Citations (71)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (6)
Pankaj Bhatia & Nirmal Singh. (2022) Tadalafil ameliorates memory deficits, oxidative stress, endothelial dysfunction and neuropathological changes in rat model of hyperhomocysteinemia induced vascular dementia. International Journal of Neuroscience 132:4, pages 384-396.
Read now
Read now
Zhihao Liu, Mingjian Liu, Zhenqing Cao, Pengsen Qiu & Gaopeng Song. (2022) Phosphodiesterase‑4 inhibitors: a review of current developments (2013–2021). Expert Opinion on Therapeutic Patents 32:3, pages 261-278.
Read now
Read now
Maria Gabriella Matera, Josuel Ora, Francesco Cavalli, Paola Rogliani & Mario Cazzola. (2021) New Avenues for Phosphodiesterase Inhibitors in Asthma. Journal of Experimental Pharmacology 13, pages 291-302.
Read now
Read now
Jos Prickaerts, Pim R. A. Heckman & Arjan Blokland. (2017) Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease. Expert Opinion on Investigational Drugs 26:9, pages 1033-1048.
Read now
Read now
Lili Liu, Lei Chen, Yu-Hang Zhang, Lai Wei, Shiwen Cheng, Xiangyin Kong, Mingyue Zheng, Tao Huang & Yu-Dong Cai. (2017) Analysis and prediction of drug–drug interaction by minimum redundancy maximum relevance and incremental feature selection. Journal of Biomolecular Structure and Dynamics 35:2, pages 312-329.
Read now
Read now
Kateřina Vávrová. (2016) Emerging small-molecule compounds for treatment of atopic dermatitis: a review. Expert Opinion on Therapeutic Patents 26:1, pages 21-34.
Read now
Read now
Articles from other publishers (65)
Baochan Du, Min Luo, Changyu Ren & Jifa Zhang. (2023) PDE4 inhibitors for disease therapy: advances and future perspective. Future Medicinal Chemistry.
Crossref
Crossref
Havva Afshari, Shokoofe Noori, Bahareh Shokri & Afshin Zarghi. (2023) Co-treatment of Naringenin and Ketoprofen-RGD Suppresses Cell Proliferation via Calmodulin/PDE/cAMP/PKA Axis Pathway in Leukemia and Ovarian Cancer Cells. Iranian Journal of Pharmaceutical Research 22:1.
Crossref
Crossref
Enass Najem Oubaid, Ahmed Abu-Raghif & Israa Mahdi Al-Sudani. (2023) Ibudilast ameliorates experimentally induced colitis in rats via down-regulation of proinflammatory cytokines and myeloperoxidase enzyme activity. Pharmacia 70:1, pages 187-195.
Crossref
Crossref
Jia-Xi Huang, Bo-Lin Zhu, Jiang-Ping Xu & Zhong-Zhen Zhou. (2023) Advances in the development of phosphodiesterase 7 inhibitors. European Journal of Medicinal Chemistry 250, pages 115194.
Crossref
Crossref
Naglaa Ahmed Mohamed Younis, Alshymaa AbdelRahman Gomaa, Alyaa Hatem Ibrahim, Mohamed S.A. Abdelkader & Samar Yehia Desoukey. (2022) The genus Agapanthus: A review of traditional uses, pharmacological and phytochemical attributes. South African Journal of Botany 150, pages 1168-1183.
Crossref
Crossref
Chuansheng Yao, Xiaoying Jiang, Xiang‐Yang Ye, Tian Xie & Renren Bai. (2022) Antidepressant Drug Discovery and Development: Mechanism and Drug Design Based on Small Molecules. Advanced Therapeutics 5:5, pages 2200007.
Crossref
Crossref
Zhendong Song, Yi-You Huang, Ke-Qiang Hou, Lu Liu, Feng Zhou, Yue Huang, Guohui Wan, Hai-Bin Luo & Xiao-Feng Xiong. (2022) Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis. Journal of Medicinal Chemistry 65:5, pages 4238-4254.
Crossref
Crossref
Chaitali P. Basole, Rebecca K. Nguyen, Katie Lamothe, Puja Billis, Mai Fujiwara, Amanda G. Vang, Robert B. Clark, Paul M. Epstein & Stefan Brocke. (2022) Treatment of Experimental Autoimmune Encephalomyelitis with an Inhibitor of Phosphodiesterase-8 (PDE8). Cells 11:4, pages 660.
