Advanced search
Publication Cover
Expert Opinion on Therapeutic Patents Volume 20, 2010 - Issue 10: Antibiotics versus resistant bacteria: recent patents
Submit an article Journal homepage
583
Views
50
CrossRef citations to date
0
Altmetric
Reviews

New aminoglycoside antibiotics

Paola Dozzo Achaogen, Inc., 7000 Shoreline Court, South San Francisco, CA 94080, USA
, PhD &
Heinz E Moser Achaogen, Inc., 7000 Shoreline Court, South San Francisco, CA 94080, USA +1 650 266 1140; +1 650 266 1154; [email protected]
, PhD
Pages 1321-1341 | Published online: 30 Jul 2010

Citations (50)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Moayad Alhariri, Majed A Majrashi, Ali H Bahkali, Faisal S Almajed, Ali O Azghani, Mohammad A Khiyami, Essam J Alyamani, Sameera M Aljohani & Majed A Halwani. (2017) Efficacy of neutral and negatively charged liposome-loaded gentamicin on planktonic bacteria and biofilm communities. International Journal of Nanomedicine 12, pages 6949-6961.
Read now
George G Zhanel, Christopher D Lawson, Sheryl Zelenitsky, Brandon Findlay, Frank Schweizer, Heather Adam, Andrew Walkty, Ethan Rubinstein, Alfred S Gin, Daryl J Hoban, Joseph P Lynch & James A Karlowsky. (2012) Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin. Expert Review of Anti-infective Therapy 10:4, pages 459-473.
Read now
Matteo Bassetti, Francesca Ginocchio, Małgorzata Mikulska, Lucia Taramasso & Daniele Roberto Giacobbe. (2011) Will new antimicrobials overcome resistance among Gram-negatives?. Expert Review of Anti-infective Therapy 9:10, pages 909-922.
Read now

Articles from other publishers (47)

