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Triggering receptor expressed on myeloid cells receptor family modulators: a patent review

, & , PhD (Biochem) PhD (Med Sci) MBA FAAAAI FAHA FAPS

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Read on this site (5)

Qing Li, Yujing Zhao, Hongyan Guo, Qiao Li, Chaoying Yan, Yansong Li, Shuxuan He, Nan Wang & Qiang Wang. (2023) Impaired lipophagy induced-microglial lipid droplets accumulation contributes to the buildup of TREM1 in diabetes-associated cognitive impairment. Autophagy 19:10, pages 2639-2656.
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L Bernal-Martínez, SM Gonçalves, B de Andres, C Cunha, I Gonzalez Jimenez, K Lagrou, E Mellado, ML Gaspar, JA Maertens, A Carvalho & L Alcazar-Fuoli. (2021) TREM1 regulates antifungal immune responses in invasive pulmonary aspergillosis. Virulence 12:1, pages 570-583.
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Harbinder Singh, Vikrant Rai, Sunil K. Nooti & Devendra K. Agrawal. (2021) Novel ligands and modulators of triggering receptor expressed on myeloid cells receptor family: 2015-2020 updates. Expert Opinion on Therapeutic Patents 31:6, pages 549-561.
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Courtney P. Rudick, Takanari Miyamoto, Melissa S. Lang & Devendra K. Agrawal. (2017) Triggering receptor expressed on myeloid cells in the pathogenesis of periodontitis: potential novel treatment strategies. Expert Review of Clinical Immunology 13:12, pages 1189-1197.
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Austin Huy Nguyen, Ilya G Berim & Devendra K Agrawal. (2015) Chronic inflammation and cancer: emerging roles of triggering receptors expressed on myeloid cells. Expert Review of Clinical Immunology 11:7, pages 849-857.
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Articles from other publishers (39)

Chenran Yue, Wenqian Wang, Sheng Gao, Jianzhong Ye, Ting Zhang, Zhouhang Xing, Yuanyuan Xie, Hengrong Qian, Xueyin Zhou, Shuting Li, Anni Yu, Liangxing Wang, Jianguang Wang & Chunyan Hua. (2023) Agomir miRNA-150-5p alleviates pristane-induced lupus by suppressing myeloid dendritic cells activation and inflammation via TREM-1 axis. Inflammation Research 72:7, pages 1391-1408.
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Federica Raggi, Martina Bartolucci, Davide Cangelosi, Chiara Rossi, Simone Pelassa, Chiara Trincianti, Andrea Petretto, Giovanni Filocamo, Adele Civino, Alessandra Eva, Angelo Ravelli, Alessandro Consolaro & Maria Carla Bosco. (2023) Proteomic profiling of extracellular vesicles in synovial fluid and plasma from Oligoarticular Juvenile Idiopathic Arthritis patients reveals novel immunopathogenic biomarkers. Frontiers in Immunology 14.
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Carlijn G.E. Thijssen, Silvy Dekker, Lidia R. Bons, Laurie W. Geenen, Arjen L. Gökalp, Johanna J.M. Takkenberg, Mostafa M. Mokhles, Jos A. Bekkers, Eric Boersma, Elke Bouwens, Roland R.J. van Kimmenade & Jolien W. Roos-Hesselink. (2023) Novel biomarkers associated with thoracic aortic disease. International Journal of Cardiology.
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M.V. Khutornaya, A.V. Sinitskaya, M.Yu. Sinitsky, M.A. Asanov, A.V. Ponasenko & E.V. Grigoryev. (2023) Soluble triggering receptor (sTREM-1) in pathogenesis of multiple organ failure after cardiac surgery. Anesteziologiya i reanimatologiya:1, pages 26.
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Anastasios Panagopoulos, Saurabhi Samant, Jules Joel Bakhos, Martin Liu, Behram Khan, Janaki Makadia, Fayaz Muhammad, Forrest M. Kievit, Devendra K. Agrawal & Yiannis S. Chatzizisis. (2022) Triggering receptor expressed on myeloid cells-1 (TREM-1) inhibition in atherosclerosis. Pharmacology & Therapeutics 238, pages 108182.
