Advanced search
Publication Cover
Expert Opinion on Therapeutic Patents Volume 24, 2014 - Issue 12
Submit an article Journal homepage
771
Views
32
CrossRef citations to date
0
Altmetric
Reviews

NMDA receptor modulators: an updated patent review (2013 – 2014)

Katie L StrongEmory University, Department of Chemistry, 1521 Dickey Drive, Atlanta, GA 30322, [email protected]
,
Yao JingEmory University, Department of Chemistry, 1521 Dickey Drive, Atlanta, GA 30322, [email protected]
,
Anthony R ProsserEmory University, Department of Chemistry, 1521 Dickey Drive, Atlanta, GA 30322, [email protected]
,
Stephen F TraynelisEmory University School of Medicine, Department of Pharmacology, 1510 Clifton Road, Atlanta, GA 30322, USA
&
Dennis C LiottaEmory University, Department of Chemistry, 1521 Dickey Drive, Atlanta, GA 30322, [email protected]
Pages 1349-1366 | Published online: 29 Oct 2014

Citations (32)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Hazem Ahmed, Ahmed Haider & Simon M. Ametamey. (2020) N-Methyl-D-Aspartate (NMDA) receptor modulators: a patent review (2015-present). Expert Opinion on Therapeutic Patents 30:10, pages 743-767.
Read now

Articles from other publishers (31)

