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Coumarin-based drugs: a patent review (2008 – present)

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Pages 437-454 | Published online: 04 Apr 2012

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Aso Hameed Hasan, Sonam Shakya, Faiq H.S. Hussain, Sankaranarayanan Murugesan, Subhash Chander, Mohammad Rizki Fadhil Pratama, Shajarahtunnur Jamil, Basundhara Das, Subhrajit Biswas & Joazaizulfazli Jamalis. (2023) Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids. Journal of Biomolecular Structure and Dynamics 41:21, pages 11450-11462.
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Sadeq M. Al-Hazmy, Donia Bensalah, Najet Aouled Dlala, Younes Bouazizi, Houcine Ghalla & Naceur Hamdi. (2023) A facile and practical p-toluenesulfonic acid catalyzed route to dicoumarols and their biological evaluation. Green Chemistry Letters and Reviews 16:1.
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Sherif M. H. Sanad & Ahmed E. M. Mekky. (2021) Efficient synthesis and characterization of novel bis(chromenes) and bis(benzo[f]chromenes) linked to thiazole units. Synthetic Communications 51:4, pages 611-624.
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Ahmed E. M. Mekky & Sherif M. H. Sanad. (2019) Synthesis of novel bis(chromenes) and bis(chromeno[3,4-C]pyridine) incorporating piperazine moiety. Synthetic Communications 49:11, pages 1385-1395.
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M. A. Salem, M. H. Helal, M. A. Gouda, Y. A. Ammar, M. S. A. El-Gaby & S. Y. Abbas. (2018) An overview on synthetic strategies to coumarins. Synthetic Communications 48:13, pages 1534-1550.
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Anastasia Detsi, Christos Kontogiorgis & Dimitra Hadjipavlou-Litina. (2017) Coumarin derivatives: an updated patent review (2015-2016). Expert Opinion on Therapeutic Patents 27:11, pages 1201-1226.
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Mert Olgun Karataş, Harun Uslu, Bülent Alıcı, Başak Gökçe, Nahit Gencer & Oktay Arslan. (2016) Some coumarins and benzoxazinones as potent paraoxonase 1 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1386-1391.
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Belma Zengin Kurt, Fatih Sönmez, Çiğdem Bilen, Adem Ergun, Nahit Gençer, Oktay Arslan & Mustafa Kucukislamoglu. (2016) Synthesis, antioxidant and carbonic anhydrase I and II inhibitory activities of novel sulphonamide-substituted coumarylthiazole derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 991-998.
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Anna-Maria Katsori & Dimitra Hadjipavlou-Litina. (2014) Coumarin derivatives: an updated patent review (2012 – 2014). Expert Opinion on Therapeutic Patents 24:12, pages 1323-1347.
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Sabrieh Ghasemi & Zohreh Habibi. (2014) A new dihydrofuranocoumarin from Opopanax hispidus (Friv.) Griseb.. Natural Product Research 28:21, pages 1808-1812.
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Karla Almaraz & Manuel Amézquita‐Valencia. (2023) Pd‐Catalyzed Intramolecular Hydroaminocarbonylation of 3‐Allyl‐4‐arylaminocoumarins: Synthesis of Six‐ and Seven‐membered Ring Lactams Fused to the Coumarin Scaffold. ChemCatChem 15:16.
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Anjoy Majhi, Katta Venkateswarlu & Palani Sasikumar‬‬‬‬. (2023) Coumarin Based Fluorescent Probe for Detecting Heavy Metal Ions. Journal of Fluorescence.
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Ranjitsinh C. Dabhi, Vinay S. Sharma, Prashant S. Arya, Unnati P. Patel, Pranav S. Shrivastav & Jayesh J. Maru. (2023) Coumarin functionalized dimeric mesogens for promising anticoagulant activity: Tuning of liquid crystalline property. Journal of Molecular Structure 1283, pages 135336.
