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Expert Opinion on Therapeutic Patents Volume 12, 2002 - Issue 1
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Review

The inhibition of metalloproteinases to treat osteoarthritis: reality and new perspectives

Y Henrotin Bone and Cartilage Research Unit (WHO Collaborating Center for Public Aspects of Osteoarticular Disorders), CHU Sart-Tilman, 4000 Liège, Belgium. [email protected]
,
C Sanchez Bone and Cartilage Research Unit (WHO Collaborating Center for Public Aspects of Osteoarticular Disorders), CHU Sart-Tilman, 4000 Liège, Belgium. [email protected]
&
J-Y Reginster Bone and Cartilage Research Unit (WHO Collaborating Center for Public Aspects of Osteoarticular Disorders), CHU Sart-Tilman, 4000 Liège, Belgium. [email protected]
Pages 29-43 | Published online: 25 Feb 2005

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Read on this site (4)

Chris T Derk. (2005) Sjogren’s syndrome: models of pathogenesis and treatment targets. Expert Opinion on Therapeutic Patents 15:11, pages 1587-1594.
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Eli Breuer, Julia Frant & Reuven Reich. (2005) Recent non-hydroxamate matrix metalloproteinase inhibitors. Expert Opinion on Therapeutic Patents 15:3, pages 253-269.
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. (2004) Cyclic sulfone hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α-converting enzymes. Expert Opinion on Therapeutic Patents 14:1, pages 121-124.
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Ian M Clark & Andrew E Parker. (2003) Metalloproteinases: their role in arthritis and potential as therapeutic targets. Expert Opinion on Therapeutic Targets 7:1, pages 19-34.
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Articles from other publishers (11)

Yun-A Shin, Min-Hwa Suk, Hee-Seung Jang & Hye-Jung Choi. (2017) Short-term effects of Theracurmin dose and exercise type on pain, walking ability, and muscle function in patients with knee osteoarthritis. Journal of Exercise Rehabilitation 13:6, pages 684-692.
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GUANGWEN WU, HUAILING FAN, YUANPENG HUANG, CHUNSONG ZHENG, JINXIA YE & XIANXIANG LIU. (2014) Duhuo Jisheng Decoction-containing serum promotes proliferation of interleukin-1β-induced chondrocytes through the p16-cyclin D1/CDK4-Rb pathway. Molecular Medicine Reports 10:5, pages 2525-2534.
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Christelle Sanchez, Laurence Pesesse, Odile Gabay, Jean-Pierre Delcour, Philippe Msika, Caroline Baudouin & Yves E. Henrotin. (2012) Regulation of subchondral bone osteoblast metabolism by cyclic compression. Arthritis & Rheumatism 64:4, pages 1193-1203.
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JungKyu Kim & SeongKyu Roh. (2009) Effect of Nordic walking and Aquatic exercise on Oxidative stress and Pain in women with Degenerative Arthritis. Exercise Science 18:4, pages 549-558.
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Jürgen Steinmeyer & Yrjö T. Konttinen. (2006) Oral treatment options for degenerative joint disease—presence and future. Advanced Drug Delivery Reviews 58:2, pages 168-211.
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Yves Henrotin, Christelle Sanchez & Marc Balligand. (2005) Pharmaceutical and nutraceutical management of canine osteoarthritis: Present and future perspectives. The Veterinary Journal 170:1, pages 113-123.
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Heike A. Wieland, Martin Michaelis, Bernhard J. Kirschbaum & Karl A. Rudolphi. (2005) Osteoarthritis — an untreatable disease?. Nature Reviews Drug Discovery 4:4, pages 331-344.
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Lawrence A. Reiter, Ralph P. Robinson, Kim F. McClure, Christopher S. Jones, Matthew R. Reese, Peter G. Mitchell, Ivan G. Otterness, Marcia L. Bliven, Jennifer Liras, Santo R. Cortina, Kathleen M. Donahue, James D. Eskra, Richard J. Griffiths, Mary E. Lame, Arturo Lopez-Anaya, Gary J. Martinelli, Shunda M. McGahee, Sue A. Yocum, Lori L. Lopresti-Morrow, Lisa M. Tobiassen & Marcie L. Vaughn-Bowser. (2004) Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorganic & Medicinal Chemistry Letters 14:13, pages 3389-3395.
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Robert J. Cherney, Ruowei Mo, Dayton T. Meyer, Karl D. Hardman, Rui-Qin Liu, Maryanne B. Covington, Mingxin Qian, Zelda R. Wasserman, David D. Christ, James M. Trzaskos, Robert C. Newton & Carl P. Decicco. (2004) Sultam Hydroxamates as Novel Matrix Metalloproteinase Inhibitors. Journal of Medicinal Chemistry 47:12, pages 2981-2983.
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Lawrence A. Reiter, Peter G. Mitchell, Gary J. Martinelli, Lori L. Lopresti-Morrow, Sue A. Yocum & James D. Eskra. (2003) Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3. Bioorganic & Medicinal Chemistry Letters 13:14, pages 2331-2336.
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Christelle Sanchez, Marianne Mathy-Hartert, Michelle A Deberg, Herve Ficheux, Jean-Yves L Reginster & Yves E Henrotin. (2003) Effects of rhein on human articular chondrocytes in alginate beads. Biochemical Pharmacology 65:3, pages 377-388.
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