Crossref
Crossref
Xiang Tao, Haiqing He, Jiangtong Peng, Rui Xu, Jing Fu, Yuting Hu, Li Li, Xiaoyan Yang, Xiuling Feng, Chao Zhang, Lingmin Zhang, Xiyong Yu, Ao Shen, Kai Huang & Qin Fu. (2022) Overexpression of PDE4D in mouse liver is sufficient to trigger NAFLD and hypertension in a CD36-TGF-β1 pathway: therapeutic role of roflumilast. Pharmacological Research 175, pages 106004.
Crossref
Crossref
Vanishree Rao, Rashmi Bhushan, Priyanka Kumari, Sri Pragnya Cheruku, V. Ravichandiran & Nitesh Kumar. 2022. Strategies to Mitigate the Toxicity of Cancer Therapeutics. Strategies to Mitigate the Toxicity of Cancer Therapeutics
29
76
.
Margarida Lorigo, Nelson Oliveira & Elisa Cairrao. (2021) PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical Perspective. Journal of Cardiovascular Development and Disease 9:1, pages 4.
Crossref
Crossref
Nada H. Ashour, Dalia M. El-Tanbouly, Nesrine S. El Sayed & Mahmoud M. Khattab. (2021) Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: Involvement of nitric oxide status, Aβ extrusion transporter ABCB1, and reversal by PKA inhibitor H89. Progress in Neuro-Psychopharmacology and Biological Psychiatry 111, pages 110366.
Crossref
Crossref
Aurélie Moniot, Julien Braux, Camille Bour, Christine Guillaume, Fabien Lamret, Ingrid Allart-Simon, Sandra Audonnet, Sarah Renault, Francoise Rédini, Marie Laronze-Cochard, Janos Sapi, Sophie C. Gangloff, Stéphane Gérard & Frédéric Velard. (2021) Pyridazinone Derivatives Limit Osteosarcoma-Cells Growth In Vitro and In Vivo. Cancers 13:23, pages 5992.
Crossref
Crossref
Divjot Virk, Amit Kumar, Amteshwar Singh Jaggi & Nirmal Singh. (2021) Ameliorative role of rolipram, PDE-4 inhibitor, against sodium arsenite–induced vascular dementia in rats. Environmental Science and Pollution Research 28:44, pages 63250-63262.
Crossref
Crossref
Xiao-Liu Dong, Yan-Hui Wang, Jing Xu & Nan Zhang. (2021) The protective effect of the PDE-4 inhibitor rolipram on intracerebral haemorrhage is associated with the cAMP/AMPK/SIRT1 pathway. Scientific Reports 11:1.
Crossref
Crossref
Zhongyuan Zhang, Meifeng Liang & Xiongfei Wan. (2021) Roflumilast, a type of phosphodiesterase 4 inhibitor, can reduce intestinal injury caused by sepsis. Experimental and Therapeutic Medicine 22:6.
Crossref
Crossref
Dana J. Ramms, Francesco Raimondi, Nadia Arang, Friedrich W. Herberg, Susan S. Taylor & J. Silvio Gutkind. (2022)
G
α
s–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant G
α
s-PKA Signaling
. Pharmacological Reviews 73:4, pages 1326-1368.
Crossref
Crossref
Ingrid Allart-Simon, Aurélie Moniot, Nicolo Bisi, Miguel Ponce-Vargas, Sandra Audonnet, Marie Laronze-Cochard, Janos Sapi, Eric Hénon, Frédéric Velard & Stéphane Gérard. (2021) Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors. RSC Medicinal Chemistry 12:4, pages 584-592.
Crossref
Crossref
Vanesa Nozal, Elisa Rojas-Prats, Inés Maestro, Carmen Gil, Daniel Perez & Ana Martinez. (2021) Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles. International Journal of Molecular Sciences 22:6, pages 3206.
Crossref
Crossref
Hiba Hashim Mahgoub Mohamed, Amna Bint Wahab Elrashid Mohammed Hussien & Ahmed Elsadig Mohammed Saeed. (2021) QSAR and docking studies of 3, 5-dimethylpyrazole as potent inhibitors of Phosphodiesterase-4. Journal of Drug Delivery and Therapeutics 11:1-s, pages 86-93.