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Nagender Thadem, Manda Rajesh & Saibal Das. (2021) Activator free diastereoselective 1,3-dipolar cycloaddition: a quick access to coumarin based spiro multi heterocyclic adducts. RSC Advances 11:48, pages 29934-29938.
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Mert Olgun Karataş, Bülent Alıcı, Vincenzo Passarelli, Ismail Özdemir, Jesús J. Pérez-Torrente & Ricardo Castarlenas. (2021) Iridium( i ) complexes bearing hemilabile coumarin-functionalised N-heterocyclic carbene ligands with application as alkyne hydrosilylation catalysts . Dalton Transactions 50:32, pages 11206-11215.
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Mainak Banerjee, Padmini C. Panjikar, Zigmee T. Bhutia, Akhil A. Bhosle & Amrita Chatterjee. (2021) Micellar nanoreactors for organic transformations with a focus on “dehydration” reactions in water: A decade update. Tetrahedron 88, pages 132142.
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Gopal Sharma, Anshul Uppal, Sumati Anthal, Madhukar Baburao Deshmukh, Priyanka Pandharinath Mohire, Tanaji Ramchandra Bhosale, Chellappanpillai Sudarsanakumar & Rajni Kant. (2020) Synthesis, X-ray structure, and DFT analysis of a binary complex of 3,3'-[(3-benzimidazolyl)methylene]bis(4-hydroxy-2H-1-benzopyran-2-one): 5-Methyl-1,3-thiazol-2(3H)-imine. European Journal of Chemistry 11:4, pages 324-333.
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Marjan Mollazadeh, Maryam Mohammadi-Khanaposhtani, Yousef Valizadeh, Afsaneh Zonouzi, Mohammad Ali Faramarzi, Parsa Hariri, Mahmood Biglar, Bagher Larijani, Haleh Hamedifar, Mohammad Mahdavi & Nima Sepehri. (2020) 2,4-Dioxochroman Moiety Linked to 1,2,3-triazole Derivatives as Novel α-glucosidase Inhibitors: Synthesis, In vitro Biological Evaluation, and Docking Study. Current Organic Chemistry 24:17, pages 2019-2027.
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I. V. Krasylov, V. S. Moskvina, S. V. Shilin & V. P. Khilya. (2020) Amino-Acid Derivatives of Pyranocoumarins. Chemistry of Natural Compounds 56:5, pages 832-836.
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Mert O. Karataş, Samir A. A. Noma, Canbolat Gürses, Sevgi Balcıoğlu, Burhan Ateş, Bülent Alıcı & Ümit Çakır. (2020) Water Soluble Coumarin Quaternary Ammonium Chlorides: Synthesis and Biological Evaluation. Chemistry & Biodiversity 17:9.
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Swati Chauhan, Pratibha Verma, Jeyakumar Kandasamy & Vandana Srivastava. (2020) A Practical Synthesis of 3‐Functionalized Coumarins from o ‐Cresols and Active Methylene Compounds under Metal and Catalyst‐Free Conditions Using tert ‐Butyl Hydrogen Peroxide . ChemistrySelect 5:29, pages 9030-9033.
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Gautam Kumar, Vagolu Siva Krishna, Dharmarajan Sriram & Sanjay M. Jachak. (2020) Pyrazole–coumarin and pyrazole–quinoline chalcones as potential antitubercular agents. Archiv der Pharmazie 353:8.
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Hanan M. Alshibl, Ebtehal S. Al-Abdullah, Mogedda E. Haiba, Hamad M. Alkahtani, Ghada E.A. Awad, Ahlam H. Mahmoud, Bassant M.M. Ibrahim, Ahmed Bari & Alexander Villinger. (2020) Synthesis and Evaluation of New Coumarin Derivatives as Antioxidant, Antimicrobial, and Anti-Inflammatory Agents. Molecules 25:14, pages 3251.
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Emad H. M. Hassanein, Ahmed M. Sayed, Omnia E. Hussein & Ayman M. Mahmoud. (2020) Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway. Oxidative Medicine and Cellular Longevity 2020, pages 1-25.
