Advanced search
Publication Cover
Expert Opinion on Investigational Drugs Volume 18, 2009 - Issue 10
Submit an article Journal homepage
1,724
Views
107
CrossRef citations to date
0
Altmetric
Drug Evaluations

VEGF Trap-Eye for the treatment of neovascular age-related macular degeneration

James A Dixon University of Colorado Denver, Rocky Mountain Lions Eye Institute, Department of Ophthalmology, 1675 North Aurora Court, PO Box 6510, Mail Stop F-731, Aurora, CO 80045-2500, USA +1 720 848 5029; +1 720 848 5014; [email protected]
, MD,
Scott CN Oliver University of Colorado Denver, Rocky Mountain Lions Eye Institute, Department of Ophthalmology, 1675 North Aurora Court, PO Box 6510, Mail Stop F-731, Aurora, CO 80045-2500, USA +1 720 848 5029; +1 720 848 5014; [email protected]
, MD,
Jeffrey L Olson University of Colorado Denver, Rocky Mountain Lions Eye Institute, Department of Ophthalmology, 1675 North Aurora Court, PO Box 6510, Mail Stop F-731, Aurora, CO 80045-2500, USA +1 720 848 5029; +1 720 848 5014; [email protected]
, MD &
Naresh Mandava University of Colorado Denver, Rocky Mountain Lions Eye Institute, Department of Ophthalmology, 1675 North Aurora Court, PO Box 6510, Mail Stop F-731, Aurora, CO 80045-2500, USA +1 720 848 5029; +1 720 848 5014; [email protected]
, MD
Pages 1573-1580 | Published online: 20 Aug 2009

Citations (107)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (16)

Paul T. Williams. (2021) Quantile-specific heritability of serum growth factor concentrations. Growth Factors 39:1-6, pages 45-58.
Read now
Pingting Zhong, Miao He, Honghua Yu, Qiaowei Wu, Qingsheng Peng, Manqing Huang, Yunlian Xue & Xiaohong Yang. (2020) A Meta-Analysis of Cardiovascular Events Associated with Intravitreal Anti-VEGF Treatment in Patients with Retinal Vein Occlusion. Current Eye Research 45:5, pages 615-622.
Read now
Ciro Costagliola, Francesco Morescalchi, Sarah Duse, Davide Romano, Giuseppina Mazza, Francesco Parmeggiani, Silvia Bartollino & Francesco Semeraro. (2019) Systemic thromboembolic adverse events in patients treated with intravitreal anti-VEGF drugs for neovascular age-related macular degeneration: an update. Expert Opinion on Drug Safety 18:9, pages 803-815.
Read now
Olivia Cundy, Mital Shah & Susan M. Downes. (2018) Intravitreal aflibercept: its role in treatment of neovascular age-related macular degeneration. Expert Review of Ophthalmology 13:2, pages 75-86.
Read now
Chandrakumar Balaratnasingam, Elona Dhrami-Gavazi, Jesse T McCann, Quraish Ghadiali & K Bailey Freund. (2015) Aflibercept: a review of its use in the treatment of choroidal neovascularization due to age-related macular degeneration. Clinical Ophthalmology 9, pages 2355-2371.
Read now
Andrew A Chang, Thomas Hong, Shaun Y Ewe, Bobak Bahrami & Geoffrey K Broadhead. (2015) The role of aflibercept in the management of diabetic macular edema. Drug Design, Development and Therapy 9, pages 4389-4396.
Read now
Michael John Tolentino, Abrahan Dennrick, Elizabeth John & Michael Steven Tolentino. (2015) Drugs in Phase II clinical trials for the treatment of age-related macular degeneration. Expert Opinion on Investigational Drugs 24:2, pages 183-199.
Read now
Dongqing Yuan, Hong Shen, Songtao Yuan, Xiaoyi Liu, Xin Xia, Ping Xie, Weiguang Li, Jialiang Hu, Qinghuai Liu & Hanmei Xu. (2014) Pharmacokinetics of HM-3 After Intravitreal Administration in Mice. Current Eye Research 39:8, pages 837-844.
Read now
F Semeraro, F Morescalchi, S Duse, F Parmeggiani, E Gambicorti & C Costagliola. (2013) Aflibercept in wet AMD: specific role and optimal use. Drug Design, Development and Therapy 7, pages 711-722.
Read now
Michael W Stewart. (2013) Aflibercept (VEGF Trap-Eye) for the treatment of exudative age-related macular degeneration. Expert Review of Clinical Pharmacology 6:2, pages 103-113.
