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Expert Opinion on Investigational Drugs Volume 11, 2002 - Issue 1
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Miscellaneous

Mucoactive drugs for asthma and COPD: any place in therapy?

Duncan F Rogers Thoracic Medicine, National Heart & Lung Institute (Imperial College), Dovehouse Street, London SW3 6LY, UK, Tel: +44 (0)207 352 8121, ext. 3051;, Fax: +44 (0)207 351 8126;, E-mail: [email protected]
Pages 15-35 | Published online: 24 Feb 2005

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Manuele Casale, Alberto Di Martino, Fabrizio Salvinelli, Marcella Trombetta & Vincenzo Denaro. (2010) MESNA for chemically assisted tissue dissection. Expert Opinion on Investigational Drugs 19:6, pages 699-707.
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Phillippa J Poole. (2006) Role of mucolytics in the management of COPD. International Journal of Chronic Obstructive Pulmonary Disease 1:2, pages 123-128.
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Duncan F. Rogers. (2006) Airway mucus hypersecretion: Rationales for pharmacotherapy. Journal of Organ Dysfunction 2:3, pages 183-191.
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Duncan F. Rogers & Peter J. Barnes. (2006) Treatment of airway mucus hypersecretion. Annals of Medicine 38:2, pages 116-125.
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Duncan F. Rogers. (2005) The Role of Airway Secretions in COPD: Pathophysiology, Epidemiology and Pharmacotherapeutic Options. COPD: Journal of Chronic Obstructive Pulmonary Disease 2:3, pages 341-353.
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Miguel Barbosa & James D. Chalmers. (2023) Bronchiectasis. La Presse Médicale 52:3, pages 104174.
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Aileen Hsieh, Najmeh Assadinia & Tillie-Louise Hackett. (2023) Airway remodeling heterogeneity in asthma and its relationship to disease outcomes. Frontiers in Physiology 14.
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Tarun Virmani, Girish Kumar, Reshu Virmani, Ashwani Sharma & Kamla Pathak. (2022) Nanocarrier-based approaches to combat chronic obstructive pulmonary disease. Nanomedicine 17:24, pages 1833-1854.
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David B. Hill, Brian Button, Michael Rubinstein & Richard C. Boucher. (2022) Physiology and pathophysiology of human airway mucus. Physiological Reviews 102:4, pages 1757-1836.
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Maria I. Pino-Argumedo, Anthony J. Fischer, Brieanna M. Hilkin, Nicholas D. Gansemer, Patrick D. Allen, Eric A. Hoffman, David A. Stoltz, Michael J. Welsh & Mahmoud H. Abou Alaiwa. (2022) Elastic mucus strands impair mucociliary clearance in cystic fibrosis pigs. Proceedings of the National Academy of Sciences 119:13.
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Brandán Pedre, Uladzimir Barayeu, Daria Ezeriņa & Tobias P. Dick. (2021) The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species. Pharmacology & Therapeutics 228, pages 107916.
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Yong Seok Jo, Ick Soo Choi & Yoon Kyoung So. (2021) The Use of Inhaled N-Acetylcysteine for Laryngopharyngeal Reflux Disease: A Randomized Controlled Trial. Journal of Voice 35:4, pages 618-624.
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Kaiser Jehan Peerzada. 2020. Chronic Lung Diseases. Chronic Lung Diseases 157 180 .
Mario Cazzola, Luigino Calzetta, Clive Page, Paola Rogliani & Maria Gabriella Matera. (2019) Thiol-Based Drugs in Pulmonary Medicine: Much More than Mucolytics. Trends in Pharmacological Sciences 40:7, pages 452-463.
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Camille Ehre, Zachary L. Rushton, Boya Wang, Lauren N. Hothem, Cameron B. Morrison, Nicholas C. Fontana, Matthew R. Markovetz, Martial F. Delion, Takafumi Kato, Diane Villalon, William R. Thelin, Charles R. EstherJr.Jr., David B. Hill, Barbara R. Grubb, Alessandra Livraghi-Butrico, Scott H. Donaldson & Richard C. Boucher. (2019) An Improved Inhaled Mucolytic to Treat Airway Muco-obstructive Diseases. American Journal of Respiratory and Critical Care Medicine 199:2, pages 171-180.
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Luke Bonser & David Erle. (2017) Airway Mucus and Asthma: The Role of MUC5AC and MUC5B. Journal of Clinical Medicine 6:12, pages 112.
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Muzafar A. Macha, Shiv Ram Krishn, Rahat Jahan, Kasturi Banerjee, Surinder K. Batra & Maneesh Jain. (2015) Emerging potential of natural products for targeting mucins for therapy against inflammation and cancer. Cancer Treatment Reviews 41:3, pages 277-288.
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Staffan Skogvall, Jonas S. Erjefält, Anders I. Olin, Jaro Ankerst & Leif Bjermer. (2014) Oral iodinated activated charcoal improves lung function in patients with COPD. Respiratory Medicine 108:6, pages 905-909.
