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Review

Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 – 2014)

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Katarzyna Jakimiuk, Jakub Gesek, Atanas G. Atanasov & Michał Tomczyk. (2021) Flavonoids as inhibitors of human neutrophil elastase. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1016-1028.
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L Crocetti, MT Quinn, IA Schepetkin & MP Giovannoni. (2019) A patenting perspective on human neutrophil elastase (HNE) inhibitors (2014-2018) and their therapeutic applications. Expert Opinion on Therapeutic Patents 29:7, pages 555-578.
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Mahdieh Shirzad, Javad Hamedi, Elahe Motevaseli & Mohammad Hossein Modarressi. (2018) Anti-elastase and anti-collagenase potential of Lactobacilli exopolysaccharides on human fibroblast. Artificial Cells, Nanomedicine, and Biotechnology 46:sup1, pages 1051-1061.
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Feryel Soualmia & Chahrazade El Amri. (2018) Serine protease inhibitors to treat inflammation: a patent review (2011-2016). Expert Opinion on Therapeutic Patents 28:2, pages 93-110.
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Maria Paola Giovannoni, Igor A. Schepetkin, Mark T. Quinn, Niccolò Cantini, Letizia Crocetti, Gabriella Guerrini, Antonella Iacovone, Paola Paoli, Patrizia Rossi, Gianluca Bartolucci, Marta Menicatti & Claudia Vergelli. (2018) Synthesis, biological evaluation, and molecular modelling studies of potent human neutrophil elastase (HNE) inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 1108-1124.
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Articles from other publishers (29)