Jesse E. Hanson, Hongjie Yuan, Riley E. Perszyk, Tue G. Banke, Hao Xing, Ming-Chi Tsai, Frank S. Menniti & Stephen F. Traynelis. (2023) Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry. Neuropsychopharmacology 49:1, pages 51-66.
Crossref
Vinod Ugale, Rutuja Deshmukh, Deepak Lokwani, P. Narayana Reddy, Saurabh Khadse, Prashant Chaudhari & Prasad P. Kulkarni. (2023) GluN2B subunit selective N-methyl-D-aspartate receptor ligands: Democratizing recent progress to assist the development of novel neurotherapeutics. Molecular Diversity.
Crossref
Steven J. Clapcote. (2022) How can we obtain truly translational mouse models to improve clinical outcomes in schizophrenia?. Disease Models & Mechanisms 15:11.
Crossref
Matthew D. Hill, Maria-Jesus Blanco, Francesco G. Salituro, Zhu Bai, Jacob T. Beckley, Michael A. Ackley, Jing Dai, James J. Doherty, Boyd L. Harrison, Ethan C. Hoffmann, Tatiana M. Kazdoba, David Lanzetta, Michael Lewis, Michael C. Quirk & Albert J. Robichaud. (2022) SAGE-718: A First-in-Class N -Methyl- d -Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment . Journal of Medicinal Chemistry 65:13, pages 9063-9075.
Crossref
Vinod Ugale, Ashish Dhote, Rushikesh Narwade, Saurabh Khadse, P. Narayana Reddy & Atul Shirkhedkar. (2021) GluN2B/N-methyl-D-aspartate Receptor Antagonists: Advances in Design, Synthesis, and Pharmacological Evaluation Studies. CNS & Neurological Disorders - Drug Targets 20:9, pages 822-862.
Crossref
Kasper B. Hansen, Lonnie P. Wollmuth, Derek Bowie, Hiro Furukawa, Frank S. Menniti, Alexander I. Sobolevsky, Geoffrey T. Swanson, Sharon A. Swanger, Ingo H. Greger, Terunaga Nakagawa, Chris J. McBain, Vasanthi Jayaraman, Chian-Ming Low, Mark L. Dell’Acqua, Jeffrey S. Diamond, Chad R. Camp, Riley E. Perszyk, Hongjie Yuan & Stephen F. Traynelis. (2022) Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels. Pharmacological Reviews 73:4, pages 1469-1658.
Crossref
Martina Kaniakova, Jan Korabecny, Kristina Holubova, Lenka Kleteckova, Marketa Chvojkova, Kristina Hakenova, Lukas Prchal, Martin Novak, Rafael Dolezal, Vendula Hepnarova, Barbora Svobodova, Tomas Kucera, Katarina Lichnerova, Barbora Krausova, Martin Horak, Karel Vales & Ondrej Soukup. (2021) 7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo. Biochemical Pharmacology 186, pages 114460.
Crossref
Martin Horak, Petra Barackova, Emily Langore, Jakub Netolicky, Paula Rivas-Ramirez & Kristyna Rehakova. (2021) The Extracellular Domains of GluN Subunits Play an Essential Role in Processing NMDA Receptors in the ER. Frontiers in Neuroscience 15.
Crossref
Katie L. Strong, Matthew P. Epplin, Kevin K. Ogden, Pieter B. Burger, Thomas M. Kaiser, Timothy J. Wilding, Hiro Kusumoto, Chad R. Camp, Gil Shaulsky, Subhrajit Bhattacharya, Riley E. Perszyk, David S. Menaldino, Miranda J. McDaniel, Jing Zhang, Phuong Le, Tue G. Banke, Kasper B. Hansen, James E. Huettner, Dennis C. Liotta & Stephen F. Traynelis. (2020) Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N -Methyl- d -aspartate Receptors . ACS Chemical Neuroscience 12:1, pages 79-98.
Crossref
Riley E. Perszyk, Scott J. Myers, Hongjie Yuan, Alasdair J. Gibb, Hiro Furukawa, Alexander I. Sobolevsky & Stephen F. Traynelis. (2020) Hodgkin–Huxley–Katz Prize Lecture: Genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif. The Journal of Physiology 598:15, pages 3071-3083.
Crossref
Matthew P. Epplin, Ayush Mohan, Lynnea D. Harris, Zongjian Zhu, Katie L. Strong, John Bacsa, Phuong Le, David S. Menaldino, Stephen F. Traynelis & Dennis C. Liotta. (2020) Discovery of Dihydropyrrolo[1,2- a ]pyrazin-3(4 H )-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N -Methyl- d -Aspartate (NMDA) Receptor . Journal of Medicinal Chemistry 63:14, pages 7569-7600.
Crossref
Fang Gu, Yanyan Wu, Ying Liu, Mei Dou, Yushan Jiang & Hui Liang. (2020) Lactobacillus casei improves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota . Food & Function 11:7, pages 6148-6157.
Crossref
Daniel S. La, Francesco G. Salituro, Gabriel Martinez Botella, Andrew M. Griffin, Zhu Bai, Michael A. Ackley, Jing Dai, James J. Doherty, Boyd L. Harrison, Ethan C. Hoffmann, Tatiana M. Kazdoba, Michael C. Lewis, Michael C. Quirk & Albert J. Robichaud. (2019) Neuroactive Steroid N -Methyl- d -aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity . Journal of Medicinal Chemistry 62:16, pages 7526-7542.
Crossref
Denise Kreutzwiser & Qutaiba A. Tawfic. (2019) Expanding Role of NMDA Receptor Antagonists in the Management of Pain. CNS Drugs 33:4, pages 347-374.
Crossref
