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Expert Opinion on Investigational Drugs Volume 18, 2009 - Issue 3
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Caprospinol: moving from a neuroactive steroid to a neurotropic drug

Laurent Lecanu McGill University Health Centre, The Research Institute of the McGill University Health Centre, 6100 Royalmount Avenue, Montreal, Quebec, H4P 2R2, Canada +1 514 283 6239; +1 514 283 6282; [email protected]
,
Laurent Tillement McGill University Health Centre, The Research Institute of the McGill University Health Centre, 6100 Royalmount Avenue, Montreal, Quebec, H4P 2R2, Canada +1 514 283 6239; +1 514 283 6282; [email protected]
,
Georges Rammouz McGill University Health Centre, The Research Institute of the McGill University Health Centre, 6100 Royalmount Avenue, Montreal, Quebec, H4P 2R2, Canada +1 514 283 6239; +1 514 283 6282; [email protected]
,
Jean Paul Tillement Académie Nationale de Médecine, 16 Rue Bonaparte, Paris, 75272, France
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Janet Greeson Samaritan Pharmaceuticals, 101 Convention Center Drive, Las Vegas, 89109, USA
&
Vassilios Papadopoulos McGill University Health Centre, The Research Institute of the McGill University Health Centre, 6100 Royalmount Avenue, Montreal, Quebec, H4P 2R2, Canada +1 514 283 6239; +1 514 283 6282; [email protected]
Pages 265-276 | Published online: 09 May 2009

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M. Oliur Rahman & Sheikh Sunzid Ahmed. (2023) Anti-angiogenic potential of bioactive phytochemicals from Helicteres isora targeting VEGFR-2 to fight cancer through molecular docking and molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics 41:15, pages 7447-7462.
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Articles from other publishers (11)

Sakshi Piplani, Puneet Singh, Nikolai Petrovsky & David A. Winkler. (2023) Identifying SARS-CoV-2 Drugs Binding to the Spike Fatty Acid Binding Pocket Using In Silico Docking and Molecular Dynamics. International Journal of Molecular Sciences 24:4, pages 4192.
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Shi‐Zhao Zhang, Peng‐Peng Liang, Ya‐Nan Feng, Guo‐Liang Yin, Feng‐Cui Sun, Chao‐Qun Ma & Feng‐Xia Zhang. (2022) Therapeutic potential and research progress of diosgenin for lipid metabolism diseases. Drug Development Research 83:8, pages 1725-1738.
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Swati Som, Justin Antony, SPalanisamy Dhanabal & Sivasankaran Ponnusankar. (2022) Neuroprotective role of Diosgenin, a NGF stimulator, against Aβ (1–42) induced neurotoxicity in animal model of Alzheimer’s disease. Metabolic Brain Disease 37:2, pages 359-372.
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Bangrong Cai, Ying Zhang, Zengtao Wang, Dujuan Xu, Yongyan Jia, Yanbin Guan, Aimei Liao, Gaizhi Liu, ChangJu Chun & Jiansheng Li. (2020) Therapeutic Potential of Diosgenin and Its Major Derivatives against Neurological Diseases: Recent Advances. Oxidative Medicine and Cellular Longevity 2020, pages 1-16.
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Bangrong Cai, Kyung-Joo Seong, Sun-Woong Bae, Min Suk Kook, Changju Chun, Jin Ho Lee, Won-Seok Choi, Ji-Yeon Jung & Won-Jae Kim. (2019) Water-Soluble Arginyl–Diosgenin Analog Attenuates Hippocampal Neurogenesis Impairment Through Blocking Microglial Activation Underlying NF-κB and JNK MAPK Signaling in Adult Mice Challenged by LPS. Molecular Neurobiology 56:9, pages 6218-6238.
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Liu He, Yuqi Jiang, Kai Liu, Victoria Gomez-Murcia, Xiaopin Ma, Alejandro Torrecillas, Qun Chen, Xiongwei Zhu, Edward Lesnefsky, Juan C. Gomez-Fernandez, Bin Xu & Shijun Zhang. (2018) Insights into the Impact of a Membrane-Anchoring Moiety on the Biological Activities of Bivalent Compounds As Potential Neuroprotectants for Alzheimer’s Disease. Journal of Medicinal Chemistry 61:3, pages 777-790.
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Laurent Lecanu & Vassilios Papadopoulos. (2013) Modeling Alzheimer's disease with non-transgenic rat models. Alzheimer's Research & Therapy 5:3.
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Yan Sai, Zhongmin Zou, Kaige Peng & Zhaojun Dong. (2012) The Parkinson's disease-related genes act in mitochondrial homeostasis. Neuroscience & Biobehavioral Reviews 36:9, pages 2034-2043.
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V. Papadopoulos & L. Lecanu. (2012) Caprospinol: Discovery of a Steroid Drug Candidate to Treat Alzheimer’s Disease Based on 22R-Hydroxycholesterol Structure and Properties. Journal of Neuroendocrinology 24:1, pages 93-101.
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Laurent Tillement, Laurent Lecanu & Vassilios Papadopoulos. (2011) Further Evidence on Mitochondrial Targeting of β-Amyloid and Specificity of β-Amyloid-Induced Mitotoxicity in Neurons. Neurodegenerative Diseases 8:5, pages 331-344.
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Laurent Tillement, Laurent Lecanu & Vassilios Papadopoulos. (2011) Alzheimer's disease: Effects of β-amyloid on mitochondria. Mitochondrion 11:1, pages 13-21.
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