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Peptide nucleic acids: a review on recent patents and technology transfer

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P. L. Lam, K. K. H. Lee, R. S. M. Wong, G. Y. M. Cheng, Z. X. Bian, C. H. Chui & R. Gambari. (2018) Recent advances on topical antimicrobials for skin and soft tissue infections and their safety concerns. Critical Reviews in Microbiology 44:1, pages 40-78.
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Xia He, Da-Fang Wu, Jun Ji, Wen-ping Ling, Xiao-ling Chen & Yue-Xuan Chen. (2016) Ultrasound microbubble-carried PNA targeting to c-myc mRNA inhibits the proliferation of rabbit iliac arterious smooth muscle cells and intimal hyperplasia. Drug Delivery 23:7, pages 2482-2487.
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Articles from other publishers (50)

Gita Matulevičiūtė, Neringa Kleizienė, Greta Račkauskienė, Vytas Martynaitis, Aurimas Bieliauskas, Urtė Šachlevičiūtė, Rokas Jankauskas, Martynas R. Bartkus, Frank A. Sløk & Algirdas Šačkus. (2023) Facile synthesis of new N -(aminocycloalkylene)amino acid compounds using chiral triflate esters with N -Boc-aminopyrrolidines and N -Boc-aminopiperidines . RSC Advances 13:31, pages 21378-21394.
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Incherah Bekkouche, Alexander Y. Shishonin & Alexandre A. Vetcher. (2023) Recent Development in Biomedical Applications of Oligonucleotides with Triplex-Forming Ability. Polymers 15:4, pages 858.
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Pradnya Kulkarni, Dhrubajyoti Datta & Krishna N. Ganesh. (2022) Gemdimethyl Peptide Nucleic Acids (α/β/γ -gdm -PNA): E/Z-Rotamers Influence the Selectivity in the Formation of Parallel/Antiparallel gdm -PNA:DNA/RNA Duplexes . ACS Omega 7:44, pages 40558-40568.
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Maria Teresa Di Martino, Mariamena Arbitrio, Daniele Caracciolo, Alessia Cordua, Onofrio Cuomo, Katia Grillone, Caterina Riillo, Giulio Caridà, Francesca Scionti, Caterina Labanca, Caterina Romeo, Maria Anna Siciliano, Maria D'Apolito, Cristina Napoli, Martina Montesano, Valentina Farenza, Valentina Uppolo, Michele Tafuni, Federica Falcone, Giuseppe D'Aquino, Natale Daniele Calandruccio, Francesco Luciano, Licia Pensabene, Pierosandro Tagliaferri & Pierfrancesco Tassone. (2022) miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review. Molecular Therapy - Nucleic Acids 27, pages 1191-1224.
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Subeen Hong, Seung Mi Lee, Sohee Oh, So Yeon Kim, Young Mi Jung, Sun Min Kim, Chan-Wook Park, Jong Kwan Jun, Byoung Jae Kim & Joong Shin Park. (2022) Simple and rapid detection of common fetal aneuploidies using peptide nucleic acid probe-based real-time polymerase chain reaction. Scientific Reports 12:1.
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Samuel J.S. Rubin & Nir Qvit. 2022. Peptide and Peptidomimetic Therapeutics. Peptide and Peptidomimetic Therapeutics 157 193 .
So Yeon Kim, Seung Mi Lee, Sun Min Kim, Byoung Jae Kim, Ja Nam Koo, Ig Hwan Oh, Sohee Oh, Chan-Wook Park, Jong Kwan Jun, Ji Hyae Lim, Hyun Mee Ryu & Joong Shin Park. (2021) Novel method of real-time PCR-based screening for common fetal trisomies. BMC Medical Genomics 14:1.
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Nitin A. Patil. (2021) Conjugation Approaches for Peptide-Mediated Delivery of Oligonucleotides Therapeutics. Australian Journal of Chemistry 75:2, pages 24-33.
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Colin S. Swenson, Hershel H. Lackey, Eric J. Reece, Joel M. Harris, Jennifer M. Heemstra & Eric M. Peterson. (2021) Evaluating the effect of ionic strength on PNA:DNA duplex formation kinetics. RSC Chemical Biology 2:4, pages 1249-1256.
