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Betulinic acid and its derivatives: a patent review (2008 – 2013)

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Elmira Khusnutdinova, Zarema Galimova, Alexander Lobov, Irina Baikova, Oxana Kazakova, Ha Nguyen Thi Thu, Nguyen Van Tuyen, Yuri Gatilov, René Csuk, Immo Serbian & Sophie Hoenke. (2022) Synthesis of messagenin and platanic acid chalcone derivatives and their biological potential. Natural Product Research 36:20, pages 5189-5198.
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Anna Hordyjewska, Aleksandra Ostapiuk, Anna Horecka & Jacek Kurzepa. (2019) Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential. Phytochemistry Reviews 18:3, pages 929-951.
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Ming Gu, Ping Zhao, Shiying Zhang, Shengjie Fan, Li Yang, Qingchun Tong, Guang Ji & Cheng Huang. (2019) Betulinic acid alleviates endoplasmic reticulum stress‐mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice. British Journal of Pharmacology 176:7, pages 847-863.
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E. Yu. Yamansarov, I. V. Saltykova, S. V. Kovalev, R. A. Petrov, D. O. Shkil’, E. I. Seleznev, E. K. Beloglazkina & A. G. Majouga. (2019) Synthesis and cytotoxicity of new alkyne derivatives of pentacyclic triterpenoids. Russian Chemical Bulletin 68:4, pages 855-861.
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Joana L. C. Sousa, Carmen S. R. Freire, Armando J. D. Silvestre & Artur M. S. Silva. (2019) Recent Developments in the Functionalization of Betulinic Acid and Its Natural Analogues: A Route to New Bioactive Compounds. Molecules 24:2, pages 355.
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Rinat R. Gubaidullin, Rezeda R. Khalitova, Darya A. Nedopekina & Anna Yu. Spivak. (2018) Homo‐ and Cross Coupling of C‐2 Propargyl Substituted Triterpenoic Acids: Synthesis of Novel Symmetrical and Unsymmetrical Triterpene 1,3‐Diynes. ChemistrySelect 3:47, pages 13526-13529.
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Anna Spivak, Rezeda Khalitova, Darya Nedopekina, Lilya Dzhemileva, Milyausha Yunusbaeva, Victor Odinokov, Vladimir D’yakonov & Usein Dzhemilev. (2018) Synthesis and Evaluation of Anticancer Activities of Novel C-28 Guanidine-Functionalized Triterpene Acid Derivatives. Molecules 23:11, pages 3000.
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Michael Kahnt, Jana Wiemann, Lucie Fischer, Sven Sommerwerk & René Csuk. (2018) Transformation of asiatic acid into a mitocanic, bimodal-acting rhodamine B conjugate of nanomolar cytotoxicity. European Journal of Medicinal Chemistry 159, pages 143-148.
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Michael Kahnt, Lucie Fischer (née Heller)Ahmed Al-Harrasi & René Csuk. (2018) Ethylenediamine Derived Carboxamides of Betulinic and Ursolic Acid as Potential Cytotoxic Agents. Molecules 23:10, pages 2558.
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Lucie Borkova, Jiri Hodon & Milan Urban. (2018) Synthesis of Betulinic Acid Derivatives with Modified A-Rings and their Application as Potential Drug Candidates. Asian Journal of Organic Chemistry 7:8, pages 1542-1560.
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Rinat R. Gubaidullin, Rezeda R. Khalitova, Zulfiya R. Galimshina & Anna Yu Spivak. (2018) Synthesis of novel [3,2-b] furan-fused pentacyclic triterpenoids via gold - Catalyzed intramolecular heterocyclization of 2-alkynyl-3-oxotriterpene acids. Tetrahedron 74:15, pages 1888-1899.
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R. R. Gubaidullin, A. Yu. Kairov & Yu. A. Prochukhan. (2018) Synthesis of Novel Alkynyl Derivatives of Betulinic Acid and Studies of their Cytotoxic Activity. Bashkir chemistry journal 25:4, pages 39.
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