Crossref
Crossref
Jéssica M. Bonato, Erika Meyer, Patrícia S. B. Mendonça, Humberto Milani, Jos Prickaerts & Rúbia Maria Oliveira. (2021) Roflumilast protects against spatial memory impairments and exerts anti‐inflammatory effects after transient global cerebral ischemia. European Journal of Neuroscience 53:4, pages 1171-1188.
Crossref
Crossref
Rui Zhang, Heng Li, Xianglei Zhang, Jian Li, Haixia Su, Qiukai Lu, Guangyu Dong, Huixia Dou, Chen Fan, Zhanni Gu, Qianwen Mu, Wei Tang, Yechun Xu & Hong Liu. (2021) Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment. European Journal of Medicinal Chemistry 211, pages 113004.
Crossref
Crossref
Susan McQuown, Dean Paes, Karsten Baumgärtel, Jos Prickaerts & Marco Peters. (2021) Pharmacological inhibition of phosphodiesterase 7 enhances consolidation processes of spatial memory. Neurobiology of Learning and Memory 177, pages 107357.
Crossref
Crossref
Yadan Huang, Xu-Nian Wu, Qian Zhou, Yinuo Wu, Dongxiao Zheng, Zhe Li, Lei Guo & Hai-Bin Luo. (2020) Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. Journal of Medicinal Chemistry 63:24, pages 15852-15863.
Crossref
Crossref
Agnieszka Jankowska, Anna Wesołowska, Maciej Pawłowski & Grażyna Chłoń-Rzepa. (2020) Multifunctional Ligands Targeting Phosphodiesterase as the Future Strategy for the Symptomatic and Disease-Modifying Treatment of Alzheimer’s Disease. Current Medicinal Chemistry 27:32, pages 5351-5373.
Crossref
Crossref
Manish Singh Kaushik, Swaroop Ranjan Pati, Shivanika Soni, Ayushi Mishra, Kumari Sushmita & Suneel Kateriya. (2020) Establishment of Optogenetic Modulation of cAMP for Analyzing Growth, Biofilm Formation, and Virulence Pathways of Bacteria Using a Light-Gated Cyclase. Applied Sciences 10:16, pages 5535.
Crossref
Crossref
Madoka Akimoto, Tianning Yu, Kody Moleschi, Katherine Van, Ganesh S. Anand & Giuseppe Melacini. (2020) An NMR based phosphodiesterase assay. Chemical Communications 56:58, pages 8091-8094.
Crossref
Crossref
Arunima Biswas, Anindita Bhattacharjee & Pijush K. Das. 2020. Vector-Borne Diseases - Recent Developments in Epidemiology and Control. Vector-Borne Diseases - Recent Developments in Epidemiology and Control.
Jiao Xiao, Rumeng Yao, Bingtian Xu, Huizhen Wen, Jiahong Zhong, Dan Li, Zhongzhen Zhou, Jiangping Xu & Haitao Wang. (2019) Inhibition of PDE4 Attenuates TNF-α-Triggered Cell Death Through Suppressing NF-κB and JNK Activation in HT-22 Neuronal Cells. Cellular and Molecular Neurobiology 40:3, pages 421-435.
Crossref
Crossref
Jinhao Liang, Yi-You Huang, Qian Zhou, Yuqi Gao, Zhe Li, Deyan Wu, Si Yu, Lei Guo, Zhen Chen, Ling Huang, Steven H. Liang, Xixin He, Ruibo Wu & Hai-Bin Luo. (2020) Discovery and Optimization of α-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. Journal of Medicinal Chemistry 63:6, pages 3370-3380.
Crossref
Crossref
Walter E. Rodriguez, Banrida Wahlang, Yali Wang, Jingwen Zhang, Manicka V. Vadhanam, Swati Joshi‐Barve, Philip Bauer, Robert Cannon, Ali Reza Ahmadi, Zhaoli Sun, Andrew Cameron, Shirish Barve, Claudio Maldonado, Craig McClain & Leila Gobejishvili. (2019) Phosphodiesterase 4 Inhibition as a Therapeutic Target for Alcoholic Liver Disease: From Bedside to Bench. Hepatology 70:6, pages 1958-1971.
