118
Views
35
CrossRef citations to date
0
Altmetric
Review

Recent advances in the development of histamine H3 antagonists

&
Pages 675-687 | Published online: 29 Jun 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Dorota Łażewska & Katarzyna Kieć-Kononowicz. (2018) Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017). Expert Opinion on Therapeutic Patents 28:3, pages 175-196.
Read now
Inder Pal Singh & Purvi Shah. (2017) Tetrahydroisoquinolines in therapeutics: a patent review (2010-2015). Expert Opinion on Therapeutic Patents 27:1, pages 17-36.
Read now
Dorota Łażewska & Katarzyna Kieć-Kononowicz. (2010) Recent advances in histamine H3 receptor antagonists/inverse agonists. Expert Opinion on Therapeutic Patents 20:9, pages 1147-1169.
Read now

Articles from other publishers (32)

Daniil Grinchii & Eliyahu Dremencov. (2020) Mechanism of Action of Atypical Antipsychotic Drugs in Mood Disorders. International Journal of Molecular Sciences 21:24, pages 9532.
Crossref
Bassem Sadek & Holger Stark. (2016) Cherry-picked ligands at histamine receptor subtypes. Neuropharmacology 106, pages 56-73.
Crossref
Ramakrishna Nirogi, Anil Shinde, Vinaykumar Tiriveedhi, Laxman Kota, Sangram Keshari Saraf, Rajesh Kumar Badange, Abdul Rasheed Mohammed, Ramkumar Subramanian, Nageshwararao Muddana, Gopinadh Bhyrapuneni & Renny Abraham. (2016) Benzamide derivatives and their constrained analogs as histamine H 3 receptor antagonists. European Journal of Medicinal Chemistry 108, pages 655-662.
Crossref
Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 247 263 .
Pertti Panula, Paul L. Chazot, Marlon Cowart, Ralf Gutzmer, Rob Leurs, Wai L. S. Liu, Holger Stark, Robin L. Thurmond & Helmut L. Haas. (2015) International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors. Pharmacological Reviews 67:3, pages 601-655.
Crossref
Fouad H. Darras, Sarah Wehle, Guozheng Huang, Christoph A. Sotriffer & Michael Decker. (2014) Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with ‘inverted’ binding mode. Bioorganic & Medicinal Chemistry 22:17, pages 4867-4881.
Crossref
Katarina Nikolic, Slavica Filipic, Danica Agbaba & Holger Stark. (2014) Procognitive Properties of Drugs with Single and Multitargeting H 3 Receptor Antagonist Activities . CNS Neuroscience & Therapeutics 20:7, pages 613-623.
Crossref
David M. Wilson, James Apps, Nicholas Bailey, Mark J. Bamford, Isabel J. Beresford, Michael A. Briggs, Andrew R. Calver, Barry Crook, Robert P. Davis, Susannah Davis, David K. Dean, Leanne Harris, Tom D. Heightman, Terry Panchal, Christopher A. Parr, Nigel Quashie, Jon G.A. Steadman, Joanne Schogger, Sanjeet S. Sehmi, Tania O. Stean, Andrew K. Takle, Brenda K. Trail, Trevor White, Jason Witherington, Angela Worby & Andrew D. Medhurst. (2013) The discovery of the benzazepine class of histamine H3 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 23:24, pages 6897-6901.
Crossref
Marlon Cowart, Gin Hsieh, Lawrence A. Black, CenChen Zhan, Erica J. Gomez, Madhavi Pai, Marina Strakhova, Arlene Manelli, Tracy Carr, Jill Wetter, Anthony Lee, Gilbert Diaz, Tiffany Garrison & Jorge D. Brioni. (2012) Pharmacological characterization of A-960656, a histamine H3 receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain. European Journal of Pharmacology 684:1-3, pages 87-94.
Crossref
Dong Xiao, Anandan Palani, Michael Sofolarides, Robert Aslanian, Robert E. WestJr.Jr., Shirley M. Williams, Ren-Long Wu, Joyce Hwa, Christopher Sondey, Jean Lachowicz & Walter A. Korfmacher. (2012) Fused bicycles as arylketone bioisosteres leading to potent, orally active thiadiazole H3 antagonists. Bioorganic & Medicinal Chemistry Letters 22:9, pages 3354-3357.