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Guillermo M. Alexander, Terry D. Heiman-Patterson, Frank Bearoff, Roger B. Sher, Laura Hennessy, Shannon Terek, Nicole Caccavo, Gregory A. Cox, Vivek M. Philip & Elizabeth A. Blankenhorn. (2022) Identification of quantitative trait loci for survival in the mutant dynactin p150Glued mouse model of motor neuron disease. PLOS ONE 17:9, pages e0274615.
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Tatiana N. Sharapova, Olga K. Ivanova, Elena A. Romanova, Lidia P. Sashchenko & Denis V. Yashin. (2022) N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor. International Journal of Molecular Sciences 23:10, pages 5752.
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Habib ZoualiJuliette LemassonAndreea Calugareanu, Christophe Battail, David Michonneau, Hélène le Buanec, Chloé GrolleauCharles Cassius, Marie Robin, Marine Merandet, Gabor DobosThibault MahevasMichel RybojadAdèle de Masson, Reyhan AmodeAnne Boland, Laurence Michel, Flore Sicre de Fontbrune, Régis Peffault de LatourPatrick Bruneval, Hafid Ait-Oufella, Maxime Battistella, Marie JachietMartine BagotJean-François DeleuzeGérard SociéJean-David Bouaziz. (2022) RNA sequencing of chronic GVHD skin lesions defines shared and unique inflammatory pathways characterizing lichen planus and morphea. Blood Advances 6:9, pages 2805-2811.
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D. Wu, Y. Weng, Y. Feng, B. Liang, H. Wang, L. Li & Z. Wang. (2021) Trem1 Induces Periodontal Inflammation via Regulating M1 Polarization. Journal of Dental Research 101:4, pages 437-447.
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Finosh G. Thankam, David J. Sanchez & Devendra K. Agrawal. (2022) Design of the lentivirus-driven sustained LR12 delivery system for TREM-1 inhibition for palliating atherosclerosis. Molecular and Cellular Biochemistry 477:3, pages 701-710.
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Ashok K. Pullikuth, Eric D. Routh, Kip D. Zimmerman, Julia Chifman, Jeff W. Chou, Michael H. Soike, Guangxu Jin, Jing Su, Qianqian Song, Michael A. Black, Cristin Print, Davide Bedognetti, Marissa Howard-McNatt, Stacey S. O’Neill, Alexandra Thomas, Carl D. Langefeld, Alexander B. Sigalov, Yong Lu & Lance D. Miller. (2021) Bulk and Single-Cell Profiling of Breast Tumors Identifies TREM-1 as a Dominant Immune Suppressive Marker Associated With Poor Outcomes. Frontiers in Oncology 11.
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George Chalikias & Dimitrios N. Tziakas. (2021) Triggering receptor expressing on myeloid cells (TREM)-1 and acute myocardial infarction: An association vs. causality conundrum. International Journal of Cardiology.
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Hui Qiu, Zhiying Shao, Xin Wen, Jinghua Jiang, Qinggong Ma, Yan Wang, Long Huang, Xin Ding & Longzhen Zhang. (2021) TREM2: Keeping Pace With Immune Checkpoint Inhibitors in Cancer Immunotherapy. Frontiers in Immunology 12.
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Qin Lu, Rui LiuPrativa SherchanReng Ren, Wei HeYuanjian Fang, Yi Huang, Hui ShiLihui Tang, Shuxu Yang, John H. Zhang & Jiping Tang. (2021) TREM (Triggering Receptor Expressed on Myeloid Cells)-1 Inhibition Attenuates Neuroinflammation via PKC (Protein Kinase C) δ/CARD9 (Caspase Recruitment Domain Family Member 9) Signaling Pathway After Intracerebral Hemorrhage in Mice. Stroke 52:6, pages 2162-2173.
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Amber M. Paul, Eliah G. Overbey, Willian A. da Silveira, Nathaniel Szewczyk, Nina C. Nishiyama, Michael J. Pecaut, Sulekha Anand, Jonathan M. Galazka & Xiao Wen Mao. (2021) Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity. Scientific Reports 11:1.