Read now
Michael W Stewart. (2012) Clinical and differential utility of VEGF inhibitors in wet age-related macular degeneration: focus on aflibercept. Clinical Ophthalmology 6, pages 1175-1186.
Read now
Palanisamy Kanakaraj, Bridget A. Puffer, Xiao-Tao Yao, Spandana Kankanala, Ernest Boyd, Rutul R. Shah, Geping Wang, Dimki Patel, Rajesh Krishnamurthy, Shashi Kaithamana, Rodger G. Smith, David W. LaFleur, Carlos F. Barbas III, David M. Hilbert, Peter A. Kiener & Viktor V. Roschke. (2012) Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis. mAbs 4:5, pages 600-613.
Read now
Matthew Ohr & Peter K Kaiser. (2012) Intravitreal aflibercept injection for neovascular (wet) age-related macular degeneration. Expert Opinion on Pharmacotherapy 13:4, pages 585-591.
Read now
Pearse A Keane & Srinivas R Sadda. (2011) Retinal vein occlusion and macular edema – critical evaluation of the clinical value of ranibizumab. Clinical Ophthalmology 5, pages 771-781.
Read now
Preeti R Poley, William M Stapleton, Fang Qui, Michael L Mulhern, David D Ingvoldstad & Eyal Margalit. (2011) Age-related macular degeneration: review of current treatments. Expert Review of Ophthalmology 6:2, pages 195-201.
Read now
Nupura S Bhise, Ron B Shmueli, Joel C Sunshine, Stephany Y Tzeng & Jordan J Green. (2011) Drug delivery strategies for therapeutic angiogenesis and antiangiogenesis. Expert Opinion on Drug Delivery 8:4, pages 485-504.
Read now

Articles from other publishers (91)

Hisashi Matsubara, Ryunosuke Nagashima, Shinichiro Chujo, Yoshitsugu Matsui, Kumiko Kato, Manami Kuze & Mineo Kondo. (2023) Subclinical Ocular Changes after Intravitreal Injections of Different Anti-VEGF Agents for Neovascular Age-Related Macular Degeneration. Journal of Clinical Medicine 12:23, pages 7401.
Crossref
Amirfarbod Yazdanyar, Charles L. Cai, Jacob V. Aranda, Eric Shrier & Kay D. Beharry. (2023) Comparison of Bevacizumab and Aflibercept for Suppression of Angiogenesis in Human Retinal Microvascular Endothelial Cells. Pharmaceuticals 16:7, pages 939.
Crossref
Nguyễn Thị Thanh Nhàn, Daniel E. Maidana & Kaori H. Yamada. (2023) Ocular Delivery of Therapeutic Agents by Cell-Penetrating Peptides. Cells 12:7, pages 1071.
Crossref
Zasim Azhar SiddiquiTrupti DhumalJay PatelTraci LeMastersArghavan AlmonyKhalid M Kamal. (2022) Cost impact of different treatment regimens of brolucizumab in neovascular age-related macular degeneration: A budget impact analysis. Journal of Managed Care & Specialty Pharmacy 28:12, pages 1350-1364.
Crossref
Yun Yuan, Wen Kong, Xiao-Mei Liu & Guo-Hua Shi. (2022) A Hypoxia-Regulated Retinal Pigment Epithelium-Specific Gene Therapy Vector Reduces Choroidal Neovascularization in a Mouse Model. Current Gene Therapy 22:5, pages 417-426.
Crossref
Mahima Mahima, Tarique Mahmood, Akash Ved, Mohammed Haris Siddiqui, Farogh Ahsan, Arshiya Shamim, Vaseem Ahamad Ansari, Afroz Ahmad & Monu Kumar Kashyap. (2022) An in-Depth Analysis of Ovarian Cancer: Pathogenesis and Clinical Manifestation. Drug Research 72:08, pages 424-434.
Crossref
Anthony A. JonesJoshua L. Morgenstern, Divneet MandairMichelle G. Pedler & Jeffrey L. Olson. (2022) EFFICACY OF INTRAVITREAL AFLIBERCEPT INJECTIONS IN THE TREATMENT OF IDIOPATHIC RETINAL VASCULITIS, ANEURYSMS, AND NEURORETINITIS SYNDROME. RETINAL Cases & Brief Reports 16:4, pages 515-519.
Crossref
Ana Rita Fernandes, Aleksandra Zielińska, Elena Sanchez-Lopez, Tiago dos Santos, Maria Luisa Garcia, Amelia M. Silva, Jacek Karczewski & Eliana B. Souto. (2022) Exudative versus Nonexudative Age-Related Macular Degeneration: Physiopathology and Treatment Options. International Journal of Molecular Sciences 23:5, pages 2592.