Crossref
Ashwin U. Rao, Ning Shao, Robert G. Aslanian, Tin-Yau Chan, Sylvia J. Degrado, Li Wang, Brian McKittrick, Mary Senior, Robert E. WestJr.Jr., Shirley M. Williams, Ren-Long Wu, Joyce Hwa, Bhuneshwari Patel, Shuqin Zheng, Christopher Sondey & Anandan Palani. (2011) Discovery of a Potent Thiadiazole Class of Histamine H 3 Receptor Antagonist for the Treatment of Diabetes . ACS Medicinal Chemistry Letters 3:3, pages 198-202.
Crossref
Robert L. Hudkins, Rita Raddatz, Ming Tao, Joanne R. Mathiasen, Lisa D. Aimone, Nadine C. Becknell, Catherine P. Prouty, Lars J. S. Knutsen, Mehran Yazdanian, Gilbert Moachon, Mark A. Ator, John P. Mallamo, Michael J. Marino, Edward R. Bacon & Michael Williams. (2011) Discovery and Characterization of 6-{4-[3-( R )-2-Methylpyrrolidin-1-yl)propoxy]phenyl}-2 H -pyridazin-3-one (CEP-26401, Irdabisant): A Potent, Selective Histamine H 3 Receptor Inverse Agonist . Journal of Medicinal Chemistry 54:13, pages 4781-4792.
Crossref
Dong Xiao, Anandan Palani, Michael Sofolarides, Ying Huang, Robert Aslanian, Henry Vaccaro, Liwu Hong, Brian McKittrick, Robert E. WestJr.Jr., Shirley M. Williams, Ren-Long Wu, Joyce Hwa, Christopher Sondey & Jean Lachowicz. (2011) Discovery of a series of potent arylthiadiazole H3 antagonists. Bioorganic & Medicinal Chemistry Letters 21:2, pages 861-864.
Crossref
M. Walter, K. Isensee, T. Kottke, X. Ligneau, J.-C. Camelin, J.-C. Schwartz & H. Stark. (2010) Azole derivatives as histamine H3 receptor antagonists, Part 2: C–C and C–S coupled heterocycles. Bioorganic & Medicinal Chemistry Letters 20:19, pages 5883-5886.
Crossref
M. Walter, Y. von Coburg, K. Isensee, K. Sander, X. Ligneau, J.-C. Camelin, J.-C. Schwartz & H. Stark. (2010) Azole derivatives as histamine H3 receptor antagonists, Part I: Thiazol-2-yl ethers. Bioorganic & Medicinal Chemistry Letters 20:19, pages 5879-5882.
Crossref
Pauline C. Ting, Joe F. Lee, Margaret M. Albanese, Jie Wu, Robert Aslanian, Leonard Favreau, Cymbelene Nardo, Walter A. Korfmacher, Robert E. West, Shirley M. Williams, John C. Anthes, Maria A. Rivelli, Michel R. Corboz & John A. Hey. (2010) The synthesis and structure–activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists. Bioorganic & Medicinal Chemistry Letters 20:17, pages 5004-5008.
Crossref
Donald J. AbrahamJeffrey M. Brown, Jie Jack Li & Michael W. Sinz. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 161 218 .
Dorota Łażewska, Małgorzata Więcek, Xavier Ligneau, Tim Kottke, Lilia Weizel, Roland Seifert, Walter Schunack, Holger Stark & Katarzyna Kieć-Kononowicz. (2009) Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates. Bioorganic & Medicinal Chemistry Letters 19:23, pages 6682-6685.
Crossref
Yuko Mitobe, Sayaka Ito, Takashi Mizutani, Tsuyoshi Nagase, Nagaaki Sato & Shigeru Tokita. (2009) Development of a selective and potent radioactive ligand for histamine H3 receptors: A compound potentially useful for receptor occupancy studies. Bioorganic & Medicinal Chemistry Letters 19:15, pages 4075-4078.
Crossref
Takahide Sasaki, Toshiyuki Takahashi, Tsuyoshi Nagase, Takashi Mizutani, Sayaka Ito, Yuko Mitobe, Yasuhisa Miyamoto, Maki Kanesaka, Ryo Yoshimoto, Takeshi Tanaka, Norihiro Takenaga, Shigeru Tokita & Nagaaki Sato. (2009) Synthesis, structure–activity relationships, and biological profiles of a dihydrobenzoxathiin class of histamine H3 receptor inverse agonists. Bioorganic & Medicinal Chemistry Letters 19:15, pages 4232-4236.
