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Orexin receptor antagonists – a patent review (2010 to August 2014)

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Christoph Boss & Catherine Roch. (2017) Orexin research: patent news from 2016. Expert Opinion on Therapeutic Patents 27:10, pages 1123-1133.
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Elena Urrestarazu & Jorge Iriarte. (2016) Clinical management of sleep disturbances in Alzheimer’s disease: current and emerging strategies. Nature and Science of Sleep 8, pages 21-33.
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Dariusz R Wozniak & Timothy G Quinnell. (2015) Unmet needs of patients with narcolepsy: perspectives on emerging treatment options. Nature and Science of Sleep 7, pages 51-61.
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Yoshikazu Uto. (2015) 1,2-Benzisoxazole compounds: a patent review (2009 – 2014). Expert Opinion on Therapeutic Patents 25:6, pages 643-662.
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Articles from other publishers (11)

Tsuyoshi Saitoh & Takeshi Sakurai. (2023) The present and future of synthetic orexin receptor agonists. Peptides 167, pages 171051.
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Idris A. Azeez, Olumayowa O. Igado & James O. Olopade. (2021) An overview of the orexinergic system in different animal species. Metabolic Brain Disease 36:7, pages 1419-1444.
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Manqing Su, Meixing Yan, Jiatong Yao, Yanpeng Fang, Hong Jin & Yanling Gong. (2020) Unacylated Ghrelin Regulates Glucose-Sensitive Neurons Activity and Glycolipid Metabolism via Orexin-A Neurons in the Lateral Hypothalamic Area. Hormone and Metabolic Research 52:10, pages 747-754.
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Peng Wang, Meng Wang, Liping Zhang, Shenjie Zhong, Wanyue Jiang, Ziyue Wang, Chen Sun, Shicui Zhang & Zhenhui Liu. (2019) Functional characterization of an orexin neuropeptide in amphioxus reveals an ancient origin of orexin/orexin receptor system in chordate. Science China Life Sciences 62:12, pages 1655-1669.
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Feifei Guo, Shengli Gao, Luo Xu, Xiangrong Sun, Nana Zhang, Yanling Gong & Xiao Luan. (2018) Arcuate Nucleus Orexin-A Signaling Alleviates Cisplatin-Induced Nausea and Vomiting Through the Paraventricular Nucleus of the Hypothalamus in Rats. Frontiers in Physiology 9.
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Anil Kumar, Priyanka Chanana & Supriti Choudhary. (2016) Emerging role of orexin antagonists in insomnia therapeutics: An update on SORAs and DORAs. Pharmacological Reports 68:2, pages 231-242.
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Nadia M. Ahmad. 2015. Innovative Drug Synthesis. Innovative Drug Synthesis 223 242 .
Christoph Boss & Catherine Roch. (2015) Recent trends in orexin research?2010 to 2015. Bioorganic & Medicinal Chemistry Letters 25:15, pages 2875-2887.
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Yu Yoshida, Yoshimitsu Naoe, Taro Terauchi, Fumihiro Ozaki, Takashi Doko, Ayumi Takemura, Toshiaki Tanaka, Keiichi Sorimachi, Carsten T. Beuckmann, Michiyuki Suzuki, Takashi Ueno, Shunsuke Ozaki & Masahiro Yonaga. (2015) Discovery of (1 R ,2 S )-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)- N -(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist . Journal of Medicinal Chemistry 58:11, pages 4648-4664.
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John A. ChristopherSarah J. AvesJason BrownJames C. ErreySuki S. KlairChristopher J. Langmead, Oliver J. MaceRichard MouldJayesh C. PatelBenjamin G. TehanAndrei ZhukovFiona H. MarshallMiles Congreve. (2015) Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties. MedChemComm 6:5, pages 947-955.
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Thierry Sifferlen, Amandine Boller, Audrey Chardonneau, Emmanuelle Cottreel, John Gatfield, Alexander Treiber, Catherine Roch, Francois Jenck, Hamed Aissaoui, Jodi T. Williams, Christine Brotschi, Bibia Heidmann, Romain Siegrist & Christoph Boss. (2015) Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2. Bioorganic & Medicinal Chemistry Letters 25:9, pages 1884-1891.
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