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Histone deacetylase inhibitors: a patent review (2009 – 2011)

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Pages 1-17 | Published online: 25 Oct 2012

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Angela Nebbioso, Rosaria Benedetti, Mariarosaria Conte, Concetta Iside & Lucia Altucci. (2015) Genetic mutations in epigenetic modifiers as therapeutic targets in acute myeloid leukemia. Expert Opinion on Therapeutic Targets 19:9, pages 1187-1202.
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Jayme L. Dahlin, Xiaoyue Chen, Michael A. Walters & Zhiguo Zhang. (2015) Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases. Critical Reviews in Biochemistry and Molecular Biology 50:1, pages 31-53.
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Franciszek Sączewski & Łukasz Balewski. (2013) Biological activities of guanidine compounds, 2008 – 2012 update. Expert Opinion on Therapeutic Patents 23:8, pages 965-995.
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Articles from other publishers (29)

Amanda E. Crunk, Aneta Przepiorski & Neil A. Hukriede. 2022. Regenerative Nephrology. Regenerative Nephrology 451 464 .
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Huanran Sun, Jiaqi Song, Mingming Sun & Changliang Shan. 2021. Epigenetic Regulation in Overcoming Chemoresistance. Epigenetic Regulation in Overcoming Chemoresistance 25 39 .
Timothé Maujean, Nicolas Girard, A. Ganesan, Mihaela Gulea & Dominique Bonnet. (2020) Three cheers for nitrogen: aza-DKPs, the aza analogues of 2,5-diketopiperazines. RSC Advances 10:71, pages 43358-43370.
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Ekta Shirbhate, Preeti Patel, Vijay K Patel, Ravichandran Veerasamy, Prabodh C Sharma & Harish Rajak. (2020) The combination of histone deacetylase inhibitors and radiotherapy: a promising novel approach for cancer treatment. Future Oncology 16:30, pages 2457-2469.
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Hao Hu, Fei Chen, Yuhong Dong, Yajing Liu & Ping Gong. (2020) Discovery of novel dual c-Met/HDAC inhibitors as a promising strategy for cancer therapy. Bioorganic Chemistry 101, pages 103970.
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Xiaodi Qiu, Xianfang Rong, Jin Yang & Yi Lu. (2019) Evaluation of the antioxidant effects of different histone deacetylase inhibitors (HDACis) on human lens epithelial cells (HLECs) after UVB exposure. BMC Ophthalmology 19:1.
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Feifei Yang, Na Zhao, Di Ge & Yihua Chen. (2019) Next-generation of selective histone deacetylase inhibitors. RSC Advances 9:34, pages 19571-19583.
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Thiago V. Damasceno Teixeira, Richard C. Fry, Angus McKinnon, Kerri L. Fry, Jennifer M. Kelly, Paul J. Verma, Chelsie Burden, Daniel F. Salamone & Andrés Gambini. (2019) Targeting epigenetic nuclear reprogramming in aggregated cloned equine embryos. Reproduction, Fertility and Development 31:12, pages 1885.
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Fernando Guzman‐Chavez, Oleksandr Salo, Marta Samol, Marco Ries, Jeroen Kuipers, Roel A. L. Bovenberg, Rob J. Vreeken & Arnold J. M. Driessen. (2018) Deregulation of secondary metabolism in a histone deacetylase mutant of Penicillium chrysogenum . MicrobiologyOpen 7:5.
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Xuexue Zhu, Yueyue Lei, Fanggen Tan, Leilei Gong, Haifeng Gong, Wei Yang, Ting Chen, Zhixuan Zhang, Weiwei Cai, Bao Hou, Xu Wang, Haijian Sun, Yuetao Zhou & Liying Qiu. (2018) Vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of HDAC1 and oxidative stress. European Journal of Pharmacology 818, pages 371-380.
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Karen Dendoncker, Steven Timmermans, Kelly Van Looveren, Lode De Cauwer, Karolien De Bosscher & Claude Libert. (2017) The nature of the GRE influences the screening for GR-activity enhancing modulators. PLOS ONE 12:7, pages e0181101.
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Angela Nebbioso, Vincenzo Carafa, Mariarosaria Conte, Francesco Paolo Tambaro, Ciro Abbondanza, Joost Martens, Matthias Nees, Rosaria Benedetti, Isabella Pallavicini, Saverio Minucci, Guillermo Garcia-Manero, Francesco Iovino, Gabriella Lania, Concetta Ingenito, Valeria Belsito Petrizzi, Hendrik G. Stunnenberg & Lucia Altucci. (2017) c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer. Clinical Cancer Research 23:10, pages 2542-2555.
