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Drug Evaluations

S-1: a promising new oral fluoropyrimidine derivative

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Pages 335-348 | Published online: 09 May 2009

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Read on this site (9)

Fahima Danesh Pouya, Yousef Rasmi & Mohadeseh Nemati. (2022) Signaling Pathways Involved in 5-FU Drug Resistance in Cancer. Cancer Investigation 40:6, pages 516-543.
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Meng He, Jinghua Sun, Danyi Zhao, Hongmei He, Bing Wang, Lingling Xu, Yu Shang, Shanling Ren, Yang Zhang & Tao Wu. (2019) Modified-FOLFIRINOX combined with deep regional hyperthermia in pancreatic cancer: a retrospective study in Chinese patients. International Journal of Hyperthermia 36:1, pages 393-401.
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Pei-Jian Peng, Hua Cheng, Xue-Qing Ou, Lin-Juan Zeng, Xuan Wu, Yu-Meng Liu, Zhong Lin, Yan-Na Tang, Si-Yang Wang, Hong-Yu Zhang & Zhi-Bin Chen. (2014) Safety and efficacy of S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy: multi-institutional retrospective analysis. Drug Design, Development and Therapy 8, pages 1083-1087.
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Yuji Miyamoto, Yasuo Sakamoto, Naoya Yoshida & Hideo Baba. (2014) Efficacy of S-1 in colorectal cancer. Expert Opinion on Pharmacotherapy 15:12, pages 1761-1770.
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Taroh Satoh & Yuh Sakata. (2012) S-1 for the treatment of gastrointestinal cancer. Expert Opinion on Pharmacotherapy 13:13, pages 1943-1959.
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Koh Miura, Tetsuhiko Shirasaka, Hiroki Yamaue & Iwao Sasaki. (2012) S-1 as a core anticancer fluoropyrimidine agent. Expert Opinion on Drug Delivery 9:3, pages 273-286.
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Jing Wang, Yanchen Hu, Ling Li, Tongying Jiang, Siling Wang & Fengkui Mo. (2010) Indomethacin-5-fluorouracil-methyl ester dry emulsion: a potential oral delivery system for 5-fluorouracil. Drug Development and Industrial Pharmacy 36:6, pages 647-656.
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R Pamela Mackenzie & A David McCollum. (2009) Novel agents for the treatment of adenocarcinoma of the pancreas. Expert Review of Anticancer Therapy 9:10, pages 1473-1485.
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Chen Chang, Xiaofen Li, Ke Cheng, Zhaolun Cai, Junjie Xiong, Wanrui Lv, Ruizhen Li, Pei Zhang & Dan Cao. (2023) A Phase I Study of Gemcitabine/Nab-Paclitaxel/S-1 Chemotherapy in Patients With Locally Advanced or Metastatic Pancreatic Ductal Adenocarcinoma. The Oncologist 28:7, pages e575-e584.
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C.J.A. Punt, V. Heinemann, T. Maughan, C. Cremolini, E. Van Cutsem, R. McDermott, G. Bodoky, T. André, P. Osterlund, A.J. Teske & P. Pfeiffer. (2023) Fluoropyrimidine-induced hand-foot syndrome and cardiotoxicity: recommendations for the use of the oral fluoropyrimidine S-1 in metastatic colorectal cancer. ESMO Open 8:2, pages 101199.
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Dongdong Luo, Xiaochun Liu, Leilei Jiang, Zhikun Guo, Yan Lv, Xiaochen Tian, Xiaoyan Wang, Shuxiang Cui, Shengbiao Wan, Xianjun Qu, Ximing Xu & Xiaoyang Li. (2022) Rational Design, Synthesis, and Biological Evaluation of Novel S1PR2 Antagonists for Reversing 5-FU-Resistance in Colorectal Cancer. Journal of Medicinal Chemistry 65:21, pages 14553-14577.
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Qianyu Wang, Xiaofei Shen, Gang Chen & Junfeng Du. (2022) Drug Resistance in Colorectal Cancer: From Mechanism to Clinic. Cancers 14:12, pages 2928.
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O. Mirallas, D. López-Valbuena, D. García-Illescas, C. Fabregat-Franco, H. Verdaguer, J. Tabernero & T. Macarulla. (2022) Advances in the systemic treatment of therapeutic approaches in biliary tract cancer. ESMO Open 7:3, pages 100503.
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Seyed Parsa Eftekhar, Sohrab Kazemi & Ali Akbar Moghadamnia. (2022) Effect of thymoquinone on pharmacokinetics of 5-fluorouracil in rats and its effect on human cell line in vitro . Human & Experimental Toxicology 41, pages 096032712211454.
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Pawlos S. Tsegay, Daniela Hernandez, Christopher Brache, Chryssostomos Chatgilialoglu, Marios G. Krokidis, Prem Chapagain & Yuan Liu. (2022) Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair. DNA Repair 109, pages 103258.
