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Toll-like receptor agonists: a patent review (2011 – 2013)

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Jiahui Zhang, Jingyi Fan, Mariusz Skwarczynski, Rachel J Stephenson, Istvan Toth & Waleed M Hussein. (2022) Peptide-Based Nanovaccines in the Treatment of Cervical Cancer: A Review of Recent Advances. International Journal of Nanomedicine 17, pages 869-900.
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Madeleine E. Kieffer, Akash M. Patel, Scott A. Hollingsworth & W. Michael Seganish. (2020) Small molecule agonists of toll-like receptors 7 and 8: a patent review 2014 – 2020. Expert Opinion on Therapeutic Patents 30:11, pages 825-845.
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Mahesh Chandra Patra & Sangdun Choi. (2016) Recent progress in the development of Toll-like receptor (TLR) antagonists. Expert Opinion on Therapeutic Patents 26:6, pages 719-730.
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Chin Yang Chang, Jiayu A. Tai, Sumin Li, Tomoyuki Nishikawa & Yasufumi Kaneda. (2016) Virus-stimulated neutrophils in the tumor microenvironment enhance T cell-mediated anti-tumor immunity. Oncotarget 7:27, pages 42195-42207.
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Shengbin Jin, Jiahui Zhang, Ummey J. Nahar, Wenbin Huang, Nedaa A. Alharbi, Ahmed O. Shalash, Prashamsa Koirala, Jieru Yang, Jolynn J. E. Kiong, Zeinab G. Khalil, Robert J. Capon, Rachel J. Stephenson, Mariusz Skwarczynski, Istvan Toth & Waleed M. Hussein. (2023) Activity Relationship of Poly(ethylenimine)-Based Liposomes as Group A Streptococcus Vaccine Delivery Systems . ACS Infectious Diseases 9:8, pages 1570-1581.
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Rui Chang, Xiaohong Chu, Jibing Zhang, Rongrong Fu, Changshun Feng, Dianlong Jia, Rui Wang, Hui Yan, Guangyong Li & Jun Li. (2023) Liposome-Based Co-Immunotherapy with TLR Agonist and CD47-SIRPα Checkpoint Blockade for Efficient Treatment of Colon Cancer. Molecules 28:7, pages 3147.
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Qi Wei, Shixian Liu, Xu Huang, Hua Xin & Jianxun Ding. (2023) Immunologically effective biomaterials-enhanced vaccines against infection of pathogenic microorganisms. Biosafety and Health 5:1, pages 45-61.
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Shuo LI, Guifang FAN, Xiaojiaoyang LI, Yajie CAI & Runping LIU. (2023) Modulation of type I interferon signaling by natural products in the treatment of immune-related diseases. Chinese Journal of Natural Medicines 21:1, pages 3-18.
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Xiong Zou, Yi Guo & Zengnan Mo. (2022) TLR3 serves as a novel diagnostic and prognostic biomarker and is closely correlated with immune microenvironment in three types of cancer. Frontiers in Genetics 13.
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Nedaa Alharbi, Mariusz Skwarczynski & Istvan Toth. (2022) The influence of component structural arrangement on peptide vaccine immunogenicity. Biotechnology Advances 60, pages 108029.
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Ye Peng, Yanzhong Wang, Manling Wang, Jianping Lan & Yirui Chen. (2022) Therapeutic applications of toll-like receptors (TLRs) agonists in AML. Clinical and Translational Oncology 24:12, pages 2319-2329.
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Wei Li, Li Wan, Shaojun Duan & Jingjing Xu. (2022) Bibliometric analysis of toll-like receptor agonists associated with cancer therapy. Medicine 101:1, pages e28520.
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Meghna Amrita Singh, Tarani Prakash Shrivastava, Ajay Sharma & Madhu Gupta. 2022. Nanotherapeutics in Cancer Vaccination and Challenges. Nanotherapeutics in Cancer Vaccination and Challenges 295 311 .
Lili Zhao, Sahra Bashiri, Istvan Toth & Mariusz Skwarczynski. 2022. Bacterial Vaccines. Bacterial Vaccines 141 149 .
Farrhana Ziana Firdaus, Mariusz Skwarczynski & Istvan Toth. 2022. Vaccine Design. Vaccine Design 145 178 .