Crossref
Shinsuke Nakamura & Hideaki Hara. (2021) Prospects and Challenges of Anti-VEGF Drug Treatment for Pathological Angiogenesis of the Retina網膜の病的血管新生に対する抗VEGF薬治療の展望と課題. YAKUGAKU ZASSHI 141:12, pages 1307-1317.
Crossref
Maitri Bhatt & Pravin Shende. (2021) Modulated approaches for strategic transportation of proteins and peptides via ocular route. Journal of Drug Delivery Science and Technology 66, pages 102835.
Crossref
Paula W. Feng, James Lin, Yoichi Sakurada, Nicolas A. Yannuzzi, William E. Smiddy, Priyanka Chilakamarri, Nitish Mehta, Yasha S. Modi & Ravi Parikh. (2020) Cost and Outcomes Analysis of Polypoidal Choroidal Vasculopathy (Aneurysmal Type 1 Neovascularization) Treatment Strategies. Journal of VitreoRetinal Diseases 5:3, pages 227-231.
Crossref
Ariel Gore, Tamar Kadar, Shlomit Dachir & Vered Horwitz. (2021) Therapeutic measures for sulfur mustard-induced ocular injury. Toxicology Letters 340, pages 58-66.
Crossref
M. Prieto-del-Cura, I. Villafruela-Güemes, E. Recio-Gamo, M. Sastre-Ibañez & M.-E. Fuentes-Ferrer. (2020) Predictors of good visual outcomes in patients with neovascular age-related macular degeneration in daily practice. Journal Français d'Ophtalmologie 43:10, pages 989-995.
Crossref
Rakeeb Kureshi, Angela Zhu, Jikui Shen, Stephany Y. Tzeng, Leilani R. Astrab, Paul R. Sargunas, Jordan J. Green, Peter A. Campochiaro & Jamie B. Spangler. (2020) Structure-Guided Molecular Engineering of a Vascular Endothelial Growth Factor Antagonist to Treat Retinal Diseases. Cellular and Molecular Bioengineering 13:5, pages 405-418.
Crossref
Nazanin Ebrahimiadib, Alireza Lashay, Hamid Riazi-Esfahani, Sepideh Jamali, Alireza Khodabandeh, Mohammad Zarei, Ramak Roohipoor, Hassan Khojasteh, Fatemeh Bazvand, Mina Ojani, Mojtaba Shahabinejad, Mehdi Yaseri, Bobeck S. Modjtahedi, Samaneh Davoudi & Mohammad Riazi-Esfahani. (2020) Intravitreal Ziv-Aflibercept in Patients With Diabetic Macular Edema Refractory to Intravitreal Bevacizumab. Ophthalmic Surgery, Lasers and Imaging Retina 51:3, pages 145-151.
Crossref
Cemile Ucgul Atilgan, Pinar Kosekahya, Dilara Ozkoyuncu Kocabas, Mustafa Koc & Yasin Sakir Goker. (2020) Densitometric analysis of cornea in patients with neovascular age-related macular degeneration after intravitreal aflibercept loading dose. Therapeutic Advances in Ophthalmology 12, pages 251584142095085.
Crossref
Jing Jiang, Ling Wang, Xiangying Kou, Zhihao Liu, Min Huang, Hongzhen Li & Chuandong Wu. (2020) In vivo characterization of RC28-E, a fusion protein targeting VEGF and bFGF: Pharmacokinetics and ocular distribution in primates. Experimental Eye Research 190, pages 107823.
Crossref
Guillermo Salcedo-Villanueva, Estephania Feria-Anzaldo, Juan C. Romo-Aguas, Andrés Lisker-Cervantes, Alejandra González-Dibildox, Edel Moreno-Paramo, Abraham A. Medina-Andrade, Raúl Velez-Montoya, Gerardo García-Aguirre, Virgilio Morales-Cantón & Hugo Quiroz-Mercado. (2018) Anti-VEGF treatment switch in neovascular age-related macular degeneration: a comparison of aflibercept versus ranibizumab after a single-dose switch. International Ophthalmology 39:9, pages 2023-2031.
Crossref
Philip P. Storey & Julia A. Haller. 2019. Handbook of Nutrition, Diet, and the Eye. Handbook of Nutrition, Diet, and the Eye 31 46 .
Masakazu Morioka, Yoshihiro Takamura, Yutaka Yamada, Takehiro Matsumura, Makoto Gozawa & Masaru Inatani. (2018) Flare levels after intravitreal injection of ranibizumab, aflibercept, or triamcinolone acetonide for diabetic macular edema. Graefe's Archive for Clinical and Experimental Ophthalmology 256:12, pages 2301-2307.
