Advanced search
Publication Cover
Expert Opinion on Therapeutic Patents Volume 14, 2004 - Issue 3
Submit an article Journal homepage
2,448
Views
61
CrossRef citations to date
0
Altmetric
Editorial

Prodrugs as therapeutics

Valentino J Stella Department of Pharmaceutical Chemistry, The University of Kansas, 66047-3729 Kansas, USA. [email protected]
Pages 277-280 | Published online: 02 Mar 2005

Citations (61)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Mohsen Sargolzaei & Hossein Nikoofard. Design of prodrug for stereoisomers of omapatrilat to cross the blood-brain barrier using docking, homology modeling, MD, and QM/MM methods. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-13.
Read now

Articles from other publishers (60)

Ruixuan He, Peida Yang, Aoxue Liu, Yueli Zhang, Yuqi Chen, Cong Chang & Bo Lu. (2023) Cascade strategy for glucose oxidase-based synergistic cancer therapy using nanomaterials. Journal of Materials Chemistry B 11:41, pages 9798-9839.
Crossref
Qais Jarrar, Rami Ayoub, Said Moshawih, Yazun Jarrar & Jamal Jilani. (2023) Synthesis and Biological Evaluation of Hydroxypropyl Ester of Mefenamic Acid as a Promising Prodrug. Letters in Drug Design & Discovery 20:2, pages 144-152.
Crossref
Weiping Wang, Fengxiao Li, Jiaqi Fan, Shuo Gan, Jiaming Zhang, Qikun Jiang & Tianhong Zhang. (2023) Development and validation of a LC-MS/MS method for the simultaneous determination of cycloicaritin and its carbamate prodrug in rat plasma: application to pharmacokinetic study. New Journal of Chemistry.
Crossref
Muhammad Atif Saleem, Muhammad Yasir Siddique, Muhammad Zubair, Muhammad Ashfaq & Muhammad Faizan Nazar. 2023. Novel Platforms for Drug Delivery Applications. Novel Platforms for Drug Delivery Applications 257 275 .
Nuraziemah Ahmad, Alina Arulsamy & Mohd. Farooq Shaikh. 2023. Handbook of Neurodegenerative Disorders. Handbook of Neurodegenerative Disorders 1 19 .
Milica Markovic, Shimon Ben‐Shabat & Arik Dahan. 2022. Targeted Drug Delivery. Targeted Drug Delivery 169 192 .
Qais Jarrar, Rami Ayoub, Kawther Alhussine, Khang Wen Goh, Said Moshawih, Chrismawan Ardianto, Bey Hing Goh & Long Chiau Ming. (2022) Prolonged Maternal Separation Reduces Anxiety State and Increases Compulsive Burying Activity in the Offspring of BALB/c Mice. Journal of Personalized Medicine 12:11, pages 1921.
Crossref
Milica Markovic, Suyash Deodhar, Jatin Machhi, Pravin Yeapuri, Maamoon Saleh, Benson J. Edagwa, Rodney Lee Mosley & Howard E. Gendelman. (2022) Prodrug Therapies for Infectious and Neurodegenerative Diseases. Pharmaceutics 14:3, pages 518.
Crossref
Sophia Harringer, Michaela Hejl, Éva A. Enyedy, Michael A. Jakupec, Mathea S. Galanski, Bernhard K. Keppler, Paul J. Dyson & Hristo P. Varbanov. (2021) Multifunctional Pt( iv ) prodrug candidates featuring the carboplatin core and deferoxamine . Dalton Transactions 50:23, pages 8167-8178.
Crossref
Medha Bhat, Reena Jatyan, Anupama Mittal, Ram I. Mahato & Deepak Chitkara. (2021) Opportunities and challenges of fatty acid conjugated therapeutics. Chemistry and Physics of Lipids 236, pages 105053.
Crossref
Eleonore Coppens, Didier Desmaële, Julie Mougin, Sandrine Tusseau-Nenez, Patrick Couvreur & Simona Mura. (2021) Gemcitabine Lipid Prodrugs: The Key Role of the Lipid Moiety on the Self-Assembly into Nanoparticles. Bioconjugate Chemistry 32:4, pages 782-793.
Crossref
Zeynep Ates-Alagoz & Adeboye Adejare. 2021. Remington. Remington 169 186 .
