247
Views
47
CrossRef citations to date
0
Altmetric
Reviews

Acylhydrazone derivatives: a patent review

, &

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Khalid Karrouchi, Saad Fettach, El Hassane Anouar, Imene Bayach, Hanan Albalwi, Suhana Arshad, Nada Kheira Sebbar, Hamza Tachalait, Khalid Bougrin, My El Abbes Faouzi & Benacer Himmi. (2023) Synthesis, Spectroscopic Characterization, DFT, Molecular Docking and Antidiabetic Activity of N-Isonicotinoyl Arylaldehyde Hydrazones. Polycyclic Aromatic Compounds 43:2, pages 1469-1481.
Read now
Gisele S. da Silva, Micheli Figueiró, Claudio F. Tormena, Fernando Coelho & Wanda P Almeida. (2016) Effects of novel acylhydrazones derived from 4-quinolone on the acetylcholinesterase activity and Aβ42 peptide fibrils formation. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1464-1470.
Read now

Articles from other publishers (45)

Vladimir Ćurčić, Mateusz Olszewski, Natalia Maciejewska, Aleksandar Višnjevac, Tatjana Srdić‐Rajić, Vladimir Dobričić, Alfonso T. García‐Sosa, Sanja B. Kokanov, Jovana B. Araškov, Romano Silvestri, Roland Schüle, Manfred Jung, Milan Nikolić & Nenad R. Filipović. (2023) Quinoline‐based thiazolyl‐hydrazones target cancer cells through autophagy inhibition. Archiv der Pharmazie.
Crossref
Zhiwei Zhang, Giang N. T. Le, Yang Ge, Xiaowen Tang, Xin Chen, Linda Ejim, Emily Bordeleau, Gerard D. Wright, Darcy C. Burns, Susannah Tran, Peter Axerio-Cilies, Yu Tian Wang, Mingxin Dong & G. Andrew Woolley. (2023) Isomerization of bioactive acylhydrazones triggered by light or thiols. Nature Chemistry 15:9, pages 1285-1295.
Crossref
A. K. Matyukhina, E. N. Zorina-Tikhonova, V. A. Novikova, I. V. Skabitsky, M. A. Kiskin & I. L. Eremenko. (2023) Synthesis and Structure of Cu(II) Coordination Compounds with N′-(3-Tert-Butyl-5-Nitro-2-Hydroxybenzylidene)-Isonicotinohydrazide. Journal of Structural Chemistry 64:8, pages 1554-1561.
Crossref
Kaan Küçükoğlu, Ulviye Acar Çevik, Hayrunnisa Nadaroglu, Ismail Celik, Ayşen Işık, Hayrani Eren Bostancı, Yusuf Özkay & Zafer Asım Kaplancıklı. (2023) Synthesis and Molecular Docking of New N-Acyl Hydrazones- Benzimidazole as hCA I and II Inhibitors. Medicinal Chemistry 19:5, pages 485-494.
Crossref
Wanjun Ni, Hongjian Song, Lizhong Wang, Yuxiu Liu & Qingmin Wang. (2023) Design, Synthesis and Various Bioactivity of Acylhydrazone-Containing Matrine Analogues. Molecules 28:10, pages 4163.
Crossref
Warakorn Akarasareenon, Supphachok Chanmungkalakul, Liu Xiaogang & Paitoon Rashatasakhon. (2023) Selective fluorescent sensors for copper(II) ion from julolidine hydrazone derivatives. Journal of Photochemistry and Photobiology A: Chemistry 437, pages 114422.
Crossref
José Maurício dos Santos Filho & Marcos Venícius Batista de Souza Castro. (2022) Synthesis, structural characterization, and antimicrobial activity of novel ferrocene-N-acyl hydrazones designed by means of molecular simplification strategy Celebrating the 100th anniversary of the birth of Professor Paulo Freire. Journal of Organometallic Chemistry 979, pages 122488.