Crossref
Luca Di Antonio, Lisa Toto, Alessandra Mastropasqua, Lorenza Brescia, Emanuele Erroi, Alessia Lamolinara, Marta Di Nicola & Leonardo Mastropasqua. (2018) Retinal vascular changes and aqueous humor cytokines changes after aflibercept intravitreal injection in treatment-naïve myopic choroidal neovascularization. Scientific Reports 8:1.
Crossref
Ariel Gore, Vered Horwitz, Maayan Cohen, Hila Gutman, Liat Cohen, Rellie Gez, Tamar Kadar & Shlomit Dachir. (2018) Successful single treatment with ziv-aflibercept for existing corneal neovascularization following ocular chemical insult in the rabbit model. Experimental Eye Research 171, pages 183-191.
Crossref
Mohammad Hossein Jabbarpoor Bonyadi, Ahmadreza Baghi, Alireza Ramezani, Mehdi Yaseri & Masoud Soheilian. (2018) One-Year Results of a Trial Comparing 2 Doses of Intravitreal Ziv-aflibercept versus Bevacizumab for Treatment of Diabetic Macular Edema. Ophthalmology Retina 2:5, pages 428-440.
Crossref
Niko Kivinen. (2018) The role of autophagy in age-related macular degeneration. Acta Ophthalmologica 96, pages 1-50.
Crossref
Irene Bravo-Osuna, Vanessa Andrés-Guerrero, Alicia Arranz-Romera, Sergio Esteban-Pérez, Irene T. Molina-Martínez & Rocío Herrero-Vanrell. (2018) Microspheres as intraocular therapeutic tools in chronic diseases of the optic nerve and retina. Advanced Drug Delivery Reviews 126, pages 127-144.
Crossref
José Carlos Rivera, Elsa Duchemin-Kermorvant, Allison Dorfman, Tianwei Ellen Zhou, Luis H. Ospina & Sylvain Chemtob. 2018. Neonatology. Neonatology 2349 2386 .
José Carlos Rivera, Elsa Duchemin-Kermorvant, Allison Dorfman, Tianwei Ellen Zhou, Luis H. Ospina & Sylvain Chemtob. 2018. Neonatology. Neonatology 1 39 .
Masayuki Hata, Kenji Yamashiro, Akio Oishi, Sotaro Ooto, Hiroshi Tamura, Manabu Miyata, Naoko Ueda-Arakawa, Yoshimasa Kuroda, Ayako Takahashi, Akitaka TsujikawaNagahisa Yoshimura. (2017) RETINAL PIGMENT EPITHELIAL ATROPHY AFTER ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTIONS FOR RETINAL ANGIOMATOUS PROLIFERATION. Retina 37:11, pages 2069-2077.
Crossref
Melissa K. Jones, Bin Lu, Sergey Girman & Shaomei Wang. (2017) Cell-based therapeutic strategies for replacement and preservation in retinal degenerative diseases. Progress in Retinal and Eye Research 58, pages 1-27.
Crossref
Eva M. del Amo, Anna-Kaisa Rimpelä, Emma Heikkinen, Otto K. Kari, Eva Ramsay, Tatu Lajunen, Mechthild Schmitt, Laura Pelkonen, Madhushree Bhattacharya, Dominique Richardson, Astrid Subrizi, Tiina Turunen, Mika Reinisalo, Jaakko Itkonen, Elisa Toropainen, Marco Casteleijn, Heidi Kidron, Maxim Antopolsky, Kati-Sisko Vellonen, Marika Ruponen & Arto Urtti. (2017) Pharmacokinetic aspects of retinal drug delivery. Progress in Retinal and Eye Research 57, pages 134-185.
Crossref
Ahmadreza Baghi, Mohammad Hossein Jabbarpoor Bonyadi, Alireza Ramezani, Mohsen Azarmina, Siamak Moradian, Mohammad Hossein Dehghan, Ramin Nourinia, Gholam A. Peyman, Mehdi Yaseri & Masoud Soheilian. (2017) Two Doses of Intravitreal Ziv-Aflibercept versus Bevacizumab in Treatment of Diabetic Macular Edema: A Three-Armed, Double-Blind Randomized Trial. Ophthalmology Retina 1:2, pages 103-110.
Crossref
Divya Ail & Muriel Perron. (2017) Retinal Degeneration and Regeneration—Lessons From Fishes and Amphibians. Current Pathobiology Reports 5:1, pages 67-78.
Crossref
. (2017) The VEGF Treatment of AMD Switch Study (The vTAS Study). Asia-Pacific Journal of Ophthalmology.