Ashutosh Pal & Bimal Krishna Banik. (2020) Highly Efficient Prodrugs: Design and Therapeutic Applications. Oriental Journal Of Chemistry 36:6, pages 985-1000.
Crossref
Milica Markovic, Shimon Ben-Shabat & Arik Dahan. (2020) Prodrugs for Improved Drug Delivery: Lessons Learned from Recently Developed and Marketed Products. Pharmaceutics 12:11, pages 1031.
Crossref
Aleksandra Tencheva, Radoslav Chayrov, Petko Mandjukov, Dancho Danalev & Ivanka Stankova. (2020) Hydrolytic Stability of New Amino Acids Analogues of Memantine. Scientia Pharmaceutica 88:3, pages 38.
Crossref
Yixin Sun, Dongyang Zhao, Gang Wang, Qikun Jiang, Mengran Guo, Qiming Kan, Zhonggui He & Jin Sun. (2019) A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates. Asian Journal of Pharmaceutical Sciences 14:6, pages 631-639.
Crossref
Arik Dahan, Milica Markovic, Aaron Aponick, Ellen M Zimmermann & Shimon Ben-Shabat. (2019) The prospects of lipidic prodrugs: an old approach with an emerging future. Future Medicinal Chemistry 11:19, pages 2563-2571.
Crossref
Milica Markovic, Shimon Ben-Shabat, Shahar Keinan, Aaron Aponick, Ellen M. Zimmermann & Arik Dahan. (2019) Molecular Modeling-Guided Design of Phospholipid-Based Prodrugs. International Journal of Molecular Sciences 20:9, pages 2210.
Crossref
Milica Markovic, Arik Dahan, Shahar Keinan, Igor Kurnikov, Aaron Aponick, Ellen M. Zimmermann & Shimon Ben-Shabat. (2019) Phospholipid-Based Prodrugs for Colon-Targeted Drug Delivery: Experimental Study and In-Silico Simulations. Pharmaceutics 11:4, pages 186.
Crossref
Milica Markovic, Shimon Ben-Shabat, Shahar Keinan, Aaron Aponick, Ellen Zimmermann & Arik Dahan. (2018) Prospects and Challenges of Phospholipid-Based Prodrugs. Pharmaceutics 10:4, pages 210.
Crossref
Denzil Furtado, Mattias Björnmalm, Scott Ayton, Ashley I. Bush, Kristian Kempe & Frank Caruso. (2018) Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases. Advanced Materials 30:46.
Crossref
Yingchao Li, Yongjun Wang, Ran Zhang, Cuiru Liu, Yue Wei, Jin Sun, Zhonggui He, Youjun Xu & Tianhong Zhang. (2018) Improving the oral bioavailability of tapentadol via a carbamate prodrug approach: synthesis, bioactivation, and pharmacokinetics. Drug Delivery and Translational Research 8:5, pages 1335-1344.
Crossref
Jarkko Rautio, Nicholas A. Meanwell, Li Di & Michael J. Hageman. (2018) The expanding role of prodrugs in contemporary drug design and development. Nature Reviews Drug Discovery 17:8, pages 559-587.
Crossref
Yingchao Li, Xingxing Zhang, Xiaochen Bai, Xiaoting Li, Qikun Jiang & Tianhong Zhang. (2018) A sensitive, high-throughput, and eco-friendly analysis of daidzein and its valine carbamate prodrug in rat plasma by supercritical fluid chromatography with tandem mass spectrometry. Journal of Separation Science 41:16, pages 3250-3257.
Crossref
Sébastien Fortin, Xavier Charest-Morin, Vanessa Turcotte, Coraline Lauvaux, Jacques Lacroix, Marie-France Côté, Stéphane Gobeil & René C.-Gaudreault. (2017) Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells. Journal of Medicinal Chemistry 60:12, pages 4963-4982.
Crossref
Meng Zhou, Rong-Hong Zhang, Min Wang, Guo-Bo Xu & Shang-Gao Liao. (2017) Prodrugs of triterpenoids and their derivatives. European Journal of Medicinal Chemistry 131, pages 222-236.
Crossref
James Hilaire & Howard E. Gendelman. 2017. Neuroimmune Pharmacology. Neuroimmune Pharmacology 831 845 .
Éanna B. Forde, Graeme Kelly, Hisham Makki, Zahraa Al-Sharshahi, Deirdre Fitzgerald-Hughes & Marc Devocelle. 2017. Antimicrobial Peptides. Antimicrobial Peptides 359 368 .