Crossref
Marwa Fray, David Mathiron, Serge Pilard, David Lesur, Rym Abidi, Thouraya Barhoumi‐Slimi, Peter J. Cragg & Mohammed Benazza. (2022) Heteroglycoclusters through Unprecedented Orthogonal Chemistry Based on N ‐Alkylation of N ‐Acylhydrazone . European Journal of Organic Chemistry 2022:33.
Crossref
Keriman Ozadali‐Sari, Serenay Ceylan, Evnur Sinem Yucel, Suna Sabuncuoglu & Oya Unsal‐Tan. (2022) Design, Synthesis and Cytotoxic Evaluation of N ‐Acylhydrazone‐Incorporated Isoxazolo[4,5‐ d ]pyridazin‐4(5 H )‐one Derivatives . Chemistry & Biodiversity 19:9.
Crossref
Keyvan Pedrood, Zahra Rezaei, Kimia Khavaninzadeh, Bagher Larijani, Aida Iraji, Samanesadat Hosseini, Somayeh Mojtabavi, Mehdi Dianatpour, Hossein Rastegar, Mohammad Ali Faramarzi, Haleh Hamedifar, Mir Hamed Hajimiri & Mohammad Mahdavi. (2022) Design, synthesis, and molecular docking studies of diphenylquinoxaline-6-carbohydrazide hybrids as potent α-glucosidase inhibitors. BMC Chemistry 16:1.
Crossref
Jovica Branković, Nevena Milivojević, Vesna Milovanović, Dušica Simijonović, Zorica D. Petrović, Zoran Marković, Dragana S. Šeklić, Marko N. Živanović, Milena D. Vukić & Vladimir P. Petrović. (2022) Evaluation of antioxidant and cytotoxic properties of phenolic N -acylhydrazones: structure–activity relationship . Royal Society Open Science 9:6.
Crossref
Pipattra Mayurachayakul, Nakorn Niamnont, Kittichai Chaiseeda & Oraphin Chantarasriwong. (2022) Catalyst‐ and Solvent‐Free Synthesis of N ‐Acylhydrazones via Solid‐State Melt Reaction . Asian Journal of Organic Chemistry 11:5.
Crossref
Ling-ling Chang, Jie Yang, Shi-qi Lai, Xiang-rong Liu, Zai-wen Yang & Shun-sheng Zhao. (2022) Synthesis, crystal structures and CT-DNA/BSA binding properties of Co(III) and Cu(II) complexes with bipyridine Schiff base ligand. Inorganica Chimica Acta 532, pages 120751.
Crossref
Khalid Karrouchi, Saad Fettach, Ömer Tamer, Davut Avci, Adil Başoğlu, Yusuf Atalay, Zeynep Ayaz, Smaail Radi, Hazem A. Ghabbour, Yahia N. Mabkhot, My El Abbes Faouzi & M'hammed Ansar. (2022) Synthesis, crystal structure, spectroscopic characterization, α-glucosidase inhibition and computational studies of (E)-5-methyl-N′-(pyridin-2-ylmethylene)-1H-pyrazole-3-carbohydrazide. Journal of Molecular Structure 1248, pages 131506.
Crossref
Luana da S. M. Forezi, Carolina G. S. Lima, Adriane A. P. Amaral, Patricia G. Ferreira, Maria Cecília B. V. de Souza, Anna C. Cunha, Fernando de C. da Silva & Vitor F. Ferreira. (2021) Bioactive 1,2,3‐Triazoles: An Account on their Synthesis, Structural Diversity and Biological Applications. The Chemical Record 21:10, pages 2782-2807.
Crossref
Lidia Moreira Lima, Tiago Fernandes da Silva, Carlos Eduardo da Silva Monteiro, Cristiane Aparecida-Silva, Walfrido Bispo Júnior, Aline Cavalcanti de Queiroz, Magna Suzana Alexandre-Moreira, Gisele Zapata-Sudo & Eliezer J. Barreiro. (2021) Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514. Molecules 26:16, pages 4828.
Crossref
Simona Nica, Axel Buchholz, Helmar Görls & Winfried Plass. (2021) Hydrazone‐Based Ligand with Pyrrolidine Donor and Its Molybdenum(VI) Complex: Synthesis, Structure, and Reactivity. Zeitschrift für anorganische und allgemeine Chemie 647:8, pages 937-942.