Prashamsa Koirala, Sahra Bashiri, Istvan Toth & Mariusz Skwarczynski. 2022. Vaccine Design. Vaccine Design 309 338 .
Arturo Orlacchio & Pellegrino Mazzone. (2021) The Role of Toll-like Receptors (TLRs) Mediated Inflammation in Pancreatic Cancer Pathophysiology. International Journal of Molecular Sciences 22:23, pages 12743.
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Deepender Kaushik, Arshpreet Kaur, Nikolai Petrovsky & Deepak B. Salunke. (2021) Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles. RSC Medicinal Chemistry 12:7, pages 1065-1120.
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T. M. Sokolova & V. V. Poloskov. (2021) The effect of Kagocel® on gene expression of Toll-like receptors of innate immunity in THP-1 human monocytes with different levels of differentiation. BIOpreparations. Prevention, Diagnosis, Treatment 21:2, pages 116-121.
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Saghar Pahlavanneshan, Ali Sayadmanesh, Hamidreza Ebrahimiyan & Mohsen Basiri. (2021) Toll-Like Receptor-Based Strategies for Cancer Immunotherapy. Journal of Immunology Research 2021, pages 1-14.
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Xin Zheng, Song Li & Hui Yang. (2021) Roles of Toll-Like Receptor 3 in Human Tumors. Frontiers in Immunology 12.
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Paree Khokhani, Nada R. Rahmani, Anne Kok, F. Cumhur Öner, Jacqueline Alblas, Harrie Weinans, Moyo C. Kruyt & Michiel Croes. (2021) Use of Therapeutic Pathogen Recognition Receptor Ligands for Osteo-Immunomodulation. Materials 14:5, pages 1119.
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Leopoldo Fabrício Marçal do Nascimento, Luana Dias de Moura, André Luis Souza dos Santos, Aarthy C Vallur & Maria do Socorro Pires e Cruz. 2021. Applications of Nanobiotechnology for Neglected Tropical Diseases. Applications of Nanobiotechnology for Neglected Tropical Diseases 29 46 .
Ali Keshavarz, Atieh Pourbagheri‐Sigaroodi, Parisa Zafari, Nader Bagheri, Seyed H. Ghaffari & Davood Bashash. (2020) Toll‐like receptors (TLRs) in cancer; with an extensive focus on TLR agonists and antagonists. IUBMB Life 73:1, pages 10-25.
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Stacey Bartlett, Mariusz Skwarczynski & Istvan Toth. (2020) Lipids as Activators of Innate Immunity in Peptide Vaccine Delivery. Current Medicinal Chemistry 27:17, pages 2887-2901.
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Yibo Wang, Shuting Zhang, Hongyuan Li, Hongshuang Wang, Tianshu Zhang, Mark R. Hutchinson, Hang Yin & Xiaohui Wang. (2020) Small-Molecule Modulators of Toll-like Receptors. Accounts of Chemical Research 53:5, pages 1046-1055.
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Lili Zhao, Wanli Jin, Jazmina Gonzalez Cruz, Nirmal Marasini, Zeinab G. Khalil, Robert J. Capon, Waleed M. Hussein, Mariusz Skwarczynski & Istvan Toth. (2020) Development of Polyelectrolyte Complexes for the Delivery of Peptide-Based Subunit Vaccines against Group A Streptococcus. Nanomaterials 10:5, pages 823.
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Mahesh Chandra Patra, Maria Batool, Muhammad Haseeb & Sangdun Choi. (2020) A Computational Probe into the Structure and Dynamics of the Full-Length Toll-Like Receptor 3 in a Phospholipid Bilayer. International Journal of Molecular Sciences 21:8, pages 2857.
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Javier Megías, Alba Martínez, Teresa San-Miguel, Rosario Gil-Benso, Lisandra Muñoz-Hidalgo, David Albert-Bellver, Amara Carratalá, Daniel Gozalbo, Concha López-Ginés, María Luisa Gil & Miguel Cerdá-Nicolás. (2019) Pam3CSK4, a TLR2 ligand, induces differentiation of glioblastoma stem cells and confers susceptibility to temozolomide. Investigational New Drugs 38:2, pages 299-310.