Crossref
Crossref
Delphine Mika, Pierre Bobin, Marta Lindner, Angele Boet, Amir Hodzic, Florence Lefebvre, Patrick Lechène, Malha Sadoune, Jane-Lise Samuel, Vincent Algalarrondo, Catherine Rucker-Martin, Virginie Lambert, Rodolphe Fischmeister, Grégoire Vandecasteele & Jérôme Leroy. (2019) Synergic PDE3 and PDE4 control intracellular cAMP and cardiac excitation-contraction coupling in a porcine model. Journal of Molecular and Cellular Cardiology 133, pages 57-66.
Crossref
Crossref
Pankaj Bhatia & Nirmal Singh. (2019) Ameliorative Effect of Phosphodiesterase-5 Inhibitor in Rat Model of Vascular Dementia. Current Neurovascular Research 16:1, pages 27-39.
Crossref
Crossref
Chang Huang, Qiu‐Ping Zhong, Lv Tang, Hai‐Tao Wang, Jiang‐Ping Xu & Zhong‐Zhen Zhou. (2018) Discovery of 2‐(3,4‐dialkoxyphenyl)‐2‐(substituted pyridazin‐3‐yl)acetonitriles as phosphodiesterase 4 inhibitors with anti‐neuroinflammation potential based on three‐dimensional quantitative structure–activity relationship study. Chemical Biology & Drug Design 93:4, pages 484-502.
Crossref
Crossref
Xiangyu Kong, Ganghao Ai, Dai Wang, Renzhen Chen, Dongbei Guo, Youliang Yao, Kai Wang, Guiye Liang, Fengjie Qi, Wenzhi Liu & Yongxing Zhang. (2019) PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway. Analytical Cellular Pathology 2019, pages 1-5.
Crossref
Crossref
Fernando Bartolome, Macarena de la Cueva, Consuelo Pascual, Desiree Antequera, Tamara Fernandez, Carmen Gil, Ana Martinez & Eva Carro. (2018) Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition. Alzheimer's Research & Therapy 10:1.
Crossref
Crossref
Heng Li, Jianping Zuo & Wei Tang. (2018) Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases. Frontiers in Pharmacology 9.
Crossref
Crossref
Shipeng Gong, Yongning Chen, Fanliang Meng, Yadi Zhang, Chanyuan Li, Guangping Zhang, Wu Huan & Fei Wu. (2018)
Roflumilast enhances cisplatin‐sensitivity and reverses cisplatin‐resistance of ovarian cancer cells via
cAMP
/
PKA
/
CREB
‐FtMt signalling axis
. Cell Proliferation 51:5.
Crossref
Crossref
Akihiro Takano, Tolga Uz, Jesus Garcia-Segovia, Max Tsai, Gezim Lahu, Nahid Amini, Ryuji Nakao, Zhisheng Jia & Christer Halldin. (2018) A Nonhuman Primate PET Study: Measurement of Brain PDE4 Occupancy by Roflumilast Using (R)-[11C]Rolipram. Molecular Imaging and Biology 20:4, pages 615-622.
Crossref
Crossref
Richard S. Roberts, Sara Sevilla, Manel Ferrer, Joan Taltavull, Begoña Hernández, Victor Segarra, Jordi Gràcia, Martin D. Lehner, Amadeu Gavaldà, Miriam Andrés, Judit Cabedo, Dolors Vilella, Peter Eichhorn, Elena Calama, Carla Carcasona & Montserrat Miralpeix. (2018)
4-Amino-7,8-dihydro-1,6-naphthyridin-5(6
H
)-ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure–Activity Relationships
. Journal of Medicinal Chemistry 61:6, pages 2472-2489.
Crossref
Crossref
Manju Sharma, Corey Levenson, John C. Browning, Emily M. Becker, Ian Clements, Paul Castella & Michael E. Cox. (2018) East Indian Sandalwood Oil Is a Phosphodiesterase Inhibitor: A New Therapeutic Option in the Treatment of Inflammatory Skin Disease. Frontiers in Pharmacology 9.
Crossref
Crossref
Nahla E. El-Ashmawy, Naglaa F. Khedr, Hoda A. El-Bahrawy & Samar A. El-Adawy. (2018) Roflumilast, type 4 phosphodiesterase inhibitor, attenuates inflammation in rats with ulcerative colitis via down-regulation of iNOS and elevation of cAMP. International Immunopharmacology 56, pages 36-42.
