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Drug Evaluations

Copper chelation in cancer therapy using tetrathiomolybdate: an evolving paradigm

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Pages 541-548 | Published online: 01 Apr 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Qian Xue, Rui Kang, Daniel J. Klionsky, Daolin Tang, Jinbao Liu & Xin Chen. (2023) Copper metabolism in cell death and autophagy. Autophagy 19:8, pages 2175-2195.
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Jiansong Qi, Yanhong Xing, Yucheng Liu, Meng-Meng Wang, Xiangqing Wei, Zhongheng Sui, Lin Ding, Yang Zhang, Chen Lu, Yuan-Hui Fei, Nan Liu, Rong Chen, Mengmei Wu, Lijuan Wang, Zhenyu Zhong, Ting Wang, Yifan Liu, Yuqing Wang, Jiamei Liu, Haoxing Xu, Feng Guo & Wuyang Wang. (2021) MCOLN1/TRPML1 finely controls oncogenic autophagy in cancer by mediating zinc influx. Autophagy 17:12, pages 4401-4422.
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Douglas W Sborov, Bradley M Haverkos & Pamela J Harris. (2015) Investigational cancer drugs targeting cell metabolism in clinical development. Expert Opinion on Investigational Drugs 24:1, pages 79-94.
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Niall Kenneth, George Hucks, Andrew Kocab, Annie McCollom & Colin Duckett. (2014) Copper is a potent inhibitor of both the canonical and non-canonical NFκB pathways. Cell Cycle 13:6, pages 1006-1014.
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Jarmila Navrátilová, Tereza Hankeová, Petr Beneš & Jan Šmarda. (2013) Low-Glucose Conditions of Tumor Microenvironment Enhance Cytotoxicity of Tetrathiomolybdate to Neuroblastoma Cells. Nutrition and Cancer 65:5, pages 702-710.
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Michelle L. Turski, Donita C. Brady, Hyung J. Kim, Byung-Eun Kim, Yasuhiro Nose, Christopher M. Counter, Dennis R. Winge & Dennis J. Thiele. (2012) A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling. Molecular and Cellular Biology 32:7, pages 1284-1295.
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Richard H Gomer & Mark L Lupher$suffix/text()$suffix/text(). (2010) Investigational approaches to therapies for idiopathic pulmonary fibrosis. Expert Opinion on Investigational Drugs 19:6, pages 737-745.
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Articles from other publishers (46)

