Advanced search
Publication Cover
Expert Opinion on Therapeutic Patents Volume 21, 2011 - Issue 2
Submit an article Journal homepage
271
Views
23
CrossRef citations to date
0
Altmetric
Perspective

Pigment epithelium-derived factor as an anticancer drug and new treatment methods following the discovery of its receptors: a patent perspective

Katrina B Manalo Master of Science, Department of Orthopaedics and University of Melbourne Department of Medicine, St. Vincent's Hospital, VIC, Australia
,
Peter FM Choong University of Melbourne Department of Surgery, VIC, Australia; Sarcoma Service, Peter MacCallum Cancer Institute, VIC, Australia
, MBBS FRACS,
S Patricia Becerra Section of Protein Structure and Function, National Eye Institute (NEI)-National Institutes of Health (NIH), Bethesda, MD 20892-0608, USA
&
Crispin R Dass School of Biomedical and Health Sciences, Victoria University, St Albans, VIC, Australia +61 3 9919 2419; +61 3 9416 3610; [email protected]
Pages 121-130 | Published online: 05 Jan 2011

Citations (23)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Naomi Brook, Emily Brook, Arun Dharmarajan, Arlene Chan & Crispin R. Dass. (2019) The role of pigment epithelium-derived factor in protecting against cellular stress. Free Radical Research 53:11-12, pages 1166-1180.
Read now

Articles from other publishers (22)