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Dong Hyuk Seo, Xiumei Che, Soochan Kim, Da Hye Kim, Hyun Woo Ma, Jae Hyeon Kim, Tae Il Kim, Won Ho Kim, Seung Won Kim & Jae Hee Cheon. (2021) Triggering Receptor Expressed on Myeloid Cells-1 Agonist Regulates Intestinal Inflammation via Cd177+ Neutrophils. Frontiers in Immunology 12.
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Jyun-Bin Huang, Nai-Ching Chen, Chien-Liang Chen, Mu-Hui Fu, Hsiu-Yung Pan, Chung-Yao Hsu, Shang-Der Chen & Yao-Chung Chuang. (2020) Serum Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 Associated with the Severity and Outcome of Acute Ischemic Stroke. Journal of Clinical Medicine 10:1, pages 61.
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Naomi-Liza Denning, Monowar Aziz, Li Diao, Jose M. Prince & Ping Wang. (2020) Targeting the eCIRP/TREM-1 interaction with a small molecule inhibitor improves cardiac dysfunction in neonatal sepsis. Molecular Medicine 26:1.
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Daniel O’Connor, Marta Valente Pinto, Dylan Sheerin, Adriana Tomic, Ruth E Drury, Samuel Channon‐Wells, Ushma Galal, Christina Dold, Hannah Robinson, Simon Kerridge, Emma Plested, Harri Hughes, Lisa Stockdale, Manish Sadarangani, Matthew D Snape, Christine S Rollier, Michael Levin & Andrew J Pollard. (2020) Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine. Molecular Systems Biology 16:11.
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Tram T. T. Nguyen, Hee Kyeong Yoon, Yoon Tae Kim, Yun Hui Choi, Won-Kyu Lee & Mirim Jin. (2020) Tryptophanyl-tRNA Synthetase 1 Signals Activate TREM-1 via TLR2 and TLR4. Biomolecules 10:9, pages 1283.
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Naomi-Liza Denning, Monowar Aziz, Mahendar Ochani, Jose M. Prince & Ping Wang. (2020) Inhibition of a triggering receptor expressed on myeloid cells-1 (TREM-1) with an extracellular cold-inducible RNA-binding protein (eCIRP)-derived peptide protects mice from intestinal ischemia-reperfusion injury. Surgery 168:3, pages 478-485.
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Si-Yu Wang, Peng-Yu Gong, Yan E, Ying-Dong Zhang & Teng Jiang. (2020) The Role of TREML2 in Alzheimer’s Disease. Journal of Alzheimer's Disease 76:3, pages 799-806.
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Federica Raggi & Maria Bosco. (2020) Targeting Mononuclear Phagocyte Receptors in Cancer Immunotherapy: New Perspectives of the Triggering Receptor Expressed on Myeloid Cells (TREM-1). Cancers 12:5, pages 1337.
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Grant R. Campbell, Rachel K. To & Stephen A. Spector. (2019) TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function. mBio 10:6.
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Yonatan Edel, Vitaly Kliminski, Elisheva Pokroy-Shapira, Shirly Oren, Ariela Dortort Lazar, Yael Pri-Paz Basson, Mohammad Egbaria & Yair Molad. (2019) Elevated plasma level of soluble triggering receptor expressed on myeloid cells-1 is associated with inflammation activity and is a potential biomarker of thrombosis in primary antiphospholipid syndrome. Arthritis Research & Therapy 21:1.
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Nagihan Bostanci, Toshiharu Abe, Georgios N. Belibasakis & George Hajishengallis. (2019) TREM-1 Is Upregulated in Experimental Periodontitis, and Its Blockade Inhibits IL-17A and RANKL Expression and Suppresses Bone loss. Journal of Clinical Medicine 8:10, pages 1579.
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Daniel K. Faria, Caroline S. Faria, Dimitria Doi, Milena M.P. Acencio & Leila Antonangelo. (2019) Hybrid panel of biomarkers can be useful in the diagnosis of pleural and peritoneal effusions. Clinica Chimica Acta 497, pages 48-53.
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Chien-Wei Feng, Nan-Fu Chen, Chun-Sung Sung, Hsiao-Mei Kuo, San-Nan Yang, Chien-Liang Chen, Han-Chun Hung, Bing-Hung Chen, Zhi-Hong Wen & Wu-Fu Chen. (2019) Therapeutic Effect of Modulating TREM-1 via Anti-inflammation and Autophagy in Parkinson’s Disease. Frontiers in Neuroscience 13.