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Nikita Brodyagin, Martins Katkevics, Venubabu Kotikam, Christopher A Ryan & Eriks Rozners. (2021) Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications. Beilstein Journal of Organic Chemistry 17, pages 1641-1688.
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Xingguo Liang, Mengqin Liu & Makoto Komiyama. (2021) Recognition of Target Site in Various Forms of DNA and RNA by Peptide Nucleic Acid (PNA): From Fundamentals to Practical Applications. Bulletin of the Chemical Society of Japan 94:6, pages 1737-1756.
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Alessia Finotti, Jessica Gasparello, Alessandro Casnati, Roberto Corradini, Roberto Gambari & Francesco Sansone. 2021. Bio-Carrier Vectors. Bio-Carrier Vectors 123 143 .
Miklós Bege, Ilona Bereczki, Dénes J. Molnár, Máté Kicsák, Krisztina Pénzes-Daku, Zsuzsanna Bereczky, Györgyi Ferenc, Lajos Kovács, Pál Herczegh & Anikó Borbás. (2020) Synthesis and oligomerization of cysteinyl nucleosides. Organic & Biomolecular Chemistry 18:40, pages 8161-8178.
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Zeyu Lu, Brenton R. PaolellaNicholas L. Truex, Alexander R. Loftis, Xiaoli Liao, Amy E. Rabideau, Meredith S. BrownJohn BusanovichRameen BeroukhimBradley L. Pentelute. (2020) Targeting Cancer Gene Dependencies with Anthrax-Mediated Delivery of Peptide Nucleic Acids. ACS Chemical Biology 15:6, pages 1358-1369.
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Penthip Muangkaew & Tirayut Vilaivan. (2020) Modulation of DNA and RNA by PNA. Bioorganic & Medicinal Chemistry Letters 30:9, pages 127064.
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Shaiq Sultan, Andrea Rozzi, Jessica Gasparello, Alex Manicardi, Roberto Corradini, Chiara Papi, Alessia Finotti, Ilaria Lampronti, Eva Reali, Giulio Cabrini, Roberto Gambari & Monica Borgatti. (2020) A Peptide Nucleic Acid (PNA) Masking the miR-145-5p Binding Site of the 3′UTR of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) mRNA Enhances CFTR Expression in Calu-3 Cells. Molecules 25:7, pages 1677.
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Enrico Cadoni, Alex Manicardi & Annemieke Madder. (2020) PNA-Based MicroRNA Detection Methodologies. Molecules 25:6, pages 1296.
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Colin S. Swenson & Jennifer M. Heemstra. (2020) Peptide nucleic acids harness dual information codes in a single molecule. Chemical Communications 56:13, pages 1926-1935.
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Feiyun Cui, Zhiru Zhou & H. Susan Zhou. (2020) Review—Measurement and Analysis of Cancer Biomarkers Based on Electrochemical Biosensors. Journal of The Electrochemical Society 167:3, pages 037525.
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Yashpal Singh Malik, Atul Verma, Naveen Kumar, Pallavi Deol, Deepak Kumar, Souvik Ghosh & Kuldeep Dhama. 2020. Genomics and Biotechnological Advances in Veterinary, Poultry, and Fisheries. Genomics and Biotechnological Advances in Veterinary, Poultry, and Fisheries 287 309 .
Boonsong Ditmangklo, Jaru Taechalertpaisarn, Khatcharin Siriwong & Tirayut Vilaivan. (2019) Clickable styryl dyes for fluorescence labeling of pyrrolidinyl PNA probes for the detection of base mutations in DNA. Organic & Biomolecular Chemistry 17:45, pages 9712-9725.
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Fabiana Mammoli, Sandra Parenti, Mariana Lomiento, Claudia Gemelli, Claudio Giacinto Atene, Alexis Grande, Roberto Corradini, Alex Manicardi, Sebastian Fantini, Tommaso Zanocco-Marani & Sergio Ferrari. (2019) Physiological expression of miR-130a during differentiation of CD34+ human hematopoietic stem cells results in the inhibition of monocyte differentiation. Experimental Cell Research 382:1, pages 111445.