Carmen Gil-Gas, Marta Sánchez-Díez, Paloma Honrubia-Gómez, Jose Luis Sánchez-Sánchez, Carmen B. Alvarez-Simón, Sebastia Sabater, Francisco Sánchez-Sánchez & Carmen Ramírez-Castillejo. (2023) Self-Renewal Inhibition in Breast Cancer Stem Cells: Moonlight Role of PEDF in Breast Cancer. Cancers 15:22, pages 5422.
Crossref
Abraham S. Moses, Ananiya A. Demessie, Olena Taratula, Tetiana Korzun, Ov D. Slayden & Oleh Taratula. (2021) Nanomedicines for Endometriosis: Lessons Learned from Cancer Research. Small 17:7, pages 2004975.
Crossref
Yolanda Diego‐Otero, Rosa María Giráldez‐Pérez, Elena Lima‐Cabello, Raúl Heredia‐Farfan, Rocío Calvo Medina, Lourdes Sanchez‐Salido & Lucía Pérez Costillas. (2020) Pigment epithelium‐derived factor ( PEDF ) and PEDF‐receptor in the adult mouse brain: Differential spatial/temporal localization pattern . Journal of Comparative Neurology 529:1, pages 141-158.
Crossref
Ji-Eun Kim, Hana Park, Min-Jeong Jeong & Tae-Cheon Kang. (2020) Epigallocatechin-3-Gallate and PEDF 335 Peptide, 67LR Activators, Attenuate Vasogenic Edema, and Astroglial Degeneration Following Status Epilepticus. Antioxidants 9:9, pages 854.
Crossref
Arina Riabinska, Marietta Zille, Menderes Yusuf Terzi, Ryan Cordell, Melina Nieminen-Kelhä, Jan Klohs & Ana Luisa Piña. (2019) Pigment Epithelium-Derived Factor Improves Paracellular Blood–Brain Barrier Integrity in the Normal and Ischemic Mouse Brain. Cellular and Molecular Neurobiology 40:5, pages 751-764.
Crossref
Paloma Honrubia-Gómez, María-Pilar López-Garrido, Carmen Gil-Gas, José Sánchez-Sánchez, Carmen Alvarez-Simon, Jorge Cuenca-Escalona, Ana Ferrer Perez, Enrique Arias, Raul Moreno, Francisco Sánchez-Sánchez & Carmen Ramirez-Castillejo. (2019) Pedf derived peptides affect colorectal cancer cell lines resistance and tumour re-growth capacity. Oncotarget 10:31, pages 2973-2986.
Crossref
Daisy S. Nakamura, Judith M. Hollander, Tomoya Uchimura, Heber C. Nielsen & Li Zeng. (2017) Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions. BMC Musculoskeletal Disorders 18:1.
Crossref
Jayoung Kim, Adam C. Mirando, Aleksander S. Popel & Jordan J. Green. (2017) Gene delivery nanoparticles to modulate angiogenesis. Advanced Drug Delivery Reviews 119, pages 20-43.
Crossref
Louiza Belkacemi & Shaun Xiaoliu Zhang. (2016) Anti-tumor effects of pigment epithelium-derived factor (PEDF): implication for cancer therapy. A mini-review. Journal of Experimental & Clinical Cancer Research 35:1.
Crossref
Haizhao Yi, Dengbo Ji, Tiancheng Zhan, Yunfeng Yao, Ming Li, Jinying Jia, Zhaowei Li & Jin Gu. (2016) Prognostic value of pigment epithelium-derived factor for neoadjuvant radiation therapy in patients with locally advanced rectal carcinoma. International Journal of Oncology 49:4, pages 1415-1426.
Crossref
Keren Goldberg, Hadas Bar-Joseph, Hadas Grossman, Noa Hasky, Shiri Uri-Belapolsky, Salomon M. Stemmer, Dana Chuderland, Ruth Shalgi & Irit Ben-Aharon. (2015) Pigment Epithelium–Derived Factor Alleviates Tamoxifen-Induced Endometrial Hyperplasia. Molecular Cancer Therapeutics 14:12, pages 2840-2849.
Crossref
Xuemin HeRui ChengSiribhinya BenyajatiJian-xing Ma. (2015) PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases. Clinical Science 128:11, pages 805-823.
Crossref
Umberto Vespasiani-Gentilucci & Krista Rombouts. (2015) Boosting pigment epithelial-derived factor: a promising approach for the treatment of early portal hypertension. Gut 64:4, pages 523-524.
Crossref
Dana Chuderland, Ido Ben-Ami, Hadas Bar-Joseph & Ruth Shalgi. (2014) Role of pigment epithelium-derived factor in the reproductive system. REPRODUCTION 148:4, pages R53-R61.
Crossref
Hadas Bar-Joseph, Ido Ben-Ami, Raphael Ron-El, Ruth Shalgi & Dana Chuderland. (2014) Pigment epithelium–derived factor exerts antioxidative effects in granulosa cells. Fertility and Sterility 102:3, pages 891-898.e3.
Crossref
Dana Chuderland, Ido Ben-Ami, Shevach Friedler, Noa Hasky, Lihi Ninio-Many, Keren Goldberg, Hadas Bar-joseph, Hadas Grossman & Ruth Shalgi. (2014) Hormonal regulation of pigment epithelium-derived factor (PEDF) expression in the endometrium. Molecular and Cellular Endocrinology 390:1-2, pages 85-92.
Crossref
Maria Demestre, Menderes Yusuf Terzi, Victor Mautner, Peter Vajkoczy, Andreas Kurtz & Ana Luisa Piña. (2013) Effects of pigment epithelium derived factor (PEDF) on malignant peripheral nerve sheath tumours (MPNSTs). Journal of Neuro-Oncology 115:3, pages 391-399.
Crossref
Dana Chuderland, Noa Hasky, Ido Ben-Ami, Ruth Kaplan-Kraicer, Hadas Grossman & Ruth Shalgi. (2013) A physiological approach for treating endometriosis by recombinant pigment epithelium-derived factor (PEDF). Human Reproduction 28:6, pages 1626-1634.
Crossref
CH Lin, CH Li, PL Liao, LS Tse, WK Huang, HW Cheng & YW Cheng. (2013) Silibinin inhibits VEGF secretion and age-related macular degeneration in a hypoxia-dependent manner through the PI-3 kinase/Akt/mTOR pathway. British Journal of Pharmacology 168:4, pages 920-931.
Crossref
Şafak Akın, Duygu Yazgan Aksoy, Neşe Çınar, Kadriye Aydın, Ergun Karaağaoğlu, Macit Arıyürek, Neşe Ersöz Gülçelik, Aydan Usman & Alper Gürlek. (2012) Pigment epithelium‐derived factor increases in type 2 diabetes after treatment with metformin. Clinical Endocrinology 77:6, pages 852-856.
Crossref
Giacomo Venturi, Alberto Gandini, Elena Monti, Luca Dalle Carbonare, Massimiliano Corradi, Monica Vincenzi, Maria Teresa Valenti, Maurizia Valli, Enrico Pelilli, Attilio Boner, Monica Mottes & Franco Antoniazzi. (2012) Lack of expression of SERPINF1 , the gene coding for pigment epithelium-derived factor, causes progressively deforming osteogenesis imperfecta with normal type I collagen . Journal of Bone and Mineral Research 27:3, pages 723-728.
Crossref
Christopher Bell. (2011) Pigment Epithelium-Derived Factor. Exercise and Sport Sciences Reviews 39:4, pages 187-190.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.