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Indirubin derivatives: a patent review (2010 – present)

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Kandasamy Saravanan, Govindasamy Hunday & Poomani Kumaradhas. (2020) Binding and stability of indirubin-3-monoxime in the GSK3β enzyme: a molecular dynamics simulation and binding free energy study. Journal of Biomolecular Structure and Dynamics 38:4, pages 957-974.
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Antonia Efstathiou, Cássio Santana Meira, Nicolas Gaboriaud-Kolar, Tanira Matutino Bastos, Vinícius Pinto Costa Rocha, Konstantina Vougogiannopoulou, Alexios-Leandros Skaltsounis, Despina Smirlis & Milena Botelho Pereira Soares. (2018) Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents. Virulence 9:1, pages 1658-1668.
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Enxue He, Hailing Li, Xiaokun Li, Xunxun Wu, Kun Lei & Yong Diao. (2022) Transdermal Delivery of Indirubin-Loaded Microemulsion Gel: Preparation, Characterization and Anti-Psoriatic Activity. International Journal of Molecular Sciences 23:7, pages 3798.
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Bin Sun, Jiahao Wang, Luohua Liu, Longfei Mao, Lizeng Peng & Yuwei Wang. (2020) Synthesis and activity of novel indirubin derivatives. Chemical Biology & Drug Design 97:3, pages 565-571.
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Qi Wang, Jun Yu, Yinan Hu, Xueying Chen, Lei Zhang, Ting Pan, Kang Miao, Yong Mou, Yongjian Xu, Weining Xiong & Yi Wang. (2020) Indirubin alleviates bleomycin-induced pulmonary fibrosis in mice by suppressing fibroblast to myofibroblast differentiation. Biomedicine & Pharmacotherapy 131, pages 110715.
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Anna Czapka, Stefanie König, Carlo Pergola, Christian Grune, Konstantina Vougogiannopoulou, Alexios-Leandros Skaltsounis, Dagmar Fischer & Oliver Werz. (2020) The indirubin derivative 6-bromoindirubin-3′-glycerol-oxime ether (6BIGOE) potently modulates inflammatory cytokine and prostaglandin release from human monocytes through GSK-3 interference. Biochemical Pharmacology 180, pages 114170.
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Dan Xu & Zhi Xu. (2020) Indole Alkaloids with Potential Anticancer Activity. Current Topics in Medicinal Chemistry 20:21, pages 1938-1949.
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Yi Zhang, Lu Song, Jiazhen Li, Yan Zhang, Xinchang Lu & Bin Zhang. (2019) Inhibitory effects of indirubin‐3′‐monoxime against human osteosarcoma. IUBMB Life 71:10, pages 1465-1474.
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Jing Wang, Li Long, Yongzheng Chen, Yingshu Xu & Lei Zhang. (2018) Design, synthesis and antineoplastic activity of novel hybrids of podophyllotoxin and indirubin against human leukaemia cancer cells as multifunctional anti-MDR agents. Bioorganic & Medicinal Chemistry Letters 28:10, pages 1817-1824.
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Liping Chen, Chunhui Huang, Jieyi Shentu, Minjun Wang, Sicheng Yan, Fei Zhou, Zaijun Zhang, Chuang Wang, Yifan Han, Qinwen Wang & Wei Cui. (2017) Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice. Frontiers in Molecular Neuroscience 10.
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Tianjie Qi, Haitao Li & Shuai Li. (2017) Indirubin improves antioxidant and anti-inflammatory functions in lipopolysaccharide-challenged mice. Oncotarget 8:22, pages 36658-36663.
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Karyn Muzinga NdoloKyeong Ryang ParkHyo Jeong LeeKyoung Bin YoonYong-Chul KimSun-Young Han. (2017) Characterization of the Indirubin Derivative LDD970 as a Small Molecule Aurora Kinase A Inhibitor in Human Colorectal Cancer Cells. Immune Network 17:2, pages 110.
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Woong-Hee Kim, Haihong Shen, Da-Woon Jung & Darren R. Williams. (2016) Some leopards can change their spots: potential repositioning of stem cell reprogramming compounds as anti-cancer agents. Cell Biology and Toxicology 32:3, pages 157-168.
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Kirsten Benkendorff, David Rudd, Bijayalakshmi Nongmaithem, Lei Liu, Fiona Young, Vicki Edwards, Cathy Avila & Catherine Abbott. (2015) Are the Traditional Medical Uses of Muricidae Molluscs Substantiated by Their Pharmacological Properties and Bioactive Compounds?. Marine Drugs 13:8, pages 5237-5275.
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Tina Blažević, Elke H. Heiss, Atanas G. Atanasov, Johannes M. Breuss, Verena M. Dirsch & Pavel Uhrin. (2015) Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-12.
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