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Integrin modulators: a patent review

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Pages 1273-1295 | Published online: 20 Sep 2013

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Wataru Kawamura, Yutaka Miura, Daisuke Kokuryo, Kazuko Toh, Naoki Yamada, Takahiro Nomoto, Yu Matsumoto, Daiki Sueyoshi, Xueying Liu, Ichio Aoki, Mitsunobu R Kano, Nobuhiro Nishiyama, Tsuneo Saga, Akihiro Kishimura & Kazunori Kataoka. (2015) Density-tunable conjugation of cyclic RGD ligands with polyion complex vesicles for the neovascular imaging of orthotopic glioblastomas. Science and Technology of Advanced Materials 16:3.
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Girieca Lorusso, Curzio Rüegg & François Kuonen. (2020) Targeting the Extra-Cellular Matrix—Tumor Cell Crosstalk for Anti-Cancer Therapy: Emerging Alternatives to Integrin Inhibitors. Frontiers in Oncology 10.
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Farshid Eslami-Kaliji, Mohsen Sarafbidabad, Jayakumar Rajadas & M. Rezaa Mohammadi. (2020) Dendritic Cells as Targets for Biomaterial-Based Immunomodulation. ACS Biomaterials Science & Engineering 6:5, pages 2726-2739.
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Ping-Hsiu Wu, Abayomi Emmanuel Opadele, Yasuhito Onodera & Jin-Min Nam. (2019) Targeting Integrins in Cancer Nanomedicine: Applications in Cancer Diagnosis and Therapy. Cancers 11:11, pages 1783.
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Silvia Dusi, Stefano Angiari, Enrica Caterina Pietronigro, Nicola Lopez, Gabriele Angelini, Elena Zenaro, Vittorina Della Bianca, Gabriele Tosadori, Francesca Paris, Antonella Amoruso, Tommaso Carlucci, Gabriela Constantin & Barbara Rossi. (2019) LFA-1 Controls Th1 and Th17 Motility Behavior in the Inflamed Central Nervous System. Frontiers in Immunology 10.
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Alday-Parejo, Stupp & Rüegg. (2019) Are Integrins Still Practicable Targets for Anti-Cancer Therapy?. Cancers 11:7, pages 978.
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Monica Baiula, Santi Spampinato, Luca Gentilucci & Alessandra Tolomelli. (2019) Novel Ligands Targeting α4β1 Integrin: Therapeutic Applications and Perspectives. Frontiers in Chemistry 7.
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Harrison M. Penrose, Chloe Cable, Sandra Heller, Nathan Ungerleider, Hani Nakhoul, Melody Baddoo, Alifiani B. Hartono, Sean B. Lee, Matthew E. Burow, Erik F. Flemington, Susan E. Crawford & Suzana D. Savkovic. (2019) Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets. Cellular and Molecular Gastroenterology and Hepatology 7:2, pages 391-408.
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Frederic Debordeaux, Lucie Chansel-Debordeaux, Jean-Baptiste Pinaquy, Philippe Fernandez & Jurgen Schulz. (2018) What about αvβ3 integrins in molecular imaging in oncology?. Nuclear Medicine and Biology 62-63, pages 31-46.
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Tobias G. Kapp, Francesco Saverio Di Leva, Johannes Notni, Andreas F. B. Räder, Maximilian Fottner, Florian Reichart, Dominik Reich, Alexander Wurzer, Katja Steiger, Ettore Novellino, Udaya Kiran Marelli, Hans-Jürgen Wester, Luciana Marinelli & Horst Kessler. (2018) N -Methylation of iso DGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent . Journal of Medicinal Chemistry 61:6, pages 2490-2499.
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Richard J. D. Hatley, Simon J. F. Macdonald, Robert J. Slack, Joelle Le, Steven B. Ludbrook & Pauline T. Lukey. (2018) An αv‐RGD Integrin Inhibitor Toolbox: Drug Discovery Insight, Challenges and Opportunities. Angewandte Chemie International Edition 57:13, pages 3298-3321.
