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Targeting silibinin in the antiproliferative pathway

, PhD, , PhD, , PhD & , MD
Pages 243-255 | Published online: 05 Jan 2010

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Ngoc-Duy Pham, Thi-Huynh-Nga Nguyen, Ngoc-Bich-Dao Vu, Thi-Ngoc-Mai Tran, Bao-Ngoc Pham, Hoang-Sinh Le, Kim-Hai Vo, Xuan-Cuong Le, Le-Bao-Ha Tran & Minh-Hiep Nguyen. (2023) Comparison of the radioprotective effects of the liposomal forms of five natural radioprotectants in alleviating the adverse effects of ionising irradiation on human lymphocytes and skin cells in radiotherapy. Journal of Microencapsulation 40:8, pages 613-629.
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Meghanath B. Shete, Ashwini S. Deshpande & Pravin Shende. (2022) Silybin-based herbal nanocarriers: an advancement in anticancer therapy. Materials Technology 37:13, pages 2832-2852.
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Raffaele Addeo. (2021) Silibinin: A New Opportunity for the Treatment of Brain Metastasis from Lung Cancer. Journal of Experimental Pharmacology 13, pages 901-903.
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Articles from other publishers (50)

R.R. Popat & H.S. Chaudhari. 2023. Nanotechnology in Herbal Medicine. Nanotechnology in Herbal Medicine 405 423 .
Majid Dadmehr, Bahareh Sadat Yousefsani & Jalal Pourahmad. 2023. Phospholipases in Physiology and Pathology. Phospholipases in Physiology and Pathology 55 66 .
Arash Ramedani, Omid Sabzevari & Abdolreza Simchi. (2022) Hybrid ultrasound-activated nanoparticles based on graphene quantum dots for cancer treatment. International Journal of Pharmaceutics 629, pages 122373.
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Osama El-Garhy, Fathia A. Soudy, Yousef M. Alharbi, Fahad A. Alshanbari, Mona S. Almujaydil, Raghad M. Alhomaid, Omar A. Ahmed-Farid, Shereen A. Mohamed, Hoda A. S. El-Garhy, Hassan Barakat & Ayman G. EL Nagar. (2022) Dietary Supplementation of Silybum marianum Seeds Improved Growth Performance and Upregulated Associated Gene Expression of Muscovy Ducklings (Cairina moschata). Antioxidants 11:11, pages 2300.
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Rina Das, Dinesh Kumar Mehta & Meenakshi Dhanawat. (2022) Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor- Kappa B (NF-kB) Inhibitors. Mini-Reviews in Medicinal Chemistry 22:15, pages 1938-1962.
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Flavia Fulvio, Tommaso Martinelli & Roberta Paris. (2021) Selection and validation of reference genes for RT-qPCR normalization in different tissues of milk thistle (Silybum marianum, Gaert.). Gene 768, pages 145272.
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M. Habán, D. Zvercová & M. Adamjaková. (2021) Evaluation of variability of silymarin complex in Silybi mariani fructus harvested during two production years. European Pharmaceutical Journal 68:1, pages 40-45.
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Siddharth S. Kesharwani, Vikas Jain, Surajit Dey, Swagat Sharma, Pooja Mallya & Vadikari Arun Kumar. (2020) An overview of advanced formulation and nanotechnology-based approaches for solubility and bioavailability enhancement of silymarin. Journal of Drug Delivery Science and Technology 60, pages 102021.
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Mikhail Durymanov, Anastasia Permyakova & Joshua Reineke. (2020) Pre-treatment With PLGA/Silibinin Nanoparticles Mitigates Dacarbazine-Induced Hepatotoxicity. Frontiers in Bioengineering and Biotechnology 8.
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Nancy Vargas-Mendoza, Ángel Morales-González, Mauricio Morales-Martínez, Marvin A. Soriano-Ursúa, Luis Delgado-Olivares, Eli Mireya Sandoval-Gallegos, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Eduardo Madrigal-Santillán & José A. Morales-Gonzalez. (2020) Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications. Biomedicines 8:5, pages 122.
