434
Views
22
CrossRef citations to date
0
Altmetric
Review

Hedgehog inhibitors: a patent review (2013 – present)

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Yifan Feng, Weiming Duan, Xiaochuan Cu, Chengyuan Liang & Minhang Xin. (2019) Bruton’s tyrosine kinase (BTK) inhibitors in treating cancer: a patent review (2010-2018). Expert Opinion on Therapeutic Patents 29:4, pages 217-241.
Read now
Fabrizio Manetti & Elena Petricci. (2016) Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof. Expert Opinion on Therapeutic Patents 26:4, pages 529-535.
Read now

Articles from other publishers (20)

Zifan Feng, Shanshan Zhu, Wenrui Li, Maojun Yao, Hualong Song & Ru-Bing Wang. (2022) Current approaches and strategies to identify Hedgehog signaling pathway inhibitors for cancer therapy. European Journal of Medicinal Chemistry 244, pages 114867.
Crossref
Yang Liu, Fang Zhou, Kang Ding, Dongxiang Xue, Zhihao Zhu, Cuixia Li, Fei Li, Yueming Xu, Fei Xu, Zhiping Le, Suwen Zhao & Houchao Tao. (2021) Structure‐Activity Relationship Studies of Hydantoin‐Cored Ligands for Smoothened Receptor. ChemistryOpen 10:10, pages 1028-1032.
Crossref
Annamil Alvarez-Trotta, Zhiqiang Wang, Elena Shersher, Bin Li, Jun Long, Ines Lohse, Claes Wahlestedt, Wael El-Rifai, David J. Robbins & Anthony J. Capobianco. (2020) The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling. Oncotarget 11:33, pages 3174-3187.
Crossref
Anna Adamiok-Ostrowska & Agnieszka Piekiełko-Witkowska. (2020) Ciliary Genes in Renal Cystic Diseases. Cells 9:4, pages 907.
Crossref
Yanan Chang, Hong Chen, Jie Duan, Wang Wu, Fangshu Le & Fen Mou. (2020) The inhibitory effect and safety of GANT61 on HeLa cells in nude mice. Experimental and Molecular Pathology 113, pages 104352.
Crossref
Álvaro Cañete-Molina, Christian Espinosa-Bustos, Marcos González-Castro, Mario Faúndez, Jaime Mella, Ricardo A. Tapia, Alan R. Cabrera, Iván Brito, Adam Aguirre & Cristian O. Salas. (2019) Design, synthesis, cytotoxicity and 3D-QSAR analysis of new 3,6-disubstituted-1,2,4,5-tetrazine derivatives as potential antitumor agents. Arabian Journal of Chemistry 12:7, pages 1092-1107.
Crossref
Dongxiang Xue, Lintao Ye, Jun Zheng, Yiran Wu, Xianjun Zhang, Yueming Xu, Tao Li, Raymond C. Stevens, Fei Xu, Min Zhuang, Suwen Zhao, Fei Zhao & Houchao Tao. (2019) The structure-based traceless specific fluorescence labeling of the smoothened receptor. Organic & Biomolecular Chemistry 17:25, pages 6136-6142.
Crossref
Minhang Xin, Liandi Zhang, Chongxing Tu, Feng Tang & Jun Wen. (2018) Novel 4-(2-pyrimidinylamino)benzamide derivatives as potent hedgehog signaling pathway inhibitors. Bioorganic & Medicinal Chemistry 26:18, pages 5029-5036.
Crossref
Chenglin Wang, Mingfei Zhu, Xiuhong Lu, Hong Wang, Weili Zhao, Xiongwen Zhang & Xiaochun Dong. (2018) Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors. Bioorganic & Medicinal Chemistry 26:12, pages 3308-3320.
Crossref
Zhihong Yao, Lei Han, Yongbin Chen, Fei He, Bin Sun, Santosh kamar, Ya Zhang, Yihao Yang, Cao Wang & Zuozhang Yang. (2018) Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma. Cell Death & Disease 9:6.
Crossref
Minhang Xin, Xinyue Ji, Ladie Kimberly De La Cruz, Suresh Thareja & Binghe Wang. (2018) Strategies to target the Hedgehog signaling pathway for cancer therapy. Medicinal Research Reviews 38:3, pages 870-913.
Crossref
Xiaochun Dong, Chenglin Wang, Zhongjian Chen & Weili Zhao. (2018) Overcoming the resistance mechanisms of Smoothened inhibitors. Drug Discovery Today 23:3, pages 704-710.
Crossref
Minhang Xin, Liandi Zhang, Jun Wen, Han Shen, Xinge Zhao, Qiu Jin & Feng Tang. (2017) Introduction of fluorine to phenyl group of 4-(2-pyrimidinylamino)benzamides leading to a series of potent hedgehog signaling pathway inhibitors. Bioorganic & Medicinal Chemistry Letters 27:15, pages 3259-3263.
Crossref
E.M. Redmond, C. Lally & P.A. Cahill. 2017. Cardio-Oncology. Cardio-Oncology 35 53 .
Xia Zhou, Li-Fei Zhou, Bo Yang, Hua-Jun Zhao, Yi-Qi Wang, Xiao-Yu Li, Yi-Ping Ye & Feng-Yang Chen. (2016) The Loss of a Sugar Chain at C(3) Position Enhances Stemucronatoside K-Induced Apoptosis, Cell Cycle Arrest, and Hedgehog Pathway Inhibition in HT-29 Cells. Chemistry & Biodiversity 13:11, pages 1484-1492.
Crossref
Kyle F. CoxCurtis E. Margo. (2016) Role of Vismodegib in the Management of Advanced Periocular Basal Cell Carcinoma. Cancer Control 23:2, pages 133-139.
Crossref
Minhang Xin, Liandi Zhang, Qiu Jin, Feng Tang, Jun Wen, Liyun Gu, Lingfei Cheng & Yong Zhao. (2016) Discovery of novel 4-(2-pyrimidinylamino)benzamide derivatives as highly potent and orally available hedgehog signaling pathway inhibitors. European Journal of Medicinal Chemistry 110, pages 115-125.
Crossref
Minhang Xin, Liandi Zhang, Jun Wen, Han Shen, Zhaoyu Liu, Xinge Zhao, Qiu Jin, Mengyu Wang, Lingfei Cheng, Wei Huang & Feng Tang. (2016) Synthesis and pharmacological evaluation of trifluoromethyl containing 4-(2-pyrimidinylamino)benzamides as Hedgehog signaling pathway inhibitors. Bioorganic & Medicinal Chemistry 24:5, pages 1079-1088.
Crossref
Mercy Odueyungbo & Desiree Ratner. (2016) Update on the Use and Treatment of Targeted Molecular Inhibitors for Locally Advanced and Metastatic Non-Melanoma Skin Cancers. Dermatologic Surgery 42:Supplement 1, pages S49-S56.
Crossref
Joseph Sinkovics. (2015) The cnidarian origin of the proto-oncogenes NF-κB/STAT and WNT-like oncogenic pathway drives the ctenophores (Review). International Journal of Oncology.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.