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Review

PDE7 inhibitors as new drugs for neurological and inflammatory disorders

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Pages 1127-1139 | Published online: 09 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Ana Martinez & Carmen Gil. (2014) cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases. Expert Opinion on Therapeutic Patents 24:12, pages 1311-1321.
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Maliheh Safavi, Maryam Baeeri & Mohammad Abdollahi. (2013) New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders. Expert Opinion on Drug Discovery 8:6, pages 733-751.
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Mercedes González & Hugo Cerecetto. (2012) Quinoxaline derivatives: a patent review (2006 – present). Expert Opinion on Therapeutic Patents 22:11, pages 1289-1302.
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Articles from other publishers (36)

Heena Khan, Chanchal Tiwari, Amarjot Kaur Grewal, Thakur Gurjeet Singh, Simran Chauhan & Gaber El-Saber Batiha. (2022) Pharmacological modulation of phosphodiesterase-7 as a novel strategy for neurodegenerative disorders. Inflammopharmacology 30:6, pages 2051-2061.
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Haobai Liu, Quan Wang, Yue Huang, Jinhui Deng, Xi Xie, Jiaqi Zhu, Yijun Yuan, Yue-Ming He, Yi-You Huang, Hai-Bin Luo & Xixin He. (2022) Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases. European Journal of Medicinal Chemistry 242, pages 114631.
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Monika Dąbrowska, Małgorzata Starek, Grażyna Chłoń-Rzepa, Agnieszka Zagórska, Łukasz Komsta, Agnieszka Jankowska, Marietta Ślusarczyk & Maciej Pawłowski. (2021) Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity. Bioorganic & Medicinal Chemistry Letters 49, pages 128318.
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Kamilia M. Amin, Gehan H. Hegazy, Riham F. George, Nahla R. Ibrahim & Nada M. Mohamed. (2021) Design, synthesis, and pharmacological characterization of some 2‐substituted‐3‐phenyl‐quinazolin‐4(3 H )‐one derivatives as phosphodiesterase inhibitors . Archiv der Pharmazie 354:9, pages 2100051.
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Agnieszka Jankowska, Maciej Pawłowski & Grażyna Chłoń-Rzepa. (2021) Diabetic Theory in Anti-Alzheimer’s Drug Research and Development. Part 2: Therapeutic Potential of cAMP-Specific Phosphodiesterase Inhibitors. Current Medicinal Chemistry 28:18, pages 3535-3553.
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Susann Schröder, Matthias Scheunemann, Barbara Wenzel & Peter Brust. (2021) Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016. International Journal of Molecular Sciences 22:8, pages 3832.
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Veronika Ručilová, Artur Świerczek, David Vanda, Petr Funk, Barbora Lemrová, Alicja Gawalska, Adam Bucki, Barbara Nowak, Monika Zadrożna, Krzysztof Pociecha, Miroslav Soural, Elżbieta Wyska, Maciej Pawłowski, Grażyna Chłoń-Rzepa & Paweł Zajdel. (2021) New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases. European Journal of Medicinal Chemistry 209, pages 112854.
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Ajmer Singh Grewal, Neelam Sharma, Sukhbir Singh & Sandeep Arora. (2019) In Silico Designing of Novel Thiazolidine-2-one Derivatives as Dual PDE4/7 Inhibitors for Inflammatory Disorders. Journal of Pharmaceutical Technology, Research and Management 5:2, pages 149-162.
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Himanshu Sharma, Viney Lather, Ajmer Singh Grewal & Deepti Pandita. (2019) Synthesis, Anti-inflammatory Activity and Docking Studies of Some Newer 1,3-Thiazolidine-2,4-dione Derivatives as Dual Inhibitors of PDE4 and PDE7. Current Computer-Aided Drug Design 15:3, pages 225-234.
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Nazanin Namazi Sarvestani, Saeedeh Saberi Firouzi, Reza Falak, Mohammad Yahya Karimi, Mohammad Davoodzadeh Gholami, Akram Rangbar & Asieh Hosseini. (2018) Phosphodiesterase 4 and 7 inhibitors produce protective effects against high glucose-induced neurotoxicity in PC12 cells via modulation of the oxidative stress, apoptosis and inflammation pathways. Metabolic Brain Disease 33:4, pages 1293-1306.