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Evangelia-Eirini N. Vlachou & Konstantinos E. Litinas. (2020) An Overview on Pyranocoumarins: Synthesis and Biological Activities. Current Organic Chemistry 23:24, pages 2679-2721.
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Sevgi Balcıoğlu, Mert Olgun Karataş, Burhan Ateş, Bülent Alıcı & İsmail Özdemir. (2020) Therapeutic potential of coumarin bearing metal complexes: Where are we headed?. Bioorganic & Medicinal Chemistry Letters 30:2, pages 126805.
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Shuangjia Zheng, Xin Yan, Qiong Gu, Yuedong Yang, Yunfei Du, Yutong Lu & Jun Xu. (2019) QBMG: quasi-biogenic molecule generator with deep recurrent neural network. Journal of Cheminformatics 11:1.
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Basem M. Abdallah & Enas M. Ali. (2019) 5′-hydroxy Auraptene stimulates osteoblast differentiation of bone marrow-derived mesenchymal stem cells via a BMP-dependent mechanism. Journal of Biomedical Science 26:1.
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Dinesh S. Reddy, Manasa Kongot, Vishal Singh, Neha Maurya, Rajan Patel, Nitin Kumar Singhal, Fernando Avecilla & Amit Kumar. (2019) Coumarin tethered cyclic imides as efficacious glucose uptake agents and investigation of hit candidate to probe its binding mechanism with human serum albumin. Bioorganic Chemistry 92, pages 103212.
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Swayansiddha Tripathy & Susanta Kumar Sahu. (2019) FtsZ inhibitors as a new genera of antibacterial agents. Bioorganic Chemistry 91, pages 103169.
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Sujin Lee, Onur Cil, Peter M. Haggie & Alan S. Verkman. (2019) 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation. Journal of Medicinal Chemistry 62:17, pages 8330-8337.
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Farnaz Jafarpour, Masoumeh Darvishmolla, Narges Azaddoost & Farid Mohaghegh. (2019) Direct C-3 alkylation of coumarins via decarboxylative coupling with carboxylic acids . New Journal of Chemistry 43:24, pages 9328-9332.
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Muhammad Islam, Ajmal Khan, Muhammad Tariq Shehzad, Abdul Hameed, Nadeem Ahmed, Sobia Ahsan Halim, Mohammed Khiat, Muhammad Usman Anwar, Javid Hussain, René Csuk, Zahid Shafiq & Ahmed Al-Harrasi. (2019) Synthesis and characterization of new thiosemicarbazones, as potent urease inhibitors: In vitro and in silico studies. Bioorganic Chemistry 87, pages 155-162.
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Nirajkumar H. Jadhav, Sachin S. Sakate, Nishant K. Rasal, Dnyaneshwar R. Shinde & Ramdas A. Pawar. (2019) Heterogeneously Catalyzed Pechmann Condensation Employing the Tailored Zn 0.925 Ti 0.075 O NPs: Synthesis of Coumarin . ACS Omega 4:5, pages 8522-8527.
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Marek K. Węcławski, Irena Deperasińska, Marzena Banasiewicz, David C. Young, Arkadiusz Leniak & Daniel T. Gryko. (2018) Building Molecular Complexity from Quinizarin: Conjoined Coumarins and Coronene Analogs. Chemistry – An Asian Journal 14:10, pages 1763-1770.
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Rajesh Kumar Sharma & Diksha Katiyar. 2019. Recent Trends in Human and Animal Mycology. Recent Trends in Human and Animal Mycology 235 263 .
Ramesh Gondru, Saikiran Reddy Peddi, Vijjulatha Manga, Manjulatha Khanapur, Rajitha Gali, Narsimha Sirassu & Rajitha Bavantula. (2018) One-pot synthesis, biological evaluation and molecular docking studies of fused thiazolo[2,3-b]pyrimidinone-pyrazolylcoumarin hybrids. Molecular Diversity 22:4, pages 943-956.