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Yizeng Fan, Tao Hou, Weichao Dan, Tianjie Liu, Jiaxin Luan, Bo Liu, Lei Li & Jin Zeng. (2020) Silibinin inhibits epithelial‑mesenchymal transition of renal cell carcinoma through autophagy‑dependent Wnt/β‑catenin signaling. International Journal of Molecular Medicine.
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Maryam Alipour, Mohammad reza Bigdeli, Hadi Aligholi, Bahram Rasoulian & Mojtaba Khaksarian. (2019) Sustained release of silibinin‐loaded chitosan nanoparticle induced apoptosis in glioma cells. Journal of Biomedical Materials Research Part A 108:3, pages 458-469.
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Jie Mao, Hongbao Yang, Tingting Cui, Pan Pan, Nadia Kabir, Duo Chen, Jinyan Ma, Xingyi Chen, Yijun Chen & Yong Yang. (2018) Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT. European Journal of Pharmacology 832, pages 39-49.
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Barbara Prack Mc Cormick, Yanina Langle, Denise Belgorosky, Silvia Vanzulli, Natalia Balarino, Eduardo Sandes & Ana M. Eiján. (2018) Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer. Journal of Cellular Biochemistry 119:7, pages 5402-5412.
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Haneen Amawi, Charles R. AshbyJr.Jr. & Amit K. Tiwari. (2017) Cancer chemoprevention through dietary flavonoids: what’s limiting?. Chinese Journal of Cancer 36:1.
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Bo Zhang, Bing Wang, Shuhua Cao, Yongqiang Wang & Di Wu. (2017) Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-κB signaling and NLRP3 activation. International Journal of Molecular Medicine 39:5, pages 1111-1118.
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Raghuraj Singh, Premlata Kumari & Satyanshu Kumar. 2017. Nutrient Delivery. Nutrient Delivery 413 456 .
L. Abenavoli & N. Milic. 2017. Liver Pathophysiology. Liver Pathophysiology 621 631 .
Yi-Hao Chen, Ching-Long Chen, Da-Wen Lu, Chang-Min Liang, Ming-Cheng Tai & Jiann-Torng Chen. (2016) Silibinin Inhibits Platelet-Derived Growth Factor-Driven Cell Proliferation via Downregulation of N-Glycosylation in Human Tenon's Fibroblasts in a Proteasome-Dependent Manner. PLOS ONE 11:12, pages e0168765.
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Navaneethakrishnan Polachi, Guirong Bai, Tingyang Li, Yang Chu, Xiangyang Wang, Shuming Li, Ning Gu, Jiang Wu, Wei Li, Yanjun Zhang, Shuiping Zhou, He Sun & Changxiao Liu. (2016) Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer – A comprehensive review. European Journal of Medicinal Chemistry 123, pages 577-595.
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Ryoiti Kiyama. (2016) Biological effects induced by estrogenic activity of lignans. Trends in Food Science & Technology 54, pages 186-196.
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Karuppaiya Palaniyandi, Shenghua Wang & Fang Chen. 2016. Medicinal Plants - Recent Advances in Research and Development. Medicinal Plants - Recent Advances in Research and Development 327 362 .
Michał Antoszczak, Greta Klejborowska, Monika Kruszyk, Ewa Maj, Joanna Wietrzyk & Adam Huczyński. (2015) Synthesis and Antiproliferative Activity of Silybin Conjugates with Salinomycin and Monensin. Chemical Biology & Drug Design 86:6, pages 1378-1386.
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ZHENKUN MA, WEI LIU, JIN ZENG, JIANCHENG ZHOU, PENG GUO, HONGJUN XIE, ZHAO YANG, LONG ZHENG, SHAN XU, XINYANG WANG, LUKE S. CHANG, DALIN HE & LEI LI. (2015) Silibinin induces apoptosis through inhibition of the mTOR-GLI1-BCL2 pathway in renal cell carcinoma. Oncology Reports 34:5, pages 2461-2468.