Crossref
Khalid Karrouchi, Saad Fettach, Mukesh M. Jotani, Abir Sagaama, Smaail Radi, Hazem A. Ghabbour, Yahia N. Mabkhot, Benacer Himmi, My El Abbes Faouzi & Noureddine Issaoui. (2020) Synthesis, crystal structure, hirshfeld surface analysis, DFT calculations, anti-diabetic activity and molecular docking studies of (E)-N’-(5-bromo-2-hydroxybenzylidene) isonicotinohydrazide. Journal of Molecular Structure 1221, pages 128800.
Crossref
Yusuf Sert, Gamal A. El-Hiti, Halil Gökce, Fatih Ucun, Bakr F. Abdel-Wahab & Benson M. Kariuki. (2020) DFT, molecular docking and experimental FT-IR, laser-Raman, NMR and UV investigations on a potential anticancer agent containing triazole ring system. Journal of Molecular Structure 1211, pages 128077.
Crossref
Raed M. Maklad, El-Shimaa M.N. AbdelHafez, Dalia Abdelhamid & Omar M. Aly. (2020) Tubulin inhibitors: Discovery of a new scaffold targeting extra-binding residues within the colchicine site through anchoring substituents properly adapted to their pocket by a semi-flexible linker. Bioorganic Chemistry 99, pages 103767.
Crossref
Xia Jiang, Genyun Tang, Jie Yang, Jiacheng Ding, Hongwei Lin & Xiaoliang Xiang. (2020) Synthesis of some new acylhydrazone compounds containing the 1,2,4-triazole structure and their neuritogenic activities in Neuro-2a cells. RSC Advances 10:32, pages 18927-18935.
Crossref
Andrei V. Bogdanov, Kamilla R. Iskhakova, Alexandra D. Voloshina, Anastasia S. Sapunova, Natalia V. Kulik, Natalia V. Terekhova, Maxim V. Arsenyev, Guzel K. Ziyatdinova & Sergey V. Bukharov. (2020) Ammonium‐Charged Sterically Hindered Phenols with Antioxidant and Selective Anti‐Gram‐Positive Bacterial Activity. Chemistry & Biodiversity 17:5.
Crossref
Natalia de Morais Cordeiro, Rosana H.C.N. Freitas, Carlos Alberto Manssour Fraga & Patricia Dias Fernandes. (2020) New 2-amino-pyridinyl-N-acylhydrazones: Synthesis and identification of their mechanism of anti-inflammatory action. Biomedicine & Pharmacotherapy 123, pages 109739.
Crossref
Anton Granzhan, Rodrigo Prado Martins, Robin Fåhraeus, Marc Blondel & Marie-Paule Teulade-Fichou. 2020. Quadruplex Nucleic Acids As Targets For Medicinal Chemistry. Quadruplex Nucleic Acids As Targets For Medicinal Chemistry 243 286 .
Davidson M. S. Wanderley, Demis F. Melo, Laryssa M. Silva, Wesley C. Silva, Lidiane P. Correia, João A. Oshiro-Junior, Marcus V. L. Fook, Ricardo O. Moura, Rosemary S. C. Lima & Bolívar P. G. L. Damasceno. (2019) Physical–chemical characterization of N-acylhydrazone derivative chitosan films using spectroscopic and thermoanalytical techniques. Journal of Thermal Analysis and Calorimetry 138:5, pages 3789-3796.
Crossref
João Batista M. de Resende Filho, Nathália Kellyne S. M. Falcão, Gilvan P. Pires, Luiz Fernando S. de Vasconcelos, Sávio M. Pinheiro, José Maurício dos Santos Filho, Marília Imaculada Frazão Barbosa, Antônio Carlos Doriguetto, Ercules E. S. Teotonio & Juliana A. Vale. (2019) Lanthanide–EDTA complexes covalently bonded on Fe 3 O 4 @SiO 2 magnetic nanoparticles promote the green, stereoselective synthesis of N -acylhydrazones . New Journal of Chemistry 43:36, pages 14257-14269.