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Chen Chang, Xiaofen Li & Dan Cao. (2021) Combination of gemcitabine, nab-paclitaxel, and S-1(GAS) as the first-line treatment for patients with locally advanced or advanced pancreatic ductal adenocarcinoma: study protocol for an open-label, single-arm phase I study. BMC Cancer 21:1.
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Akhil Chawla & Cristina R. Ferrone. (2019) Neoadjuvant Therapy for Resectable Pancreatic Cancer: An Evolving Paradigm Shift. Frontiers in Oncology 9.
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Li Song, Huajie Liu & Qiang Liu. (2019) Matrix metalloproteinase 1 promotes tumorigenesis and inhibits the sensitivity to 5-fluorouracil of nasopharyngeal carcinoma. Biomedicine & Pharmacotherapy 118, pages 109120.
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Sheng Zhong, Shuai Qie, Liu Yang, Qi Yan, Linna Ge & Zhongfeng Wang. (2017) S-1 monotherapy versus S-1 combination therapy in gemcitabine-refractory advanced pancreatic cancer. Medicine 96:30, pages e7611.
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Seiichiro Mitani, Shigenori Kadowaki, Azusa Komori, Keiji Sugiyama, Yukiya Narita, Hiroya Taniguchi, Takashi Ura, Masashi Ando, Yozo Sato, Hidekazu Yamaura, Yoshitaka Inaba, Makoto Ishihara, Tsutomu Tanaka, Masahiro Tajika & Kei Muro. (2017) Acute hyperammonemic encephalopathy after fluoropyrimidine-based chemotherapy. Medicine 96:22, pages e6874.
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Jorge Hernando-Cubero, Ignacio Matos-García, Vicente Alonso-Orduña & Jaume Capdevila. (2017) The Role of Fluoropirimidines in Gastrointestinal Tumours: from the Bench to the Bed. Journal of Gastrointestinal Cancer 48:2, pages 135-147.
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Pei-Jian Peng, Bao-Jun Lv, Zhi-Hui Wang, Hai Liao, Yu-Meng Liu, Zhong Lin, Yun-Yan Con & Pei-Yu Huang. (2016) Multi-institutional prospective study of nedaplatin plus S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-containing regimens. Therapeutic Advances in Medical Oncology 9:2, pages 68-74.
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Hao Li, Zheng-Yun Zhang, Zun-Qiang Zhou, Jiao Guan, Da-Nian Tong & Guang-Wen Zhou. (2016) Combined gemcitabine and S-1 chemotherapy for treating unresectable hilar cholangiocarcinoma: a randomized open-label clinical trial. Oncotarget 7:18, pages 26888-26897.
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PeiJian Peng, XueQing Ou, Hai Liao, YuMeng Liu, SiYang Wang, ZhiBin Cheng & Zhong Lin. (2016) Phase II study of gemcitabine plus S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy. Therapeutic Advances in Medical Oncology 8:3, pages 153-159.
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Doudou Li, Changhao Chen, Yu Zhou, Rufu Chen, Xinxiang Fan, Zhuofei Bi, Zhihua Li & Yimin Liu. (2015) Gemcitabine Compared With Gemcitabine and S-1 Combination Therapy in Advanced Pancreatic Cancer. Medicine 94:35, pages e1345.
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Jing Zhou, Rongce Zhao, Feng Wen, Pengfei Zhang, Ruilei Tang, Zedong Du, Xiaofeng He, Jian Zhang & Qiu Li. (2015) Cost-effectiveness analysis of gemcitabine, S-1 and gemcitabine plus S-1 for treatment of advanced pancreatic cancer based on GEST study. Medical Oncology 32:4.
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Qin Li, Han Yan, Wenting Liu, Hongchao Zhen, Yifan Yang & Bangwei Cao. (2014) Efficacy and Safety of Gemcitabine-Fluorouracil Combination Therapy in the Management of Advanced Pancreatic Cancer: A Meta-Analysis of Randomized Controlled Trials. PLoS ONE 9:8, pages e104346.
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Isha Rani, Kim Vaiphei & Navneet Agnihotri. (2014) Supplementation of fish oil augments efficacy and attenuates toxicity of 5-fluorouracil in 1,2-dimethylhydrazine dihydrochloride/dextran sulfate sodium-induced colon carcinogenesis. Cancer Chemotherapy and Pharmacology 74:2, pages 309-322.
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Hidenori Takahashi, Hiroaki Ohigashi, Kunihito Gotoh, Shigeru Marubashi, Terumasa Yamada, Masayuki Murata, Tatsuya Ioka, Hiroyuki Uehara, Masahiko Yano & Osamu Ishikawa. (2013) Preoperative Gemcitabine-Based Chemoradiation Therapy for Resectable and Borderline Resectable Pancreatic Cancer. Annals of Surgery 258:6, pages 1040-1050.
