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Expert Opinion on Investigational Drugs Volume 18, 2009 - Issue 3
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Drug Evaluations

Targeting apoptosis: preclinical and early clinical experience with mapatumumab, an agonist monoclonal antibody targeting TRAIL-R1

Patricia Moretto The Margaret and Charles Juravinski Cancer Centre Department of Oncology, 699 Concession Street, Hamilton, ON, L8V 5C2, Canada, USA +1 905 387 9495, ext. 64605; +1 905 575 6326; [email protected]
&
Sébastien J Hotte The Margaret and Charles Juravinski Cancer Centre Department of Oncology, 699 Concession Street, Hamilton, ON, L8V 5C2, Canada, USA +1 905 387 9495, ext. 64605; +1 905 575 6326; [email protected]
, MD MSc (HRM) FRCPC
Pages 311-325 | Published online: 09 May 2009

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Wenyan Xiao, Ganchimeg Ishdorj, Jinmei Sun, James B. Johnston & Spencer B. Gibson. (2011) Death receptor 4 is preferentially recruited to lipid rafts in chronic lymphocytic leukemia cells contributing to tumor necrosis related apoptosis inducing ligand-induced synergistic apoptotic responses. Leukemia & Lymphoma 52:7, pages 1290-1301.
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Niels Murawski, Carsten Zwick & Michael Pfreundschuh. (2010) Unresolved issues in diffuse large B-cell lymphomas. Expert Review of Anticancer Therapy 10:3, pages 387-402.
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Norma Lynn Fox, Robin Humphreys, Troy A Luster, Jerry Klein & Gilles Gallant. (2010) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-1 and receptor-2 agonists for cancer therapy. Expert Opinion on Biological Therapy 10:1, pages 1-18.
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Articles from other publishers (14)

Ga Yeong Yi, Min Ju Kim, Hyo In Kim, Jinbong Park & Seung Ho Baek. (2022) Hyperthermia Treatment as a Promising Anti-Cancer Strategy: Therapeutic Targets, Perspective Mechanisms and Synergistic Combinations in Experimental Approaches. Antioxidants 11:4, pages 625.
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Hirofumi TenshinJumpei TeramachiAsuka OdaRyota Amachi, Masahiro HiasaAriunzaya Bat-ErdeneKeiichiro Watanabe, Masami IwasaTakeshi HaradaShiro FujiiKumiko KagawaKimiko SogabeShingen NakamuraHirokazu Miki, Kiyoe KurahashiSumiko YoshidaKenichi AiharaItsuro EndoEiji Tanaka, Toshio Matsumoto & Masahiro Abe. (2017) TAK1 inhibition subverts the osteoclastogenic action of TRAIL while potentiating its antimyeloma effects. Blood Advances 1:24, pages 2124-2137.
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Szu-Yuan Wu, Alexander T.H. Wu & Shing-Hwa Liu. (2016) MicroRNA-17-5p regulated apoptosis-related protein expression and radiosensitivity in oral squamous cell carcinoma caused by betel nut chewing. Oncotarget 7:32, pages 51482-51493.
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Adam Nagy, Katalin Eder, Mary A. Selak & Bernadette Kalman. (2015) Mitochondrial energy metabolism and apoptosis regulation in glioblastoma. Brain Research 1595, pages 127-142.
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S Cristofanon & S Fulda. (2012) ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells. Cell Death & Disease 3:11, pages e432-e432.
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Kumiko Kagawa, Ayako Nakano, Hirokazu Miki, Asuka Oda, Hiroe Amou, Kyoko Takeuchi, Shingen Nakamura, Takeshi Harada, Shiro Fujii, Kenichiro Yata, Shuji Ozaki, Toshio Matsumoto & Masahiro Abe. (2012) Inhibition of TACE Activity Enhances the Susceptibility of Myeloma Cells to TRAIL. PLoS ONE 7:2, pages e31594.
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Thomas Unterkircher, Silvia Cristofanon, Sri Hari Krishna Vellanki, Lisa Nonnenmacher, Georg Karpel-Massler, Christian Rainer Wirtz, Klaus-Michael Debatin & Simone Fulda. (2011) Bortezomib Primes Glioblastoma, Including Glioblastoma Stem Cells, for TRAIL by Increasing tBid Stability and Mitochondrial Apoptosis. Clinical Cancer Research 17:12, pages 4019-4030.
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Daniela Opel, Ivonne Naumann, Maxi Schneider, Daniela Bertele, Klaus-Michael Debatin & Simone Fulda. (2011) Targeting Aberrant PI3K/Akt Activation by PI103 Restores Sensitivity to TRAIL-Induced Apoptosis in Neuroblastoma. Clinical Cancer Research 17:10, pages 3233-3247.
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Ivonne Naumann, Roland Kappler, Dietrich von Schweinitz, Klaus-Michael Debatin & Simone Fulda. (2011) Bortezomib Primes Neuroblastoma Cells for TRAIL-Induced Apoptosis by Linking the Death Receptor to the Mitochondrial Pathway. Clinical Cancer Research 17:10, pages 3204-3218.
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Pappanaicken R. Kumaresan, Yan Wang, Mary Saunders, Yoshiko Maeda, Ruiwu Liu, Xiaobing Wang & Kit Sang Lam. (2011) Rapid Discovery of Death Ligands with One-Bead-Two-Compound Combinatorial Library Methods. ACS Combinatorial Science 13:3, pages 259-264.
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Dominic Stadel, Andrea Mohr, Caroline Ref, Marion MacFarlane, Shaoxia Zhou, Robin Humphreys, Max Bachem, Gerry Cohen, Peter Möller, Ralf M. Zwacka, Klaus-Michael Debatin & Simone Fulda. (2010) TRAIL-Induced Apoptosis Is Preferentially Mediated via TRAIL Receptor 1 in Pancreatic Carcinoma Cells and Profoundly Enhanced by XIAP Inhibitors. Clinical Cancer Research 16:23, pages 5734-5749.
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Jonathan Hall, Patrick Dennler, Stephanie Haller, Anna Pratsinis, Katharina Säuberli, Harry Towbin, Katja Walther & Janine Woytschak. (2010) Genomics drugs in clinical trials. Nature Reviews Drug Discovery 9:12, pages 988-988.
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Stefan Grimm & Mathieu Noteborn. (2010) Anticancer genes: inducers of tumour-specific cell death signalling. Trends in Molecular Medicine 16:2, pages 88-96.
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Sang Rye ParkKyoung Duk LeeUk Kyu KimYoung Gi GilKyu Seon OhBong Soo ParkGyoo Cheon Kim. (2010) Pseudomonas aeruginosa Exotoxin A Reduces Chemoresistance of Oral Squamous Carcinoma Cell via Inhibition of Heat Shock Proteins 70 (HSP70) . Yonsei Medical Journal 51:5, pages 708.
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