Crossref
Sevil Şenkardeş, Esra Tatar, Ridvan Nepravishta, Dorisa Cela, Maurizio Paci, Özlem Bingöl Özakpınar, Turgut Şekerler, Erik De Clercq, Christophe Pannecouque, Ş. Güniz Küçükgüzel & İlkay Küçükgüzel. (2019) Synthesis and Biological Activity of N-(arylsulfonyl) Valine Hydrazones and Assistance of NMR Spectroscopy for Definitive 3D Structure. Letters in Drug Design & Discovery 16:9, pages 974-983.
Crossref
Oksana Reznichenko, Alicia Quillévéré, Rodrigo Prado Martins, Nadège Loaëc, Hang Kang, María José Lista, Claire Beauvineau, Jorge González-García, Régis Guillot, Cécile Voisset, Chrysoula Daskalogianni, Robin Fåhraeus, Marie-Paule Teulade-Fichou, Marc Blondel & Anton Granzhan. (2019) Novel cationic bis(acylhydrazones) as modulators of Epstein–Barr virus immune evasion acting through disruption of interaction between nucleolin and G-quadruplexes of EBNA1 mRNA. European Journal of Medicinal Chemistry 178, pages 13-29.
Crossref
Eloísa G Sampiron, Giovana F Costacurta, Vanessa P Baldin, Aryadne L Almeida, Andressa L Ieque, Nathally CS Santos, Vanessa G Alves-Olher, Fábio Vandresen, Ana CR Gimenes, Vera LD Siqueira, Katiany R Caleffi-Ferracioli, Rosilene F Cardoso & Regiane BL Scodro. (2019) Hydrazone, benzohydrazones and isoniazid-acylhydrazones as potential antituberculosis agents. Future Microbiology 14:11, pages 981-994.
Crossref
Fang Sun, Tingrui Yin, Anni Feng, Yong Hu, Chenxia Yu, Tuanjie Li & Changsheng Yao. (2019) Base-promoted regiodivergent allylation of N -acylhydrazones with Morita–Baylis–Hillman carbonates by tuning the catalyst . Organic & Biomolecular Chemistry 17:21, pages 5283-5293.
Crossref
Sreekanth Thota, Daniel A. Rodrigues, Pedro de Sena Murteira Pinheiro, Lídia M. Lima, Carlos A.M. Fraga & Eliezer J. Barreiro. (2018) N-Acylhydrazones as drugs. Bioorganic & Medicinal Chemistry Letters 28:17, pages 2797-2806.
Crossref
Cássio S. Meira, José Maurício dos Santos Filho, Caroline C. Sousa, Pâmela S. Anjos, Jéssica V. Cerqueira, Humberto A. Dias Neto, Rafael G. da Silveira, Helena M. Russo, Jean-Luc Wolfender, Emerson F. Queiroz, Diogo R.M. Moreira & Milena B.P. Soares. (2018) Structural design, synthesis and substituent effect of hydrazone-N-acylhydrazones reveal potent immunomodulatory agents. Bioorganic & Medicinal Chemistry 26:8, pages 1971-1985.
Crossref
Joonsung Hwang, Nak Kyun Soung, Ho Jin Han, Yongjun Lee, Tae Woong Choi, Jiyun Mun, Hyunjoo Cha-Molstad, Kyung Ho Lee, Hyo Joon Kim, Hee Gu Lee, Jin Tae Hong, Jong Seog Ahn, Yong Tae Kwon & Bo Yeon Kim. (2018) A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model. Experimental Dermatology 27:3, pages 285-288.
Crossref
Ling-Yu Li, Jia-Di Peng, Wenjuan Zhou, Hui Qiao, Xin Deng, Zhou-Hua Li, Ji-Deng Li, Yun-Dong Fu, Song Li, Kai Sun, Hong-Min Liu & Wen Zhao. (2018) Potent hydrazone derivatives targeting esophageal cancer cells. European Journal of Medicinal Chemistry 148, pages 359-371.