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Yinuo Wu, Zhe Li, Yi-You Huang, Deyan Wu & Hai-Bin Luo. (2018) Novel Phosphodiesterase Inhibitors for Cognitive Improvement in Alzheimer’s Disease. Journal of Medicinal Chemistry 61:13, pages 5467-5483.
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Vinny Lather, Ajmer Singh Grewal, Pardeep Kumar & Jagdeep Singh Dua. (2017) Synthesis, Docking and Anti-inflammatory Activity of Some Newer Triazole Derivatives as Potential PDE7 Inhibitors. Journal of Medicinal Chemistry and Toxicology 2:2, pages 55-61.
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R. Martín-Álvarez, N. Paúl-Fernández, V. Palomo, C. Gil, A. Martínez & G. Mengod. (2017) A preliminary investigation of phoshodiesterase 7 inhibitor VP3.15 as therapeutic agent for the treatment of experimental autoimmune encephalomyelitis mice. Journal of Chemical Neuroanatomy 80, pages 27-36.
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J. Mercier, L. Provins & J. Hannestad. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 20 64 .
Susann Schröder, Barbara Wenzel, Winnie Deuther-Conrad, Matthias Scheunemann & Peter Brust. (2016) Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012. Molecules 21:5, pages 650.
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Tarana Umar & Nasimul Hoda. (2015) Selective inhibitors of phosphodiesterases: therapeutic promise for neurodegenerative disorders. MedChemComm 6:12, pages 2063-2080.
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David Thomae, Stijn Servaes, Naiara Vazquez, Leonie wyffels, Stefanie Dedeurwaerdere, Pieter Van der Veken, Jurgen Joossens, Koen Augustyns, Sigrid Stroobants & Steven Staelens. (2015) Synthesis and preclinical evaluation of an 18 F labeled PDE7 inhibitor for PET neuroimaging. Nuclear Medicine and Biology 42:12, pages 975-981.
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Ana M. García, José Brea, Jose A. Morales-GarcíaDaniel I. Perez, Alejandro González, Sandra Alonso-GilIrene Gracia-Rubio, Clara Ros-Simó, Santiago Conde, María Isabel Cadavid, María Isabel Loza, Ana Perez-CastilloOlga Valverde, Ana Martinez & Carmen Gil. (2014) Modulation of cAMP-Specific PDE without Emetogenic Activity: New Sulfide-Like PDE7 Inhibitors. Journal of Medicinal Chemistry 57:20, pages 8590-8607.
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Frank S. Menniti, Niels Plath, Niels Svenstrup & Christopher J. Schmidt. 2014. Cyclic-Nucleotide Phosphodiesterases In The Central Nervous System. Cyclic-Nucleotide Phosphodiesterases In The Central Nervous System 77 114 .
Nigel A. Swain & Rainer Gewald. 2014. Phosphodiesterases and Their Inhibitors. Phosphodiesterases and Their Inhibitors 165 190 .
Ana I. Sánchez, Ricardo Meneses, José M. Mínguez, Araceli Núñez, Rafael R. Castillo, Fabiana Filace, Carolina Burgos, Juan J. Vaquero, Julio Álvarez-Builla, Alvaro Cortés-Cabrera, Federico Gago, Emma Terricabras & Víctor Segarra. (2014) Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold. Org. Biomol. Chem. 12:24, pages 4233-4242.
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Rocio Perez-Gonzalez, Consuelo Pascual, Desiree Antequera, Marta Bolos, Miriam Redondo, Daniel I. Perez, Virginia Pérez-Grijalba, Agnieszka Krzyzanowska, Manuel Sarasa, Carmen Gil, Isidro Ferrer, Ana Martinez & Eva Carro. (2013) Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease. Neurobiology of Aging 34:9, pages 2133-2145.
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Ana Martinez & Carmen Gil. 2013. Emerging Drugs and Targets for Parkinson’s Disease. Emerging Drugs and Targets for Parkinson’s Disease 294 307 .
Ana I. Sánchez, Valentín Martínez-Barrasa, Carolina Burgos, Juan J. Vaquero, Julio Alvarez-Builla, Emma Terricabras & Víctor Segarra. (2013) Synthesis and evaluation of quinazoline derivatives as phosphodiesterase 7 inhibitors. Bioorganic & Medicinal Chemistry 21:8, pages 2370-2378.
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Ma José Jerez, Miguel Jerez, Coral González-García, Sara Ballester & Ana Castro. (2013) Combined use of pharmacophoric models together with drug metabolism and genotoxicity “in silico” studies in the hit finding process. Journal of Computer-Aided Molecular Design 27:1, pages 79-90.