Dengyuan Hao, Qian Meng, Chaonan Li, Shaojin Lu, Xiujuan Xiang, Qing Pei, Xiabin Jing & Zhigang Xie. (2023) A Paclitaxel Prodrug with Copper Depletion for Combined Therapy toward Triple-Negative Breast Cancer. ACS Nano 17:13, pages 12383-12393.
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Li Nan, Wan Yuan, Chen Guodong & Huang Yonghui. (2023) Multitargeting Strategy Using Tetrathiomolybdate and Lenvatinib: Maximizing Antiangiogenesis Activity in a Preclinical Liver Cancer Model. Anti-Cancer Agents in Medicinal Chemistry 23:7, pages 786-793.
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Zhiliang Xiao, Menglei Zhang, Zhenduo Shi, Guanghui Zang, Qing Liang, Lin Hao, Yang Dong, Kun Pang, Yabin Wang & Conghui Han. (2023) Prediction of the Prognosis of Clear Cell Renal Cell Carcinoma by Cuproptosis-Related lncRNA Signals Based on Machine Learning and Construction of ceRNA Network. Journal of Oncology 2023, pages 1-19.
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Ashwin Ambi, Aleksandra Stanisavljevic, Tiffany W. Victor, Adam W. Lowery, Judianne Davis, William E. Van Nostrand & Lisa M. Miller. (2023) Evaluation of Copper Chelation Therapy in a Transgenic Rat Model of Cerebral Amyloid Angiopathy. ACS Chemical Neuroscience 14:3, pages 378-388.
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Irena Kostova. (2023) The Role of Complexes of Biogenic Metals in Living Organisms. Inorganics 11:2, pages 56.
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Ni Zeng, Ye Wang, Yuan Wan, Hongyu Wang & Nan Li. (2023) The Antitumor Impact of Combining Hepatic Artery Ligation With Copper Chelators for Liver Cancer. Clinical Medicine Insights: Oncology 17.
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. (2022) Characterization of metal (Mg, Ni & Zn) complexes with β-sitosterol for antimicrobial studies. Biomedical Letters 8:2, pages 84-95.
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Agnieszka Dawczak-Dębicka, Joanna Kufel-Grabowska, Mikołaj Bartoszkiewicz, Adrian Perdyan & Jacek Jassem. (2022) Complementary and Alternative Therapies in Oncology. International Journal of Environmental Research and Public Health 19:9, pages 5071.
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Justin J. O'Sullivan, Valentina Medici & Marie C. Heffern. (2022) A caged imidazopyrazinone for selective bioluminescence detection of labile extracellular copper( ii ) . Chemical Science 13:15, pages 4352-4363.
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Nahid Shahabadi, Farshad Shiri & Reza Khodarahmi. (2022) A Cu(I) complex groove binder with a high affinity towards DNA denaturation. Journal of Molecular Liquids 345, pages 117904.
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Hao Li, Wei Zhou, Huiping Wei, Longlong Li, Xu Wang, Yongli Li, Shaoshan Li & Changzheng Li. (2021) Ferritinophagic Flux Was a Driving Force in Determination of Status of EMT, Ferroptosis, and NDRG1 Activation in Action of Mechanism of 2-Pyridylhydrazone Dithiocarbamate S-Acetic Acid. Journal of Oncology 2021, pages 1-12.
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Shariq Yousuf, Farukh Arjmand & Sartaj Tabassum. (2021) Design, synthesis, ligand’s scaffold variation and structure elucidation of Cu(II) complexes; In vitro DNA binding, morphological studies and their anticancer activity. Polyhedron 209, pages 115450.
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Longlong Li, Hao Li, Yongli Li, Jiankang Feng, Deng Guan, Yalei Zhang, Yun Fu, Shaoshan Li & Changzheng Li. (2021) Ferritinophagy-Mediated ROS Production Contributed to Proliferation Inhibition, Apoptosis, and Ferroptosis Induction in Action of Mechanism of 2-Pyridylhydrazone Dithiocarbamate Acetate. Oxidative Medicine and Cellular Longevity 2021, pages 1-17.
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Melissa Y. Lucero, Yuqi Tang, Chloe J. Zhang, Shengzhang Su, Joseph A. Forzano, Valeria Garcia, Xin Huang, David Moreno & Jefferson Chan. (2021) Activity-based photoacoustic probe for biopsy-free assessment of copper in murine models of Wilson’s disease and liver metastasis. Proceedings of the National Academy of Sciences 118:36.
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Salah S. Massoud, Febee R. Louka, Madison T. Dial, Andrew J. Malek, Roland C. Fischer, Franz A. Mautner, Ján Vančo, Tomáš Malina, Zdeněk Dvořák & Zdeněk Trávníček. (2021) Identification of potent anticancer copper( ii ) complexes containing tripodal bis[2-ethyl-di(3,5-dialkyl-1 H -pyrazol-1-yl)]amine moiety . Dalton Transactions 50:33, pages 11521-11534.
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Nahid Shahabadi, Farshad Shiri, Saba Hadidi, Kaveh Farshadfar, Maryam Darbemamieh & S. Mark Roe. (2021) The role of both intercalation and groove binding at AT-rich DNA regions in the interaction process of a dinuclear Cu(I) complex probed by spectroscopic and simulation analysis. Journal of Molecular Liquids 335, pages 116290.
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Tiziano Marzo & Diego La Mendola. (2021) The Effects on Angiogenesis of Relevant Inorganic Chemotherapeutics. Current Topics in Medicinal Chemistry 21:1, pages 73-86.
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Silvia Baldari, Giuliana Di Rocco, Marie C. Heffern, Timothy A. Su, Christopher J. Chang & Gabriele Toietta. (2019) Effects of Copper Chelation on BRAFV600E Positive Colon Carcinoma Cells. Cancers 11:5, pages 659.
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Dong Li, Jun Wang & Jinnan Gao. (2019) Primary breast cancer in a patient with Wilson disease. Medicine 98:19, pages e15266.
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Ze Yu, Rongtao Zhou, Yicheng Zhao, Yi Pan, Hao Liang, Jin‐San Zhang, Sheng Tai, Liang Jin & Chun‐Bo Teng. (2019) Blockage of SLC31A1‐dependent copper absorption increases pancreatic cancer cell autophagy to resist cell death. Cell Proliferation 52:2.
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Tingting Wang, Youxun Liu, Yun Fu, Tengfei Huang, Yun Yang, Shaoshan Li & Changzheng Li. (2017) Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy. International Journal of Oncology 51:6, pages 1909-1919.
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