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Miscellaneous

Human peptide transporters: therapeutic applications

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Pages 1329-1350 | Published online: 25 Feb 2005

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Carsten Uhd Nielsen, Jon Våbenø, Rikke Andersen, Birger Brodin & Bente Steffansen. (2005) Recent advances in therapeutic applications of human peptide transporters. Expert Opinion on Therapeutic Patents 15:2, pages 153-166.
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Articles from other publishers (45)

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Jia-An Liu, Xiao-Peng Guo, Shuang Liang, Fei An, Hong-Yan Shen & You-Jun Xu. (2015) Regioselective synthesis of 5′-amino acid esters of some nucleosides via orthogonal protecting protocol. Tetrahedron 71:9, pages 1409-1412.
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Hanne Mørck Nielsen. 2014. Mucosal Delivery of Biopharmaceuticals. Mucosal Delivery of Biopharmaceuticals 99 122 .
Youxi Zhang, Jin Sun, Yikun Gao, Ling Jin, Youjun Xu, He Lian, Yongbing Sun, Yinghua Sun, Jianyu Liu, Rui Fan, Tianhong Zhang & Zhonggui He. (2013) A Carrier-Mediated Prodrug Approach To Improve the Oral Absorption of Antileukemic Drug Decitabine. Molecular Pharmaceutics 10:8, pages 3195-3202.
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Katharina Mertsch. 2013. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays 745 777 .
Bente Steffansen, Carsten Uhd Nielsen & Birger Brodin. 2013. Transporters in Drug Development. Transporters in Drug Development 1 22 .
Stephanie Haller, Franz Schuler, Stanley E. Lazic, Dalila Bachir-Cherif, Stefanie D. Krämer, Neil J. Parrott, Guido Steiner & Sara Belli. (2012) Expression Profiles of Metabolic Enzymes and Drug Transporters in the Liver and along the Intestine of Beagle Dogs. Drug Metabolism and Disposition 40:8, pages 1603-1611.
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Mark J. Macielag. 2012. Antibiotic Discovery and Development. Antibiotic Discovery and Development 793 820 .
Zhongtian Yan, Jin Sun, Yannan Chang, Yanhua Liu, Qiang Fu, Youjun Xu, Yongbing Sun, Xiaohui Pu, Youxi Zhang, Yongkui Jing, Shiliang Yin, Meng Zhu, Yongjun Wang & Zhonggui He. (2011) Bifunctional Peptidomimetic Prodrugs of Didanosine for Improved Intestinal Permeability and Enhanced Acidic Stability: Synthesis, Transepithelial Transport, Chemical Stability and Pharmacokinetics. Molecular Pharmaceutics 8:2, pages 319-329.
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Diana Højmark Omkvist, Dennis Jespersen Trangbæk, Jemma Mildon, James S. Paine, Birger Brodin, Mikael Begtrup & Carsten Uhd Nielsen. (2011) Affinity and translocation relationships via hPEPT1 of H-Xaa-Ser-OH dipeptides: Evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs. European Journal of Pharmaceutics and Biopharmaceutics 77:2, pages 327-331.
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Diana Højmark Omkvist, Birger Brodin & Carsten Uhd Nielsen. (2010) Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen. British Journal of Pharmacology 161:8, pages 1793-1805.
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Diana Højmark Omkvist, Simon Birksø Larsen, Carsten Uhd Nielsen, Bente Steffansen, Lars Olsen, Flemming Steen Jørgensen & Birger Brodin. (2010) A Quantitative Structure–Activity Relationship for Translocation of Tripeptides via the Human Proton-Coupled Peptide Transporter, hPEPT1 (SLC15A1). The AAPS Journal 12:3, pages 385-396.
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S Frølund, OC Marquez, M Larsen, B Brodin & CU Nielsen. (2010) δ‐Aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1). British Journal of Pharmacology 159:6, pages 1339-1353.
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Matthias Brandsch, Ilka Knütter & Eva Bosse-Doenecke. (2008) Pharmaceutical and pharmacological importance of peptide transporters. Journal of Pharmacy and Pharmacology 60:5, pages 543-585.