Crossref
Yi-Yin Ku, Tim Grieme, Yu-Ming Pu & Ashok V. Bhatia. (2009) A Highly Efficient Synthesis of a Naphthalenoid Histamine-3 Antagonist. Advanced Synthesis & Catalysis 351:11-12, pages 2024-2030.
Crossref
J. Phillip Kennedy, P. Jeffrey Conn & Craig W. Lindsley. (2009) A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin. Bioorganic & Medicinal Chemistry Letters 19:12, pages 3204-3208.
Crossref
Dorota Łażewska, Kamil Kuder, Xavier Ligneau, Jean-Claude Camelin, Walter Schunack, Holger Stark & Katarzyna Kieć-Kononowicz. (2009) Diether derivatives of homo- or substituted piperidines as non-imidazole histamine H3 receptor ligands. Bioorganic & Medicinal Chemistry 17:8, pages 3037-3042.
Crossref
Takashi Mizutani, Tsuyoshi Nagase, Sayaka Ito, Yasuhisa Miyamoto, Takeshi Tanaka, Norihiro Takenaga, Shigeru Tokita & Nagaaki Sato. (2008) Development of novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists. Bioorganic & Medicinal Chemistry Letters 18:23, pages 6041-6045.
Crossref
Sylvain Celanire, Florence Lebon & Holger Stark. 2008. The Third Histamine Receptor. The Third Histamine Receptor 103 165 .
Tsuyoshi Nagase, Takashi Mizutani, Etsuko Sekino, Shiho Ishikawa, Sayaka Ito, Yuko Mitobe, Yasuhisa Miyamoto, Ryo Yoshimoto, Takeshi Tanaka, Akane Ishihara, Norihiro Takenaga, Shigeru Tokita & Nagaaki Sato. (2008) Synthesis and Evaluation of Structurally Constrained Quinazolinone Derivatives as Potent and Selective Histamine H 3 Receptor Inverse Agonists . Journal of Medicinal Chemistry 51:21, pages 6889-6901.
Crossref
J. Phillip Kennedy, John T. Brogan & Craig W. Lindsley. (2008) Total Synthesis and Biological Evaluation of the Marine Bromopyrrole Alkaloid Dispyrin: Elucidation of Discrete Molecular Targets with Therapeutic Potential. Journal of Natural Products 71:10, pages 1783-1786.
Crossref
Robert Aslanian, Xiaohong Zhu, Henry A. Vaccaro, Neng-Yang Shih, John J. Piwinski, Shirley M. Williams & Robert E. WestJr.Jr.. (2008) Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands. Bioorganic & Medicinal Chemistry Letters 18:18, pages 5032-5036.
Crossref
Makoto Jitsuoka, Daisuke Tsukahara, Sayaka Ito, Takeshi Tanaka, Norihiro Takenaga, Shigeru Tokita & Nagaaki Sato. (2008) Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3 receptor inverse agonists. Bioorganic & Medicinal Chemistry Letters 18:18, pages 5101-5106.
Crossref
Dorota Łażewska, Kamil Kuder, Xavier Ligneau, Jean-Charles Schwartz, Walter Schunack, Holger Stark & Katarzyna Kieć-Kononowicz. (2008) Piperidine variations in search for non-imidazole histamine H3 receptor ligands. Bioorganic & Medicinal Chemistry 16:18, pages 8729-8736.
Crossref
Tsuyoshi Nagase, Takashi Mizutani, Shiho Ishikawa, Etsuko Sekino, Takahide Sasaki, Takashi Fujimura, Sayaka Ito, Yuko Mitobe, Yasuhisa Miyamoto, Ryo Yoshimoto, Takeshi Tanaka, Akane Ishihara, Norihiro Takenaga, Shigeru Tokita, Takehiro Fukami & Nagaaki Sato. (2008) Synthesis, Structure−Activity Relationships, and Biological Profiles of a Quinazolinone Class of Histamine H 3 Receptor Inverse Agonists . Journal of Medicinal Chemistry 51:15, pages 4780-4789.
Crossref
Kerstin Sander, Tim Kottke & Holger Stark. (2008) Histamine H3 Receptor Antagonists Go to Clinics. Biological and Pharmaceutical Bulletin 31:12, pages 2163-2181.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.