Dora Pedroso, Ana Neves-Costa, Luís F. Moita, José Manuel Fernández-Real, António Vidal-Puig, Ana Domingos, Miguel López & Colin Adrain. (2020) Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis. Molecular Metabolism 31, pages 67-84.
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Michelle Heib, Stefan Rose-John & Dieter Adam. 2020. Cell Death Regulation In Health And Disease - Part C. Cell Death Regulation In Health And Disease - Part C 83 152 .
Charles J. Malemud. (2019) Inhibition of MMPs and ADAM/ADAMTS. Biochemical Pharmacology 165, pages 33-40.
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Hainiang Liu, Haoren Wang, Dong Cheng, Qinfu Wang, Zuowei Pei, Ning Zhu, Weiyi Fang & Qin Yu. (2019) Potential role of a disintegrin and metalloproteinase-17 (ADAM17) in age-associated ventricular remodeling of rats. RSC Advances 9:25, pages 14321-14330.
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Ioanna Oikonomidi, Emma Burbridge, Miguel Cavadas, Graeme Sullivan, Blanka Collis, Heike Naegele, Danielle Clancy, Jana Brezinova, Tianyi Hu, Andrea Bileck, Christopher Gerner, Alfonso Bolado, Alex von Kriegsheim, Seamus J Martin, Florian Steinberg, Kvido Strisovsky & Colin Adrain. (2018) iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE. eLife 7.
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Peter Dobranowski, Fuqiang Ban, Alberto Contreras-Sanz, Artem Cherkasov & Peter C. Black. (2018) Perspectives on the discovery of NOTCH2-specific inhibitors. Chemical Biology & Drug Design 91:3, pages 691-706.
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Jean-Guy Boiteau, Gilles Ouvry, Jean-Marie Arlabosse, Stéphanie Astri, Audrey Beillard, Yushma Bhurruth-Alcor, Laetitia Bonnary, Claire Bouix-Peter, Karine Bouquet, Marilyne Bourotte, Isabelle Cardinaud, Catherine Comino, Benoît Deprez, Denis Duvert, Angélique Féret, Feriel Hacini-Rachinel, Craig S. Harris, Anne-Pascale Luzy, Arnaud Mathieu, Corinne Millois, Nicolas Orsini, Jonathan Pascau, Artur Pinto, David Piwnica, Gaëlle Polge, Arnaud Reitz, Kevin Reversé, Nicolas Rodeville, Patricia Rossio, Delphine Spiesse, Samuel Tabet, Nathalie Taquet, Loïc Tomas, Emmanuel Vial & Laurent F. Hennequin. (2018) Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis. Bioorganic & Medicinal Chemistry 26:4, pages 945-956.
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Bezawit W. Megra, Eliseo A. Eugenin & Joan W. Berman. (2017) The Role of Shed PrPc in the Neuropathogenesis of HIV Infection. The Journal of Immunology 199:1, pages 224-232.
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Gilles Ouvry, Yaël Berton, Yushma Bhurruth-Alcor, Laetitia Bonnary, Claire Bouix-Peter, Karine Bouquet, Marilyne Bourotte, Sandrine Chambon, Catherine Comino, Benoît Deprez, Denis Duvert, Gwenaëlle Duvert, Feriel Hacini-Rachinel, Craig S. Harris, Anne-Pascale Luzy, Arnaud Mathieu, Corinne Millois, Jonathan Pascau, Artur Pinto, Gaëlle Polge, Arnaud Reitz, Kevin Reversé, Carine Rosignoli, Nathalie Taquet & Laurent F. Hennequin. (2017) Identification of novel TACE inhibitors compatible with topical application. Bioorganic & Medicinal Chemistry Letters 27:8, pages 1848-1853.
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Zhen-Li Wang, Shuai Gao, Lei Li, Xin-You Li, Shu-Ling Huan & Kai Wang. (2016) Demethylation of tumor necrosis factor-α converting enzyme predicts poor prognosis in acute-on-chronic hepatitis B liver failure. Clinics and Research in Hepatology and Gastroenterology 40:4, pages 457-464.
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Jennifer C. JonesShelly RustagiPeter J. Dempsey. (2016) ADAM Proteases and Gastrointestinal Function. Annual Review of Physiology 78:1, pages 243-276.
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Anna M. Knapinska, Daniela Dreymuller, Andreas Ludwig, Lyndsay Smith, Vladislav Golubkov, Anjum Sohail, Rafael Fridman, Marc Giulianotti, Travis M. LaVoi, Richard A. Houghten, Gregg B. Fields & Dmitriy Minond. (2015) SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A D isintegrin A nd M etalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes . Journal of Medicinal Chemistry 58:15, pages 5808-5824.
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Renzhong Li, Lalita Uttarwar, Bo Gao, Martine Charbonneau, Yixuan Shi, John S.D. Chan, Claire M. Dubois & Joan C. Krepinsky. (2015) High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial Cells. Journal of Biological Chemistry 290:35, pages 21603-21614.