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Duncan F. Rogers. 2014. Middleton's Allergy. Middleton's Allergy 739 753 .
Wenju Lu & Jinping Zheng. (2013) The function of mucins in the COPD airway. Current Respiratory Care Reports 2:3, pages 155-166.
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R. Balsamo, L. Lanata & C. G. Egan. (2010) Mucoactive drugs. European Respiratory Review 19:116, pages 127-133.
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Rachel Kettle, Jennifer Simmons, Francis Schindler, Peter Jones, Tina Dicker, Gerald Dubois, June Giddings, Gino Van Heeke & Carol E. Jones. (2010) Regulation of Neuregulin 1β1–Induced MUC5AC and MUC5B Expression in Human Airway Epithelium. American Journal of Respiratory Cell and Molecular Biology 42:4, pages 472-481.
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Laurent Laforest, Eric Van Ganse, Gilles Devouassoux, A. El Hasnaoui, Liesl M. Osman, Gisele Bauguil & Genevieve Chamba. (2008) Dispensing of antibiotics, antitussives and mucolytics to asthma patients: A pharmacy-based observational survey. Respiratory Medicine 102:1, pages 57-63.
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Evangelia DAVISKAS, Sandra D. ANDERSON & Iven H. YOUNG. (2007) Inhaled mannitol changes the sputum properties in asthmatics with mucus hypersecretion. Respirology 12:5, pages 683-691.
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Niek N. Sanders, Vincent G.H. Eijsink, Petra S. van den Pangaart, R.J. Joost van Neerven, Peter J. Simons, Stefaan C. De Smedt & Joseph Demeester. (2007) Mucolytic activity of bacterial and human chitinases. Biochimica et Biophysica Acta (BBA) - General Subjects 1770:5, pages 839-846.
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Robert A. Stockley, Stephen I. Rennard, Klaus Rabe & Bartolome CelliDuncan F. Rogers & Bruce K. Rubin. 2007. Chronic Obstructive Pulmonary Disease. Chronic Obstructive Pulmonary Disease 756 768 .
Raffaele Antonelli Incalzi, Andrea Corsonello, Claudio Pedone, Giulio Masotti, Vincenzo Bellia, Vittorio Grassi & Franco Rengo. (2006) From Global Initiative for Chronic Obstructive Lung Disease (GOLD) Guidelines to Current Clinical Practice. Drugs & Aging 23:5, pages 411-420.
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Annette Robichaud, Stephanie A. Tuck, Stacia Kargman, John Tam, Elizabeth Wong, Mark Abramovitz, James Mortimer, Helen E. Burston, Paul Masson, Jeremy Hirota, Deborah Slipetz, Brian Kennedy, Gary O'Neill & Steven Xanthoudakis. (2005) Gob-5 Is Not Essential for Mucus Overproduction in Preclinical Murine Models of Allergic Asthma. American Journal of Respiratory Cell and Molecular Biology 33:3, pages 303-314.
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Duncan F. Rogers. (2005) Mucociliary dysfunction in COPD: effect of current pharmacotherapeutic options. Pulmonary Pharmacology & Therapeutics 18:1, pages 1-8.
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Ilknur Basyigit, Fusun Yildiz, Mustafa Cekmen, Can Duman & Olcay Bulut. (2005) Effects of Erdosteine on Smoking-Induced Lipid Peroxidation in Healthy Smokers. Drugs in R & D 6:2, pages 83-89.
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Duncan Rogers. 2004. Therapy for Mucus-Clearance Disorders. Therapy for Mucus-Clearance Disorders 1 27 .
Malcolm King. 2004. Therapy for Mucus-Clearance Disorders. Therapy for Mucus-Clearance Disorders 201 224 .
Duncan F. Rogers. 2004. Recent Advances in the Pathophysiology of COPD. Recent Advances in the Pathophysiology of COPD 101 119 .
Michele A. Faulkner & Daniel E. Hilleman. (2012) Pharmacologic Treatment of Chronic Obstructive Pulmonary Disease: Past, Present, and Future. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 23:10, pages 1300-1315.
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Phillippa J. Poole & Peter N. Black. (2012) Preventing Exacerbations of Chronic Bronchitis and COPD. American Journal of Respiratory Medicine 2:5, pages 367-370.
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Duncan F. Rogers. (2003) Pulmonary mucus: Pediatric perspective. Pediatric Pulmonology 36:3, pages 178-188.
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Duncan F. Rogers. (2003) Airway hypersecretion in allergic rhinitis and asthma: New pharmacotherapy. Current Allergy and Asthma Reports 3:3, pages 238-248.
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Jonathan E Phillips, John A Hey & Michel R Corboz. (2003) Tachykinin NK 3 and NK 1 receptor activation elicits secretion from porcine airway submucosal glands . British Journal of Pharmacology 138:1, pages 254-260.
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Bruce K. Rubin. 2003. Cough: Causes, Mechanisms and Therapy. Cough: Causes, Mechanisms and Therapy 269 281 .

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