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Drug Evaluations

Tagatose: from a sweetener to a new diabetic medication?

, DO & , MD
Pages 285-294 | Published online: 06 Jan 2010

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Read on this site (4)

Amar D. E. Van Laar, Charlotte Grootaert & John Van Camp. (2021) Rare mono- and disaccharides as healthy alternative for traditional sugars and sweeteners?. Critical Reviews in Food Science and Nutrition 61:5, pages 713-741.
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Konstantinos Kakleas, Foteini Christodouli & Kyriaki Karavanaki. (2020) Nonalcoholic fatty liver disease, insulin resistance, and sweeteners: a literature review. Expert Review of Endocrinology & Metabolism 15:2, pages 83-93.
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Muhammad Bilal, Hafiz M. N. Iqbal, Hongbo Hu, Wei Wang & Xuehong Zhang. (2018) Metabolic engineering pathways for rare sugars biosynthesis, physiological functionalities, and applications—a review. Critical Reviews in Food Science and Nutrition 58:16, pages 2768-2778.
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Jerry R Colca. (2013) Discontinued drugs in 2012: endocrine and metabolic. Expert Opinion on Investigational Drugs 22:10, pages 1305-1313.
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Articles from other publishers (40)

Peiyu Miao, Qiang Wang, Kexin Ren, Zigang Zhang, Tongtong Xu, Meijuan Xu, Xian Zhang & Zhiming Rao. (2023) Advances and Prospects of d-Tagatose Production Based on a Biocatalytic Isomerization Pathway. Catalysts 13:11, pages 1437.
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Eun Jung Jeon, Young-Mi Lee, Eun Jung Choi, Seong-Bo Kim & Ki Jun Jeong. (2023) Production of Tagatose by Whole-cell Bioconversion from Fructose Using Corynebacterium glutamicum. Biotechnology and Bioprocess Engineering 28:3, pages 419-427.
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Anurag Kumar, Jinglin Li, Sanath Kondaveeti, Bakul Singh, Ramasamy Shanmugam, Vipin Chandra Kalia, In-Won Kim & Jung-Kul Lee. (2022) Characterization of a xylitol dehydrogenase from Aspergillus flavus and its application in l-xylulose production. Frontiers in Bioengineering and Biotechnology 10.
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Melinda M. Moss, Erin N. Caswell, Andrew W. Yeargin, Nathan A. Volz, Jessica C. Woodland, Leah C. Guthrie, Gene J. Ahlborn, Dennis L. Eggett & Bradley J. Taylor. (2022) Optimization of flour-replacing ingredients for low-carbohydrate, gluten-free muffins via a mixture design with complete sucrose substitution by d-allulose or d-tagatose. LWT 167, pages 113779.
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Kyung-Chul Shin, Min-Ju Seo, Sang Jin Kim, Yeong-Su Kim & Chang-Su Park. (2022) Characterization of l-Arabinose Isomerase from Klebsiella pneumoniae and Its Application in the Production of d-Tagatose from d-Galactose. Applied Sciences 12:9, pages 4696.
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Xue-Yong Li, Meng-Qiu Xu, Hui Liu, Qiang Zhou, Jian Gao & Ye-Wang Zhang. (2021) Preparation of combined cross-linked enzyme aggregates containing galactitol dehydrogenase and NADH oxidase for l-tagatose synthesis via in situ cofactor regeneration. Bioprocess and Biosystems Engineering 45:2, pages 353-364.
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Amar van Laar, Charlotte Grootaert, Filip Van Nieuwerburgh, Dieter Deforce, Tom Desmet, Koen Beerens & John Van Camp. (2022) Metabolism and Health Effects of Rare Sugars in a CACO-2/HepG2 Coculture Model. Nutrients 14:3, pages 611.
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Amna Ahmed, Tauseef A Khan, D Dan Ramdath, Cyril W C Kendall & John L Sievenpiper. (2022) Rare sugars and their health effects in humans: a systematic review and narrative synthesis of the evidence from human trials. Nutrition Reviews 80:2, pages 255-270.
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Abdessalem Chahed, Andrea Nesler, Aziz Aziz, Essaid A. Barka, Ilaria Pertot & Michele Perazzolli. (2021) A review of knowledge on the mechanisms of action of the rare sugar d ‐tagatose against phytopathogenic oomycetes . Plant Pathology 70:9, pages 1979-1986.
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Edita Voitechovič, Jonita Stankevičiūtė, Aušra Vektarienė, Gytis Vektaris, Regina Jančienė, Nomeda Kuisienė, Julija Razumienė & Rolandas Meškys. (2021) Bioamperometric Systems with Fructose Dehydrogenase From Gluconobacter japonicus for D‐Tagatose Monitoring . Electroanalysis 33:6, pages 1393-1397.