Mariangela Chisari, Timothy J. Wilding, Samuel Brunwasser, Kathiresan Krishnan, Mingxing Qian, Ann Benz, James E. Huettner, Charles F. Zorumski, Douglas F. Covey & Steven Mennerick. (2019) Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization. Neuropharmacology 144, pages 91-103.
Crossref
Tonghui Su, Yi Lu, Yang Geng, Wei Lu & Yelin Chen. (2019) How could N-Methyl-D-Aspartate Receptor Antagonists Lead to Excitation Instead of Inhibition?. Brain Science Advances 4:2, pages 73-98.
Crossref
Martina Kaniakova, Lenka Kleteckova, Katarina Lichnerova, Kristina Holubova, Kristyna Skrenkova, Miloslav Korinek, Jan Krusek, Tereza Smejkalova, Jan Korabecny, Karel Vales, Ondrej Soukup & Martin Horak. (2018) 7-Methoxyderivative of tacrine is a ‘foot-in-the-door’ open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo. Neuropharmacology 140, pages 217-232.
Crossref
Kasper B. Hansen, Feng Yi, Riley E. Perszyk, Hiro Furukawa, Lonnie P. Wollmuth, Alasdair J. Gibb & Stephen F. Traynelis. (2018) Structure, function, and allosteric modulation of NMDA receptors. Journal of General Physiology 150:8, pages 1081-1105.
Crossref
Riley Perszyk, Brooke M Katzman, Hirofumi Kusumoto, Steven A Kell, Matthew P Epplin, Yesim A Tahirovic, Rhonda L Moore, David Menaldino, Pieter Burger, Dennis C Liotta & Stephen F Traynelis. (2018) An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups. eLife 7.
Crossref
Thomas M. Kaiser, Steven A. Kell, Hirofumi Kusumoto, Gil Shaulsky, Subhrajit Bhattacharya, Matthew P. Epplin, Katie L. Strong, Eric J. Miller, Bryan D. Cox, David S. Menaldino, Dennis C. Liotta, Stephen F. Traynelis & Pieter B. Burger. (2018) The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor. Molecular Pharmacology 93:2, pages 141-156.
Crossref
Maria-Jesus Blanco, Daniel La, Quinn Coughlin, Caitlin A. Newman, Andrew M. Griffin, Boyd L. Harrison & Francesco G. Salituro. (2018) Breakthroughs in neuroactive steroid drug discovery. Bioorganic & Medicinal Chemistry Letters 28:2, pages 61-70.
Crossref
Genevieve E. LindTung-Chung MouLucia TamboriniMartin G. PomperCarlo De MicheliPaola ContiAndrea Pinto & Kasper B. Hansen. (2017) Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits. Proceedings of the National Academy of Sciences 114:33.
Crossref
Maja Jessen, Kristen Frederiksen, Feng Yi, Rasmus P. Clausen, Kasper B. Hansen, Hans Bräuner-Osborne, Paul Kilburn & Anders Damholt. (2017) Identification of AICP as a GluN2C-Selective N -Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site . Molecular Pharmacology 92:2, pages 151-161.
Crossref
Katie L. Strong, Matthew P. Epplin, John Bacsa, Christopher J. Butch, Pieter B. Burger, David S. Menaldino, Stephen F. Traynelis & Dennis C. Liotta. (2017) The Structure–Activity Relationship of a Tetrahydroisoquinoline Class of N -Methyl- d -Aspartate Receptor Modulators that Potentiates GluN2B-Containing N -Methyl- d -Aspartate Receptors . Journal of Medicinal Chemistry 60:13, pages 5556-5585.
Crossref
Ainhoa Oñatibia-Astibia, Rafael Franco & Eva Martínez-Pinilla. (2017) Health benefits of methylxanthines in neurodegenerative diseases. Molecular Nutrition & Food Research 61:6, pages 1600670.
Crossref
Margarida Espadinha, Jorge Dourado, Rocio Lajarin-Cuesta, Clara Herrera-Arozamena, Lidia M. D. Gonçalves, María Isabel Rodríguez-Franco, Cristobal de los Rios & Maria M. M. Santos. (2017) Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists. ChemMedChem 12:7, pages 537-545.
Crossref
Miao Zhong, Catherine Shoemake, Amber Fuller, David White, Chris Hanks, Derek Brocksmith, Jason Liu, Shayne Gad, Guy Bouchard & Alain Stricker-Krongrad. (2017) Development of a Functional Observational Battery in the Minipig for Regulatory Neurotoxicity Assessments. International Journal of Toxicology 36:2, pages 113-123.
Crossref
Max K. Leong, Ren-Guei Syu, Yi-Lung Ding & Ching-Feng Weng. (2017) Prediction of N-Methyl-D-Aspartate Receptor GluN1-Ligand Binding Affinity by a Novel SVM-Pose/SVM-Score Combinatorial Ensemble Docking Scheme. Scientific Reports 7:1.
Crossref
Kasper B. Hansen, Feng Yi, Riley E. Perszyk, Frank S. Menniti & Stephen F. Traynelis. 2017. NMDA Receptors. NMDA Receptors 1 80 .
Zixiu Xiang & P. Jeffrey Conn. (2016) Novel PAMs Targeting NMDAR GluN2A Subunit. Neuron 89:5, pages 884-886.
Crossref
Philip C. Biggin, Matteo Aldeghi, Michael J. Bodkin & Alexander Heifetz. 2016. The Next Generation in Membrane Protein Structure Determination. The Next Generation in Membrane Protein Structure Determination 161 181 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.