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Abdul
M. Rasheed, Rambabu Namala, Narendra Manne, Sreelatha Vanjivaka, Ravi Dhamjewar & Gopalan Balasubramanian. (2008) Concise and Efficient Synthesis of Highly Potent and Selective Dipeptidyl Peptidase II Inhibitors. Synthetic Communications 38:2, pages 162-169.
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Koen Augustyns, Pieter Van der Veken & Achiel Haemers. (2005) Inhibitors of proline-specific dipeptidyl peptidases: DPP IV inhibitors as a novel approach for the treatment of Type 2 diabetes. Expert Opinion on Therapeutic Patents 15:10, pages 1387-1407.
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Rolf Mentlein. (2005) Therapeutic assessment of glucagon-like peptide-1 agonists compared with dipeptidyl peptidase IV inhibitors as potential antidiabetic drugs. Expert Opinion on Investigational Drugs 14:1, pages 57-64.
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Daniela Istrate & Luminita Crisan. (2022) Natural Compounds as DPP-4 Inhibitors: 3D-Similarity Search, ADME Toxicity, and Molecular Docking Approaches. Symmetry 14:9, pages 1842.
Crossref
Crossref
Oya Unsal Tan & Keriman Ozadali Sari. (2021)
Azolo[
d
]pyridazinones in medicinal chemistry
. Future Medicinal Chemistry 13:3, pages 287-311.
Crossref
Crossref
Sumeet Gupta, Anroop Nair, Vikas Jhawat, Nazia Mustaq, Abhishek Sharma, Meenakshi Dhanawat & Shah Alam Khan. (2020) Unwinding Complexities of Diabetic Alzheimer by Potent Novel Molecules. American Journal of Alzheimer's Disease & Other Dementiasr 35, pages 153331752093754.
Crossref
Crossref
M. C. Sharma & S. Jain. (2019) Design and prediction of favorable substitution site in trifluorophenyl-substituted homopiperazine, pyrazoline, triazepane derivatives as dipeptidyl peptidase IV Inhibitors: HQSAR and docking studies. Network Modeling Analysis in Health Informatics and Bioinformatics 8:1.
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Crossref
Yasmin M. Syam, Somaia S. Abd El-Karim, Tamer Nasr, Samia A. Elseginy, Manal M. Anwar, Mohsen M. Kamel & Hanan F. Ali. (2019) Design, Synthesis and Biological Evaluation of Spiro Cyclohexane-1,2- Quinazoline Derivatives as Potent Dipeptidyl Peptidase IV Inhibitors. Mini-Reviews in Medicinal Chemistry 19:3, pages 250-269.
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Crossref
Somaia S. Abd El-Karim, Manal M. Anwar, Yasmin M. Syam, Manal A. Nael, Hanan F. Ali & Mohamed A. Motaleb. (2018) Rational design and synthesis of new tetralin-sulfonamide derivatives as potent anti-diabetics and DPP-4 inhibitors: 2D & 3D QSAR, in vivo radiolabeling and bio distribution studies. Bioorganic Chemistry 81, pages 481-493.
Crossref
Crossref
Ram N. Kushwaha, Rohit Srivastava, Akansha Mishra, Arun K. Rawat, Arvind K. Srivastava, Wahajul Haq & Seturam B. Katti. (2015) Design, Synthesis, Biological Screening, and Molecular Docking Studies of Piperazine-Derived Constrained Inhibitors of DPP-IV for the Treatment of Type 2 Diabetes. Chemical Biology & Drug Design 85:4, pages 439-446.
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Xiaoyan Yang, Minjie Li, Qiang Su, Milin Wu, Tianhong Gu & Wencong Lu. (2013) QSAR studies on pyrrolidine amides derivatives as DPP-IV inhibitors for type 2 diabetes. Medicinal Chemistry Research 22:11, pages 5274-5283.
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Aiko Nitta, Hideaki Fujii, Satoshi Sakami, Mikiya Satoh, Junko Nakaki, Shiho Satoh, Hiroki Kumagai & Hideki Kawai. (2012) Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 22:23, pages 7036-7040.
