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Expert Opinion on Investigational Drugs Volume 19, 2010 - Issue 4
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New therapies for pulmonary arterial hypertension: an update on current bench to bedside translation

Laurence Dewachter Free University of Brussels, Department of Physiology, Faculty of Medicine, Erasme Campus CP 604, Lennik Road 808, B-1070 Brussels, Belgium +32 2 5554989; +32 2 5554124; [email protected]
,
Céline Dewachter Free University of Brussels, Department of Physiology, Faculty of Medicine, Erasme Campus CP 604, Lennik Road 808, B-1070 Brussels, Belgium +32 2 5554989; +32 2 5554124; [email protected]
&
Robert Naeije Free University of Brussels, Department of Physiology, Faculty of Medicine, Erasme Campus CP 604, Lennik Road 808, B-1070 Brussels, Belgium +32 2 5554989; +32 2 5554124; [email protected]
Pages 469-488 | Published online: 31 Mar 2010

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Ronald Zolty. (2023) Advances in the discovery of drugs that treat pulmonary arterial hypertension. Expert Opinion on Drug Discovery 18:4, pages 445-466.
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Simon Malenfant, Guillaume Margaillan, Jérémy Edwin Loehr, Sébastien Bonnet & Steeve Provencher. (2013) The emergence of new therapeutic targets in pulmonary arterial hypertension: from now to the near future. Expert Review of Respiratory Medicine 7:1, pages 43-55.
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Articles from other publishers (21)

Qiwei Wilton Sun & Zhongjie Sun. (2022) Stem cell therapy for pulmonary arterial hypertension: An update. The Journal of Heart and Lung Transplantation 41:6, pages 692-703.
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Chetan Sharma, Joseph Burns, Aparna Kulkarni, Jane E. Cerise, Fernando Molina Berganza & Denise A. Hayes. (2021) Continuous and intermittent administration of intravenous sildenafil in critically ill infants with pulmonary hypertension. Pediatric Pulmonology 56:9, pages 2973-2978.
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Jingyuan Zhang, Xiaohui Lu, Mei Liu, Hanlu Fan, Han Zheng, Shanshan Zhang, Nafis Rahman, Sławomir Wołczyński, Adam Kretowski & Xiangdong Li. (2020) Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension. Cardiovascular Research 116:13, pages 2156-2169.
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Ronald Zolty. (2020) Pulmonary arterial hypertension specific therapy: The old and the new. Pharmacology & Therapeutics 214, pages 107576.
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Liang Li, Wenpeng Zhang, Feng Lin, Xinqiang Lu, Wei Chen, Xingzhou Li, Xinbo Zhou, Ruibin Su, Lili Wang, Zhibing Zheng & Song Li. (2019) Synthesis and biological evaluation of pyrazolo[3,4-b]pyridine-3-yl pyrimidine derivatives as sGC stimulators for the treatment of pulmonary hypertension. European Journal of Medicinal Chemistry 173, pages 107-116.
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Wei Li, Aili Guo, Lijuan Wang, Qingyu Kong, Rong Wang, Li Han & Cuifen Zhao. (2016) Expression of peptide fragments from proADM and involvement of mitogen-activated protein kinase signaling pathways in pulmonary remodeling induced by high pulmonary blood flow. Congenital Anomalies 56:1, pages 28-34.
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Mala Sharma, Sowmya Pinnamaneni, Wilbert S. Aronow, Bartosz Jozwik & William H. Frishman. (2014) Existing Drugs and Agents Under Investigation for Pulmonary Arterial Hypertension. Cardiology in Review 22:6, pages 297-305.
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Jinyan FuYiu-Fai ChenXiangmin ZhaoJudy R. CreightonYuanyuan GuoFadi G. HageSuzanne OparilDaisy D. Xing. (2014) Targeted Delivery of Pulmonary Arterial Endothelial Cells Overexpressing Interleukin-8 Receptors Attenuates Monocrotaline-Induced Pulmonary Vascular Remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology 34:7, pages 1539-1547.
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Sara B. Seidelmann, Janet K. Lighthouse & Daniel M. Greif. (2013) Development and pathologies of the arterial wall. Cellular and Molecular Life Sciences 71:11, pages 1977-1999.
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Nikki L. Jernigan & Thomas C. Resta. (2014) Calcium Homeostasis and Sensitization in Pulmonary Arterial Smooth Muscle. Microcirculation 21:3, pages 259-271.
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W. Li, Q.Y. Kong, C.F. Zhao, F. Zhao, F.H. Li, W. Xia, R. Wang, Y.M. Hu & M. Hua. (2013) Adrenomedullin and adrenotensin regulate collagen synthesis and proliferation in pulmonary arterial smooth muscle cells. Brazilian Journal of Medical and Biological Research 46:12, pages 1047-1055.
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Baktybek Kojonazarov, Himal Luitel, Akylbek Sydykov, Bhola K. Dahal, Mark J. Paul‐Clark, Sara Bonvini, Anna Reed, Ralph T. Schermuly & Jane A. Mitchell. (2013) The Peroxisome Proliferator–Activated Receptor β/δ Agonist GW0742 has Direct Protective Effects on Right Heart Hypertrophy. Pulmonary Circulation 3:4, pages 926-935.
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Caroline O’Connell, Dermot S. O’Callaghan & Marc Humbert. (2013) Novel Medical Therapies for Pulmonary Arterial Hypertension. Clinics in Chest Medicine 34:4, pages 867-880.
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Hans‐Jürgen Seyfarth, Stefan Hammerschmidt, Michael Halank, Petra Neuhaus & Hubert R. Wirtz. (2013) Everolimus in Patients with Severe Pulmonary Hypertension: A Safety and Efficacy Pilot Trial. Pulmonary Circulation 3:3, pages 632-638.
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. (2011) Current World Literature. Current Opinion in Cardiology 26:4, pages 356-361.
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Niki Katsiki, Anthony S Wierzbicki & Dimitri P Mikhailidis. (2011) Pulmonary arterial hypertension and statins: an update. Current Opinion in Cardiology 26:4, pages 322-326.
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Kenji Kuwasako, Kazuo Kitamura, Sayaka Nagata, Tomomi Hikosaka, Yoshio Takei & Johji Kato. (2011) Shared and separate functions of the RAMP-based adrenomedullin receptors. Peptides 32:7, pages 1540-1550.
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Jean-Luc Vachiéry. (2011) Prostacyclins in pulmonary arterial hypertension: the need for earlier therapy. Advances in Therapy 28:4, pages 251-269.
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Se-Na Lee, Myung-Gyou Kim, Myoung-Hee Kim, Hyung-Jun Kim, Hak-Jun Jo & Kang-Hyun Leem. (2011) Effects of Yukmigeehwang-hwan Extracts on the Elastase Activity and DPPH and NO Scavenging Activities Original Articles. Journal of Pharmacopuncture 14:1, pages 61-69.
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Sarah M. WeakleyJun JiangJianming LuXinwen WangPeter H. LinQizhi YaoChangyi Chen. (2011) Natural antioxidant dihydroxybenzyl alcohol blocks ritonavir-induced endothelial dysfunction in porcine pulmonary arteries and human endothelial cells. Medical Science Monitor 17:9, pages BR235-BR241.
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Jing Tian, Sohrab Fratz, Yali Hou, Qing Lu, Agnes Görlach, John Hess, Christian Schreiber, Sanjeev A. Datar, Peter Oishi, John NechtmanRobert PodolskyJin-Xiong SheJeffrey R. Fineman & Stephen M. Black. (2011) Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease. Physiological Genomics 43:2, pages 87-98.
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