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Yuichiro Onishi, Yuya Furushiro, Shuji Adachi & Takashi Kobayashi. (2021) Isomerization and Epimerization of Galactose to Tagatose and Talose in a Phosphate Buffer Containing Organic Solvents under Subcritical Water Conditions. Industrial & Engineering Chemistry Research 60:14, pages 5084-5089.
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MacLean G. Kohlmeier, Ben A. Bailey-Elkin, Brian L. Mark & Ivan J. Oresnik. (2021) Characterization of the sorbitol dehydrogenase SmoS from Sinorhizobium meliloti 1021 . Acta Crystallographica Section D Structural Biology 77:3, pages 380-390.
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Kyung-Chul Shin, Tae-Eui Lee, Min-Ju Seo, Dae Wook Kim, Lin-Woo Kang & Deok-Kun Oh. (2020) Development of Tagaturonate 3-Epimerase into Tagatose 4-Epimerase with a Biocatalytic Route from Fructose to Tagatose. ACS Catalysis 10:20, pages 12212-12222.
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Fadia V. Cervantes, Sawssan Neifar, Zoran Merdzo, Javier Viña-Gonzalez, Lucia Fernandez-Arrojo, Antonio O. Ballesteros, Maria Fernandez-Lobato, Samir Bejar & Francisco J. Plou. (2020) A Three-Step Process for the Bioconversion of Whey Permeate into a Glucose-Free D-Tagatose Syrup. Catalysts 10:6, pages 647.
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Muhammad Bilal & Hafiz M.N. Iqbal. (2019) Sustainable bioconversion of food waste into high-value products by immobilized enzymes to meet bio-economy challenges and opportunities – A review. Food Research International 123, pages 226-240.
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Ochuko L. Erukainure, Chika I. Chukwuma & Md Shahidul Islam. (2019) Raffia palm (Raphia hookeri) wine: Qualitative sugar profile, functional chemistry, and antidiabetic properties. Food Bioscience 30, pages 100423.
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Yanyi Xu, Wanjun Wang, Ji Zhou, Minjie Chen, Xingke Huang, Yaning Zhu, Xiaoyun Xie, Weihua Li, Yuhao Zhang, Haidong Kan & Zhekang Ying. (2019) Metabolomics analysis of a mouse model for chronic exposure to ambient PM2.5. Environmental Pollution 247, pages 953-963.
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Sara Ali, Rania El Gedaily, Andrei Mocan, Mohamed Farag & Hesham El-Seedi. (2019) Profiling Metabolites and Biological Activities of Sugarcane (Saccharum officinarum Linn.) Juice and its Product Molasses via a Multiplex Metabolomics Approach. Molecules 24:5, pages 934.
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Tien-Kieu Nguyen, Moon-Gi Hong, Pahn-Shick Chang, Byung-Hoo Lee & Sang-Ho Yoo. (2018) Biochemical properties of L-arabinose isomerase from Clostridium hylemonae to produce D-tagatose as a functional sweetener. PLOS ONE 13:4, pages e0196099.
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Dhananjay Yadav, Suk-Jeong Kim, Myung Ae Bae, Jae-Ryong Kim & Kyung-Hyun Cho. (2018) The Ability of Different Ketohexoses to Alter Apo-A-I Structure and Function In Vitro and to Induce Hepatosteatosis, Oxidative Stress, and Impaired Plasma Lipid Profile in Hyperlipidemic Zebrafish. Oxidative Medicine and Cellular Longevity 2018, pages 1-12.
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Kyung-Chul Shin, Dong-Hyun Sim, Min-Ju Seo & Deok-Kun Oh. (2016) Increased Production of Food-Grade d -Tagatose from d -Galactose by Permeabilized and Immobilized Cells of Corynebacterium glutamicum , a GRAS Host, Expressing d -Galactose Isomerase from Geobacillus thermodenitrificans . Journal of Agricultural and Food Chemistry 64:43, pages 8146-8153.
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Liuqing Wen, Kenneth Huang, Yuan Zheng, Junqiang Fang, Shukkoor Muhammed Kondengaden & Peng George Wang. (2016) Two-step enzymatic synthesis of 6-deoxy-l-psicose. Tetrahedron Letters 57:34, pages 3819-3822.
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Ji Hoon Koh, Seung Hye Choi, Seung Won Park, Nag-Jin Choi, Younghoon Kim & Sae Hun Kim. (2013) Synbiotic impact of tagatose on viability of Lactobacillus rhamnosus strain GG mediated by the phosphotransferase system (PTS). Food Microbiology 36:1, pages 7-13.
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Jung Hyun Kwak, Min Sun Kim, Jin Hee Lee, Yoon Jung Yang, Ki Ho Lee, Oh Yoen Kim & Jong Ho Lee. (2013) Beneficial effect of tagatose consumption on postprandial hyperglycemia in Koreans: a double-blind crossover designed study. Food & Function 4:8, pages 1223.
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