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Yohei Ikuma, Hitoshi Hochigai, Hidenori Kimura, Noriko Nunami, Tomonori Kobayashi, Katsuya Uchiyama, Yudai Furuta, Mutsuko Sakai, Masakuni Horiguchi, Yumi Masui, Kazuhiko Okazaki, Yasuhiro Sato & Hiroyuki Nakahira. (2012) Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors. Bioorganic & Medicinal Chemistry 20:19, pages 5864-5883.
Crossref
Crossref
Yohei Ikuma & Hiroyuki Nakahira. (2011) Preparation of 2-aminosubstituted 3H-imidazo[4,5-c]quinolin-4(5H)-ones by palladium-assisted internal biaryl coupling reaction. Tetrahedron 67:49, pages 9509-9517.
Crossref
Crossref
Liang Desheng, Gao Jian, Cheng Yuanhua, Cui Wei, Zhang Huai & Ji Mingjuan. (2011) Molecular dynamics simulations and MM/GBSA methods to investigate binding mechanisms of aminomethylpyrimidine inhibitors with DPP-IV. Bioorganic & Medicinal Chemistry Letters 21:22, pages 6630-6635.
Crossref
Crossref
Heung Jae Kim, Woo Young Kwak, Jong Pil Min, Jae Young Lee, Tae Hyun Yoon, Ha Dong Kim, Chang Yell Shin, Mi Kyung Kim, Song Hyen Choi, Hae Sun Kim, Eun Kyoung Yang, Ye Hwang Cheong, Yu Na Chae, Kyung Jin Park, Ji Myun Jang, Soo Jung Choi, Moon Ho Son, Soon Hoe Kim, Moohi Yoo & Bong Jin Lee. (2011) Discovery of DA-1229: A potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes. Bioorganic & Medicinal Chemistry Letters 21:12, pages 3809-3812.
Crossref
Crossref
Yasufumi Miyamoto, Yoshihiro Banno, Tohru Yamashita, Tatsuhiko Fujimoto, Satoru Oi, Yusuke Moritoh, Tomoko Asakawa, Osamu Kataoka, Koji Takeuchi, Nobuhiro Suzuki, Koji Ikedo, Takuo Kosaka, Shigetoshi Tsubotani, Akiyoshi Tani, Miyuki Funami, Michiko Amano, Yoshio Yamamoto, Kathleen Aertgeerts, Jason Yano & Hironobu Maezaki. (2011) Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125. Bioorganic & Medicinal Chemistry 19:1, pages 172-185.
Crossref
Crossref
Yukihiro Nishio, Hidenori Kimura, Shinya Tosaki, Eiji Sugaru, Mutsuko Sakai, Masakuni Horiguchi, Yumi Masui, Michiko Ono, Tsutomu Nakagawa & Hiroyuki Nakahira. (2010) Discovery of new chemotype dipeptidyl peptidase IV inhibitors having (R)-3-amino-3-methyl piperidine as a pharmacophore. Bioorganic & Medicinal Chemistry Letters 20:24, pages 7246-7249.
Crossref
Crossref
Yan-Ke Jiang. (2010) Molecular docking and 3D-QSAR studies on β-phenylalanine derivatives as dipeptidyl peptidase IV inhibitors. Journal of Molecular Modeling 16:7, pages 1239-1249.
Crossref
Crossref
Aiko Nitta, Hideaki Fujii, Satoshi Sakami, Yutaka Nishimura, Tomofumi Ohyama, Mikiya Satoh, Junko Nakaki, Shiho Satoh, Chifumi Inada, Hideki Kozono, Hiroki Kumagai, Masahiro Shimamura, Tominaga Fukazawa & Hideki Kawai. (2008) (3R)-3-Amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorganic & Medicinal Chemistry Letters 18:20, pages 5435-5438.
Crossref
Crossref
Bong Chan Kim, Kyu-Young Kim, Hee Bong Lee & Hyunik Shin. (2008)
Development of a Kilogram-Scale Synthesis of
cis
-LC15-0133 Tartrate, a Potent Dipeptidyl Peptidase IV Inhibitor
. Organic Process Research & Development 12:4, pages 626-631.
Crossref
Crossref
John T. Welch. 2008. Fluorine and Health. Fluorine and Health
699
735
.
David E. Kaelin, Abigail L. Smenton, George J. Eiermann, Huaibing He, Barbara Leiting, Kathryn A. Lyons, Reshma A. Patel, Sangita B. Patel, Alexsandr Petrov, Giovanna Scapin, Joseph K. Wu, Nancy A. Thornberry, Ann E. Weber & Joseph L. Duffy. (2007) 4-Arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV. Bioorganic & Medicinal Chemistry Letters 17:21, pages 5806-5811.