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P.M. Woster. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 297 328 .
Eleonora Ciarlo, Tytti Heinonen, Jacobus Herderschee, Craig Fenwick, Matteo Mombelli, Didier Le Roy & Thierry Roger. (2016) Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo. Scientific Reports 6:1.
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Qinghua Xia, Yi Zheng, Wei Jiang, Zhongxian Huang, Muwen Wang, Ronald Rodriguez & Xunbo Jin. (2016) Valproic acid induces autophagy by suppressing the Akt/mTOR pathway in human prostate cancer cells. Oncology Letters 12:3, pages 1826-1832.
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Jiachen Wen, Yu Bao, Qun Niu, Jiang Liu, Jinyu Yang, Wanqiao Wang, Tao Jiang, Yinbo Fan, Kun Li, Jian Wang, Linxiang Zhao & Dan Liu. (2016) Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents. Bioorganic & Medicinal Chemistry Letters 26:17, pages 4372-4376.
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SI-YING CHEN, XIAO-WEI ZHENG, JIANG-XIA CAI, WEI-PENG ZHANG, HAI-SHENG YOU, JIAN-FENG XING & YA-LIN DONG. (2016) Histone deacetylase inhibitor reverses multidrug resistance by attenuating the nucleophosmin level through PI3K/Akt pathway in breast cancer. International Journal of Oncology 49:1, pages 294-304.
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Weipeng Zhang, Xiaowei Zheng, Ti Meng, Haisheng You, Yalin Dong, Jianfeng Xing & Siying Chen. (2016) HDACI regulates the PI3K/Akt signaling pathway to reverse MCF-7/PTX resistance by inhibiting SET. RSC Advances 6:53, pages 48072-48082.
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Alice Pasini, Angelo Delmonte, Anna Tesei, Daniele Calistri & Emanuele Giordano. (2015) Targeting Chromatin-Mediated Transcriptional Control of Gene Expression in Non-Small Cell Lung Cancer Therapy: Preclinical Rationale and Clinical Results. Drugs 75:15, pages 1757-1771.
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Roshan Yedery & Ann Jerse. (2015) Augmentation of Cationic Antimicrobial Peptide Production with Histone Deacetylase Inhibitors as a Novel Epigenetic Therapy for Bacterial Infections. Antibiotics 4:1, pages 44-61.
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Junfeng Wang, Weijun He, Xiaochu Qin, Xiaoyi Wei, Xinpeng Tian, Li Liao, Shengrong Liao, Bin Yang, Zhengchao Tu, Bo Chen, Fazuo Wang, Xiaojiang Zhou & Yonghong Liu. (2015) Three new indolyl diketopiperazine metabolites from the antarctic soil-derived fungus Penicillium sp. SCSIO 05705. RSC Advances 5:84, pages 68736-68742.
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Bin Wang, Ting-yu Liu, Chun-Hsiang Lai, Yan-hua Rao, Moon-Chang Choi, Jen-Tsan Chi, Jian-wu Dai, Jeffrey C. Rathmell & Tso-Pang Yao. (2014) Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. Molecular Biology of the Cell 25:21, pages 3300-3307.
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Marco Miceli, Paola Bontempo, Angela Nebbioso & Lucia Altucci. (2014) Natural compounds in epigenetics: A current view. Food and Chemical Toxicology 73, pages 71-83.
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Elisa Giacomini, Angela Nebbioso, Alfonso Ciotta, Cristina Ianni, Federico Falchi, Marinella Roberti, Manlio Tolomeo, Stefania Grimaudo, Antonietta Di Cristina, Rosaria Maria Pipitone, Lucia Altucci & Maurizio Recanatini. (2014) Novel Antiproliferative Chimeric Compounds with Marked Histone Deacetylase Inhibitory Activity. ACS Medicinal Chemistry Letters 5:9, pages 973-978.
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Stephen Hanessian. 2014. Natural Products in Medicinal Chemistry. Natural Products in Medicinal Chemistry 565 610 .
Boobalan Pachaiyappan & Patrick M. Woster. (2014) Design of small molecule epigenetic modulators. Bioorganic & Medicinal Chemistry Letters 24:1, pages 21-32.
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Minghui Li, Xu Liu, Xiaolin Sun, Zhenhua Wang, Weikang Guo, Fanlei Hu, Haihong Yao, Xuefeng Cao, Jin Jin, Peng G. Wang, Jie Shen & Zhanguo Li. (2013) Therapeutic Effects of NK-HDAC-1, a Novel Histone Deacetylase Inhibitor, on Collagen-Induced Arthritis Through the Induction of Apoptosis of Fibroblast-Like Synoviocytes. Inflammation 36:4, pages 888-896.
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Giseli Capaci Rodrigues, Flavia Alexandra Gomes de Souza, Whei Oh Lin & Alane Beatriz Vermelho. 2013. Hydroxamic Acids. Hydroxamic Acids 255 279 .

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