Xia Ji, Ruojing Yu, Meilian Zhu, Cuilin Zhang, Libin Zhou, Tianshu Cai & Weiwei Li. (2023) Diadenosine tetraphosphate modulated quorum sensing in bacteria treated with kanamycin. BMC Microbiology 23:1.
Crossref
Weina Shi, Junwan Lu, Chunlin Feng, Mengdi Gao, Anqi Li, Shuang Liu, Lei Zhang, Xueya Zhang, Qiaoling Li, Hailong Lin, Xi Lin, Kewei Li, Hailin Zhang, Yunliang Hu, Guangli Wang, Qiyu Bao & Weiyan Jiang. (2023) Functional characterization of a novel aminoglycoside phosphotransferase, APH(9)-Ic, and its variant from Stenotrophomonas maltophilia. Frontiers in Cellular and Infection Microbiology 12.
Crossref
V. V. Belakhov. (2023) Polyfunctional Drugs: Search, Development, Use in Medical Practice, and Environmental Aspects of Preparation and Application (A Review). Russian Journal of General Chemistry 92:13, pages 3030-3055.
Crossref
Ribai YAN, Youhong NIU, Yuheng LIU, Junfeng DENG & Xinshan YE. (2022) Design, synthesis, and bioassay of 5-epi-aminoglycosides. Chinese Journal of Natural Medicines 20:11, pages 854-862.
Crossref
Kaicheng Yan, Beibei Liang, Guanxuanzi Zhang, Jin Wang, Man Zhu & Yun Cai. (2022) Efficacy and Safety of Plazomicin in the Treatment of Enterobacterales Infections: A Meta-analysis of Randomized Controlled Trials. Open Forum Infectious Diseases 9:9.
Crossref
Ragi Jadimurthy, Shilpa Borehalli Mayegowda, S.Chandra Nayak, Chakrabhavi Dhananjaya Mohan & Kanchugarakoppal S. Rangappa. (2022) Escaping mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds. Biotechnology Reports 34, pages e00728.
Crossref
Nuoyan Wang, Jing Luo, Fei Deng, Yasi Huang & Hong Zhou. (2022) Antibiotic Combination Therapy: A Strategy to Overcome Bacterial Resistance to Aminoglycoside Antibiotics. Frontiers in Pharmacology 13.
Crossref
Shaotong Zhou, Xiaotang Chen, Xianpu Ni, Yu Liu, Hui Zhang, Min Dong & Huanzhang Xia. (2021) Pyridoxal-5′-phosphate-dependent enzyme GenB3 Catalyzes C-3′,4′-dideoxygenation in gentamicin biosynthesis. Microbial Cell Factories 20:1.
Crossref
Amala Maxwell, Vivek Ghate, Jesil Aranjani & Shaila Lewis. (2021) Breaking the barriers for the delivery of amikacin: Challenges, strategies, and opportunities. Life Sciences 284, pages 119883.
Crossref
Adriana Elena Bulboacă, Alina Porfire, Sorana D. Bolboacă, Cristina Ariadna Nicula, Dana Gabriela Feștilă, Alexandra Roman, Ruxandra Mioara Râjnoveanu, Armand Râjnoveanu, Gabriela Dogaru, Paul-Mihai Boarescu, Vasile Rus, Corneliu Angelo Bulboacă, Alexandra Ina Bulboacă & Ioana Stănescu. (2021) Protective Effects of Liposomal Curcumin on Oxidative Stress/Antioxidant Imbalance, Metalloproteinases 2 and -9, Histological Changes and Renal Function in Experimental Nephrotoxicity Induced by Gentamicin. Antioxidants 10:2, pages 325.
Crossref
Adam Baraka, German M. Traglia, Sabrina Montaña, Marcelo E. Tolmasky & Maria Soledad Ramirez. (2020) An Acinetobacter non-baumannii Population Study: Antimicrobial Resistance Genes (ARGs). Antibiotics 10:1, pages 16.
Crossref
Fatemeh Hemmati, Roya Salehi, Reza Ghotaslou, Hossein Samadi Kafil, Alka Hasani, Pourya Gholizadeh & Mohammad Ahangarzadeh Rezaee. (2020) The assessment of antibiofilm activity of chitosan-zinc oxide-gentamicin nanocomposite on Pseudomonas aeruginosa and Staphylococcus aureus. International Journal of Biological Macromolecules 163, pages 2248-2258.
Crossref
Yeon Hee Ban, Myoung Chong Song, Hee Jin Kim, Heejeong Lee, Jae Bok Wi, Je Won Park, Dong Gun Lee & Yeo Joon Yoon. (2020) Development of 6′-N-Acylated Isepamicin Analogs with Improved Antibacterial Activity against Isepamicin-Resistant Pathogens. Biomolecules 10:6, pages 893.
Crossref
Zifang Shang, Siew Yin Chan, Qing Song, Peng Li & Wei Huang. (2020) The Strategies of Pathogen-Oriented Therapy on Circumventing Antimicrobial Resistance. Research 2020.
Crossref
Khalid Eljaaly, Aisha Alharbi, Samah Alshehri, Jessica K. Ortwine & Jason M. Pogue. (2019) Plazomicin: A Novel Aminoglycoside for the Treatment of Resistant Gram-Negative Bacterial Infections. Drugs 79:3, pages 243-269.
Crossref
Alisa W. Serio, Tiffany Keepers, Logan Andrews & Kevin M. Krause. (2018) Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation. EcoSal Plus 8:1.
Crossref
Maria Ramirez & Marcelo Tolmasky. (2017) Amikacin: Uses, Resistance, and Prospects for Inhibition. Molecules 22:12, pages 2267.
Crossref
Louis Zimmermann, Indrajit Das, Jérôme Désiré, Guillaume Sautrey, Vinicius Barros R. S., Micheline El Khoury, Marie-Paule Mingeot-Leclercq & Jean-Luc Décout. (2016) New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. Journal of Medicinal Chemistry 59:20, pages 9350-9369.
Crossref
Bopha Kong, Tanmaya Joshi, Matthew J. Belousoff, Yitzhak Tor, Bim Graham & Leone Spiccia. (2016) Neomycin B-cyclen conjugates and their Zn(II) complexes as RNA-binding agents. Journal of Inorganic Biochemistry 162, pages 334-342.
Crossref
Mathieu F. Chellat, Luka Raguž & Rainer Riedl. (2016) Targeting Antibiotic Resistance. Angewandte Chemie International Edition 55:23, pages 6600-6626.
Crossref
Mathieu F. Chellat, Luka Raguž & Rainer Riedl. (2016) Antibiotikaresistenzen gezielt überwinden. Angewandte Chemie 128:23, pages 6710-6738.
Crossref
V. G. Alekseev & E. V. Markova. (2016) Constants of acid?base equilibria in an aqueous amikacin aminoglycoside solution at 298 K. Russian Journal of Physical Chemistry A 90:3, pages 586-591.