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Sandra Santos-Sierra. (2020) Developments in anticancer vaccination: budding new adjuvants. Biological Chemistry 401:4, pages 435-446.
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Sezer Okay, Öznur Özge Özcan & Mesut Karahan. (2020) Nanoparticle-based delivery platforms for mRNA vaccine development. AIMS Biophysics 7:4, pages 323-338.
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Reshma J. Nevagi, Wei Dai, Zeinab G. Khalil, Waleed M. Hussein, Robert J. Capon, Mariusz Skwarczynski & Istvan Toth. (2019) Structure-activity relationship of group A streptococcus lipopeptide vaccine candidates in trimethyl chitosan-based self-adjuvanting delivery system. European Journal of Medicinal Chemistry 179, pages 100-108.
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Azuar, Jin, Mukaida, Hussein, Toth & Skwarczynski. (2019) Recent Advances in the Development of Peptide Vaccines and Their Delivery Systems Against Group A Streptococcus. Vaccines 7:3, pages 58.
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Yi Wang, Qilu Fang, Yiyi Jin, Zhoudi Liu, Chunpeng Zou, Weihui Yu, Weixin Li, Xiaoou Shan, Ruijie Chen, Zia Khan & Guang Liang. (2019) Blockade of myeloid differentiation 2 attenuates diabetic nephropathy by reducing activation of the renin‐angiotensin system in mouse kidneys. British Journal of Pharmacology 176:14, pages 2642-2657.
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Jieru Yang, Yacheng Luo, Mohini Anjna Shibu, Istvan Toth & Mariusz Skwarczynskia. (2019) Cell-penetrating Peptides: Efficient Vectors for Vaccine Delivery. Current Drug Delivery 16:5, pages 430-443.
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Piyush Baindara & Santi M. Mandal. (2019) Antimicrobial Peptides and Vaccine Development to Control Multi-drug Resistant Bacteria. Protein & Peptide Letters 26:5, pages 324-331.
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Eva Villamón, Javier González-Fernández, Esperanza Such, José Vicente Cervera, Daniel Gozalbo & M. Luisa Gil. (2018) Imiquimod inhibits growth and induces differentiation of myeloid leukemia cell lines. Cancer Cell International 18:1.
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Chao Huang, Jian Wang, Xiaodong Zheng, Yongyan Chen, Haiming Wei, Rui Sun & Zhigang Tian. (2018) Activation of TLR Signaling in Sensitization-Recruited Inflammatory Monocytes Attenuates OVA-Induced Allergic Asthma. Frontiers in Immunology 9.
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Sharareh Eskandari, David J. Pattinson, Rachel J. Stephenson, Penny L. Groves, Simon H. Apte, Bita Sedaghat, Saranya Chandurudu, Denise L. Doolan & Istvan Toth. (2018) Influence of Physicochemical Properties of Lipopeptide Adjuvants on the Immune Response: A Rationale for Engineering a Potent Vaccine. Chemistry - A European Journal 24:39, pages 9892-9902.
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Reshma J. Nevagi, Istvan Toth & Mariusz Skwarczynski. 2018. Peptide Applications in Biomedicine, Biotechnology and Bioengineering. Peptide Applications in Biomedicine, Biotechnology and Bioengineering 327 358 .
Amir Fakhari, Sean Nugent, James Elvecrog, John Vasilakos, Marta Corcoran, Ashenafi Tilahun, Kristen Siebenaler, Jenny Sun, J. Anand Subramony & Alexander Schwarz. (2017) Thermosensitive Gel–Based Formulation for Intratumoral Delivery of Toll-Like Receptor 7/8 Dual Agonist, MEDI9197. Journal of Pharmaceutical Sciences 106:8, pages 2037-2045.
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Guangzu Zhao, Saranya Chandrudu, Mariusz Skwarczynski & Istvan Toth. (2017) The application of self-assembled nanostructures in peptide-based subunit vaccine development. European Polymer Journal 93, pages 670-681.
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Lei Zhang, Varun Dewan & Hang Yin. (2017) Discovery of Small Molecules as Multi-Toll-like Receptor Agonists with Proinflammatory and Anticancer Activities. Journal of Medicinal Chemistry 60:12, pages 5029-5044.
