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FK506-binding protein 12 ligands: a patent review

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Pages 1435-1449 | Published online: 19 Aug 2013

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Feng Zheng, Biao Zhang, Yanan Sun, Mingfeng Qiu & Jing Su. (2015) Evaluation of WO2011045166A1, Fkbp52–tau interaction as a novel therapeutical target for treating the neurological disorders involving tau dysfunction. Expert Opinion on Therapeutic Patents 25:7, pages 831-835.
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Yi Zhang, Haifeng Xu, Sainan Pi, Huiqian Tan, Bihui Huang & Youpeng Chen. (2023) The prognostic and immunological role of FKBP1A in an integrated muti-omics cancers analysis, especially lung cancer. Journal of Cancer Research and Clinical Oncology 149:18, pages 16589-16608.
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Yue Shi, Jinyao Zhang, Zheng Ma, Yongyong Zhang, Andreas Bechthold & Xiaoping Yu. (2023) Double‐reporter‐guided targeted activation of the oxytetracycline silent gene cluster in Streptomyces rimosus M527 . Biotechnology and Bioengineering 120:5, pages 1411-1422.
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Tianbai Zhong, Xiuyun Sun, Li Yu, Yongbo Liu, Xin Lin, Yu Rao & Wei Wu. (2022) PROTAC mediated FKBP12 degradation enhances Hepcidin expression via BMP signaling without immunosuppression activity. Signal Transduction and Targeted Therapy 7:1.
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Donghuan Sun, Jing Zhang, Guoqiang Dong, Shipeng He & Chunquan Sheng. (2022) Blocking Non-enzymatic Functions by PROTAC-Mediated Targeted Protein Degradation. Journal of Medicinal Chemistry 65:21, pages 14276-14288.
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Gabriella Caminati & Piero Procacci. (2020) Mounting evidence of FKBP12 implication in neurodegeneration. Neural Regeneration Research 15:12, pages 2195.
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Dorota Kostrz, Hannah K. Wayment-Steele, Jing L. Wang, Maryne Follenfant, Vijay S. Pande, Terence R. Strick & Charlie Gosse. (2019) A modular DNA scaffold to study protein–protein interactions at single-molecule resolution. Nature Nanotechnology 14:10, pages 988-993.
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Zahra Nadia Sharifi, Hamid Zaferani Arani, Maedeh Olya, Hesam Adin Atashi & Shabnam Movassaghi. (2019) Effect of Different Doses and Times of FK506 on Different Areas of the Hippocampus in the Rat Model of Transient Global Cerebral Ischemia-Reperfusion. Neurology Research International 2019, pages 1-7.
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Carmelo Luca Smeralda, Gian Luigi Gigli, Alberto Vogrig, Alessandro Marini & Mariarosaria Valente. (2019) Tacrolimus-induced severe headache associated with diffuse leukoencephalopathy: Evidence for an immune-mediated pathogenesis. Journal of Neuroimmunology 330, pages 55-58.
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Mario D. Galigniana. 2019. Heat Shock Protein 90 in Human Diseases and Disorders. Heat Shock Protein 90 in Human Diseases and Disorders 19 45 .
Gleb Solomentsev, Carl Diehl & Mikael Akke. (2018) Conformational Entropy of FK506 Binding to FKBP12 Determined by Nuclear Magnetic Resonance Relaxation and Molecular Dynamics Simulations. Biochemistry 57:9, pages 1451-1461.
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Yao Zong Ng, Pedro A. Baldera-Aguayo & Virginia W. Cornish. (2017) Fluorescence Polarization Assay for Small Molecule Screening of FK506 Biosynthesized in 96-Well Microtiter Plates. Biochemistry 56:40, pages 5260-5268.
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Marine Bacchi, Magali Jullian, Serena Sirigu, Benjamin Fould, Tiphaine Huet, Lisa Bruyand, Mathias Antoine, Laurent Vuillard, Luisa Ronga, Leonard M. G. Chavas, Olivier Nosjean, Gilles Ferry, Karine Puget & Jean A. Boutin. (2016) Total chemical synthesis, refolding, and crystallographic structure of fully active immunophilin calstabin 2 (FKBP12.6). Protein Science 25:12, pages 2225-2242.
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Gisela I. Mazaira, María F. Camisay, Sonia De Leo, Alejandra G. Erlejman & Mario D. Galigniana. (2016) Biological relevance of Hsp90-binding immunophilins in cancer development and treatment. International Journal of Cancer 138:4, pages 797-808.
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A. Sean Alemi, Kristina W. Rosbe, Dylan K. Chan & Anna K. Meyer. (2015) Airway response to sirolimus therapy for the treatment of complex pediatric lymphatic malformations. International Journal of Pediatric Otorhinolaryngology 79:12, pages 2466-2469.
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A.A. Stepanenko & V.V. Dmitrenko. (2015) Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability. Gene 574:2, pages 193-203.
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Ana Gil-Bona, Lucía Monteoliva & Concha Gil. (2015) Global Proteomic Profiling of the Secretome of Candida albicans ecm33 Cell Wall Mutant Reveals the Involvement of Ecm33 in Sap2 Secretion . Journal of Proteome Research 14:10, pages 4270-4281.
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Gianluca Lorenzo Perrucci, Aoife Gowran, Marco Zanobini, Maurizio Colognesi Capogrossi, Giulio Pompilio & Patrizia Nigro. (2015) Peptidyl-prolyl isomerases: a full cast of critical actors in cardiovascular diseases. Cardiovascular Research 106:3, pages 353-364.
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Muhamad A Rostam, Terrence J Piva, Hossein B Rezaei, Danielle Kamato, Peter J Little, Wenhua Zheng & Narin Osman. (2015) Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease. Clinical and Experimental Pharmacology and Physiology 42:2, pages 117-124.
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