Crossref
Crossref
Stephen W. Wright, Mark J. Ammirati, Kim M. Andrews, Anne M. Brodeur, Dennis E. Danley, Shawn D. Doran, Jay S. Lillquist, Shenping Liu, Lester D. McClure, R. Kirk McPherson, Thanh V. Olson, Stephen J. Orena, Janice C. Parker, Benjamin N. Rocke, Walter C. Soeller, Carolyn B. Soglia, Judith L. Treadway, Maria A. VanVolkenburg, Zhengrong Zhao & Eric D. Cox. (2007) (3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: Synthesis, in vitro, in vivo, and X-ray crystallographic characterization. Bioorganic & Medicinal Chemistry Letters 17:20, pages 5638-5642.
Crossref
Crossref
Takashi Kondo, Isamu Sugimoto, Takahiro Nekado, Kenya Ochi, Tazumi Ohtani, Yohei Tajima, Susumu Yamamoto, Kazuhito Kawabata, Hisao Nakai & Masaaki Toda. (2007) Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV. Bioorganic & Medicinal Chemistry 15:7, pages 2715-2735.
Crossref
Crossref
Scott M. Sheehan, Hans-Juergen Mest, Brian M. Watson, Valentine J. Klimkowski, David E. Timm, Annick Cauvin, Stephen H. Parsons, Qing Shi, Emily J. Canada, Michael R. Wiley, Gerd Ruehter, Britta Evers, Soenke Petersen, Larry C. Blaszczak, Shon R. Pulley, Brandon J. Margolis, Graham N. Wishart, Beatrice Renson, Dirk Hankotius, Michael Mohr, Johann-Christian Zechel, J. Michael Kalbfleisch, Elizabeth A. Dingess-Hammond, Andre Boelke & Andreas G. Weichert. (2007) Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site. Bioorganic & Medicinal Chemistry Letters 17:6, pages 1765-1768.
Crossref
Crossref
Paul E. Wiedeman. 2007. Progress in Medicinal Chemistry Volume 45. Progress in Medicinal Chemistry Volume 45
63
109
.
David R. Magnin, Prakash C. Taunk, James G. Robertson, Aiying Wang, Jovita Marcinkeviciene, Mark S. Kirby & Lawrence G. Hamann. (2006) Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1. Bioorganic & Medicinal Chemistry Letters 16:6, pages 1731-1734.
Crossref
Crossref
Jinyou Xu, Lan Wei, Robert Mathvink, Scott D. Edmondson, Anthony Mastracchio, George J. Eiermann, Huaibing He, Joseph F. Leone, Barbara Leiting, Kathryn A. Lyons, Frank Marsilio, Reshma A. Patel, Aleksandr Petrov, Joseph K. Wu, Nancy A. Thornberry & Ann E. Weber. (2006) Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors. Bioorganic & Medicinal Chemistry Letters 16:5, pages 1346-1349.
Crossref
Crossref
Christian Rummey, Sonja Nordhoff, Meinolf Thiemann & Günther Metz. (2006) In silico fragment-based discovery of DPP-IV S1 pocket binders. Bioorganic & Medicinal Chemistry Letters 16:5, pages 1405-1409.
Crossref
Crossref
Bernard Hulin, Shawn Cabral, Michael G. Lopaze, Maria A. Van Volkenburg, Kim M. Andrews & Janice C. Parker. (2005) New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 15:21, pages 4770-4773.
Crossref
Crossref
Guohua Zhao, Prakash C. Taunk, David R. Magnin, Ligaya M. Simpkins, Jeffrey A. Robl, Aiying Wang, James G. Robertson, Jovita Marcinkeviciene, Doree F. Sitkoff, Rex A. Parker, Mark S. Kirby & Lawrence G. Hamann. (2005) Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 15:18, pages 3992-3995.
Crossref
Crossref
Hans-Ulrich Demuth, Christopher H.S. McIntosh & Raymond A. Pederson. (2005) Type 2 diabetes—Therapy with dipeptidyl peptidase IV inhibitors. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1751:1, pages 33-44.