Crossref
Ali Zineddine Boumehira, Hesham Ali El-Enshasy, Hocine Hacène, Elsayed Ahmed Elsayed, Ramlan Aziz & Enoch Y. Park. (2016) Recent progress on the development of antibiotics from the genus Micromonospora. Biotechnology and Bioprocess Engineering 21:2, pages 199-223.
Crossref
Nishad Thamban Chandrika & Sylvie Garneau-Tsodikova. (2016) A review of patents (2011–2015) towards combating resistance to and toxicity of aminoglycosides. MedChemComm 7:1, pages 50-68.
Crossref
Marie-Paule Mingeot-Leclercq & Jean-Luc Décout. (2016) Bacterial lipid membranes as promising targets to fight antimicrobial resistance, molecular foundations and illustration through the renewal of aminoglycoside antibiotics and emergence of amphiphilic aminoglycosides. MedChemComm 7:4, pages 586-611.
Crossref
Tanmaya Joshi, Zhi Xiang Voo, Bim Graham, Leone Spiccia & Lisandra L. Martin. (2015) Real-time examination of aminoglycoside activity towards bacterial mimetic membranes using Quartz Crystal Microbalance with Dissipation monitoring (QCM-D). Biochimica et Biophysica Acta (BBA) - Biomembranes 1848:2, pages 385-391.
Crossref
Pamela Brown & Michael J. Dawson. 2015. 135 184 .
James E. Leggett. 2015. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases 310 321.e7 .
Thomas A Keating, Troy Lister & Jeroen C Verheijen. (2014) New antibacterial agents: patent applications published in 2011. Pharmaceutical Patent Analyst 3:1, pages 87-112.
Crossref
Yossi Paitan & Eliora Z. Ron. 2014. Antimicrobials. Antimicrobials 29 56 .
Herbert A. Kirst & Flavia Marinelli. 2014. Antimicrobials. Antimicrobials 193 209 .
Maralise Perigolo de Oliveira, Jean-François Constant, Marine Peuchmaur, Ivan Pitta & Jean-Luc Décout. (2013) Antibiotic Drugs Aminoglycosides Cleave DNA at Abasic Sites: Shedding New Light on Their Toxicity?. Chemical Research in Toxicology 26:11, pages 1710-1719.
Crossref
Louis Zimmermann, Antoine Bussière, Myriam Ouberai, Isabelle Baussanne, Claude Jolivalt, Marie-Paule Mingeot-Leclercq & Jean-Luc Décout. (2013) Tuning the Antibacterial Activity of Amphiphilic Neamine Derivatives and Comparison to Paromamine Homologues. Journal of Medicinal Chemistry 56:19, pages 7691-7705.
Crossref
Kristin J Labby & Sylvie Garneau-Tsodikova. (2013) Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections. Future Medicinal Chemistry 5:11, pages 1285-1309.
Crossref
K. Kumar & S. Chopra. (2013) New drugs for methicillin-resistant Staphylococcus aureus: an update. Journal of Antimicrobial Chemotherapy 68:7, pages 1465-1470.
Crossref
Manjunath P. Pai, Wen Zhen Chen, Adinoyi Garba, Huadong Cui, Barbara Zaffo, Hassan A. N. El-Fawal & Shaker A. Mousa. (2013) Effects of Obesity and Sex on Antimicrobial Pharmacokinetics and Acute Kidney Injury: Validation of a Preclinical Model. Antimicrobial Agents and Chemotherapy 57:2, pages 716-722.
Crossref
Bernd Becker & Matthew A. Cooper. (2012) Aminoglycoside Antibiotics in the 21st Century. ACS Chemical Biology 8:1, pages 105-115.
Crossref
Sung Ryeol Park, Je Won Park, Yeon Hee Ban, Jae Kyung Sohng & Yeo Joon Yoon. (2013) 2-Deoxystreptamine-containing aminoglycoside antibiotics: Recent advances in the characterization and manipulation of their biosynthetic pathways. Nat. Prod. Rep. 30:1, pages 11-20.
Crossref
Suzanne S Stokes, Marshall Morningstar, Helena Kocis & Jeroen C Verheijen. (2012) New antibacterial agents: patent applications published in 2010. Pharmaceutical Patent Analyst 1:5, pages 601-620.
Crossref
Indrajit Das, Jérôme Désiré, Dinesh Manvar, Isabelle Baussanne, Virendra N. Pandey & Jean-Luc Décout. (2012) A Peptide Nucleic Acid–Aminosugar Conjugate Targeting Transactivation Response Element of HIV-1 RNA Genome Shows a High Bioavailability in Human Cells and Strongly Inhibits Tat-Mediated Transactivation of HIV-1 Transcription. Journal of Medicinal Chemistry 55:13, pages 6021-6032.
Crossref
Nicolas Gernigon, Val?rie Bordeau, Fabienne Berr?e, Brice Felden & Bertrand Carboni. (2012) Synthesis and antibacterial activity of novel neamine derivatives: preponderant role of the substituent position on the neamine core. Organic & Biomolecular Chemistry 10:24, pages 4720.
Crossref
Kenward Vong & Karine Auclair. (2012) Understanding and overcoming aminoglycoside resistance caused by N-6?-acetyltransferase. MedChemComm 3:4, pages 397.
Crossref
Olivier Jackowski, Antoine Bussière, Cécile Vanhaverbeke, Isabelle Baussanne, Eric Peyrin, Marie-Paule Mingeot-Leclercq & Jean-Luc Décout. (2012) Major increases of the reactivity and selectivity in aminoglycoside O-alkylation due to the presence of fluoride ions. Tetrahedron 68:2, pages 737-746.
Crossref
Ryan Hudson & Brooke Olson Blair. (2011) Inhaled antibiotics for Gram-negative respiratory infections. Future Medicinal Chemistry 3:13, pages 1663-1677.
Crossref
Daniela Vullo, Isao Nishimori, Tomoko Minakuchi, Andrea Scozzafava & Claudiu T. Supuran. (2011) Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium. Bioorganic & Medicinal Chemistry Letters 21:12, pages 3591-3595.
Crossref
Matteo Bassetti, Francesca Ginocchio, Daniele Roberto Giacobbe & Malgorzata Mikulska. (2011) Development of antibiotics for Gram-negatives: where now?. Clinical Investigation 1:2, pages 211-227.
Crossref
D. Obrecht, F. Bernardini, G. Dale & K. Dembowsky. 2011. 245 262 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.