Crossref
Michael W. StewartMichael W. Stewart. 2017. Diabetic Retinopathy. Diabetic Retinopathy 99 139 .
Orly Gal-Or, Eitan Livny, Ruti Sella, Yael Nisgav, Dov Weinberger, Tami Livnat & Irit Bahar. (2016) Efficacy of Subconjunctival Aflibercept Versus Bevacizumab for Prevention of Corneal Neovascularization in a Rat Model. Cornea 35:7, pages 991-996.
Crossref
Daniel W. DroletLouis S. GreenLarry GoldNebojsa Janjic. (2016) Fit for the Eye: Aptamers in Ocular Disorders. Nucleic Acid Therapeutics 26:3, pages 127-146.
Crossref
Ruti Sella, Orly Gal-Or, Eitan Livny, Mor Dachbash, Yael Nisgav, Dov Weinberger, Tami Livnat & Irit Bahar. (2016) Efficacy of topical aflibercept versus topical bevacizumab for the prevention of corneal neovascularization in a rat model. Experimental Eye Research 146, pages 224-232.
Crossref
Valentina Sarao, Mariacristina Parravano, Daniele Veritti, Luis Arias, Monica Varano & Paolo Lanzetta. (2016) INTRAVITREAL AFLIBERCEPT FOR CHOROIDAL NEOVASCULARIZATION DUE TO AGE-RELATED MACULAR DEGENERATION UNRESPONSIVE TO RANIBIZUMAB THERAPY. Retina 36:4, pages 770-777.
Crossref
Marialaura Amadio, Stefano Govoni & Alessia Pascale. (2016) Targeting VEGF in eye neovascularization: What's new?. Pharmacological Research 103, pages 253-269.
Crossref
José Carlos Rivera, Elsa Duchemin-Kermorvant, Allison Dorfman, Tianwei Ellen Zhou, Luis H. Ospina & Sylvain Chemtob. 2016. Neonatology. Neonatology 1 38 .
SD Finley, P Angelikopoulos, P Koumoutsakos & AS Popel. (2015) Pharmacokinetics of Anti‐VEGF Agent Aflibercept in Cancer Predicted by Data‐Driven, Molecular‐Detailed Model. CPT: Pharmacometrics & Systems Pharmacology 4:11, pages 641-649.
Crossref
L. Kodjikian, E. Fourmaux, F. Coscas, S. Dumas, C. Français, C. Morel, H. Oubraham & S. Razavi. (2015) Traitement de la dégénérescence maculaire liée à l’âge : avis d’experts et algorithme thérapeutique. Journal Français d'Ophtalmologie 38:7, pages 639-645.
Crossref
Leena-Stiina Kontturi, Estelle C. Collin, Lasse Murtomäki, Abhay S. Pandit, Marjo Yliperttula & Arto Urtti. (2015) Encapsulated cells for long-term secretion of soluble VEGF receptor 1: Material optimization and simulation of ocular drug response. European Journal of Pharmaceutics and Biopharmaceutics 95, pages 387-397.
Crossref
Jong Ha KimNam Chun ChoWoo Jin Kim. (2015) Intravitreal Aflibercept for Neovascular Age-Related Macular Degeneration Resistant to Bevacizumab and Ranibizumab. Journal of the Korean Ophthalmological Society 56:9, pages 1359.
Crossref
Yuichiro Ogura, Johann Roider, Jean-François Korobelnik, Frank G. Holz, Christian Simader, Ursula Schmidt-Erfurth, Robert Vitti, Alyson J. Berliner, Florian Hiemeyer, Brigitte Stemper, Oliver Zeitz, Rupert Sandbrink, Mark Gillies, Jennifer Arnold, Ian McAllister, Simon Chen, Paul Mitchell, Lyndell Lim, Ursula Schmidt-Erfurth, Ulrich Schoenherr, Siegfried Priglinger, Jean-François Korobelnik, François Devin, Michel Paques, Gabriel Quentel, Michel Weber, Catherine Creuzot-Garcher, Frank Holz, Sabine Aisenbrey, Lutz Lothar Hansen, Johann Roider, Peter Wiedemann, Chris Patrick Lohmann, Norbert Pfeiffer, Stefan Dithmar, Dirk Sandner, Bernd Kirchhof, Helmut Sachs, Salvatore Grisanti, Nicolas Feltgen, Karl Heinz Emmerich, Lars-Olaf Hattenbach, Peter Walter, Katrin Engelmann, Norbert Bornfeld, Andreea Gamulescu, Gisbert Richard, Berthold Seitz, Stefan Mennel, Daniel Pauleikhoff, Frank Koch, András Papp, József Ferenc Györy, Ágnes Kerényi, András Seres, András Berta, Lajos Szalczer, Francesco Boscia, Alfonso Giovannini, Ugo Menchini, Frederico Ricci, Monica Varanno, Francesco Viola, Rosangela Lattanzio, Alfredo Reibaldi, Frederico Grignolo, Yuichiro Ogura, Miki Honda, Hiroko Terasaki, Nagahisa Yoshimura, Mitsuko Yuzawa, Motohiro Kamei, Ilze Zarinova, Guna Laganovska, Ranjana Mathur, Caroline Chee, Dong-Heun Nam, Se-Joon Woo, Young-Hee Yoon, Won-Ki Lee, Hyeong-Gon Yu & Hyoung-Jun Koh. (2014) Intravitreal Aflibercept for Macular Edema Secondary to Central Retinal Vein Occlusion: 18-Month Results of the Phase 3 GALILEO Study. American Journal of Ophthalmology 158:5, pages 1032-1038.e2.