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Martina Banchelli, Carlo Guardiani, Robert B. Sandberg, Stefano Menichetti, Piero Procacci & Gabriella Caminati. (2015) Media effects in modulating the conformational equilibrium of a model compound for tumor necrosis factor converting enzyme inhibition. Journal of Molecular Structure 1091, pages 65-73.
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Chung-Hang Leung, Li-Juan Liu, Lihua Lu, Bingyong He, Daniel W. J. Kwong, Chun-Yuen Wong & Dik-Lung Ma. (2015) A metal-based tumour necrosis factor-alpha converting enzyme inhibitor. Chemical Communications 51:19, pages 3973-3976.
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Li-Juan Liu, Ka-Ho Leung, Sheng Lin, Daniel Shiu-Hin Chan, Dewi Susanti, Weidong Rao, Philip Wai Hong Chan, Dik-Lung Ma & Chung-Hang Leung. (2015) Pharmacophore modeling for the identification of small-molecule inhibitors of TACE. Methods 71, pages 92-97.
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Prashant R. Murumkar, Mayank Kumar Sharma, Rajani Giridhar & Mange Ram Yadav. (2014) Virtual screening-based identification of lead molecules as selective TACE inhibitors. Medicinal Chemistry Research 24:1, pages 226-244.
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Massimo Girardis & Andrea Cossarizza. (2013) A Janus role for MerTK in the outcome of septic shock. Intensive Care Medicine 39:12, pages 2217-2219.
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Prashant R. Murumkar, Mayank Kumar Sharma, Anurag C. Shinde & Kailash G. Bothara. (2013) Three-dimensional quantitative structure–activity relationship CoMFA/CoMSIA on pyrrolidine-based tartrate diamides as TACE inhibitors. Medicinal Chemistry Research 22:9, pages 4192-4201.
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Liu Sen, Dong Pei, Song Liu & Xiao Hong Ma. (2013) A Computational Model for Predicting ADAM17 Substrate Specificity. Advanced Materials Research 740, pages 525-529.
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Gaetano Zizzo, Justus Guerrieri, Lindsay M Dittman, Joan T Merrill & Philip L Cohen. (2013) Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity. Arthritis Research & Therapy 15:6, pages R212.
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Fabio Penna, Gabriella Bonelli, Francesco M. Baccino & Paola Costelli. 2013. Anorexia. Anorexia 271 299 .
Gillian Murphy. 2013. Handbook of Proteolytic Enzymes. Handbook of Proteolytic Enzymes 1126 1130 .
Bonnie F. Sloane, Karin List, Barbara Fingleton & Lynn Matrisian. 2013. Proteases: Structure and Function. Proteases: Structure and Function 491 550 .
Dmitriy Minond, Mare Cudic, Nina Bionda, Marc Giulianotti, Laura Maida, Richard A. Houghten & Gregg B. Fields. (2012) Discovery of Novel Inhibitors of a Disintegrin and Metalloprotease 17 (ADAM17) Using Glycosylated and Non-glycosylated Substrates. Journal of Biological Chemistry 287:43, pages 36473-36487.
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Ebrahim Haroon, Charles L Raison & Andrew H Miller. (2011) Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior. Neuropsychopharmacology 37:1, pages 137-162.
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Dongsheng Cai & Tiewen Liu. (2011) Hypothalamic inflammation: a double-edged sword to nutritional diseases. Annals of the New York Academy of Sciences 1243:1, pages E1-E39.
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Paul Saftig & Karina Reiss. (2011) The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?. European Journal of Cell Biology 90:6-7, pages 527-535.
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Carmen Berasain, María Ujue Latasa, Raquel Urtasun, Saioa Goñi, María Elizalde, Oihane Garcia-Irigoyen, María Azcona, Jesús Prieto & Matías A. Ávila. (2011) Epidermal Growth Factor Receptor (EGFR) Crosstalks in Liver Cancer. Cancers 3:2, pages 2444-2461.
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L.J. Mark Cross & Michael A. Matthay. (2011) Biomarkers in Acute Lung Injury: Insights into the Pathogenesis of Acute Lung Injury. Critical Care Clinics 27:2, pages 355-377.
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Swaminathan Sethu & Alirio J. Melendez. (2010) New developments on the TNFα-mediated signalling pathways. Bioscience Reports 31:1, pages 63-76.
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Rosamaria Lappano & Marcello Maggiolini. (2010) G protein-coupled receptors: novel targets for drug discovery in cancer. Nature Reviews Drug Discovery 10:1, pages 47-60.
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Steven De Jonghe, Arnaud Marchand, Ling-Jie Gao, Agnes Calleja, Eva Cuveliers, Ilse Sienaert, Jean Herman, Gavin Clydesdale, Hassane Sefrioui, Yuan Lin, Wolfgang Pfleiderer, Mark Waer & Piet Herdewijn. (2011) Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters 21:1, pages 145-149.
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Prashant Revan Murumkar, Vishal Prakash Zambre & Mange Ram Yadav. (2010) Development of predictive pharmacophore model for in silico screening, and 3D QSAR CoMFA and CoMSIA studies for lead optimization, for designing of potent tumor necrosis factor alpha converting enzyme inhibitors. Journal of Computer-Aided Molecular Design 24:2, pages 143-156.
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