Crossref
Crossref
Jiajia Chen, Hui Yu, Jiahong Zhong, Hongfang Feng, Haitao Wang, Yufang Cheng, Zhengqiang Zou, Chang Huang, Zhongzhen Zhou, Wenhua Zheng & Jiangping Xu. (2018) The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion. Brain Research Bulletin 137, pages 98-106.
Crossref
Crossref
Chantal Barberot, Aurélie Moniot, Ingrid Allart-Simon, Laurette Malleret, Tatiana Yegorova, Marie Laronze-Cochard, Abderrazzaq Bentaher, Maurice Médebielle, Jean-Philippe Bouillon, Eric Hénon, Janos Sapi, Frédéric Velard & Stéphane Gérard. (2018) Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents. European Journal of Medicinal Chemistry 146, pages 139-146.
Crossref
Crossref
Shipeng Gong, Yongning Chen, Fanliang Meng, Yadi Zhang, Huan Wu & Fei Wu. (2017) Roflumilast restores cAMP/PKA/CREB signaling axis for FtMt-mediated tumor inhibition of ovarian cancer. Oncotarget 8:68, pages 112341-112353.
Crossref
Crossref
Graeme Barker, Euan Parnell, Boy van Basten, Hanna Buist, David Adams & Stephen Yarwood. (2017) The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation. Journal of Cardiovascular Development and Disease 4:4, pages 22.
Crossref
Crossref
Tingting You, Yufang Cheng, Jiahong Zhong, Bingtian Bi, Bingqing Zeng, Wenhua Zheng, Haitao Wang & Jiangping Xu. (2017) Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells. ACS Chemical Neuroscience 8:11, pages 2381-2392.
Crossref
Crossref
Zhiyu Guan, Winxin Zhuang, Hui Lei, Dai Wang, Youliang Yao, Dongbei Guo, Qian Sun, Yun Chen, Xiaoyi Chen, Hongyan Lin, Bogang Teng & Yongxing Zhang. (2017) Epac1, PDE4, and PKC protein expression and their correlation with AKAP95 and Cx43 in esophagus cancer tissues. Thoracic Cancer 8:6, pages 572-576.
Crossref
Crossref
Meenakshi Tanwar, Lohit Khera, Nemneineng Haokip, Rajeev Kaul, Aruna Naorem & Suneel Kateriya. (2017) Modulation of cyclic nucleotide-mediated cellular signaling and gene expression using photoactivated adenylyl cyclase as an optogenetic tool. Scientific Reports 7:1.
Crossref
Crossref
Ping Huang, Qian Sun, Wenxin Zhuang, Kuan Peng, Dai Wang, Youliang Yao, Dongbei Guo, Lu Zhang, Chuhan Shen, Mengyun Sun, Chaoying Tang, Bogang Teng & Yongxing Zhang. (2017) Epac1, PDE4, and PKC protein expression and their association with AKAP95, Cx43, and cyclinD2/E1 in breast cancer tissues. Thoracic Cancer 8:5, pages 495-500.
Crossref
Crossref
Liu Chen, Danqi Chen, Le Tang, Jing Ren, Jiaojiao Chen, Xuechu Zhen, Yu-Chih Liu, Chenhua Zhang, Haibin Luo, Jingkang Shen & Bing Xiong. (2017) Design and optimization of purine derivatives as in vivo active PDE10A inhibitors. Bioorganic & Medicinal Chemistry 25:13, pages 3315-3329.
Crossref
Crossref
Amit Kumar & Nirmal Singh. (2017) Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer’s Type. Biomedicine & Pharmacotherapy 88, pages 698-707.
Crossref
Crossref
Zhong-Zhen Zhou, Yu-Fang Cheng, Zheng-Qiang Zou, Bing-Chen Ge, Hui Yu, Cang Huang, Hai-Tao Wang, Xue-Mei Yang & Jiang-Ping Xu. (2016)
Discovery of
N
-Alkyl Catecholamides as Selective Phosphodiesterase-4 Inhibitors with Anti-neuroinflammation Potential Exhibiting Antidepressant-like Effects at Non-emetic Doses
. ACS Chemical Neuroscience 8:1, pages 135-146.
