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Expert Opinion on Therapeutic Patents Volume 18, 2008 - Issue 6
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Review

Phenol-containing antagonists of the CXCR2 receptor

Jakob Busch-Petersen GlaxoSmithKline, King of Prussia, PA 19406, USA +1 610 270 7831; [email protected]
&
Yonghui Wang GlaxoSmithKline, King of Prussia, PA 19406, USA +1 610 270 7831; [email protected]
Pages 629-637 | Published online: 26 May 2008

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Michael P Dwyer & Younong Yu. (2014) CXCR2 modulators: a patent review (2009 – 2013). Expert Opinion on Therapeutic Patents 24:5, pages 519-534.
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Peter Norman. (2013) Evaluation of WO2012080456 and WO2012080457; Boheringer Ingleheim's first CXCR2 antagonists. Expert Opinion on Therapeutic Patents 23:3, pages 383-388.
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Peter Norman. (2013) Evidence on the identity of the CXCR2 antagonist AZD-5069. Expert Opinion on Therapeutic Patents 23:1, pages 113-117.
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James E Pease & Richard Horuk. (2009) Chemokine receptor antagonists: part 2. Expert Opinion on Therapeutic Patents 19:2, pages 199-221.
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Articles from other publishers (12)

Kai Tang, Shu Wang, Wenshuo Gao, Yihui Song & Bin Yu. (2022) Harnessing the cyclization strategy for new drug discovery. Acta Pharmaceutica Sinica B 12:12, pages 4309-4326.
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Reda M. Abdelhameed, Mohammed Abu-Elghait & Mahmoud El-Shahat. (2022) Engineering titanium-organic framework decorated silver molybdate and silver vanadate as antimicrobial, anticancer agents, and photo-induced hydroxylation reactions. Journal of Photochemistry and Photobiology A: Chemistry 423, pages 113572.
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Yi Dong, Rong Fu, Jiajing Chen, Kehui Zhang, Ming Ji, Mingjin Wang, Huimin Jiang, Wei Ye, Jinping Hu, Yan Li, Jing Jin, Xiaoguang Chen & Heng Xu. (2021) Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. Journal of Medicinal Chemistry 64:22, pages 16626-16640.
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Jan Chasák, Veronika Šlachtová, Milan Urban & Lucie Brulíková. (2021) Squaric acid analogues in medicinal chemistry. European Journal of Medicinal Chemistry 209, pages 112872.
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Jinxin Che, Rui Song, Binhui Chen & Xiaowu Dong. (2020) Targeting CXCR1/2: The medicinal potential as cancer immunotherapy agents, antagonists research highlights and challenges ahead. European Journal of Medicinal Chemistry 185, pages 111853.
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Hongfu Lu, Ting Yang, Zhongmiao Xu, Xichen Lin, Qian Ding, Yueting Zhang, Xin Cai, Kelly Dong, Sophie Gong, Wei Zhang, Metul PatelRoyston C. B. CopleyJianing Xiang, Xiaoming Guan, Paul Wren & Feng Ren. (2018) Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. Journal of Medicinal Chemistry 61:6, pages 2518-2532.
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Heng Xu, Hongfu Lu, Zhongmiao Xu, Linbo Luan, Chengyong Li, Yan Xu, Kelly Dong, Jinqiang Zhang, Xiong Li, Yvonne Li, Gentao Liu, Sophie Gong, Yong-Gang Zhao, Ailian Liu, Yueting Zhang, Wei Zhang, Xin Cai, Jia-Ning Xiang, John D. Elliott & Xichen Lin. (2016) Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders. ACS Medicinal Chemistry Letters 7:4, pages 397-402.
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Hongfu Lu, Ting Yang, Zhongmiao Xu, Paul B. Wren, Yueting Zhang, Xin Cai, Metul Patel, Kelly Dong, Qing Zhang, Wei Zhang, Xiaoming Guan, Jianing Xiang, John D. Elliott, Xichen Lin & Feng Ren. (2014) 2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: Discovery of novel and potent CXCR2 antagonists. Bioorganic & Medicinal Chemistry Letters 24:23, pages 5493-5496.
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David W. Porter, Michelle Bradley, Zarin Brown, Steven J. Charlton, Brian Cox, Peter Hunt, Diana Janus, Sarah Lewis, Paul Oakley, Des O’Connor, John Reilly, Nichola Smith & Neil J. Press. (2014) The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 24:15, pages 3285-3290.
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R. Ian Storer, Caroline Aciro & Lyn H. Jones. (2011) Squaramides: physical properties, synthesis and applications. Chemical Society Reviews 40:5, pages 2330.
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Katsuhiro Mihara & Jac Wijkmans. 2010. Chemokine Receptors as Drug Targets. Chemokine Receptors as Drug Targets 279 299 .
Simon J. Teague & Simon Barber. (2010) Synthesis of 6-substituted 5-cyano-7-hydroxy-2-carboxybenzofurans. Tetrahedron Letters 51:36, pages 4720-4722.
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