Crossref
Nathália M. dos Santos, Nayara C. Pereira, Angélica P.S. de Albuquerque, Flávia P. Dias Viegas, Clarice Veloso, Fabiana C. Vilela, Alexandre Giusti-Paiva, Marcelo L. da Silva, Josie R.T. da Silva & Claudio Viegas Jr.. (2018) 3-Hydroxy-piperidinyl-N-benzyl-acyl-arylhydrazone derivatives reduce neuropathic pain and increase thermal threshold mediated by opioid system. Biomedicine & Pharmacotherapy 99, pages 492-498.
Crossref
Pedro de Sena Murteira Pinheiro, Daniel Alencar Rodrigues, Marina Amaral Alves, Luzineide Wanderley Tinoco, Glaucio Braga Ferreira, Carlos Mauricio Rabello de Sant’Anna & Carlos Alberto Manssour Fraga. (2018) Theoretical and experimental characterization of 1,4-N⋯S σ-hole intramolecular interactions in bioactive N -acylhydrazone derivatives . New Journal of Chemistry 42:1, pages 497-505.
Crossref
Krisada Sakchaisri, Sun-Ok Kim, Joonsung Hwang, Nak Kyun Soung, Kyung Ho Lee, Tae Woong Choi, Yongjun Lee, Chan-Mi Park, Naraganahalli R. Thimmegowda, Phil Young Lee, Bettaswamigowda Shwetha, Ganipisetti Srinivasrao, Thi Thu Huong Pham, Jae-Hyuk Jang, Hye-Won Yum, Young-Joon Surh, Kyung S. Lee, Hwangseo Park, Seung Jun Kim, Yong Tae Kwon, Jong Seog Ahn & Bo Yeon Kim. (2017) Anticancer activity of a novel small molecule tubulin inhibitor STK899704. PLOS ONE 12:3, pages e0173311.
Crossref
Jolanta Dyniewicz, Piotr F. J. Lipiński, Piotr Kosson, Anna Leśniak, Marta Bochyńska-Czyż, Adriana Muchowska, Dirk Tourwé, Steven Ballet, Aleksandra Misicka & Andrzej W. Lipkowski. (2016) Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds. ACS Medicinal Chemistry Letters 8:1, pages 73-77.
Crossref
José Maurício dos Santos Filho & Savio Moita Pinheiro. (2017) Stereoselective, solvent free, highly efficient synthesis of aldo- and keto-N-acylhydrazones applying grindstone chemistry. Green Chemistry 19:9, pages 2212-2224.
Crossref
A.M. Jones. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 116 152 .
Mario R. Senger, Carlos A.M. Fraga, Rafael F. Dantas & Floriano P. SilvaJr.Jr.. (2016) Filtering promiscuous compounds in early drug discovery: is it a good idea?. Drug Discovery Today 21:6, pages 868-872.
Crossref
Imane Hamzi, Thouraya M. Barhoumi-Slimi & Rym Abidi. (2016) Synthesis, Characterization, and Conformational Study of Acylhydrazones of α,β-Unsaturated Aldehydes. Heteroatom Chemistry 27:3, pages 139-148.
Crossref
Nenad R. Filipović, Snežana Bjelogrlić, Tamara R. Todorović, Vladimir A. Blagojević, Christian D. Muller, Aleksandar Marinković, Miroslava Vujčić, Barbara Janović, Aleksandar S. Malešević, Nebojša Begović, Milan Senćanski & Dragica M. Minić. (2016) Ni( ii ) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines . RSC Advances 6:110, pages 108726-108740.
Crossref
Aleksandra Božić, Aleksandar Marinković, Snežana Bjelogrlić, Tamara R. Todorović, Ilija N. Cvijetić, Irena Novaković, Christian D. Muller & Nenad R. Filipović. (2016) Quinoline based mono- and bis-(thio)carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models. RSC Advances 6:106, pages 104763-104781.
Crossref
José Maurício dos Santos Filho & Marcos Venícius Batista de Souza Castro. (2022) Synthesis, Structural Characterization, and Antimicrobial Activity of Novel Ferrocene-N-Acyl Hydrazones Designed by Means of Molecular Simplification Strategy Celebrating the 100th Anniversary of the Birth of Professor Paulo Freire. SSRN Electronic Journal.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.