Crossref
Crossref
Federico Carlos Blanco, Marcelo Abel Soria, Laura Inés Klepp & Fabiana Bigi. (2017) <b><i>ERAP1</i></b> and <b><i>PDE8A</i></b> Are Downregulated in Cattle Protected against Bovine Tuberculosis. Microbial Physiology 27:4, pages 237-245.
Crossref
Crossref
Jordi Gràcia, Maria Antonia Buil, Jordi Castro, Peter Eichhorn, Manel Ferrer, Amadeu Gavaldà, Begoña Hernández, Victor Segarra, Martin D. Lehner, Imma Moreno, Lluís Pagès, Richard S. Roberts, Jordi Serrat, Sara Sevilla, Joan Taltavull, Miriam Andrés, Judit Cabedo, Dolors Vilella, Elena Calama, Carla Carcasona & Montserrat Miralpeix. (2016) Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure–Activity Relationships. Journal of Medicinal Chemistry 59:23, pages 10479-10497.
Crossref
Crossref
Daniel Brie, Amirhossein Sahebkar, Peter E. Penson, Madalina Dinca, Sorin Ursoniu, Maria-Corina Serban, Alberto Zanchetti, George Howard, Ali Ahmed, Wilbert S. Aronow, Paul Muntner, Gregory Y.H. Lip, Nathan D. Wong, Jacek Rysz & Maciej Banach. (2016) Effects of pentoxifylline on inflammatory markers and blood pressure. Journal of Hypertension 34:12, pages 2318-2329.
Crossref
Crossref
Diana V Avila, David F Barker, JingWen Zhang, Craig J McClain, Shirish Barve & Leila Gobejishvili. (2016) Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis. The Journal of Pathology 240:1, pages 96-107.
Crossref
Crossref
Amanda G. Vang, Chaitali Basole, Hongli Dong, Rebecca K. Nguyen, William Housley, Linda Guernsey, Alexander J. Adami, Roger S. Thrall, Robert B. Clark, Paul M. Epstein & Stefan Brocke. (2016) Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation. Frontiers in Pharmacology 7.
Crossref
Crossref
Tim Vanmierlo, Pim Creemers, Sven Akkerman, Marlies van Duinen, Anke Sambeth, Jochen De Vry, Tolga Uz, Arjan Blokland & Jos Prickaerts. (2016) The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses. Behavioural Brain Research 303, pages 26-33.
Crossref
Crossref
Alejandro Best-Rocha, Kalyani Patel, John Hicks, Joseph L. Edmonds, Michael J. Paldino & Hao Wu. (2016) Novel Association of Odontogenic Myxoma with Constitutional Chromosomal 1q21 Microduplication: Case Report and Review of the Literature. Pediatric and Developmental Pathology 19:2, pages 139-145.
Crossref
Crossref
Nicole M. Wilson, David J. Titus, Anthony A. Oliva, Concepcion Furones & Coleen M. Atkins. (2016) Traumatic Brain Injury Upregulates Phosphodiesterase Expression in the Hippocampus. Frontiers in Systems Neuroscience 10.
Crossref
Crossref
Michael D. Deel, Jenny J. Li, Lisa E. S. Crose & Corinne M. Linardic. (2015) A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft-Tissue Sarcomas. Frontiers in Oncology 5.
Crossref
Crossref
Piotr Minkiewicz, Małgorzata Darewicz, Anna Iwaniak, Jolanta Sokołowska, Piotr Starowicz, Justyna Bucholska & Monika Hrynkiewicz. (2015) Common Amino Acid Subsequences in a Universal Proteome—Relevance for Food Science. International Journal of Molecular Sciences 16:9, pages 20748-20773.
Crossref
Crossref
L Mestre, M Redondo, F J Carrillo-Salinas, J A Morales-García, S Alonso-Gil, A Pérez-Castillo, C Gil, A Martínez & C Guaza. (2015) PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis. British Journal of Pharmacology 172:17, pages 4277-4290.
Crossref
Crossref
Sharma A, Goyal A & Garabadu D. (2019) Phosphodiesterase Inhibitors: A Therapeutic Augmentation for Treatment of Cognitive Impairment. SSRN Electronic Journal.
Crossref
Crossref