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Expert Opinion on Therapeutic Patents Volume 23, 2013 - Issue 9
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Patent Evaluations

Evaluation of WO2012177707 and WO2012097269: Vertex's phosphate prodrugs of gyrase and topoisomerase antibacterial agents

John FinnTrius Therapeutics, 6310 Nancy Ridge Dr, San Diego, CA 92121, USA+1 858 452 0370; [email protected]
Pages 1233-1237 | Published online: 07 Aug 2013

Citations (9)

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Read on this site (2)

Kevin L. Winthrop, Patrick Flume & Kamal A. Hamed. (2023) Nontuberculous mycobacterial pulmonary disease and the potential role of SPR720. Expert Review of Anti-infective Therapy 21:11, pages 1177-1187.
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Martina Durcik, Tihomir Tomašič, Nace Zidar, Anamarija Zega, Danijel Kikelj, Lucija Peterlin Mašič & Janez Ilaš. (2019) ATP-competitive DNA gyrase and topoisomerase IV inhibitors as antibacterial agents. Expert Opinion on Therapeutic Patents 29:3, pages 171-180.
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Articles from other publishers (7)

Suzanne S. Stokes, Rajender Vemula & Michael J. Pucci. (2020) Advancement of GyrB Inhibitors for Treatment of Infections Caused by Mycobacterium tuberculosis and Non-tuberculous Mycobacteria . ACS Infectious Diseases 6:6, pages 1323-1331.
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Anna Bielenica, Karolina Stępień, Agnieszka Napiórkowska, Ewa Augustynowicz-Kopeć, Sylwester Krukowski, Marta Włodarczyk & Marta Struga. (2016) Synthesis and Antimicrobial Activity of 4-Chloro-3-Nitrophenylthiourea Derivatives Targeting Bacterial Type II Topoisomerases. Chemical Biology & Drug Design 87:6, pages 905-917.
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Philipp Klahn & Mark Brönstrup. 2016. How to Overcome the Antibiotic Crisis. How to Overcome the Antibiotic Crisis 365 417 .
Mohammed Afzal Azam, Janarthanan Thathan & Selvaraj Jubie. (2015) Dual targeting DNA gyrase B (GyrB) and topoisomerse IV (ParE) inhibitors: A review. Bioorganic Chemistry 62, pages 41-63.
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Gregory S. Bisacchi & John I. Manchester. (2014) A New-Class Antibacterial—Almost. Lessons in Drug Discovery and Development: A Critical Analysis of More than 50 Years of Effort toward ATPase Inhibitors of DNA Gyrase and Topoisomerase IV. ACS Infectious Diseases 1:1, pages 4-41.
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David E Ehmann & Sushmita D. Lahiri. (2014) Novel compounds targeting bacterial DNA topoisomerase/DNA gyrase. Current Opinion in Pharmacology 18, pages 76-83.
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Claudine Mayer & Yves L. Janin. (2013) Non-quinolone Inhibitors of Bacterial Type IIA Topoisomerases: A Feat of Bioisosterism. Chemical Reviews 114:4, pages 2313-2342.
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