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Hui-Po Wang & Chun-Li Wang. (2009) Biological Transporters as Targets for New Drug Design. Journal of Experimental & Clinical Medicine 1:1, pages 31-38.
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David R. FosterJeffrey P. GonzalesGordon L. AmidonLynda S. Welage. (2009) Intestinal Dipeptide Absorption Is Preserved During Thermal Injury and Cytokine Treatment. Journal of Parenteral and Enteral Nutrition 33:5, pages 520-528.
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Stefan Balaz. (2009) Modeling Kinetics of Subcellular Disposition of Chemicals. Chemical Reviews 109:5, pages 1793-1899.
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Yongbing Sun, Jin Sun, Shiliang Shi, Yongkui Jing, Shiliang Yin, Ying Chen, Gang Li, Youjun Xu & Zhonggui He. (2008) Synthesis, Transport and Pharmacokinetics of 5′-Amino Acid Ester Prodrugs of 1-β- d -Arabinofuranosylcytosine . Molecular Pharmaceutics 6:1, pages 315-325.
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Pascale Anderle & Carsten U. Nielsen. 2008. Drug Bioavailability. Drug Bioavailability 221 276 .
Helle Bach Søndergaard, Birger Brodin & Carsten Uhd Nielsen. (2007) hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3. Pflügers Archiv - European Journal of Physiology 456:3, pages 611-622.
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Fujun Li, Hans Maag & Tom Alfredson. (2008) Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting. Journal of Pharmaceutical Sciences 97:3, pages 1109-1134.
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Simon Birksø Larsen, Flemming Steen Jørgensen & Lars Olsen. (2007) QSAR Models for the Human H + /Peptide Symporter, hPEPT1:  Affinity Prediction Using Alignment-Independent Descriptors . Journal of Chemical Information and Modeling 48:1, pages 233-241.
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Rajinder K. Bhardwaj, Dea R. Herrera-Ruiz, Yan Xu, Stephen M. Carl, Thomas J. Cook, Nicholi Vorsa & Gregory T. Knipp. 2008. Biopharmaceutics Applications in Drug Development. Biopharmaceutics Applications in Drug Development 175 261 .
Karina Thorn, Rikke Andersen, Jon Christensen, Palle Jakobsen, Carsten Uhd Nielsen, Bente Steffansen & Mikael Begtrup. (2007) Design, Synthesis, and Evaluation of Tripeptidic Promoieties Targeting the Intestinal Peptide Transporter hPEPT1. ChemMedChem 2:4, pages 479-487.
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Jurre Kamphorst, Lourdes Cucurull‐Sanchez & Barry Jones. (2007) A performance evaluation of multiple classification models of human PEPT1 inhibitors and non‐inhibitors. QSAR & Combinatorial Science 26:2, pages 220-226.
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Xiaozhong Fu, Saihong Jiang, Chuan Li, Jian Xin, Yushe Yang & Ruyun Ji. (2007) Design and synthesis of novel bis(l-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activity. Bioorganic & Medicinal Chemistry Letters 17:2, pages 465-470.
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A. Biegel, I. Knütter, B. Hartrodt, S. Gebauer, S. Theis, P. Luckner, G. Kottra, M. Rastetter, K. Zebisch, I. Thondorf, H. Daniel, K. Neubert & M. Brandsch. (2006) The renal type H+/peptide symporter PEPT2: structure-affinity relationships. Amino Acids 31:2, pages 137-156.
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M. Brandsch. (2006) Transport of L-proline, L-proline-containing peptides and related drugs at mammalian epithelial cell membranes. Amino Acids 31:2, pages 119-136.
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Balvinder S. Vig, Terry R. Stouch, Julita K. Timoszyk, Yong Quan, Doris A. Wall, Ronald L. Smith & Teresa N. Faria. (2006) Human PEPT1 Pharmacophore Distinguishes between Dipeptide Transport and Binding. Journal of Medicinal Chemistry 49:12, pages 3636-3644.