Crossref
Crossref
David J. Augeri, Jeffrey A. Robl, David A. Betebenner, David R. Magnin, Ashish Khanna, James G. Robertson, Aiying Wang, Ligaya M. Simpkins, Prakash Taunk, Qi Huang, Song-Ping Han, Benoni Abboa-Offei, Michael Cap, Li Xin, Li Tao, Effie Tozzo, Gustav E. Welzel, Donald M. Egan, Jovita Marcinkeviciene, Shu Y. Chang, Scott A. Biller, Mark S. Kirby, Rex A. Parker & Lawrence G. Hamann. (2005) Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes. Journal of Medicinal Chemistry 48:15, pages 5025-5037.
Crossref
Crossref
Inger Brandt, Jurgen Joossens, Xin Chen, Marie-Berthe Maes, Simon Scharpé, Ingrid De Meester & Anne-Marie Lambeir. (2005) Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile). Biochemical Pharmacology 70:1, pages 134-143.
Crossref
Crossref
Jinyou Xu, Lan Wei, Robert Mathvink, Jiafang He, You-Jung Park, Huaibing He, Barbara Leiting, Kathryn A. Lyons, Frank Marsilio, Reshma A. Patel, Joseph K. Wu, Nancy A. Thornberry & Ann E. Weber. (2005) Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 15:10, pages 2533-2536.
Crossref
Crossref
Wallace T. Ashton, Rosemary M. Sisco, Hong Dong, Kathryn A. Lyons, Huaibing He, George A. Doss, Barbara Leiting, Reshma A. Patel, Joseph K. Wu, Frank Marsilio, Nancy A. Thornberry & Ann E. Weber. (2005) Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole. Bioorganic & Medicinal Chemistry Letters 15:9, pages 2253-2258.
Crossref
Crossref
Mark D. GORRELL. (2005) Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders. Clinical Science 108:4, pages 277-292.
Crossref
Crossref
Pieter Van der Veken, Kristel Senten, István Kertèsz, Ingrid De Meester, Anne-Marie Lambeir, Marie-Berthe Maes, Simon Scharpé, Achiel Haemers & Koen Augustyns. (2004) Fluoro-Olefins as Peptidomimetic Inhibitors of Dipeptidyl Peptidases. Journal of Medicinal Chemistry 48:6, pages 1768-1780.
Crossref
Crossref
Scott D. Edmondson, Anthony Mastracchio, Maria Beconi, Lawrence F. ColwellJr.Jr., Bahanu Habulihaz, Huaibing He, Sanjeev Kumar, Barbara Leiting, Kathryn A. Lyons, Ann Mao, Frank Marsilio, Reshma A. Patel, Joseph K. Wu, Lan Zhu, Nancy A. Thornberry, Ann E. Weber & Emma R. Parmee. (2004) Potent and selective proline derived dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 14:20, pages 5151-5155.
Crossref
Crossref
Jinyou Xu, Hyun O. Ok, Edward J. Gonzalez, Lawrence F. ColwellJr.Jr., Bahanu Habulihaz, Huaibing He, Barbara Leiting, Kathryn A. Lyons, Frank Marsilio, Reshma A. Patel, Joseph K. Wu, Nancy A. Thornberry, Ann E. Weber & Emma R. Parmee. (2004) Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 14:18, pages 4759-4762.
Crossref
Crossref
Roger Léger, Karen Thibaudeau, Martin Robitaille, Omar Quraishi, Pieter van Wyk, Nathalie Bousquet-Gagnon, Julie Carette, Jean-Paul Castaigne & Dominique P. Bridon. (2004) Identification of CJC-1131-albumin bioconjugate as a stable and bioactive GLP-1(7–36) analog. Bioorganic & Medicinal Chemistry Letters 14:17, pages 4395-4398.
Crossref
Crossref
Ann E. Weber. (2004) Dipeptidyl Peptidase IV Inhibitors for the Treatment of Diabetes. Journal of Medicinal Chemistry 47:17, pages 4135-4141.
Crossref
Crossref
Jens-Uwe Peters, Silja Weber, Stéphane Kritter, Peter Weiss, Angelina Wallier, Daniel Zimmerli, Markus Boehringer, Matthias Steger & Bernd-Michael Loeffler. (2004) Aminomethylpyridines as DPP-IV inhibitors. Bioorganic & Medicinal Chemistry Letters 14:13, pages 3579-3580.
