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TRP channels as therapeutic targets in airway disorders: a patent review

, PhD, , MD PhD &
Pages 663-695 | Published online: 06 Jun 2012

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Huifen Chen & Jack A. Terrett. (2020) Transient receptor potential ankyrin 1 (TRPA1) antagonists: a patent review (2015–2019). Expert Opinion on Therapeutic Patents 30:9, pages 643-657.
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Mohaddeseh Sadat Alavi, Ali Shamsizadeh, Gholamreza Karimi & Ali Roohbakhsh. (2020) Transient receptor potential ankyrin 1 (TRPA1)-mediated toxicity: friend or foe?. Toxicology Mechanisms and Methods 30:1, pages 1-18.
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Arpad Szallasi & Mohamed Sheta. (2012) Targeting TRPV1 for pain relief: limits, losers and laurels. Expert Opinion on Investigational Drugs 21:9, pages 1351-1369.
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Qi Liang, Jing-Wen Wang, Yu-Ru Bai, Ruo-Lan Li, Chun-Jie Wu & Wei Peng. (2023) Targeting TRPV1 and TRPA1: A feasible strategy for natural herbal medicines to combat postoperative ileus. Pharmacological Research, pages 106923.
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Eleonóra Spekker, Tamás Körtési & László Vécsei. (2022) TRP Channels: Recent Development in Translational Research and Potential Therapeutic Targets in Migraine. International Journal of Molecular Sciences 24:1, pages 700.
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Akhilesh, Ankit Uniyal, Anagha Gadepalli, Vineeta Tiwari, Meghana Allani, Deepak Chouhan, Obulapathi Ummadisetty, Nimisha Verma & Vinod Tiwari. (2022) Unlocking the potential of TRPV1 based siRNA therapeutics for the treatment of chemotherapy-induced neuropathic pain. Life Sciences 288, pages 120187.
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Theerasuk Kawamatawong. (2021) Phosphodiesterase-4 Inhibitors for Non-COPD Respiratory Diseases. Frontiers in Pharmacology 12.
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Alessandro Rimessi, Veronica A. M. Vitto, Simone Patergnani & Paolo Pinton. (2021) Update on Calcium Signaling in Cystic Fibrosis Lung Disease. Frontiers in Pharmacology 12.
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Tunyu Jian, Jian Chen, Xiaoqin Ding, Han Lv, Jiawei Li, Yuexian Wu, Bingru Ren, Bei Tong, Yuanyuan Zuo, Kelei Su & Weilin Li. (2020) Flavonoids isolated from loquat ( Eriobotrya japonica ) leaves inhibit oxidative stress and inflammation induced by cigarette smoke in COPD mice: the role of TRPV1 signaling pathways . Food & Function 11:4, pages 3516-3526.
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Karel Talavera, Justyna B. Startek, Julio Alvarez-Collazo, Brett Boonen, Yeranddy A. Alpizar, Alicia Sanchez, Robbe Naert & Bernd Nilius. (2020) Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease. Physiological Reviews 100:2, pages 725-803.
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Qingzi Chen, Yubo Zhou, Lifen Zhou, Zhaodi Fu, Chuntao Yang, Lei Zhao, Shuni Li, Yan Chen, Yousen Wu, Zhenwei Ling, Yufeng Wang, Jianrong Huang & Jianhua Li. (2020) TRPC6-dependent Ca2+ signaling mediates airway inflammation in response to oxidative stress via ERK pathway. Cell Death & Disease 11:3.
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Amritlal Mandal, Anup Srivastava, Tapati Chakraborti & Sajal Chakraborti. 2020. Oxidative Stress in Lung Diseases. Oxidative Stress in Lung Diseases 223 243 .
Chloé Grebert, Frederic Becq & Clarisse Vandebrouck. (2019) Focus on TRP channels in cystic fibrosis. Cell Calcium 81, pages 29-37.
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Takahisa Shimada, Kenji Takahashi, Makoto Tominaga & Toshio Ohta. (2019) Identification of molecular targets for toxic action by persulfate, an industrial sulfur compound. NeuroToxicology 72, pages 29-37.
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Qing-Zi Chen, Yu-Bo Zhou, Li-Fen Zhou, Zhao-Di Fu, You-Sen Wu, Yan Chen, Shu-Ni Li, Jian-Rong Huang & Jian-Hua Li. (2019) TRPC6 modulates adhesion of neutrophils to airway epithelial cells via NF-κB activation and ICAM-1 expression with ozone exposure. Experimental Cell Research 377:1-2, pages 56-66.
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Muyun Wang, Yanbei Zhang, Mengmeng Xu, Hai Zhang, Yuqing Chen, Kian Fan Chung, Ian M. Adcock & Feng Li. (2019) Roles of TRPA1 and TRPV1 in cigarette smoke -induced airway epithelial cell injury model. Free Radical Biology and Medicine 134, pages 229-238.
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Raffaella Barbero, Cristina Vercelli, Barbara Cuniberti, Maria Federica della Valle, Marina Martano & Giovanni Re. (2018) Expression of functional TRPV1 receptor in primary culture of canine keratinocytes. Journal of Veterinary Pharmacology and Therapeutics 41:6, pages 795-804.
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Yang Xia, Lexin Xia, Lingyun Lou, Rui Jin, Huahao Shen & Wen Li. (2018) Transient Receptor Potential Channels and Chronic Airway Inflammatory Diseases: A Comprehensive Review. Lung 196:5, pages 505-516.
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Xiaoyu Zhang, Zhixin Zhao, Lijun Ma, Yali Guo, Xiaosu Li, Limin Zhao, Cuijie Tian, Xueyi Tang, Dongjun Cheng, Zhuochang Chen & Luoxian Zhang. (2018) The effects of transient receptor potential channel (TRPC) on airway smooth muscle cell isolated from asthma model mice. Journal of Cellular Biochemistry 119:7, pages 6033-6044.
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Li-Fen Zhou, Qing-Zi Chen, Chun-Tao Yang, Zhao-Di Fu, Shen-Ting Zhao, Yan Chen, Shu-Ni Li, Li Liao, Yu-Bo Zhou, Jian-Rong Huang & Jian-Hua Li. (2018) TRPC6 contributes to LPS-induced inflammation through ERK1/2 and p38 pathways in bronchial epithelial cells. American Journal of Physiology-Cell Physiology 314:3, pages C278-C288.
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Shadia Omar, Rebecca Clarke, Haniah Abdullah, Clare Brady, John Corry, Hanagh Winter, Olivier Touzelet, Ultan F. Power, Fionnuala Lundy, Lorcan P. A. McGarvey & S. Louise Cosby. (2017) Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells. PLOS ONE 12:2, pages e0171681.
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