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Sheng Gao, Yongdong Yi, Guojun Xia, Chengyang Yu, Chenmin Ye, Fuyang Tu, Leibin Shen, Wenqian Wang & Chunyan Hua. (2019) The characteristics and pivotal roles of triggering receptor expressed on myeloid cells-1 in autoimmune diseases. Autoimmunity Reviews 18:1, pages 25-35.
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Monika Jedynak, Andrzej Siemiatkowski, Barbara Mroczko, Magdalena Groblewska, Robert Milewski & Maciej Szmitkowski. (2017) Soluble TREM-1 Serum Level can Early Predict Mortality of Patients with Sepsis, Severe Sepsis and Septic Shock. Archivum Immunologiae et Therapiae Experimentalis 66:4, pages 299-306.
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Marie Dubar, Kevin Carrasco, Sebastien Gibot & Catherine Bisson. (2018) Effects of Porphyromonas gingivalis LPS and LR12 peptide on TREM-1 expression by monocytes . Journal of Clinical Periodontology 45:7, pages 799-805.
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Fang Wang, Chang Li, Feng Hua Ding, Ying Shen, Jie Gao, Zhu Hui Liu, Jia Wei Chen, Rui Yan Zhang, Wei Feng Shen, Xiao Qun Wang & Lin Lu. (2017) Increased serum TREM-1 level is associated with in-stent restenosis, and activation of TREM-1 promotes inflammation, proliferation and migration in vascular smooth muscle cells. Atherosclerosis 267, pages 10-18.
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Zhihong Yuan, Xian Fan, Bashar Staitieh, Chetna Bedi, Paul Spearman, David M Guidot & Ruxana T Sadikot. (2017) HIV-related proteins prolong macrophage survival through induction of Triggering receptor expressed on myeloid cells-1. Scientific Reports 7:1.
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Tian Liu, Yong Zhou, Ping Li, Jia-Xi Duan, Yong-Ping Liu, Guo-Ying Sun, Li Wan, Liang Dong, Xiang Fang, Jian-Xin Jiang & Cha-Xiang Guan. (2016) Blocking triggering receptor expressed on myeloid cells-1 attenuates lipopolysaccharide-induced acute lung injury via inhibiting NLRP3 inflammasome activation. Scientific Reports 6:1.
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Huaili Jiang, Yu Si, Zhuohao Li, Xi Huang, Suijun Chen, Yiqing Zheng, Guo Xu, Ximing Chen, Yubin Chen, Yi Liu, Hao Xiong, Qiuhong Huang, Maojin Liang & Zhigang Zhang. (2016) TREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 signaling pathway and osteoclasts activation. Scientific Reports 6:1.
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Jia Cheng, XiaoFeng Guo, Tian Zhang, Li Zhong, GuoJun Bu & XiaoFen Chen. (2016) TREMs in Alzheimer's disease: Genetic and clinical investigations. Clinica Chimica Acta 463, pages 88-95.
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Finosh G. Thankam, Matthew F. Dilisio, Nicholas E. Dietz & Devendra K. Agrawal. (2016) TREM-1, HMGB1 and RAGE in the Shoulder Tendon: Dual Mechanisms for Inflammation Based on the Coincidence of Glenohumeral Arthritis. PLOS ONE 11:10, pages e0165492.
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Daniele Pierobon, Federica Raggi, Irene Cambieri, Simone Pelassa, Sergio Occhipinti, Paola Cappello, Francesco Novelli, Tiziana Musso, Alessandra Eva, Carlotta Castagnoli, Luigi Varesio, Mirella Giovarelli & Maria Carla Bosco. (2016) Regulation of Langerhans cell functions in a hypoxic environment. Journal of Molecular Medicine 94:8, pages 943-955.
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Austin Huy Nguyen, Carleigh Koenck, Shannon K. Quirk, Victoria M. Lim, Mario V. Mitkov, Ryan M. Trowbridge, William J. HunterIIIIII & Devendra K. Agrawal. (2015) Triggering Receptor Expressed on Myeloid Cells in Cutaneous Melanoma. Clinical and Translational Science 8:5, pages 441-444.
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