Jaya Preethi Peesa, Prasanna Raju Yalavarthi, Arun Rasheed & Venkata Basaveswara Rao Mandava. (2016) A perspective review on role of novel NSAID prodrugs in the management of acute inflammation. Journal of Acute Disease 5:5, pages 364-381.
Crossref
Peng-Cheng LvMohamed S. A. ElsayedKeli Agama, Christophe Marchand, Yves Pommier & Mark Cushman. (2016) Design, Synthesis, and Biological Evaluation of Potential Prodrugs Related to the Experimental Anticancer Agent Indotecan (LMP400). Journal of Medicinal Chemistry 59:10, pages 4890-4899.
Crossref
G. J. Kelly, A. Foltyn-Arfa Kia, F. Hassan, S. O'Grady, M. P. Morgan, B. S. Creaven, S. McClean, J. H. Harmey & M. Devocelle. (2016) Polymeric prodrug combination to exploit the therapeutic potential of antimicrobial peptides against cancer cells. Organic & Biomolecular Chemistry 14:39, pages 9278-9286.
Crossref
Ajazuddin, Amit Alexander & Parijat Kanaujia. 2015. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 475 490 .
Saujanya Acharya, Raja Reddy Kuppili, Lalith K. Chaganti & Kakoli Bose. 2015. Proteases in Apoptosis: Pathways, Protocols and Translational Advances. Proteases in Apoptosis: Pathways, Protocols and Translational Advances 143 202 .
Santi M. Mandal, Anupam Roy, Ananta K. Ghosh, Tapas K. Hazra, Amit Basak & Octavio L. Franco. (2014) Challenges and future prospects of antibiotic therapy: from peptides to phages utilization. Frontiers in Pharmacology 5.
Crossref
Scott C. McKellarAlan R. KennedyNeil C. McCloyEileen McBrideAlastair J. Florence. (2014) Formulation of Liquid Propofol as a Cocrystalline Solid. Crystal Growth & Design 14:5, pages 2422-2430.
Crossref
Rafik Karaman, Alaa Qtait, Khulod Khayyat Dajani & Saleh Abu Lafi. (2014) Design, Synthesis, and In Vitro Kinetics Study of Atenolol Prodrugs for the Use in Aqueous Formulations . The Scientific World Journal 2014, pages 1-13.
Crossref
Morten Rohde, Niels M∅rk, Anders E. Håkansson, Klaus G. Jensen, Henrik Pedersen, Tina Dige, Erling B. J∅rgensen & René Holm. (2014) Biological conversion of aripiprazole lauroxil − An N-acyloxymethyl aripiprazole prodrug. Results in Pharma Sciences 4, pages 19-25.
Crossref
Sophie-Dorothee Clas, Rosa I. Sanchez & Rebecca Nofsinger. (2014) Chemistry-enabled drug delivery (prodrugs): recent progress and challenges. Drug Discovery Today 19:1, pages 79-87.
Crossref
Ivan S. Krylov & Charles E. McKenna. 2013. Enzyme Technologies. Enzyme Technologies 253 300 .
Margaret S Landis. (2013) Physicochemical property trends of marketed prodrugs. Therapeutic Delivery 4:2, pages 225-237.
Crossref
Michelle P. Mcintosh & Roger A. Rajewski. (2012) Comparative canine Pharmacokinetics–Pharmacodynamics of Fospropofol Disodium Injection, Propofol Eemulsion, and Cyclodextrin-Enabled Propofol Solution Following Bolus Parenteral Administration. Journal of Pharmaceutical Sciences 101:9, pages 3547-3552.
Crossref
Mohammad H. El-Dakdouki & Paul W. Erhardt. (2012) Analogue-based drug discovery: Contributions to medicinal chemistry principles and drug design strategies. Microtubule stabilizers as a case in point (Special Topic Article). Pure and Applied Chemistry 84:7, pages 1479-1542.
Crossref
Congrong Lin, Gangadhar Sunkara, John B Cannon & Vasant Ranade. (2012) Recent Advances in Prodrugs as Drug Delivery Systems. American Journal of Therapeutics 19:1, pages 33-43.
Crossref
Stéphane Desgranges, Carol C. Ruddle, Liam P. Burke, Tara M. McFadden, John E. O'Brien, Deirdre Fitzgerald-Hughes, Hilary Humphreys, Timothy P. Smyth & Marc Devocelle. (2012) β-Lactam-host defence peptide conjugates as antibiotic prodrug candidates targeting resistant bacteria. RSC Advances 2:6, pages 2480.
