Advanced search
Publication Cover
Expert Opinion on Therapeutic Patents Volume 24, 2014 - Issue 11
Submit an article Journal homepage
648
Views
31
CrossRef citations to date
0
Altmetric
Reviews

Novel histamine H4 receptor ligands and their potential therapeutic applications: an update

Róbert KissResearch Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
&
György M KeseruResearch Centre for Natural Sciences, Hungarian Academy of Sciences, Pusztaszeri ut 59-67, Budapest, 1025, [email protected]
, DSc
Pages 1185-1197 | Published online: 15 Sep 2014

Citations (31)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Abbas Fazlinia & Setareh Sheikh. (2020) Liquid Glass Catalyzed Three-Component Preparation of 2-Amino-4-Aryl-5H-Indeno[1,2-d]Pyrimidin-5-One Derivatives. Polycyclic Aromatic Compounds 40:5, pages 1362-1366.
Read now
Kateřina Vávrová. (2016) Emerging small-molecule compounds for treatment of atopic dermatitis: a review. Expert Opinion on Therapeutic Patents 26:1, pages 21-34.
Read now

Articles from other publishers (29)

Michael Strupp, Thomas Brandt & Marianne DieterichMichael Strupp, Thomas Brandt & Marianne Dieterich. 2023. Vertigo and Dizziness. Vertigo and Dizziness 119 145 .
Gábor Wágner, Tamara A. M. Mocking, Xiaoyuan Ma, Inna Slynko, Daniel Da Costa Pereira, Robin Breeuwer, Niek J. N. Rood, Cas van der Horst, Henry F. Vischer, Chris de Graaf, Iwan J. P. de Esch, Maikel Wijtmans & Rob Leurs. (2022) SAR exploration of the non‐imidazole histamine H 3 receptor ligand ZEL‐H16 reveals potent inverse agonism . Archiv der Pharmazie 356:1.
Crossref
Giulia Radi, Anna Campanti, Federico Diotallevi, Emanuela Martina, Andrea Marani & Annamaria Offidani. (2022) A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside. Biomedicines 10:11, pages 2700.
Crossref
Weiwei Wang, Hongwei Yu, Yongliang Pan & Shengwen Shao. (2021) Combined Treatment With H1 and H4 Receptor Antagonists Improves Th2 Inflammatory Responses in the Nasal Mucosa of Allergic Rhinitis Rats. American Journal of Rhinology & Allergy 35:6, pages 809-816.
Crossref
Choongheon Lee & Timothy A. Jones. (2021) Effects of Several Therapeutic Agents on Mammalian Vestibular Function: Meclizine, Diazepam, and JNJ7777120. Journal of the Association for Research in Otolaryngology 22:5, pages 527-549.
Crossref
Fernando Valenzuela & Rodrigo Flores. (2021) Antihistamínicos: Usos clásicos, nuevos y anecdóticos en dermatología. Parte 1: Histamina, sus receptores y antagonistas. Piel 36:2, pages 95-103.
Crossref
Mizuki Watanabe, Takaaki Kobayashi, Yoshihiko Ito, Shizuo Yamada & Satoshi Shuto. (2020) Conformational Restriction of Histamine with a Rigid Bicyclo[3.1.0]hexane Scaffold Provided Selective H3 Receptor Ligands. Molecules 25:16, pages 3562.
Crossref
Pakhuri Mehta, Przemysław Miszta, Przemysław Rzodkiewicz, Olga Michalak, Piotr Krzeczyński & Sławomir Filipek. (2020) Enigmatic Histamine Receptor H4 for Potential Treatment of Multiple Inflammatory, Autoimmune, and Related Diseases. Life 10:4, pages 50.
Crossref
Michael Strupp & Andreas Zwergal. 2020. The Senses: A Comprehensive Reference. The Senses: A Comprehensive Reference 600 608 .
Gábor Wágner, Tamara A. M. Mocking, Marta Arimont, Gustavo Provensi, Barbara Rani, Bruna Silva-Marques, Gniewomir Latacz, Daniel Da Costa Pereira, Christina Karatzidou, Henry F. Vischer, Maikel Wijtmans, Katarzyna Kieć-Kononowicz, Iwan J. P. de Esch & Rob Leurs. (2019) 4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H 3 Receptor Agonists with in Vivo Central Nervous System Activity . Journal of Medicinal Chemistry 62:23, pages 10848-10866.
Crossref
Thomas Bieber. (2019) Neuartige Therapien auf der Grundlage der Pathophysiologie der atopischen Dermatitis. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 17:11, pages 1150-1163.
Crossref
Thomas Bieber. (2019) Novel therapies based on the pathophysiology of atopic dermatitis. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 17:11, pages 1150-1162.
Crossref
Amarilla Mandola, Asako Nozawa & Thomas Eiwegger. (2019) Histamine, histamine receptors, and anti-histamines in the context of allergic responses. LymphoSign Journal 6:2, pages 35-51.
Crossref
Wei Wei Wang, Yong Liang Pan, Hong Wei Yu, Bo Zhang & Sheng Wen Shao. (2019) Histamine H4 receptor regulates Th2-cytokine profile through thymic stromal lymphopoietin in allergic rhinitis. European Archives of Oto-Rhino-Laryngology 276:6, pages 1655-1661.
Crossref
