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Expert Opinion on Therapeutic Patents Volume 25, 2015 - Issue 5
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Review

PDK1 disruptors and modulators: a patent review

Muhammad Jahangir HossenSungkyunkwan University, Department of Genetic Engineering, 300 Chuncheon-Dong, Suwon 440-746, Korea+82 31 290 7868; +82 31 290 7870; [email protected];Patuakhali Science and Technology University, Department of Animal Science, Patuakhali 88-8602, Bangladesh
,
Seung Cheol KimEwha Womans University, Ewha Womans University Mokdong Hospital College of Medicine, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Seoul 158-710, Republic of Korea
,
Sungjae YangSungkyunkwan University, Department of Genetic Engineering, 300 Chuncheon-Dong, Suwon 440-746, Korea+82 31 290 7868; +82 31 290 7870; [email protected]
,
Han Gyung KimSungkyunkwan University, Department of Genetic Engineering, 300 Chuncheon-Dong, Suwon 440-746, Korea+82 31 290 7868; +82 31 290 7870; [email protected]
,
Deok JeongSungkyunkwan University, Department of Genetic Engineering, 300 Chuncheon-Dong, Suwon 440-746, Korea+82 31 290 7868; +82 31 290 7870; [email protected]
,
Young-Su YiSungkyunkwan University, Department of Genetic Engineering, 300 Chuncheon-Dong, Suwon 440-746, Korea+82 31 290 7868; +82 31 290 7870; [email protected]
,
Nak Yoon SungSungkyunkwan University, Department of Genetic Engineering, 300 Chuncheon-Dong, Suwon 440-746, Korea+82 31 290 7868; +82 31 290 7870; [email protected]
,
Jeong-Oog LeeKonkuk University, Department of Aerospace Information Engineering, Bio-inspired Aerospace Information Laboratory, Seoul 143-701, Republic of Korea
,
Jong-Hoon KimBiosafety Research Institute, Chonbuk National University, College of Veterinary Medicine, Department of Veterinary Physiology, Jeonju 561-756, Korea+82 63 270 2563; +82 63 270 3780; [email protected]
, PhD &
Jae Youl ChoSungkyunkwan University, Department of Genetic Engineering, 300 Chuncheon-Dong, Suwon 440-746, Korea+82 31 290 7868; +82 31 290 7870; [email protected]
, PhD show all
Pages 513-537 | Published online: 15 Feb 2015

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Simona Sestito & Simona Rapposelli. (2019) A patent update on PDK1 inhibitors (2015-present). Expert Opinion on Therapeutic Patents 29:4, pages 271-282.
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Articles from other publishers (14)