Crossref
Bin Wu, Haixiang Wu, Xiaoyan Liu, Houwen Lin & Jin Li. (2014) Ranibizumab versus Bevacizumab for Ophthalmic Diseases Related to Neovascularisation: A Meta-Analysis of Randomised Controlled Trials. PLoS ONE 9:7, pages e101253.
Crossref
Florian M. Heussen, Qing Shao, Yanling Ouyang, Antonia M. Joussen & Bert Müller. (2013) Clinical outcomes after switching treatment from intravitreal ranibizumab to aflibercept in neovascular age-related macular degeneration. Graefe's Archive for Clinical and Experimental Ophthalmology 252:6, pages 909-915.
Crossref
Raul Velez-Montoya, Scott C. N. Oliver, Jeffrey L. Olson, Stuart L. Fine, Hugo Quiroz-Mercado & Naresh Mandava. (2014) CURRENT KNOWLEDGE AND TRENDS IN AGE-RELATED MACULAR DEGENERATION. Retina 34:3, pages 423-441.
Crossref
Angela L. Linderholm & Steven M. Chamow. 2014. Therapeutic Fc‐Fusion Proteins. Therapeutic Fc‐Fusion Proteins 311 350 .
P. Fernández-Robredo, A. Sancho, S. Johnen, S. Recalde, N. Gama, G. Thumann, J. Groll & A. García-Layana. (2014) Current Treatment Limitations in Age-Related Macular Degeneration and Future Approaches Based on Cell Therapy and Tissue Engineering. Journal of Ophthalmology 2014, pages 1-13.
Crossref
Philip Storey, Lisa Hark & Julia A. Haller. 2014. Handbook of Nutrition, Diet and the Eye. Handbook of Nutrition, Diet and the Eye 11 20 .
Michael W Stewart. (2013) Aflibercept ophthalmic solution: drug development and clinical uses. Clinical Investigation 3:11, pages 1045-1056.
Crossref
Leisa L. Marshall & J. Michael Roach. (2013) Prevention and Treatment of Age-Related Macular Degeneration: An Update for Pharmacists. The Consultant Pharmacist 28:11, pages 723-737.
Crossref
Patricia A. Tang & Malcom J. Moore. (2013) Aflibercept in the treatment of patients with metastatic colorectal cancer: latest findings and interpretations. Therapeutic Advances in Gastroenterology 6:6, pages 459-473.
Crossref
Raul Velez-Montoya, Scott C. N. Oliver, Jeffrey L. Olson, Stuart L. Fine, Naresh Mandava & Hugo Quiroz-Mercado. (2013) CURRENT KNOWLEDGE AND TRENDS IN AGE-RELATED MACULAR DEGENERATION. Retina 33:8, pages 1487-1502.
Crossref
Lei-Lei Wang, Yue Sun, Kun Huang & Ling Zheng. (2013) Curcumin, a potential therapeutic candidate for retinal diseases. Molecular Nutrition & Food Research 57:9, pages 1557-1568.
Crossref
Ok Ran Shin & Yeong Hoon Kim. (2013) Age-related macular degeneration (AMD): Current concepts in pathogenesis and prospects for treatment. Tissue Engineering and Regenerative Medicine 10:4, pages 164-175.
Crossref
Lily K. Cheung & Angie Eaton. (2013) Age-Related Macular Degeneration. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 33:8, pages 838-855.
Crossref
Sven Schnichels, Ulrike Hagemann, Kai Januschowski, Johanna Hofmann, Karl-Ulrich Bartz-Schmidt, Peter Szurman, Martin S Spitzer & Sabine Aisenbrey. (2013) Comparative toxicity and proliferation testing of aflibercept, bevacizumab and ranibizumab on different ocular cells. British Journal of Ophthalmology 97:7, pages 917-923.