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Lamya H. Al-Wahaibi, Hanaa M. Abu-Melha & Diaa A. Ibrahim. (2018) Synthesis of Novel 1,2,4-Triazolyl Coumarin Derivatives as Potential Anticancer Agents. Journal of Chemistry 2018, pages 1-8.
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Andrea Angeli, Elena Trallori, Fabrizio Carta, Lorenzo Di Cesare Mannelli, Carla Ghelardini & Claudiu T. Supuran. (2018) Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines. ACS Medicinal Chemistry Letters 9:9, pages 947-951.
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Fan Cheng, Hua-Hua Wang, Atif Ali, Jaipal Kandhadi, Hui Wang, Xiang-Li Wang & Hai-Yang Liu. (2018) Photophysical properties and photodynamic anti-tumor activity of corrole-coumarin dyads. Journal of Porphyrins and Phthalocyanines 22:09n10, pages 886-898.
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Zoltán Pünkösti, Péter Kele & András Herner. (2018) Synthesis of 7‐Azido‐3‐Formylcoumarin – A Key Precursor in Bioorthogonally Applicable Fluorogenic Dye Synthesis. Journal of Heterocyclic Chemistry 55:5, pages 1183-1188.
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Dinesh S. Reddy, Manasa Kongot, Sandeep P. Netalkar, Mahantesh M. Kurjogi, Rakesh Kumar, Fernando Avecilla & Amit Kumar. (2018) Synthesis and evaluation of novel coumarin-oxime ethers as potential anti-tubercular agents: Their DNA cleavage ability and BSA interaction study. European Journal of Medicinal Chemistry 150, pages 864-875.
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Md Yousof Ali, Hyun Ah Jung, Susoma Jannat & Jae Sue Choi. (2017) Dihydroxanthyletin-type coumarins from Angelica decursiva that inhibits the formation of advanced glycation end products and human recombinant aldose reductase. Archives of Pharmacal Research 41:2, pages 196-207.
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Kinga Ostrowska, Wioletta Olejarz, Małgorzata Wrzosek, Alicja Głuszko, Grażyna Nowicka, Mirosław Szczepański, Ilona B. Materek, Anna E. Kozioł & Marta Struga. (2017) Anticancer effects of O-aminoalkyl derivatives of alloxanthoxyletin and seselin. Biomedicine & Pharmacotherapy 95, pages 1412-1424.
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Suchita Prasad, Bipul Kumar, Shiv Kumar, Karam Chand, Shashank S. Kamble, Hemant K. Gautam & Sunil K. Sharma. (2017) Acetamide Derivatives of Chromen-2-ones as Potent Cholinesterase Inhibitors. Archiv der Pharmazie 350:8, pages 1700076.
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Hrishikesh Mohan Revankar, Syed Nasir Abbas Bukhari, Gajjela Bharath Kumar & Hua-Li Qin. (2017) Coumarins scaffolds as COX inhibitors. Bioorganic Chemistry 71, pages 146-159.
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Gustavo Padilha, Paloma T. Birmann, Micaela Domingues, Teodoro S. Kaufman, Lucielli Savegnago & Claudio C. Silveira. (2017) Convenient Michael addition/β-elimination approach to the synthesis of 4-benzyl- and 4-aryl-selenyl coumarins using diselenides as selenium sources. Tetrahedron Letters 58:10, pages 985-990.
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Mahtab Kiani & Bahador Karami. (2016) Nanosilica molybdic acid: synthesis, characterization and application as a green and reusable catalyst for the Pechmann condensation. Journal of the Iranian Chemical Society 14:3, pages 655-663.
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Jorgelina L. Pergomet, Andrea B. J. Bracca & Teodoro S. Kaufman. (2017) Total syntheses of gerberinol I and the pterophyllins 2 and 4 using the Casnati–Skattebøl reaction under different conditions. Organic & Biomolecular Chemistry 15:33, pages 7040-7049.
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