Dorota Łażewska, Szczepan Mogilski, Stefanie Hagenow, Kamil Kuder, Monika Głuch-Lutwin, Agata Siwek, Małgorzata Więcek, Maria Kaleta, Ulla Seibel, Armin Buschauer, Barbara Filipek, Holger Stark & Katarzyna Kieć-Kononowicz. (2019) Alkyl derivatives of 1,3,5-triazine as histamine H4 receptor ligands. Bioorganic & Medicinal Chemistry 27:7, pages 1254-1262.
Crossref
Mizuki Watanabe, Takaaki Kobayashi, Yoshihiko Ito, Hayato Fukuda, Shizuo Yamada, Mitsuhiro Arisawa & Satoshi Shuto. (2018) Design and synthesis of histamine H3/H4 receptor ligands with a cyclopropane scaffold. Bioorganic & Medicinal Chemistry Letters 28:23-24, pages 3630-3633.
Crossref
Alessandro Pini, Cristina Grange, Eleonora Veglia, Monica Argenziano, Roberta Cavalli, Daniele Guasti, Laura Calosi, Corrado Ghè, Roberto Solarino, Robin L. Thurmond, Giovanni Camussi, Paul L. Chazot & Arianna Carolina Rosa. (2018) Histamine H 4 receptor antagonism prevents the progression of diabetic nephropathy in male DBA2/J mice. Pharmacological Research 128, pages 18-28.
Crossref
Daniel C. Batista, Daiany P. B. Silva, Iziara F. Florentino, Carina S. Cardoso, Merita P. Gonçalves, Marize C. Valadares, Luciano M. Lião, Germán Sanz, Boniek G. Vaz, Elson A. Costa & Ricardo Menegatti. (2017) Anti-inflammatory effect of a new piperazine derivative: (4-methylpiperazin-1-yl)(1-phenyl-1H-pyrazol-4-yl)methanone. Inflammopharmacology 26:1, pages 217-226.
Crossref
Bryan L Roth, John J Irwin & Brian K Shoichet. (2017) Discovery of new GPCR ligands to illuminate new biology. Nature Chemical Biology 13:11, pages 1143-1151.
Crossref
Roopesh Singh Gangwar, Nadine Landolina, Ludovica Arpinati & Francesca Levi-Schaffer. (2017) Mast cell and eosinophil surface receptors as targets for anti-allergic therapy. Pharmacology & Therapeutics 170, pages 37-63.
Crossref
B. C. Bhavya & Madathilkovilakath Haridas. 2017. Bioresources and Bioprocess in Biotechnology. Bioresources and Bioprocess in Biotechnology 235 268 .
Olivier Labeeuw, Nicolas Levoin, Xavier Billot, Denis Danvy, Thierry Calmels, Stéphane Krief, Xavier Ligneau, Isabelle Berrebi-Bertrand, Philippe Robert, Jeanne-Marie Lecomte, Jean-Charles Schwartz & Marc Capet. (2016) Synthesis and evaluation of a 2-benzothiazolylphenylmethyl ether class of histamine H4 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 26:21, pages 5263-5266.
Crossref
Gniewomir Latacz, Petros Kechagioglou, Rigini Papi, Dorota Łażewska, Małgorzata Więcek, Katarzyna Kamińska, Przemysław Wencel, Tadeusz Karcz, Johannes S. Schwed, Holger Stark, Dimitrios A. Kyriakidis & Katarzyna Kieć-Kononowicz. (2016) The Synthesis of 1,3,5-triazine Derivatives and JNJ7777120 Analogues with Histamine H 4 Receptor Affinity and Their Interaction with PTEN Promoter . Chemical Biology & Drug Design 88:2, pages 254-263.
Crossref
Bassem Sadek & Holger Stark. (2016) Cherry-picked ligands at histamine receptor subtypes. Neuropharmacology 106, pages 56-73.
Crossref
Roland Geyer, Uwe Nordemann, Andrea Strasser, Hans-Joachim Wittmann & Armin Buschauer. (2016) Conformational Restriction and Enantioseparation Increase Potency and Selectivity of Cyanoguanidine-Type Histamine H 4 Receptor Agonists . Journal of Medicinal Chemistry 59:7, pages 3452-3470.
Crossref
Sebastian G. Hammer, Susanne Gobleder, Franziska Naporra, Hans-Joachim Wittmann, Sigurd Elz, Markus R. Heinrich & Andrea Strasser. (2016) 2,4-Diaminopyrimidines as dual ligands at the histamine H 1 and H 4 receptor—H 1 /H 4 -receptor selectivity. Bioorganic & Medicinal Chemistry Letters 26:2, pages 292-300.
Crossref
Katarzyna Kamińska, Julia Ziemba, Joanna Ner, Johannes Stephan Schwed, Dorota Łażewska, Małgorzata Więcek, Tadeusz Karcz, Agnieszka Olejarz, Gniewomir Latacz, Kamil Kuder, Tim Kottke, Małgorzata Zygmunt, Jacek Sapa, Janina Karolak-Wojciechowska, Holger Stark & Katarzyna Kieć-Kononowicz. (2015) (2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands. European Journal of Medicinal Chemistry 103, pages 238-251.
Crossref
Mark S. Tichenor, Robin L. Thurmond, Jennifer D. Venable & Brad M. Savall. (2015) Functional Profiling of 2-Aminopyrimidine Histamine H 4 Receptor Modulators . Journal of Medicinal Chemistry 58:18, pages 7119-7127.
Crossref
Anna De Benedetto, Takeshi Yoshida, Sade Fridy, Joo-Eun Park, I.-Hsin Kuo & Lisa Beck. (2015) Histamine and Skin Barrier: Are Histamine Antagonists Useful for the Prevention or Treatment of Atopic Dermatitis?. Journal of Clinical Medicine 4:4, pages 741-755.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.