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Jun Sung Hong, Dokyun Kim, Eun-Jeong Yoon, Hyukmin Lee & Seok Hoon Jeong. (2019) Performance evaluation of the PANA RealTyper™ CRE Kit for detecting carbapenemase genes in Gram-negative bacilli. Journal of Global Antimicrobial Resistance 18, pages 100-103.
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Elnaz Ghaffari, Seyedeh Elham Rezatofighi, Mohammad Roayaei Ardakani & Saadat Rastegarzadeh. (2019) Delivery of antisense peptide nucleic acid by gold nanoparticles for the inhibition of virus replication. Nanomedicine 14:14, pages 1827-1840.
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Nitin A. Patil, John A. Karas, Bradley J. Turner & Fazel Shabanpoor. (2019) Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide–PNA Conjugates. Bioconjugate Chemistry 30:3, pages 793-799.
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Jessica Gasparello, Alex Manicardi, Alessandro Casnati, Roberto Corradini, Roberto Gambari, Alessia Finotti & Francesco Sansone. (2019) Efficient cell penetration and delivery of peptide nucleic acids by an argininocalix[4]arene. Scientific Reports 9:1.
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Marcin Równicki, Zofia Dąbrowska, Monika Wojciechowska, Aleksandra J. Wierzba, Ksenia Maximova, Dorota Gryko & Joanna Trylska. (2019) Inhibition of Escherichia coli Growth by Vitamin B 12 –Peptide Nucleic Acid Conjugates . ACS Omega 4:1, pages 819-824.
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Vijay N. Kadam, Kayarat Saikrishnan & Krishna N. Ganesh. (2018) 5-Amidodansyl-U (U D ) Peptide Nucleic Acid (PNA) as a Fluorescent Sensor of the Local Dielectric Constant (ε) in PNA Duplexes: Major Grooves in PNA Duplexes Are More Hydrophobic Than Major Grooves in DNA–DNA Duplexes . The Journal of Physical Chemistry C 122:25, pages 14004-14013.
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Prasanna Ramani, Silvia Cauteruccio, Emanuela Licandro & Clara Baldoli. (2018) Synthesis of luminescent 2,3-diphenylmaleimide-labelled peptide nucleic acid oligomers. Tetrahedron Letters 59:23, pages 2229-2231.
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Amphawan Maitarad, Nattawee Poomsuk, Chotima Vilaivan, Tirayut Vilaivan & Khatcharin Siriwong. (2018) Insight into a conformation of the PNA-PNA duplex with (2′R,4′R)- and (2′R,4′S)-prolyl-(1S,2S)-2-aminocyclopentanecarboxylic acid backbones. Chemical Physics Letters 698, pages 132-137.
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Roberta D’Agata, Maria Giuffrida & Giuseppe Spoto. (2017) Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis. Molecules 22:11, pages 1951.
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Şevket Hakan Üngören & Şerife Boz. (2017) DBU-catalyzed, aromatization-oriented, regioselective domino synthesis of 2-aminopyrimidines from $$\upbeta $$ β -dicarbonyl compounds, DMF-DMA, and cyanamide. Molecular Diversity 21:4, pages 925-932.
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Leszek Błaszczyk, Wojciech Rypniewski & Agnieszka Kiliszek. (2017) Structures of RNA repeats associated with neurological diseases. Wiley Interdisciplinary Reviews: RNA 8:4, pages e1412.
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Giulia Montagner, Valentino Bezzerri, Giulio Cabrini, Enrica Fabbri, Monica Borgatti, Ilaria Lampronti, Alessia Finotti, Peter E. Nielsen & Roberto Gambari. (2017) An antisense peptide nucleic acid against Pseudomonas aeruginosa inhibiting bacterial-induced inflammatory responses in the cystic fibrosis IB3-1 cellular model system. International Journal of Biological Macromolecules 99, pages 492-498.
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Bao T. Le, Keiji Murayama, Fazel Shabanpoor, Hiroyuki Asanuma & Rakesh N. Veedu. (2017) Antisense oligonucleotide modified with serinol nucleic acid (SNA) induces exon skipping in mdx myotubes. RSC Advances 7:54, pages 34049-34052.
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J.M. Withers, G. Padroni, S.M. Pauff, A.W. Clark, S.P. Mackay & G.A. Burley. 2017. Comprehensive Supramolecular Chemistry II. Comprehensive Supramolecular Chemistry II 149 178 .