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Miriam Redondo, Valle Palomo, José Brea, Daniel I. Pérez, Rocío Martín-Álvarez, Concepción Pérez, Nuria Paúl-Fernández, Santiago Conde, María Isabel Cadavid, María Isabel Loza, Guadalupe Mengod, Ana Martínez, Carmen Gil & Nuria E. Campillo. (2012) Identification in Silico and Experimental Validation of Novel Phosphodiesterase 7 Inhibitors with Efficacy in Experimental Autoimmune Encephalomyelitis Mice . ACS Chemical Neuroscience 3:10, pages 793-803.
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Abhisek Banerjee, Sandip Patil, Mahesh Y. Pawar, Srinivas Gullapalli, Praveen K. Gupta, Maulik N. Gandhi, Deepak K. Bhateja, Malini Bajpai, Ramachandra Rao Sangana, Girish S. Gudi, Neelima Khairatkar-Joshi & Laxmikant A. Gharat. (2012) Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson’s disease model. Bioorganic & Medicinal Chemistry Letters 22:19, pages 6286-6291.
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Abhisek Banerjee, Pravin S. Yadav, Malini Bajpai, Ramachandra Rao Sangana, Srinivas Gullapalli, Girish S. Gudi & Laxmikant A. Gharat. (2012) Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation. Bioorganic & Medicinal Chemistry Letters 22:9, pages 3223-3228.
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Miriam Redondo, José Brea, Daniel I. Perez, Ignacio Soteras, Cristina Val, Concepción Perez, Jose A. Morales-García, Sandra Alonso-Gil, Nuria Paul-Fernandez, Rocío Martin-Alvarez, María Isabel Cadavid, María Isabel Loza, Ana Perez-Castillo, Guadalupe Mengod, Nuria E. Campillo, Ana Martinez & Carmen Gil. (2012) Effect of Phosphodiesterase 7 (PDE7) Inhibitors in Experimental Autoimmune Encephalomyelitis Mice. Discovery of a New Chemically Diverse Family of Compounds. Journal of Medicinal Chemistry 55:7, pages 3274-3284.
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Daniel I. Pérez, Marco Pistolozzi, Valle Palomo, Miriam Redondo, Cecilia Fortugno, Carmen Gil, Guy Felix, Ana Martinez & Carlo Bertucci. (2012) 5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3β (GSK-3β) and phosphodiesterase 7 (PDE7) inhibitors: Determination of blood–brain barrier penetration and binding to human serum albumin. European Journal of Pharmaceutical Sciences 45:5, pages 677-684.
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Miriam Redondo, Juan G. Zarruk, Placido Ceballos, Daniel I. Pérez, Concepción Pérez, Ana Perez-Castillo, María A. Moro, José Brea, Cristina Val, María I. Cadavid, María I. Loza, Nuria E. Campillo, Ana Martínez & Carmen Gil. (2012) Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model. European Journal of Medicinal Chemistry 47, pages 175-185.
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Rainer Gewald, Carla Rueger, Christian Grunwald, Ute Egerland & Norbert Hoefgen. (2011) Synthesis and structure–activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors. Bioorganic & Medicinal Chemistry Letters 21:22, pages 6652-6656.
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Irene Paterniti, Emanuela Mazzon, Carmen Gil, Daniela Impellizzeri, Valle Palomo, Myriam Redondo, Daniel I. Perez, Emanuela Esposito, Ana Martinez & Salvatore Cuzzocrea. (2011) PDE 7 Inhibitors: New Potential Drugs for the Therapy of Spinal Cord Injury. PLoS ONE 6:1, pages e15937.
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Mark A. Giembycz & Robert Newton. 2011. Phosphodiesterases as Drug Targets. Phosphodiesterases as Drug Targets 415 446 .
Kelly R. Bales, Niels Plath, Niels Svenstrup & Frank S. Menniti. 2010. Neurodegenerative Diseases. Neurodegenerative Diseases 57 90 .
Tania Castaño, Huanchen Wang, Nuria E. Campillo, Sara Ballester, Coral González-García, Javier Hernández, Concepción Pérez, Jimena Cuenca, Ana Pérez-Castillo, Ana Martínez, Oscar Huertas, José Luis Gelpí, F. Javier Luque, Hengming Ke & Carmen Gil. (2009) Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors. ChemMedChem 4:5, pages 866-876.
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