Crossref
P.K. Vemula, N.R. Campbell, F. Zhao, B. Xu, G. John & J.M. Karp. 2011. Comprehensive Biomaterials. Comprehensive Biomaterials 339 355 .
Krista Laine & Kristiina Huttunen. 2010. Prodrugs and Targeted Delivery. Prodrugs and Targeted Delivery 231 252 .
Jarkko Rautio. 2010. Prodrugs and Targeted Delivery. Prodrugs and Targeted Delivery 1 30 .
Roberto Parise Filho, Michelle Carneiro Polli, Silvio Barberato Filho, Monique Garcia & Elizabeth Igne Ferreira. (2010) Prodrugs available on the Brazilian pharmaceutical market and their corresponding bioactivation pathways. Brazilian Journal of Pharmaceutical Sciences 46:3, pages 393-420.
Crossref
Kristiina M. Huttunen, Jarkko Rautio, Jukka Leppänen, Jouko Vepsäläinen & Pekka Keski-Rahkonen. (2009) Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 50:3, pages 469-474.
Crossref
Joachim A. Stellmach. (2009) The influences of the structure and activity of biologically active compounds on the assessment of inventive step. World Patent Information 31:3, pages 226-234.
Crossref
Judit Tulla-Puche, Ángela Torres, Pilar Calvo, Miriam Royo & Fernando Albericio. (2008) N,N,N′,N′ -Tetramethylchloroformamidinium Hexafluorophosphate (TCFH), a Powerful Coupling Reagent for Bioconjugation . Bioconjugate Chemistry 19:10, pages 1968-1971.
Crossref
Jarkko Rautio, Krista Laine, Mikko Gynther & Jouko Savolainen. (2008) Prodrug Approaches for CNS Delivery. The AAPS Journal 10:1, pages 92-102.
Crossref
Jarkko Rautio, Hanna Kumpulainen, Tycho Heimbach, Reza Oliyai, Dooman Oh, Tomi Järvinen & Jouko Savolainen. (2008) Prodrugs: design and clinical applications. Nature Reviews Drug Discovery 7:3, pages 255-270.
Crossref
Valentino J. Stella & Kwame W. Nti-Addae. (2007) Prodrug strategies to overcome poor water solubility. Advanced Drug Delivery Reviews 59:7, pages 677-694.
Crossref
E.H. Kerns & L. Di. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 489 507 .
Tycho Heimbach, David Fleisher & Amal Kaddoumi. 2007. Prodrugs. Prodrugs 157 215 .
Mariusz Skwarczynski, Yoshio Hayashi & Yoshiaki Kiso. (2006) Paclitaxel Prodrugs:  Toward Smarter Delivery of Anticancer Agents. Journal of Medicinal Chemistry 49:25, pages 7253-7269.
Crossref
Yong Gong, J. Kent Barbay, Alexey B. Dyatkin, Tamara A. Miskowski, Edward S. Kimball, Stephen M. Prouty, M. Carolyn Fisher, Rosemary J. Santulli, Craig R. Schneider, Nathaniel H. Wallace, Scott A. Ballentine, William E. Hageman, John A. Masucci, Bruce E. Maryanoff, Bruce P. Damiano, Patricia Andrade-Gordon, Dennis J. Hlasta, Pamela J. Hornby & Wei He. (2006) Synthesis and Biological Evaluation of Novel Pyridazinone-Based α 4 Integrin Receptor Antagonists . Journal of Medicinal Chemistry 49:11, pages 3402-3411.
Crossref
Valentino J. Stella. 2006. Optimizing the “Drug-Like” Properties of Leads in Drug Discovery. Optimizing the “Drug-Like” Properties of Leads in Drug Discovery 221 242 .
Mariusz Skwarczynski, Youhei Sohma, Mayo Noguchi, Maiko Kimura, Yoshio Hayashi, Yoshio Hamada, Tooru Kimura & Yoshiaki Kiso. (2005) No Auxiliary, No Byproduct Strategy for Water-Soluble Prodrugs of Taxoids:  Scope and Limitation of O−N Intramolecular Acyl and Acyloxy Migration Reactions. Journal of Medicinal Chemistry 48:7, pages 2655-2666.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.