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Phenylpiperazine derivatives: a patent review (2006 – present)

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Pages 1169-1178 | Published online: 07 Sep 2012

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Kajalben B. Patel, Rahul V. Patel, Iqrar Ahmad, Dhanji Rajani, Harun Patel, Sudipta Mukherjee & Premlata Kumari. (2023) Design, synthesis, molecular docking, molecular dynamic simulation, and MMGBSA analysis of 7-O-substituted 5-hydroxy flavone derivatives. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-15.
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Maria Novella Romanelli, Dina Manetti, Laura Braconi, Silvia Dei, Alessio Gabellini & Elisabetta Teodori. (2022) The piperazine scaffold for novel drug discovery efforts: the evidence to date. Expert Opinion on Drug Discovery 17:9, pages 969-984.
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Run-Hui Zhang, Hong-Yan Guo, Hao Deng, Jinzi Li & Zhe-Shan Quan. (2021) Piperazine skeleton in the structural modification of natural products: a review. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1165-1197.
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Anuj K. Rathi, Riyaz Syed, Han-Seung Shin & Rahul V. Patel. (2016) Piperazine derivatives for therapeutic use: a patent review (2010-present). Expert Opinion on Therapeutic Patents 26:7, pages 777-797.
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Articles from other publishers (15)

Yong Zhang, Xing Liu, Yue Zou, Sheng Wang, Hongyi Song, Qingfeng Cai, Ju Peng, Chongfen Yi & Jixiang Chen. (2023) Research progress of piperazine and morpholine derivatives in the discovery of agricultural chemicals. Journal of Heterocyclic Chemistry 60:11, pages 1826-1837.
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Ruijue Wang, Yuhan Li, Peng Gao, Jia Lv, Yiyun Cheng & Hui Wang. (2023) Piperazine-modified dendrimer achieves efficient intracellular protein delivery via caveolar endocytosis bypassing the endo-lysosomal pathway. Acta Biomaterialia 158, pages 725-733.
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Bhupinder Kumar, Naveen Kumar, Amandeep Thakur, Vijay Kumar, Rakesh Kumar & Vinod Kumar. (2022) A Review on the Arylpiperazine Derivatives as Potential Therapeutics for the Treatment of Various Neurological Disorders. Current Drug Targets 23:7, pages 729-751.
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Magdalena Popławska, Elżbieta Bednarek, Beata Naumczuk & Agata Błażewicz. (2021) Identification and structural characterization of three psychoactive substances, phenylpiperazines (pBPP and 3,4-CFPP) and a cocaine analogue (troparil), in collected samples. Forensic Toxicology 40:1, pages 132-143.
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Udhayasuriyan Sathya, Jeyaraman Selvaraj Nirmal Ram, Sundaramoorthy Gomathi, Shyamaladevi Ramu, Samson Jegan Jennifer & Abdul Razak Ibrahim. (2021) 4-(2,3-Dichlorophenyl)piperazin-1-ium picrate. IUCrData 6:4.
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Vallabhaneni S. Murthy, Yasinalli Tamboli, Vagolu Siva Krishna, Dharmarajan Sriram, Fang Xiong Zhang, Gerald W. Zamponi & Vijayaparthasarathi Vijayakumar. (2021) Synthesis and Biological Evaluation of Novel Benzhydrylpiperazine-Coupled Nitrobenzenesulfonamide Hybrids. ACS Omega 6:14, pages 9731-9740.
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Tereza Padrtová, Pavlína Marvanová, Renáta Kubínová, Jozef Csöllei, Oldřich Farsa, Tomáš Goněc, Klára Odehnalová, Radka Opatřilová, Jiří Pazourek, Alice Sychrová, Karel Šmejkal & Petr Mokrý. (2020) Indol-2-Carboxylic Acid Esters Containing N-Phenylpiperazine Moiety - Preparation and Cholinesterase-inhibiting Activity. Current Organic Synthesis 17:7, pages 576-587.
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Kai Zhao & Hon-Cheong So. (2019) Drug Repositioning for Schizophrenia and Depression/Anxiety Disorders: A Machine Learning Approach Leveraging Expression Data. IEEE Journal of Biomedical and Health Informatics 23:3, pages 1304-1315.
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Kartikey Singh, Chandan Sona, Vikash Ojha, Maninder Singh, Ankita Mishra, Ajeet Kumar, Mohammad Imran Siddiqi, Rama P. Tripathi & Prem N. Yadav. (2019) Identification of dual role of piperazine-linked phenyl cyclopropyl methanone as positive allosteric modulator of 5-HT2C and negative allosteric modulator of 5-HT2B receptors. European Journal of Medicinal Chemistry 164, pages 499-516.
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Katarzyna Szczepańska, Tadeusz Karcz, Magdalena Kotańska, Agata Siwek, Kamil J. Kuder, Gniewomir Latacz, Szczepan Mogilski, Stefanie Hagenow, Annamaria Lubelska, Michał Sobolewski, Holger Stark & Katarzyna Kieć-Kononowicz. (2018) Optimization and preclinical evaluation of novel histamine H3receptor ligands: Acetyl and propionyl phenoxyalkyl piperazine derivatives. Bioorganic & Medicinal Chemistry 26:23-24, pages 6056-6066.
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Dayane Moreira da Silva, Germán Sanz, Boniek Gontijo Vaz, Flávio Silva de Carvalho, Luciano Morais Lião, Danillo Ramos de Oliveira, Lorrane Kelle da Silva Moreira, Carina Sofia Cardoso, Adriane Ferreira de Brito, Daiany Priscilla Bueno da Silva, Fabio Fagundes da Rocha, Ianca Gontijo Cavalcante Santana, Pablinny Moreira Galdino, Elson Alves Costa & Ricardo Menegatti. (2018) Tert-butyl 4-((1-phenyl-1H-pyrazol-4-yl) methyl) piperazine-1-carboxylate (LQFM104)– New piperazine derivative with antianxiety and antidepressant-like effects: Putative role of serotonergic system. Biomedicine & Pharmacotherapy 103, pages 546-552.
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Jarosław Lewkowski, Andrzej Jóźwiak, Paweł Tokarz, Piotr M. Zagórski, Róża Hamera, Dariusz Cal, Grzegorz Satała & Andrzej J. Bojarski. (2015) Synthesis of Some Aminophosphonates Bearing N -(Fluorophenyl)-piperazynyl Moiety and Their Activity toward Serotonin Receptors . Heteroatom Chemistry 26:4, pages 290-298.
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Leonid I. Belen'kii & Yu B. Evdokimenkova. 2015. 193 363 .
Anvesh Jallapally, Dinesh Addla, Perumal Yogeeswari, Dharmarajan Sriram & Srinivas Kantevari. (2014) 2-Butyl-4-chloroimidazole based substituted piperazine-thiosemicarbazone hybrids as potent inhibitors of Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry Letters 24:23, pages 5520-5524.
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Andrés Navarrete, Francisco X. Flores-Machorro, Ruth I. Téllez-Ballesteros, Alejandro Alfaro-Romero, José Luis Balderas & Adelfo Reyes. (2014) Study on Action Mechanism of 1-(4-Methoxy-2-Methylphenyl)Piperazine (MMPP) in Acquisition, Formation, and Consolidation of Memory in Mice. Drug Development Research 75:2, pages 59-67.
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