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Expert Opinion on Therapeutic Patents Volume 15, 2005 - Issue 6
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Review

Glucokinase: old enzyme, new target

Thomas Kietzmann Department Biochemistry, Faculty of Chemistry, University of Kaiserslautern, Erwin-Schrödinger-Str. Geb. 54, D-67663 Kaiserslautern, Germany. [email protected]
&
Goutham Kumar Ganjam Department Biochemistry, Faculty of Chemistry, University of Kaiserslautern, Erwin-Schrödinger-Str. Geb. 54, D-67663 Kaiserslautern, Germany. [email protected]
Pages 705-713 | Published online: 14 Jun 2005

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Ramakanth Sarabu, Steven J Berthel, Robert F Kester & Jefferson W Tilley. (2008) Glucokinase activators as new type 2 diabetes therapeutic agents. Expert Opinion on Therapeutic Patents 18:7, pages 759-768.
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Articles from other publishers (12)

Larry Yet. 2018. Privileged Structures in Drug Discovery. Privileged Structures in Drug Discovery 284 320 .
博 李. (2018) Progress in Hypoglycemic and Lipid-Lowering Drugs. Journal of Comparative Chemistry 02:04, pages 142-160.
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Mutasem O. Taha, Maha Habash & Mohammad A. Khanfar. (2014) The use of docking-based comparative intermolecular contacts analysis to identify optimal docking conditions within glucokinase and to discover of new GK activators. Journal of Computer-Aided Molecular Design 28:5, pages 509-547.
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Nicholas A. Magnus, Timothy M. Braden, Jonas Y. Buser, Amy C. DeBaillie, Perry C. Heath, Christopher P. Ley, Jacob R. Remacle, David L. Varie & Thomas M. Wilson. (2012) Development of an Enantioselective Hydrogenation Based Synthesis of a Glucokinase Activator. Organic Process Research & Development 16:5, pages 830-835.
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Martin Lang, Markus H.-J. Seifert, Kristina K. Wolf, Andrea Aschenbrenner, Roland Baumgartner, Tanja Wieber, Viola Trentinaglia, Marcus Blisse, Nobumitsu Tajima, Tokuyuki Yamashita, Daniel Vitt & Hitoshi Noda. (2011) Discovery and hit-to-lead optimization of novel allosteric glucokinase activators. Bioorganic & Medicinal Chemistry Letters 21:18, pages 5417-5422.
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Donald J. AbrahamJefferson Tilley, Joseph Grimsby, Shawn Erickson & Steven Berthel. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 38 .
Mi Ja Chung, Sung-Yun Cho, Muhammad Javidul Haque Bhuiyan, Kyoung Heon Kim & Sung-Joon Lee. (2010) Anti-diabetic effects of lemon balm ( Melissa officinalis ) essential oil on glucose- and lipid-regulating enzymes in type 2 diabetic mice . British Journal of Nutrition 104:2, pages 180-188.
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Lisa S. Bertram, Daniel Black, Paul H. Briner, Rosemary Chatfield, Andrew Cooke, Matthew C. T. Fyfe, P. John Murray, Frédéric Naud, Masao Nawano, Martin J. Procter, Günaj Rakipovski, Chrystelle M. Rasamison, Christine Reynet, Karen L. Schofield, Vilas K. Shah, Felix Spindler, Amanda Taylor, Roy Turton, Geoffrey M. Williams, Philippe Wong-Kai-In & Kosuke Yasuda. (2008) SAR, Pharmacokinetics, Safety, and Efficacy of Glucokinase Activating 2-(4-Sulfonylphenyl)- N -thiazol-2-ylacetamides: Discovery of PSN-GK1 . Journal of Medicinal Chemistry 51:14, pages 4340-4345.
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Ramakanth Sarabu, Rebecca Taub & Joseph Grimsby. (2007) Glucokinase activation–a strategy for T2D therapy: recent developments. Drug Discovery Today: Therapeutic Strategies 4:2, pages 111-115.
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M. C. T. Fyfe, J. R. White, A. Taylor, R. Chatfield, E. Wargent, R. L. Printz, T. Sulpice, J. G. McCormack, M. J. Procter, C. Reynet, P. S. Widdowson & P. Wong-Kai-In. (2007) Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions. Diabetologia 50:6, pages 1277-1287.
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J.G. McCormack. (2006) Applying science to drug discovery. Biochemical Society Transactions 34:2, pages 238-242.
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Theodore O. Johnson & Paul S. Humphries. 2006. Annual Reports in Medicinal Chemistry Volume 41. Annual Reports in Medicinal Chemistry Volume 41 141 154 .

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