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Richard J. D. Hatley, Simon J. F. Macdonald, Robert J. Slack, Joelle Le, Steven B. Ludbrook & Pauline T. Lukey. (2018) Ein Instrumentarium von αv-RGD-Integrin-Inhibitoren: Wirkstoffsuche, Herausforderungen und Möglichkeiten. Angewandte Chemie 130:13, pages 3354-3379.
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Liming Shang, Xinping Ye, Guangzhi Zhu, Hao Su, Zhixiong Su, Bin Chen, Kaiyin Xiao, Lequn Li, Minhao Peng & Tao Peng. (2017) Prognostic value of integrin variants and expression in post-operative patients with HBV-related hepatocellular carcinoma. Oncotarget 8:44, pages 76816-76831.
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Qian Yang, Prashant Bavi, Julia Y. Wang & Michael H. Roehrl. (2017) Immuno-proteomic discovery of tumor tissue autoantigens identifies olfactomedin 4, CD11b, and integrin alpha-2 as markers of colorectal cancer with liver metastases. Journal of Proteomics 168, pages 53-65.
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Peng Jiang, Zhonghu Li, Feng Tian, Xiaowu Li & Jin Yang. (2017) Fyn/heterogeneous nuclear ribonucleoprotein E1 signaling regulates pancreatic cancer metastasis by affecting the alternative splicing of integrin β1. International Journal of Oncology 51:1, pages 169-183.
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Eva M. Hahn, Natalia Estrada‐Ortiz, Jiaying Han, Vera F. C. Ferreira, Tobias G. Kapp, João D. G. Correia, Angela Casini & Fritz E. Kühn. (2016) Functionalization of Ruthenium(II) Terpyridine Complexes with Cyclic RGD Peptides To Target Integrin Receptors in Cancer Cells. European Journal of Inorganic Chemistry 2017:12, pages 1667-1672.
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Tobias G. Kapp, Florian Rechenmacher, Stefanie Neubauer, Oleg V. Maltsev, Elisabetta A. Cavalcanti-Adam, Revital Zarka, Ute Reuning, Johannes Notni, Hans-Jürgen Wester, Carlos Mas-Moruno, Joachim Spatz, Benjamin Geiger & Horst Kessler. (2017) A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins. Scientific Reports 7:1.
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Carlos Mas-Moruno, Roberta Fraioli, Florian Rechenmacher, Stefanie Neubauer, Tobias G. Kapp & Horst Kessler. (2016) αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating. Angewandte Chemie International Edition 55:25, pages 7048-7067.
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Carlos Mas-Moruno, Roberta Fraioli, Florian Rechenmacher, Stefanie Neubauer, Tobias G. Kapp & Horst Kessler. (2016) αvβ3- oder α5β1-Integrin-selektive Peptidmimetika für die Oberflächenbeschichtung. Angewandte Chemie 128:25, pages 7162-7183.
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Dominique Heymann, Carmen Ruiz-Velasco, Julie Chesneau, Jacqueline Ratiskol, Corinne Sinquin & Sylvia Colliec-Jouault. (2016) Anti-Metastatic Properties of a Marine Bacterial Exopolysaccharide-Based Derivative Designed to Mimic Glycosaminoglycans. Molecules 21:3, pages 309.
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Tobias G. Kapp, Maximilian Fottner, Oleg V. Maltsev & Horst Kessler. (2016) Small Cause, Great Impact: Modification of the Guanidine Group in the RGD Motif Controls Integrin Subtype Selectivity. Angewandte Chemie International Edition 55:4, pages 1540-1543.
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Oleg V. Maltsev, Udaya Kiran Marelli, Tobias G. Kapp, Francesco Saverio Di Leva, Salvatore Di Maro, Markus Nieberler, Ute Reuning, Markus Schwaiger, Ettore Novellino, Luciana Marinelli & Horst Kessler. (2016) Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands. Angewandte Chemie International Edition 55:4, pages 1535-1539.
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Tobias G. Kapp, Maximilian Fottner, Oleg V. Maltsev & Horst Kessler. (2016) Kleine Ursache, große Wirkung: Modifikation der Guanidiniumgruppe im RGD-Motiv reguliert die Integrinsubtypselektivität. Angewandte Chemie 128:4, pages 1564-1568.
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