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Katharina Mertsch. 2006. Drug Discovery and Evaluation. Drug Discovery and Evaluation 437 459 .
Bente Steffansen, Carsten Uhd Nielsen & Sven Frokjaer. (2005) Delivery aspects of small peptides and substrates for peptide transporters. European Journal of Pharmaceutics and Biopharmaceutics 60:2, pages 241-245.
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Xueqin Song, Philip L. Lorenzi, Christopher P. Landowski, Balvinder S. Vig, John M. Hilfinger & Gordon L. Amidon. (2005) Amino Acid Ester Prodrugs of the Anticancer Agent Gemcitabine:  Synthesis, Bioconversion, Metabolic Bioevasion, and hPEPT1-Mediated Transport. Molecular Pharmaceutics 2:2, pages 157-167.
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Jon Våbenø, Carsten Uhd Nielsen, Bente Steffansen, Tore Lejon, Ingebrigt Sylte, Flemming Steen Jørgensen & Kristina Luthman. (2005) Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted prodrugs. Bioorganic & Medicinal Chemistry 13:6, pages 1977-1988.
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Xueqin Song, Balvinder S. Vig, Philip L. Lorenzi, John C. Drach, Leroy B. Townsend & Gordon L. Amidon. (2005) Amino Acid Ester Prodrugs of the Antiviral Agent 2-Bromo-5,6-dichloro-1-(β- d -ribofuranosyl)benzimidazole as Potential Substrates of hPEPT1 Transporter . Journal of Medicinal Chemistry 48:4, pages 1274-1277.
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Julia Pinsonneault, Carsten Uhd Nielsen & Wolfgang Sadée. (2004) Genetic Variants of the Human H + /Dipeptide Transporter PEPT2: Analysis of Haplotype Functions . Journal of Pharmacology and Experimental Therapeutics 311:3, pages 1088-1096.
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Jon Våbenø, Carsten Uhd Nielsen, Truls Ingebrigtsen, Tore Lejon, Bente Steffansen & Kristina Luthman. (2004) Dipeptidomimetic Ketomethylene Isosteres as Pro-moieties for Drug Transport via the Human Intestinal Di-/Tripeptide Transporter hPEPT1:  Design, Synthesis, Stability, and Biological Investigations. Journal of Medicinal Chemistry 47:19, pages 4755-4765.
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Jana Neumann, Mandy Bruch, Sabine Gebauer & Matthias Brandsch. (2004) Transport of the phosphonodipeptide alafosfalin by the H + /peptide cotransporters PEPT1 and PEPT2 in intestinal and renal epithelial cells . European Journal of Biochemistry 271:10, pages 2012-2017.
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Jon Våbenø, Tore Lejon, Carsten Uhd Nielsen, Bente Steffansen, Weiqing Chen, Hui Ouyang, Ronald T. Borchardt & Kristina Luthman. (2004) Phe-Gly Dipeptidomimetics Designed for the Di-/Tripeptide Transporters PEPT1 and PEPT2:  Synthesis and Biological Investigations. Journal of Medicinal Chemistry 47:4, pages 1060-1069.
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Teresa N. Faria, Julita K. Timoszyk, Terry R. Stouch, Balvinder S. Vig, Christopher P. Landowski, Gordon L. Amidon, C. David Weaver, Doris A. Wall & Ronald L. Smith. (2003) A Novel High-Throughput PepT1 Transporter Assay Differentiates between Substrates and Antagonists. Molecular Pharmaceutics 1:1, pages 67-76.
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Bente Steffansen, Carsten Uhd Nielsen, Birger Brodin, André Huss Eriksson, Rikke Andersen & Sven Frokjaer. (2004) Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption. European Journal of Pharmaceutical Sciences 21:1, pages 3-16.
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Matthias Brandsch, Ilka Knütter & Frederick H. Leibach. (2004) The intestinal H+/peptide symporter PEPT1: structure–affinity relationships. European Journal of Pharmaceutical Sciences 21:1, pages 53-60.
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