Yi Liu, Changlan Xiang, Zhenni Que, Chenglong Li, Wen Wang, Lijuan Yin, Chenyu Chu & Yin Zhou. (2023) Neutrophil heterogeneity and aging: implications for COVID-19 and wound healing. Frontiers in Immunology 14.
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Jhonnatan Styver Ocampo‐Gallego, David Pedroza‐Escobar, Ana Ruth Caicedo‐Ortega, María Teresa Berumen‐Murra, Ana Lucía Novelo‐Aguirre, Rebeca Denis de Sotelo‐León & Dealmy Delgadillo‐Guzmán. (2023) Human neutrophil elastase inhibitors: Classification, biological‐synthetic sources and their relevance in related diseases. Fundamental & Clinical Pharmacology.
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Nora Tromsdorf, Fabian T. H. Ullrich, Markus Rethmeier, Christian P. Sommerhoff & Norbert Schaschke. (2023) E‐64c‐Hydrazide Based Cathepsin C Inhibitors: Optimizing the Interactions with the S1’‐S2’ Area. ChemMedChem.
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Karolina H. Czarnecka-Chrebelska, Debjita Mukherjee, Sofya V. Maryanchik & Magdalena Rudzinska-Radecka. (2023) Biological and Genetic Mechanisms of COPD, Its Diagnosis, Treatment, and Relationship with Lung Cancer. Biomedicines 11:2, pages 448.
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Lisha Li, Hao Zhang, Xiujie Wang, Zixi Wang, Le Cui, Yingyang Xu & Kai Guan. (2022) Upregulated antimicrobial immune response mediated by neutrophils in the development from allergic rhinitis to asthma. Frontiers in Immunology 13.
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Hsiu‐Yang Tseng, Yi‐Wen Chen, Bor‐Shiunn Lee, Po‐Chun Chang, Yi‐Ping Wang, Chun‐Pin Lin, Shih‐Jung Cheng, Mark Yen‐Ping Kuo & Hsin‐Han Hou. (2022) The neutrophil elastase‐upregulated placenta growth factor promotes the pathogenesis and progression of periodontal disease. Journal of Periodontology 93:9, pages 1401-1410.
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Federica Boraldi, Francesco Demetrio Lofaro, Andrea Cossarizza & Daniela Quaglino. (2022) The “Elastic Perspective” of SARS-CoV-2 Infection and the Role of Intrinsic and Extrinsic Factors. International Journal of Molecular Sciences 23:3, pages 1559.
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Rami A. Al-Horani, Kholoud F. Aliter, Srabani Kar & Madhusoodanan Mottamal. (2021) Sulfonated Nonsaccharide Heparin Mimetics Are Potent and Noncompetitive Inhibitors of Human Neutrophil Elastase. ACS Omega 6:19, pages 12699-12710.
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Chahrazade El Amri. 2021. Lung Inflammation in Health and Disease, Volume II. Lung Inflammation in Health and Disease, Volume II 215 226 .
Wiem Elloumi, Ahlem Jebali, Amina Maalej, Mohamed Chamkha & Sami Sayadi. (2020) Effect of Mild Salinity Stress on the Growth, Fatty Acid and Carotenoid Compositions, and Biological Activities of the Thermal Freshwater Microalgae Scenedesmus sp.. Biomolecules 10:11, pages 1515.
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Vincent D. Giacalone, Brian S. Dobosh, Amit Gaggar, Rabindra Tirouvanziam & Camilla Margaroli. (2020) Immunomodulation in Cystic Fibrosis: Why and How?. International Journal of Molecular Sciences 21:9, pages 3331.
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Mohamad Tarhini, Anne Pizzoccaro, Ihsane Benlyamani, Chloé Rebaud, Hélène Greige-Gerges, Hatem Fessi, Abdelhamid Elaissari & Abderrazzak Bentaher. (2020) Human serum albumin nanoparticles as nanovector carriers for proteins: Application to the antibacterial proteins “neutrophil elastase” and “secretory leukocyte protease inhibitor”. International Journal of Pharmaceutics 579, pages 119150.
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P. Barth, P. Bruijnzeel, A. Wach, O. Sellier Kessler, L. Hooftman, J. Zimmermann, N. Naue, B. Huber, I. Heimbeck, D. Kappeler, W. Timmer & E. Chevalier. (2020) Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis. Journal of Cystic Fibrosis 19:2, pages 299-304.
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Vincent D. Giacalone, Camilla Margaroli, Marcus A. Mall & Rabindra Tirouvanziam. (2020) Neutrophil Adaptations upon Recruitment to the Lung: New Concepts and Implications for Homeostasis and Disease. International Journal of Molecular Sciences 21:3, pages 851.
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Yung-Fong Tsai, Chun-Yu Chen, Wen-Yi Chang, Yu-Ting Syu & Tsong-Long Hwang. (2019) Resveratrol suppresses neutrophil activation via inhibition of Src family kinases to attenuate lung injury. Free Radical Biology and Medicine 145, pages 67-77.
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Valentina Sala, Alessandra Murabito & Alessandra Ghigo. (2019) Inhaled Biologicals for the Treatment of Cystic Fibrosis. Recent Patents on Inflammation & Allergy Drug Discovery 13:1, pages 19-26.
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Sho Hiroyasu, Christopher T. Turner, Katlyn C. Richardson & David J. Granville. (2019) Proteases in Pemphigoid Diseases. Frontiers in Immunology 10.
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Elena M. Vasilieva, I. E. Smirnov, A. P. Fisenko, M. I. Bakanov, A. O. Bogatyryova, G. I. Smirnova, A. G. Kucherenko & O. I. Simonova. (2019) PROTEOLYTIC ENZYMES AND CYTOKINES IN CHRONIC BRONCHOPULMONARY DISEASES IN CHILDREN. Russian Pediatric Journal 21:6, pages 350-356.
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Mayla Gabryele Miranda de Melo, Eliene Denites Duarte Mesquita, Martha M. Oliveira, Caio da Silva-Monteiro, Anna K. A. Silveira, Thiago S. Malaquias, Tatiana C. P. Dutra, Rafael M. Galliez, Afrânio L. Kritski & Elisangela C. Silva. (2019) Imbalance of NET and Alpha-1-Antitrypsin in Tuberculosis Patients Is Related With Hyper Inflammation and Severe Lung Tissue Damage. Frontiers in Immunology 9.
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Graeme P. Sullivan, Conor M. Henry, Danielle M. Clancy, Tazhir Mametnabiev, Ekaterina Belotcerkovskaya, Pavel Davidovich, Sylvia Sura-Trueba, Alexander V. Garabadzhiu & Seamus J. Martin. (2018) Suppressing IL-36-driven inflammation using peptide pseudosubstrates for neutrophil proteases. Cell Death & Disease 9:3.
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Kailash C. Pandey, Sajal De & Pradyumna K. Mishra. (2017) Role of Proteases in Chronic Obstructive Pulmonary Disease. Frontiers in Pharmacology 8.
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Simon Finch, Holly R. Keir, Alison J. Dicker & James D. Chalmers. (2017) The past decade in bench research into pulmonary infectious diseases: What do clinicians need to know?. Respirology 22:6, pages 1062-1072.
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Fu-Chao Liu, Huang-Ping Yu, Yu-Ting Syu, Jia-You Fang, Chwan-Fwu Lin, Shih-Hsin Chang, Yen-Tung Lee & Tsong-Long Hwang. (2017) Honokiol suppresses formyl peptide-induced human neutrophil activation by blocking formyl peptide receptor 1. Scientific Reports 7:1.
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Weifeng Yao, Haobo Li, Gangjian Luo, Xiang Li, Chaojin Chen, Dongdong Yuan, Xinjin Chi, Zhengyuan Xia & Ziqing Hei. (2017) SERPINB1 ameliorates acute lung injury in liver transplantation through ERK1/2-mediated STAT3-dependent HO-1 induction. Free Radical Biology and Medicine 108, pages 542-553.
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Shun-Chin Yang, Shih-Hsin Chang, Pei-Wen Hsieh, Yin-Ting Huang, Chiu-Ming Ho, Yung-Fong Tsai & Tsong-Long Hwang. (2017) Dipeptide HCH6-1 inhibits neutrophil activation and protects against acute lung injury by blocking FPR1. Free Radical Biology and Medicine 106, pages 254-269.
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Balázs Rada. (2017) Interactions between Neutrophils and Pseudomonas aeruginosa in Cystic Fibrosis. Pathogens 6:1, pages 10.
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Katharina Maria KlingElena Lopez-RodriguezChristiane Pfarrer, Christian Mühlfeld & Christina Brandenberger. (2017) Aging exacerbates acute lung injury-induced changes of the air-blood barrier, lung function, and inflammation in the mouse. American Journal of Physiology-Lung Cellular and Molecular Physiology 312:1, pages L1-L12.
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Shining Loo, Antony Kam, Tianshu Xiao, Giang K. T. Nguyen, Chuan Fa Liu & James P. Tam. (2016) Identification and Characterization of Roseltide, a Knottin-type Neutrophil Elastase Inhibitor Derived from Hibiscus sabdariffa. Scientific Reports 6:1.
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Fariz NurwidyaTriya DamayantiFaisal Yunus. (2016) The Role of Innate and Adaptive Immune Cells in the Immunopathogenesis of Chronic Obstructive Pulmonary Disease. Tuberculosis and Respiratory Diseases 79:1, pages 5.
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