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Joaquim Bosch-Barrera & Javier A. Menendez. (2015) Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy. Cancer Treatment Reviews 41:6, pages 540-546.
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Peter Surai. (2015) Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives. Antioxidants 4:1, pages 204-247.
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Seema PatelSeema Patel. 2015. Emerging Bioresources with Nutraceutical and Pharmaceutical Prospects. Emerging Bioresources with Nutraceutical and Pharmaceutical Prospects 101 114 .
Yan Wang, Wei-Cheng Liang, Wen-Liang Pan, Wai-Kit Law, Jian-Shu Hu, Denis Tsz-Ming Ip, Mary Miu-Yee Waye, Tzi-Bun Ng & David Chi-Cheong Wan. (2014) Silibinin, a novel chemokine receptor type 4 antagonist, inhibits chemokine ligand 12-induced migration in breast cancer cells. Phytomedicine 21:11, pages 1310-1317.
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Yi-Xin Wang, Hong Cai, Gang Jiang, Tian-Bao Zhou & Hai Wu. (2014) Silibinin Inhibits Proliferation, Induces Apoptosis and Causes Cell Cycle Arrest in Human Gastric Cancer MGC803 Cells Via STAT3 Pathway Inhibition. Asian Pacific Journal of Cancer Prevention 15:16, pages 6791-6798.
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Deep Pooja, Dileep J. Babu Bikkina, Hitesh Kulhari, Nalla Nikhila, Srinivas Chinde, Y.M. Raghavendra, B. Sreedhar & Ashok K. Tiwari. (2014) Fabrication, characterization and bioevaluation of silibinin loaded chitosan nanoparticles. International Journal of Biological Macromolecules 69, pages 267-273.
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L. Gándara, E. Sandes, G. Di Venosa, B. Prack Mc Cormick, L. Rodriguez, L. Mamone, A. Batlle, A.M. Eiján & A. Casas. (2014) The natural flavonoid silybin improves the response to Photodynamic Therapy of bladder cancer cells. Journal of Photochemistry and Photobiology B: Biology 133, pages 55-64.
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Caterina Grillo, Silvia Chichiarelli, Elisa Gaucci, Fabio Altieri, Carlo Turano & Laura Cervoni. (2014) The binding of silibinin to ERp57. Chemico-Biological Interactions 213, pages 37-43.
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Yi-Hao Chen, Ching-Long Chen, Chang-Min Liang, Jy-Been Liang, Ming-Cheng Tai, Yun-Hsiang Chang, Da-Wen Lu & Jiann-Torng Chen. (2014) Silibinin Inhibits ICAM-1 Expression via Regulation of N-Linked and O-Linked Glycosylation in ARPE-19 Cells. BioMed Research International 2014, pages 1-13.
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Kaijie Wu, Zhongyun Ning, Jin Zeng, Jinhai Fan, Jiancheng Zhou, Tingting Zhang, Linlin Zhang, Yule Chen, Yang Gao, Bin Wang, Peng Guo, Lei Li, Xinyang Wang & Dalin He. (2013) Silibinin inhibits β-catenin/ZEB1 signaling and suppresses bladder cancer metastasis via dual-blocking epithelial–mesenchymal transition and stemness. Cellular Signalling 25:12, pages 2625-2633.
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Matthieu Huet & Jacques Fleurentin. (2013) Curcuma, thé vert et chardon-marie : quelle stratégie adopter en prévention du cancer ou en complément des traitements ?. Hegel N° 4:4, pages 268-281.
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Matthieu Huet & Jacques Fleurentin. (2013) Curcuma, thé vert et chardon-marie : quelle stratégie adopter en prévention du cancer ou en complément des traitements ?. Hegel N° 4:4, pages 268-281.