Crossref
Vincent Y. Ho, Steven Yeh, Timothy W. Olsen, Chris S. Bergstrom, Jiong Yan, Blaine E. Cribbs & G. Baker HubbardIIIIII. (2013) Short-Term Outcomes of Aflibercept for Neovascular Age-Related Macular Degeneration in Eyes Previously Treated With Other Vascular Endothelial Growth Factor Inhibitors. American Journal of Ophthalmology 156:1, pages 23-28.e2.
Crossref
Edith P. Mitchell. (2013) Targeted Therapy for Metastatic Colorectal Cancer: Role of Aflibercept. Clinical Colorectal Cancer 12:2, pages 73-85.
Crossref
Peter K. Kaiser. (2013) Emerging Therapies for Neovascular Age-Related Macular Degeneration. Ophthalmology 120:5, pages S11-S15.
Crossref
Michael W. Stewart. (2017) Review of Aflibercept for the Treatment of Neovascular Age-Related Macular Degeneration. Clinical Medicine Insights: Therapeutics 5, pages CMT.S8921.
Crossref
Liu Jian, Ye Panpan & Xu Wen. (2013) Current Choroidal Neovascularization Treatment. Ophthalmologica 230:2, pages 55-61.
Crossref
Gang Wu, Keqiang Han & Fenglin Lv. (2013) Use of fast conformational sampling to improve the characterization of VEGF A–peptide interactions. Journal of Theoretical Biology 317, pages 293-300.
Crossref
P. Mitchell & S. Foran. 2013. Age-related Macular Degeneration. Age-related Macular Degeneration 233 245 .
Jin-Hong Chang, Nitin K. Garg, Elisa Lunde, Kyu-Yeon Han, Sandeep Jain & Dimitri T. Azar. (2012) Corneal Neovascularization: An Anti-VEGF Therapy Review. Survey of Ophthalmology 57:5, pages 415-429.
Crossref
Isabel García Lozano, Santiago López García & Isabel Elosua de Juán. (2012) Actualización en el manejo de la degeneración macular asociada a la edad. Revista Española de Geriatría y Gerontología 47:5, pages 214-219.
Crossref
Umesh C.S. Yadav, Satish K. Srivastava & Kota V. Ramana. (2012) Prevention of VEGF-induced growth and tube formation in human retinal endothelial cells by aldose reductase inhibition. Journal of Diabetes and its Complications 26:5, pages 369-377.
Crossref
Andrew Gaya & Vivien Tse. (2012) A preclinical and clinical review of aflibercept for the management of cancer. Cancer Treatment Reviews 38:5, pages 484-493.
Crossref
Matthew Ohr & Peter K. Kaiser. (2012) Aflibercept in wet age-related macular degeneration: a perspective review. Therapeutic Advances in Chronic Disease 3:4, pages 153-161.
Crossref
Alan F. Cruess, Alan Berger, Kevin Colleaux, Mark Greve, Patricia Harvey, Peter J. Kertes, Thomas Sheidow, Eric Tourville, Geoff Williams & David Wong. (2012) Canadian expert consensus: optimal treatment of neovascular age-related macular degeneration. Canadian Journal of Ophthalmology 47:3, pages 227-235.
Crossref
Dieter Schwache & Gerhard Müller-Newen. (2012) Receptor fusion proteins for the inhibition of cytokines. European Journal of Cell Biology 91:6-7, pages 428-434.
Crossref
Laurence S Lim, Paul Mitchell, Johanna M Seddon, Frank G Holz & Tien Y Wong. (2012) Age-related macular degeneration. The Lancet 379:9827, pages 1728-1738.
Crossref
Daniele Veritti, Valentina Sarao & Paolo Lanzetta. (2012) Neovascular Age-Related Macular Degeneration. Ophthalmologica 227:s1, pages 11-20.
Crossref
Young Gun Park, Hyun Wook Rhu, Seungbum Kang & Young Jung Roh. (2012) New Approach of Anti-VEGF Agents for Age-Related Macular Degeneration. Journal of Ophthalmology 2012, pages 1-7.
Crossref
Pearse A. Keane & Srinivas R. Sadda. (2012) Development of Anti-VEGF Therapies for Intraocular Use: A Guide for Clinicians. Journal of Ophthalmology 2012, pages 1-13.