Crossref
Crossref
Jens-Uwe Peters, Daniel Hunziker, Holger Fischer, Manfred Kansy, Silja Weber, Stéphane Kritter, Aranka Müller, Angelina Wallier, Fabienne Ricklin, Markus Boehringer, Sonia Maria Poli, Miklos Csato & Bernd-Michael Loeffler. (2004) An aminomethylpyrimidine DPP-IV inhibitor with improved properties. Bioorganic & Medicinal Chemistry Letters 14:13, pages 3575-3578.
Crossref
Crossref
Katerina Ajami, Catherine A Abbott, Geoffrey W McCaughan & Mark D Gorrell. (2004) Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1679:1, pages 18-28.
Crossref
Crossref
David R. Magnin, Jeffrey A. Robl, Richard B. Sulsky, David J. Augeri, Yanting Huang, Ligaya M. Simpkins, Prakash C. Taunk, David A. Betebenner, James G. Robertson, Benoni E. Abboa-Offei, Aiying Wang, Michael Cap, Li Xin, Li Tao, Doree F. Sitkoff, Mary F. Malley, Jack Z. Gougoutas, Ashish Khanna, Qi Huang, Song-Ping Han, Rex A. Parker & Lawrence G. Hamann. (2004)
Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability: Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Group of α-Aminoacyl-
l
-
cis
-4,5-methanoprolinenitrile-Based Inhibitors
. Journal of Medicinal Chemistry 47:10, pages 2587-2598.
Crossref
Crossref
Kristel Senten, Pieter Van der Veken, Ingrid De Meester, Anne-Marie Lambeir, Simon Scharpé, Achiel Haemers & Koen Augustyns. (2004)
γ-Amino-Substituted Analogues of 1-[(
S
)-2,4-Diaminobutanoyl]piperidine as Highly Potent and Selective Dipeptidyl Peptidase II Inhibitors
. Journal of Medicinal Chemistry 47:11, pages 2906-2916.
Crossref
Crossref
Jens-Uwe Peters, Silja Weber, Stéphane Kritter, Peter Weiss, Angelina Wallier, Markus Boehringer, Michael Hennig, Bernd Kuhn & Bernd-Michael Loeffler. (2004) Aminomethylpyrimidines as novel DPP-IV inhibitors: A 105-fold activity increase by optimization of aromatic substituents. Bioorganic & Medicinal Chemistry Letters 14:6, pages 1491-1493.
Crossref
Crossref
Charles G. Caldwell, Ping Chen, Jiafang He, Emma R. Parmee, Barbara Leiting, Frank Marsilio, Reshma A. Patel, Joseph K. Wu, George J. Eiermann, Aleksandr Petrov, Huaibing He, Kathryn A. Lyons, Nancy A. Thornberry & Ann E. Weber. (2004) Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 14:5, pages 1265-1268.
Crossref
Crossref
Anthony Mastracchio, Emma R. Parmee, Barbara Leiting, Frank Marsilio, Reshma Patel, Nancy A. Thornberry, Ann E. Weber & Scott D. Edmondson. (2004) Heterocycle Fused Cyclohexyl-glycine Derivatives as Novel Dipeptidyl Peptidase-IV Inhibitors. HETEROCYCLES 62:1, pages 203.
Crossref
Crossref
Emma R. Parmee, Jiafang He, Anthony Mastracchio, Scott D. Edmondson, Larry Colwell, George Eiermann, William P. Feeney, Bahanu Habulihaz, Huaibing He, Ruth Kilburn, Barbara Leiting, Kathryn Lyons, Frank Marsilio, Reshma A. Patel, Aleksandr Petrov, Jerry Di Salvo, Joseph K. Wu, Nancy A. Thornberry & Ann E. Weber. (2004) 4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 14:1, pages 43-46.
Crossref
Crossref
Rolf Mentlein. 2004.
165
213
.
Kristel Senten, Pieter Van der Veken, Ingrid De Meester, Anne-Marie Lambeir, Simon Scharpé, Achiel Haemers & Koen Augustyns. (2003) Design, Synthesis, and SAR of Potent and Selective Dipeptide-Derived Inhibitors for Dipeptidyl Peptidases. Journal of Medicinal Chemistry 46:23, pages 5005-5014.
Crossref
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