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Expert Opinion on Therapeutic Patents Volume 24, 2014 - Issue 8

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Patent Evaluations

The use of salt-inducible kinase inhibitors to treat autoimmune and inflammatory diseases: evaluation of WO2013136070

Peter NormanNorman Consulting, 18 Pink Lane, Burnham, SL1 8JW, [email protected]

Pages 943-946 | Published online: 19 Apr 2014

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https://doi.org/10.1517/13543776.2014.908851
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Jie Huang, Hua Fan, Yan-Mei Chen, Cheng-Niu Wang, Wei Guan, Wei-Yu Li, Tian-Shun Shi, Wei-Jia Chen, Bao-Lun Zhu, Jian-Feng Liu & Bo Jiang. (2023) The salt-inducible kinases inhibitor HG-9-91-01 exhibits antidepressant-like actions in mice exposed to chronic unpredictable mild stress. Neuropharmacology 227, pages 109437.
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Yong Fu, Gailing Ma, Yuqian Zhang, Wenli Wang, Tongguo Shi, Jie Zhu, Junfeng Zhang, Zhen Huang & Jiangning Chen. (2021) HG-9-91-01 Attenuates Murine Experimental Colitis by Promoting Interleukin-10 Production in Colonic Macrophages Through the SIK/CRTC3 Pathway. Inflammatory Bowel Diseases 27:11, pages 1821-1831.
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Mingsong Shi, Min Zhao, Lun Wang, Kongjun Liu, Penghui Li, Jiang Liu, Xiaoying Cai, Lijuan Chen & Dingguo Xu. (2021) Exploring the stability of inhibitor binding to SIK2 using molecular dynamics simulation and binding free energy calculation. Physical Chemistry Chemical Physics 23:23, pages 13216-13227.
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Mingsong Shi, Lun Wang, Penghui Li, Jiang Liu, Lijuan Chen & Dingguo Xu. (2021) Dasatinib–SIK2 Binding Elucidated by Homology Modeling, Molecular Docking, and Dynamics Simulations. ACS Omega 6:16, pages 11025-11038.
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