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Hideki UenoTatsuya IokaMasafumi IkedaShinichi OhkawaHiroaki YanagimotoNarikazu BokuAkira FukutomiKazuya SugimoriHideo BabaKenji YamaoTomotaka ShimamuraMasayuki ShoMasayuki KitanoAnn-Lii ChengKazuhiro MizumotoJen-Shi ChenJunji FuruseAkihiro FunakoshiTakashi HatoriTaketo YamaguchiShinichi EgawaAtsushi SatoYasuo OhashiTakuji OkusakaMasao Tanaka. (2013) Randomized Phase III Study of Gemcitabine Plus S-1, S-1 Alone, or Gemcitabine Alone in Patients With Locally Advanced and Metastatic Pancreatic Cancer in Japan and Taiwan: GEST Study. Journal of Clinical Oncology 31:13, pages 1640-1648.
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Zhi-xiang Zhuang, Hong Zhu, Ji Wang, Min-gao Zhu, Hui Wang, Wang-yang Pu, Hua-hui Bian, Lei Chen & Hong Zhang. (2013) Pharmacokinetic evaluation of novel oral fluorouracil antitumor drug S-1 in Chinese cancer patients. Acta Pharmacologica Sinica 34:4, pages 570-580.
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Eun Mi Lee, Yong Sang Hong, Kyu‐pyo Kim, Jae‐Lyun Lee, Sun Young Kim, Young Suk Park, Doo Ho Choi, Jong Hoon Kim, Seok‐Byung Lim, Chang Sik Yu, Jin Cheon Kim, Ju Hee Lee, Ah Young Kim & Tae Won Kim. (2012) Phase II study of preoperative chemoradiation with S‐1 plus oxaliplatin in patients with locally advanced rectal cancer . Cancer Science 104:1, pages 111-115.
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Byung Woog Kang, Jong Gwang Kim, Yee Soo Chae, Yoo Jin Lee, Soo Jung Lee, Joon Ho Moon, Sang Kyun Sohn, Min Kyu Jung, Seong Woo Jeon, Yun-Jin Jang, Jongduk Seo, Yong Hyun Lee, Ohkyung Kwon, Ho Young Chung & Wansik Yu. (2011) Pilot study of adjuvant chemotherapy with 3-week combination of S-1 and cisplatin for patients with stage II-IV (M0) gastric cancer. Investigational New Drugs 30:4, pages 1671-1675.
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Su Jin Lee, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Won Ki Kang, Jongtae Lee, Dong-Seok Yim & Ho Yeong Lim. (2011) Phase 1 trial of S-1 in combination with sorafenib for patients with advanced hepatocellular carcinoma. Investigational New Drugs 30:4, pages 1540-1547.
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Masato Ozaka, Yuji Matsumura, Hiroshi Ishii, Yasushi Omuro, Takao Itoi, Hisatsugu Mouri, Keiji Hanada, Yasutoshi Kimura, Iruru Maetani, Yoshinobu Okabe, Masaji Tani, Takaaki Ikeda, Susumu Hijioka, Ryouhei Watanabe, Shinya Ohoka, Yuki Hirose, Masafumi Suyama, Naoto Egawa, Atsushi Sofuni, Takaaki Ikari & Toshifusa Nakajima. (2012) Randomized phase II study of gemcitabine and S-1 combination versus gemcitabine alone in the treatment of unresectable advanced pancreatic cancer (Japan Clinical Cancer Research Organization PC-01 study). Cancer Chemotherapy and Pharmacology 69:5, pages 1197-1204.
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H. Ueno, T. Okusaka, J. Furuse, K. Yamao, A. Funakoshi, N. Boku, S. Ohkawa, O. Yokosuka, K. Tanaka, F. Moriyasu, S. Nakamori & T. Sato. (2011) Multicenter Phase II Study of Gemcitabine and S-1 Combination Therapy (GS Therapy) in Patients With Metastatic Pancreatic Cancer. Japanese Journal of Clinical Oncology 41:8, pages 953-958.
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Trung The Van, Masaki Hanibuchi, Soji Kakiuchi, Seidai Sato, Takuya Kuramoto, Hisatsugu Goto, Atsushi Mitsuhashi, Yasuhiko Nishioka, Shin-ichi Akiyama & Saburo Sone. (2010) The therapeutic efficacy of S-1 against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice. Cancer Chemotherapy and Pharmacology 68:2, pages 497-504.
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Koh Miura, Makoto Kinouchi, Kazuyuki Ishida, Wataru Fujibuchi, Takeshi Naitoh, Hitoshi Ogawa, Toshinori Ando, Nobuki Yazaki, Kazuhiro Watanabe, Sho Haneda, Chikashi Shibata & Iwao Sasaki. (2010) 5-FU Metabolism in Cancer and Orally-Administrable 5-FU Drugs. Cancers 2:3, pages 1717-1730.
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