Crossref
Ilias Zampros, Anna Praidou, Periklis Brazitikos, Panagiotis Ekonomidis & Sofia Androudi. (2012) Antivascular Endothelial Growth Factor Agents for Neovascular Age-Related Macular Degeneration. Journal of Ophthalmology 2012, pages 1-12.
Crossref
Raafay Sophie, Abeer Akhtar, Yasir J. Sepah, Mohamed Ibrahim, Millena Bittencourt, Diana V. Do & Quan Dong Nguyen. (2012) Aflibercept: a Potent Vascular Endothelial Growth Factor Antagonist for Neovascular Age-Related Macular Degeneration and Other Retinal Vascular Diseases. Biologics in Therapy 2:1.
Crossref
Alexa Klettner & Johann Roider. 2012. Studies on Retinal and Choroidal Disorders. Studies on Retinal and Choroidal Disorders 277 305 .
Stephanie DebetteSophie Visvikis-SiestMing-Huen ChenNdeye-Coumba NdiayeCi SongAnita DestefanoRadwan SafaMohsen Azimi NezhadDouglas SawyerJean-Brice MarteauVanessa XanthakisGerard SiestLisa SullivanMichele PfisterHolly SmithSeung-Hoan ChoiJohn LamontLars LindQiong YangPeter FitzgeraldErik IngelssonRamachandran S. VasanSudha Seshadri. (2011) Identification of cis - and trans -Acting Genetic Variants Explaining Up to Half the Variation in Circulating Vascular Endothelial Growth Factor Levels . Circulation Research 109:5, pages 554-563.
Crossref
Johannes Steinberg, Stefanie Uibel, Thomas Berndt, Daniel Müller, David Quarcoo & David A. Groneberg. (2014) Die altersabhängige Makuladegeneration — eine ÜbersichtAge-related macular degeneration. Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie 61:8, pages 270-286.
Crossref
Hu Huang, Jikui Shen & Stanley A. Vinores. (2011) Blockade of VEGFR1 and 2 Suppresses Pathological Angiogenesis and Vascular Leakage in the Eye. PLoS ONE 6:6, pages e21411.
Crossref
Raymond M. Schiffelers, Tjitske K. van der Vaart & Gert Storm. (2011) Neovascular Age-Related Macular Degeneration. BioDrugs 25:3, pages 171-189.
Crossref
Jeffrey S. Heier, David Boyer, Quan Dong Nguyen, Dennis Marcus, Daniel B. Roth, George Yancopoulos, Neil Stahl, Avner Ingerman, Robert Vitti, Alyson J. Berliner, Ke Yang & David M. Brown. (2011) The 1-year Results of CLEAR-IT 2, a Phase 2 Study of Vascular Endothelial Growth Factor Trap-Eye Dosed As-needed After 12-week Fixed Dosing. Ophthalmology 118:6, pages 1098-1106.
Crossref
David M. Brown, Jeffrey S. Heier, Thomas Ciulla, Matthew Benz, Prema Abraham, George Yancopoulos, Neil Stahl, Avner Ingerman, Robert Vitti, Alyson J. Berliner, Ke Yang & Quan Dong Nguyen. (2011) Primary Endpoint Results of a Phase II Study of Vascular Endothelial Growth Factor Trap-Eye in Wet Age-related Macular Degeneration. Ophthalmology 118:6, pages 1089-1097.
Crossref
I-Liang Lee, Pei-Shan Li, Wei-Lin Yu & Hsin-Hsin Shen. (2011) Prokaryotic expression, refolding, and purification of functional human vascular endothelial growth factor isoform 165: Purification procedures and refolding conditions revisited. Protein Expression and Purification 76:1, pages 54-58.
Crossref
Simin F. Rymo, Holger Gerhardt, Fredrik Wolfhagen Sand, Richard Lang, Anne Uv & Christer Betsholtz. (2011) A Two-Way Communication between Microglial Cells and Angiogenic Sprouts Regulates Angiogenesis in Aortic Ring Cultures. PLoS ONE 6:1, pages e15846.
Crossref
Frank G. Holz, Daniel Pauleikhoff, Richard F. Spaide & Alan C. BirdPaul Mitchell & S. Foran. 2011. Altersabhängige Makuladegeneration. Altersabhängige Makuladegeneration 237 251 .
Dong Hyun Jo, Jin Hyoung Kim & Jeong Hun Kim. (2010) How to overcome retinal neuropathy: The fight against angiogenesisrelated blindness. Archives of Pharmacal Research 33:10, pages 1557-1565.
Crossref
Shaker A. Mousa & Shaymaa S. Mousa. (2010) Current Status of Vascular Endothelial Growth Factor Inhibition in Age-Related Macular Degeneration. BioDrugs 24:3, pages 183-194.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.