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Dai Nozawa, Shigeyuki Chaki & Atsuro Nakazato. (2008) Recent advances in the development of melanocortin-4 receptor ligands. Expert Opinion on Therapeutic Patents 18:4, pages 403-427.
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Kenneth A. Gruber, Ren-Lai Ji, Fabio Gallazzi, Shaokai Jiang, Steven R. Van Doren, Ya-Xiong Tao & Jessica Newton Northup. (2022) Development of a Therapeutic Peptide for Cachexia Suggests a Platform Approach for Drug-like Peptides. ACS Pharmacology & Translational Science 5:5, pages 344-361.
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Margit Pissarek & Ulrich Disko. (2013) Non-peptide ligands in the characterization of peptide receptors at the interface between neuroendocrine and mental diseases. World Journal of Neuroscience 03:02, pages 100-125.
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Jerzy R. Szewczyk, Chris P. Laudeman, Doug M. Sammond, Manon Villeneuve, Douglas J. Minick, Mary K. Grizzle, Alejandro J. Daniels, John L. Andrews & Diane M. Ignar. (2010) A concise synthesis of 1,4-dihydro-[1,4]diazepine-5,7-dione, a novel 7-TM receptor ligand core structure with melanocortin receptor agonist activity. Bioorganic & Medicinal Chemistry 18:5, pages 1822-1833.
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Thomas R. Webb, Luyong Jiang, Sergey Sviridov, Ruben E. Venegas, Anna V. Vlaskina, Douglas McGrath, John Tucker, Jian Wang, Alain Deschenes & Rongshi Li. (2007) Application of a Novel Design Paradigm to Generate General Nonpeptide Combinatorial Templates Mimicking β-Turns: Synthesis of Ligands for Melanocortin Receptors. Journal of Combinatorial Chemistry 9:4, pages 704-710.
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Sergei Kopanchuk, Santa Veiksina, Felikss Mutulis, Ilze Mutule, Sviatlana Yahorava, Ilona Mandrika, Ramona Petrovska, Ago Rinken & Jarl E.S. Wikberg. (2006) Kinetic evidence for tandemly arranged ligand binding sites in melanocortin 4 receptor complexes. Neurochemistry International 49:5, pages 533-542.
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James P. Cain, Alexander V. Mayorov, Minying Cai, Hui Wang, Bahar Tan, Kevin Chandler, YeonSun Lee, Ravil R. Petrov, Dev Trivedi & Victor J. Hruby. (2006) Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors. Bioorganic & Medicinal Chemistry Letters 16:20, pages 5462-5467.
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Ravi P. Nargund, Alison M. Strack & Tung M. Fong. (2006) Melanocortin-4 Receptor (MC4R) Agonists for the Treatment of Obesity. Journal of Medicinal Chemistry 49:14, pages 4035-4043.
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Raman K. Bakshi, Qingmei Hong, Rui Tang, Rubana N. Kalyani, Tanya MacNeil, David H. Weinberg, Lex H.T. Van der Ploeg, Arthur A. Patchett & Ravi P. Nargund. (2006) Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands. Bioorganic & Medicinal Chemistry Letters 16:5, pages 1130-1133.
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Raman K. Bakshi, Qingmei Hong, J.T. Olson, Zhixiong Ye, Iyassue K. Sebhat, David H. Weinberg, Tanya MacNeil, Rubana N. Kalyani, Rui Tang, William J. Martin, Alison Strack, Erin McGowan, Constantin Tamvakopoulos, Randy R. Miller, Ralph A. Stearns, Wei Tang, D. Euan Maclntyre, Lex H.T. van der Ploeg, Arthur A. Patchett & Ravi P. Nargund. (2005) 1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists. Bioorganic & Medicinal Chemistry Letters 15:14, pages 3430-3433.
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Brenda L. Palucki, Min K. Park, Ravi P. Nargund, Rui Tang, Tanya MacNeil, David H. Weinberg, Aurawan Vongs, Charles I. Rosenblum, George A. Doss, Randall R. Miller, Ralph A. Stearns, Qianping Peng, Constantin Tamvakopoulos, Lex H.T. Van der Ploeg & Arthur A. Patchett. (2005) 2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists. Bioorganic & Medicinal Chemistry Letters 15:8, pages 1993-1996.
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Brenda L. Palucki, Min K. Park, Ravi P. Nargund, Zhixiong Ye, Iyassu K. Sebhat, Patrick G. Pollard, Rubana N. Kalyani, Rui Tang, Tanya MacNeil, David H. Weinberg, Aurawan Vongs, Charles I. Rosenblum, George A. Doss, Randall R. Miller, Ralph A. Stearns, Qianping Peng, Constantin Tamvakopoulos, Erin McGowan, William J. Martin, Joseph M. Metzger, Cherrie A. Shepherd, Alison M. Strack, D. Euan MacIntyre, Lex H.T. Van der Ploeg & Arthur A. Patchett. (2005) Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist. Bioorganic & Medicinal Chemistry Letters 15:1, pages 171-175.
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