Mohadese Piri, Shabnam Hooshmand, Nicole R. Sciotti & Tahereh Naeimi. (2023) Investigating the Common Pharmacophoric Points of PDK1 Inhibitors as Anti-Cancer Agents Using an Alignment Independent 3D-QSAR, Molecular Docking and Molecular Dynamic Simulation. Journal of Molecular Structure, pages 136968.
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Garth Powis, Emmanuelle J. Meuillet, Martin Indarte, Garrett Booher & Lynn Kirkpatrick. (2023) Pleckstrin Homology [PH] domain, structure, mechanism, and contribution to human disease. Biomedicine & Pharmacotherapy 165, pages 115024.
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Ismail M. Meraz, Mourad Majidi, Bingliang Fang, Feng Meng, Lihui Gao, RuPing Shao, Renduo Song, Feng Li, Yonathan Lissanu, Huiqin Chen, Min Jin Ha, Qi Wang, Jing Wang, Elizabeth Shpall, Sung Yun Jung, Franziska Haderk, Philippe Gui, Jonathan Wesley Riess, Victor Olivas, Trever G. Bivona & Jack A. Roth. (2023) 3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib. Communications Biology 6:1.
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Aftab Amin, Muhammad Jahangir Hossen, Xiu-Qiong Fu, Ji-Yao Chou, Jia-Ying Wu, Xiao-Qi Wang, Ying-Jie Chen, Ying Wu, Cheng-Le Yin, Xiao-Bing Dou, Chun Liang, Gui-Xin Chou & Zhi-Ling Yu. (2022) Inhibition of the Akt/NF-κB pathway is involved in the anti-gastritis effects of an ethanolic extract of the rhizome of Atractylodes macrocephala. Journal of Ethnopharmacology 293, pages 115251.
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Shaobin Yang, Yaqin Du, Xiaoqian Zhao, Chendong Wu & Peng Yu. (2022) Reducing PDK1/Akt Activity: An Effective Therapeutic Target in the Treatment of Alzheimer’s Disease. Cells 11:11, pages 1735.
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Laura Llorach-Pares, Alfons Nonell-Canals, Conxita Avila & Melchor Sanchez-Martinez. (2022) Computer-Aided Drug Design (CADD) to De-Orphanize Marine Molecules: Finding Potential Therapeutic Agents for Neurodegenerative and Cardiovascular Diseases. Marine Drugs 20:1, pages 53.
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Eva Hitz, Natalie Wiedemar, Armin Passecker, Beatriz A. S. Graça, Christian Scheurer, Sergio Wittlin, Nicolas M. B. Brancucci, Ioannis Vakonakis, Pascal Mäser & Till S. Voss. (2021) The 3-phosphoinositide–dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites. PLOS Biology 19:12, pages e3001483.
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Muhammad Jahangir Hossen, Aftab Amin, Xiu-Qiong Fu, Ji-Yao Chou, Jia-Ying Wu, Xiao-Qi Wang, Ying-Jie Chen, Ying Wu, Junkui Li, Cheng-Le Yin, Chun Liang, Gui-Xin Chou & Zhi-Ling Yu. (2021) The anti-inflammatory effects of an ethanolic extract of the rhizome of Atractylodes lancea, involves Akt/NF-κB signaling pathway inhibition. Journal of Ethnopharmacology 277, pages 114183.
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Muhammad Jahangir Hossen, Ji-Yao Chou, Su-Mei Li, Xiu-Qiong Fu, Chengle Yin, Hui Guo, Aftab Amin, Gui-Xin Chou & Zhi-Ling Yu. (2019) An ethanol extract of the rhizome of Atractylodes chinensis exerts anti-gastritis activities and inhibits Akt/NF-κB signaling. Journal of Ethnopharmacology 228, pages 18-25.
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Marius Mioc, Sorin Avram, Vasile Bercean, Ludovic Kurunczi, Roxana M. Ghiulai, Camelia Oprean, Dorina E. Coricovac, Cristina Dehelean, Alexandra Mioc, Mihaela Balan-Porcarasu, Calin Tatu & Codruta Soica. (2018) Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer. Frontiers in Chemistry 6.
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Muhammad Jahangir Hossen, Yong Deog Hong, Kwang-Soo Baek, Sulgi Yoo, Yo Han Hong, Ji Hye Kim, Jeong-Oog Lee, Donghyun Kim, Junseong Park & Jae Youl Cho. (2017) In vitro antioxidative and anti-inflammatory effects of the compound K-rich fraction BIOGF1K, prepared from Panax ginseng. Journal of Ginseng Research 41:1, pages 43-51.
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Muhammad Jahangir Hossen, Jae Youl Cho & Daewon Kim. (2016) PDK1 in NF-κB signaling is a target of Xanthium strumarium methanolic extract-mediated anti-inflammatory activities. Journal of Ethnopharmacology 190, pages 251-260.
Crossref
Katherine M. Moxley, Luyao Wang, Alana L. Welm & Magdalena Bieniasz. (2016) Short-form Ron is a novel determinant of ovarian cancer initiation and progression. Genes & Cancer 7:5-6, pages 169-181.
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Margarita Wucherer-Plietker, Eugen Merkul, Thomas J.J. Müller, Christina Esdar, Thorsten Knöchel, Timo Heinrich, Hans-Peter Buchstaller, Hartmut Greiner, Dieter Dorsch, Dirk Finsinger, Michel Calderini, David Bruge & Ulrich Grädler. (2016) Discovery of novel 7-azaindoles as PDK1 inhibitors. Bioorganic & Medicinal Chemistry Letters 26:13, pages 3073-3080.
Crossref

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