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Yifeng Gao, Hanyan Xiao, Yongbo Wang & Feng Xu. (2017) Association of single-nucleotide polymorphisms in toll-like receptor 2 gene with asthma susceptibility. Medicine 96:20, pages e6822.
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D. Hu, Z. Zhang, X. Ke, H. Kang & S. Hong. (2017) A functional variant of miRNA-149 confers risk for allergic rhinitis and comorbid asthma in Chinese children. International Journal of Immunogenetics 44:2, pages 62-70.
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Waleed M. Hussein, Saori Mukaida, Fazren Azmi, Stacey Bartlett, Celine Olivier, Michael R. Batzloff, Michael F. Good, Mariusz Skwarczynski & Istvan Toth. (2017) Comparison of Fluorinated and Nonfluorinated Lipids in Self-Adjuvanting Delivery Systems for Peptide-Based Vaccines. ACS Medicinal Chemistry Letters 8:2, pages 227-232.
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Manuela S. Murgueitio, Christin Rakers, Anne Frank & Gerhard Wolber. (2017) Balancing Inflammation: Computational Design of Small-Molecule Toll-like Receptor Modulators. Trends in Pharmacological Sciences 38:2, pages 155-168.
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Mehfuz Zaman, Victoria Ozberk, Emma L. Langshaw, Virginia McPhun, Jessica L. Powell, Zachary N. Phillips, Mei Fong Ho, Ainslie Calcutt, Michael R. Batzloff, Istvan Toth, Geoffrey R. Hill, Manisha Pandey & Michael F. Good. (2016) Novel platform technology for modular mucosal vaccine that protects against streptococcus. Scientific Reports 6:1.
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Daniel Menendez, Julie M. Lowe, Joyce Snipe & Michael A. Resnick. (2016) Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells. Oncotarget 7:38, pages 61630-61642.
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Saranya Chandrudu, Stacey Bartlett, Zeinab G Khalil, Zhongfan Jia, Waleed M Hussein, Robert J Capon, Michael R Batzloff, Michael F Good, Michael J Monteiro, Mariusz Skwarczynski & Istvan Toth. (2016) Linear and branched polyacrylates as a delivery platform for peptide-based vaccines. Therapeutic Delivery 7:9, pages 601-609.
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Waleed M. Hussein, Tzu-Yu Liu, Zhongfan Jia, Nigel A.J. McMillan, Michael J. Monteiro, Istvan Toth & Mariusz Skwarczynski. (2016) Multiantigenic peptide–polymer conjugates as therapeutic vaccines against cervical cancer. Bioorganic & Medicinal Chemistry 24:18, pages 4372-4380.
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Tom Y.-H. Wu. (2016) Strategies for designing synthetic immune agonists. Immunology 148:4, pages 315-325.
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Tatiana Paula Teixeira Ferreira, L?via Lacerda Mariano, Roberta Ghilosso-Bortolini, Ana Carolina Santos de Arantes, Andrey Junior Fernandes, Michelle Berni, Valentina Cecchinato, Mariagrazia Uguccioni, Roberto Maj, Alcide Barberis, Patricia Machado Rodrigues e Silva & Marco Aur?lio Martins. (2016) Potential of PEGylated Toll-Like Receptor 7 Ligands for Controlling Inflammation and Functional Changes in Mouse Models of Asthma and Silicosis. Frontiers in Immunology 7.
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Yu Wang, Erfei Song, Bo Bai & Paul M. Vanhoutte. (2016) Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes. Pharmacology & Therapeutics 158, pages 91-100.
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Mariusz Skwarczynski & Istvan Toth. (2016) Peptide-based synthetic vaccines. Chemical Science 7:2, pages 842-854.
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Mariusz Skwarczynski & Istvan Toth. (2014) Recent advances in peptide-based subunit nanovaccines. Nanomedicine 9:17, pages 2657-2669.
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Frank Wunderlich, Saleh Al-Quraishy, Holger Steinbrenner, Helmut Sies & Mohamed A. Dkhil. (2014) Towards identifying novel anti-Eimeria agents: trace elements, vitamins, and plant-based natural products. Parasitology Research 113:10, pages 3547-3556.
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