Chalothorn Boonlua, Chayan Charoenpakdee, Tirayut Vilaivan & Thanit Praneenararat. (2016) Preparation and Performance Evaluation of a Pyrrolidinyl Peptide Nucleic-Acid-Based Displacement Probe as a DNA Sensor. ChemistrySelect 1:18, pages 5691-5697.
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Agnieszka Kiliszek, Katarzyna Banaszak, Zbigniew Dauter & Wojciech Rypniewski. (2016) The first crystal structures of RNA–PNA duplexes and a PNA-PNA duplex containing mismatches—toward anti-sense therapy against TREDs. Nucleic Acids Research 44:4, pages 1937-1943.
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A. Manicardi, E. Gyssels, R. Corradini & A. Madder. (2016) Furan-PNA: a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA. Chemical Communications 52:42, pages 6930-6933.
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Christopher S Hong, Chunzhang Yang & Zhengping Zhuang. (2016) Application of Peptide Nucleic Acid-based Assays Toward Detection of Somatic Mosaicism. Molecular Therapy - Nucleic Acids 5, pages e314.
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Kiran M. Patil & Gang Chen. 2016. Modified Nucleic Acids in Biology and Medicine. Modified Nucleic Acids in Biology and Medicine 299 317 .
Xing-Liang Zhao, Bi-Cheng Chen, Jin-Chao Han, Lai Wei & Xiao-Ben Pan. (2015) Delivery of cell-penetrating peptide-peptide nucleic acid conjugates by assembly on an oligonucleotide scaffold. Scientific Reports 5:1.
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Daniel Schindler & Torsten Waldminghaus. (2015) Synthetic chromosomes. FEMS Microbiology Reviews 39:6, pages 871-891.
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Satheesh Ellipilli & Krishna N. Ganesh. (2015) Fluorous Peptide Nucleic Acids: PNA Analogues with Fluorine in Backbone (γ-CF 2 - apg -PNA) Enhance Cellular Uptake . The Journal of Organic Chemistry 80:18, pages 9185-9191.
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Concetta Avitabile, Antonella Accardo, Paola Ringhieri, Giancarlo Morelli, Michele Saviano, Giulia Montagner, Enrica Fabbri, Eleonora Gallerani, Roberto Gambari & Alessandra Romanelli. (2015) Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery. Bioconjugate Chemistry 26:8, pages 1533-1541.
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GIULIO CABRINI, ENRICA FABBRI, CRISTIANA LO NIGRO, MARIA CRISTINA DECHECCHI & ROBERTO GAMBARI. (2015) Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review). International Journal of Oncology 47:2, pages 417-428.
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. (2015) Thalassemia Modular Stratification System for Personalized Therapy of Beta-Thalassemia (THALAMOSS). Human Gene Therapy Clinical Development 26:2, pages 100-102.
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Seri Jeong, Jung Ok Kim, Seok Hoon Jeong, Il Kwon Bae & Wonkeun Song. (2015) Evaluation of peptide nucleic acid-mediated multiplex real-time PCR kits for rapid detection of carbapenemase genes in gram-negative clinical isolates. Journal of Microbiological Methods 113, pages 4-9.
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GIULIA MONTAGNER, CHIARA GEMMO, ENRICA FABBRI, ALEX MANICARDI, IGEA ACCARDO, NICOLETTA BIANCHI, ALESSIA FINOTTI, GIULIA BREVEGLIERI, FRANCESCA SALVATORI, MONICA BORGATTI, ILARIA LAMPRONTI, ALBERTO BRESCIANI, SERGIO ALTAMURA, ROBERTO CORRADINI & ROBERTO GAMBARI. (2015) Peptide nucleic acids targeting β-globin mRNAs selectively inhibit hemoglobin production in murine erythroleukemia cells. International Journal of Molecular Medicine 35:1, pages 51-58.
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Reuben Ovadia, Aurélien Lebrun, Ivan Barvik, Jean-Jacques Vasseur, Carine Baraguey & Karine Alvarez. (2015) Synthesis and structural characterization of monomeric and dimeric peptide nucleic acids prepared by using microwave-promoted multicomponent reactions. Organic & Biomolecular Chemistry 13:45, pages 11052-11071.
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