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Yi-Hao Chen, Chang-Min Liang, Ching-Long Chen, Jiann-Torng Chen, Yun-Hsiang Chang, Da-Wen Lu, Ke-Hung Chien & Ming-Cheng Tai. (2013) Silibinin inhibits myofibroblast transdifferentiation in human tenon fibroblasts and reduces fibrosis in a rabbit trabeculectomy model. Acta Ophthalmologica 91:7, pages e506-e515.
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Yangyang Hu, Shengpeng Wang, Xu Wu, Jinming Zhang, Ruie Chen, Meiwan Chen & Yitao Wang. (2013) Chinese herbal medicine-derived compounds for cancer therapy: A focus on hepatocellular carcinoma. Journal of Ethnopharmacology 149:3, pages 601-612.
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P. Corchete & R. Bru. (2013) Proteome alterations monitored by DIGE analysis in Silybum marianum cell cultures elicited with methyl jasmonate and methyl B cyclodextrin. Journal of Proteomics 85, pages 99-108.
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Xi-Wen Zhu & Jian-Ping Gong. (2013) Expression and Role of ICAM-1 in the Occurrence and Development of Hepatocellular Carcinoma. Asian Pacific Journal of Cancer Prevention 14:3, pages 1579-1583.
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Mengzhu Xue, Shoude Zhang, Chaoqian Cai, Xiaojuan Yu, Lei Shan, Xiaofeng Liu, Weidong Zhang & Honglin Li. (2013) Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-11.
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Wenyan Lu, Cuihong Lin, Taj D. King, Honghong Chen, Robert C. Reynolds & Yonghe Li. (2012) Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells. Cellular Signalling 24:12, pages 2291-2296.
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Su-Ni Tang, Sharmila Shankar & Rakesh K. Srivastava. 2012. Nutrition, Diet and Cancer. Nutrition, Diet and Cancer 149 167 .
Wen Tan, Jinjian Lu, Mingqing Huang, Yingbo Li, Meiwan Chen, Guosheng Wu, Jian Gong, Zhangfeng Zhong, Zengtao Xu, Yuanye Dang, Jiajie Guo, Xiuping Chen & Yitao Wang. (2011) Anti-cancer natural products isolated from chinese medicinal herbs. Chinese Medicine 6:1.
Crossref
Corrado TringaliDale Nagle & Yu-Dong Zhou. 2011. Bioactive Compounds from Natural Sources, Second Edition. Bioactive Compounds from Natural Sources, Second Edition 187 264 .
Xudong Li, Bin Su, Runming Liu, Dapeng Wu & Dalin He. (2011) Tetrandrine Induces Apoptosis and Triggers Caspase Cascade in Human Bladder Cancer Cells. Journal of Surgical Research 166:1, pages e45-e51.
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June K. Dunnick, Bhanu Singh, Abraham Nyska, John Peckham, Grace E. Kissling & J. Michael Sanders. (2011) Investigating the Potential for Toxicity from Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle. Toxicologic Pathology 39:2, pages 398-409.
Crossref
Jin Zeng, Yi Sun, Kaijie Wu, Lei Li, Gang Zhang, Zenglei Yang, Zhiqiang Wang, Dong Zhang, Yan Xue, Yule Chen, Guodong Zhu, Xinyang Wang & Dalin He. (2011) Chemopreventive and Chemotherapeutic Effects of Intravesical Silibinin against Bladder Cancer by Acting on Mitochondria. Molecular Cancer Therapeutics 10:1, pages 104-116.
Crossref
Ludovico Abenavoli, Raffaele Capasso, Natasa Milic & Francesco Capasso. (2010) Milk thistle in liver diseases: past, present, future. Phytotherapy Research 24:10, pages 1423-1432.
Crossref
Gagan Deep & Rajesh Agarwal. (2010) Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer and Metastasis Reviews 29:3, pages 447-463.
Crossref

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