70
Views
34
CrossRef citations to date
0
Altmetric
Review

Recent developments in the discovery of hepatitis C virus serine protease inhibitors – towards a new class of antiviral agents?

, &
Pages 153-163 | Published online: 02 Mar 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Markus Reiser & Jörg Timm. (2009) Serine protease inhibitors as anti-hepatitis C virus agents. Expert Review of Anti-infective Therapy 7:5, pages 537-547.
Read now
Nathalie Goudreau & Montse Llinàs-Brunet. (2005) The therapeutic potential of NS3 protease inhibitors in HCV infection. Expert Opinion on Investigational Drugs 14:9, pages 1129-1144.
Read now
Per Hoffmann, Maria Quasdorff, Maria Á González-Carmona & Wolfgang H Caselmann. (2003) Recent patents on experimental therapy for hepatitis C virus infection (1999 – 2002). Expert Opinion on Therapeutic Patents 13:11, pages 1707-1723.
Read now
David Durantel, Vanessa Escuret & Fabien Zoulim. (2003) Current and emerging therapeutic approaches to hepatitis C infection. Expert Review of Anti-infective Therapy 1:3, pages 441-454.
Read now
Michelle P Walker, Nanhua Yao & Zhi Hong. (2003) Promising candidates for the treatment of chronic hepatitis C. Expert Opinion on Investigational Drugs 12:8, pages 1269-1280.
Read now

Articles from other publishers (29)

Nan Yang, Qiushi Sun, Zihua Xu, Xiuyun Wang, Xin Zhao, Yuqing Cao, Li Chen & Guorong Fan. (2015) LC-ESI-MS/MS Analysis and Pharmacokinetics of GP205, an Innovative Potent Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease in Rats. Molecules 20:3, pages 4319-4336.
Crossref
Vaishali M. Patil, Neeraj Masand & Satya Prakash Gupta. 2013. Proteases in Health and Disease. Proteases in Health and Disease 335 360 .
Stéphane L. Bogen, Ashok Arasappan, Francisco Velazquez, Melissa Blackman, Regina Huelgas, Weidong Pan, Elise Siegel, Latha G. Nair, Srikanth Venkatraman, Zhuyan Guo, Ronald Doll, Neng-Yang Shih & F. George Njoroge. (2010) Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species. Bioorganic & Medicinal Chemistry 18:5, pages 1854-1865.
Crossref
Stéphane L. Bogen, Weidong Pan, Sumei Ruan, Latha G. Nair, Ashok Arasappan, Frank Bennett, Kevin X. Chen, Edwin Jao, Srikanth Venkatraman, Bancha Vibulbhan, Rong Liu, Kuo-Chi Cheng, Zhuyan Guo, Xiao Tong, Anil K. Saksena, Viyyoor Girijavallabhan & F. George Njoroge. (2009) Toward the Back-Up of Boceprevir (SCH 503034): Discovery of New Extended P 4 -Capped Ketoamide Inhibitors of Hepatitis C Virus NS3 Serine Protease with Improved Potency and Pharmacokinetic Profiles . Journal of Medicinal Chemistry 52:12, pages 3679-3688.
Crossref
S. Bogen, A. Arasappan, W. Pan, S. Ruan, A. Padilla, A.K. Saksena, V. Girijavallabhan & F.G. Njoroge. (2008) Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034. Bioorganic & Medicinal Chemistry Letters 18:14, pages 4219-4223.
Crossref
Hsin-Yuan Wei, Chien-Sheng Lu & Thy-Hou Lin. (2008) Exploring the P2 and P3 ligand binding features for Hepatitis C virus NS3 protease using some 3D QSAR techniques. Journal of Molecular Graphics and Modelling 26:7, pages 1131-1144.
Crossref
Marcus Bäck, Per-Ola Johansson, Fredrik Wångsell, Fredrik Thorstensson, Ingemar Kvarnström, Susana Ayesa, Horst Wähling, Mikael Pelcman, Katarina Jansson, Stefan Lindström, Hans Wallberg, Björn Classon, Christina Rydergård, Lotta Vrang, Elizabeth Hamelink, Anders Hallberg, Åsa Rosenquist & Bertil Samuelsson. (2007) Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: Use of cyclopentane and cyclopentene P2-motifs. Bioorganic & Medicinal Chemistry 15:22, pages 7184-7202.
Crossref
Gyongyi Szabo, Serena Chang & Angela Dolganiuc. (2007) Altered innate immunity in chronic hepatitis C infection: Cause or effect?. Hepatology 46:4, pages 1279-1290.
Crossref
Gary L. Davis, Kris Krawczynski & Gyongyi Szabo. (2007) Hepatitis C Virus Infection—Pathobiology and Implications for New Therapeutic Options. Digestive Diseases and Sciences 52:4, pages 857-875.
Crossref
U. Schmitz, L. Lou, C. Roberts & R. Griffith. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 373 417 .
Alpeshkumar K. Malde, Santosh A. Khedkar & Evans C. Coutinho. (2006) Stationary Points on the PES of N- Methoxy Peptides and Their Boron Isosteres:  An Ab Initio Study . Journal of Chemical Theory and Computation 2:6, pages 1664-1674.
Crossref
Zhuhui Huang, Michael G. Murray & John A. SecristIIIIII. (2006) Recent development of therapeutics for chronic HCV infection. Antiviral Research 71:2-3, pages 351-362.
Crossref
Stéphane L. Bogen, Ashok Arasappan, Frank Bennett, Kevin Chen, Edwin Jao, Yi-Tsung Liu, Raymond G. Lovey, Srikanth Venkatraman, Weidong Pan, Tajel Parekh, Russel E. Pike, Sumei Ruan, Rong Liu, Bahige Baroudy, Sony Agrawal, Robert Chase, Paul Ingravallo, John Pichardo, Andrew Prongay, Jean-Marc Brisson, Tony Y. Hsieh, Kuo-Chi Cheng, Scott J. Kemp, Odile E. Levy, Marguerita Lim-Wilby, Susan Y. Tamura, Anil K. Saksena, Viyyoor Girijavallabhan & F. George Njoroge. (2006) Discovery of SCH446211 (SCH6):  A New Ketoamide Inhibitor of the HCV NS3 Serine Protease and HCV Subgenomic RNA Replication. Journal of Medicinal Chemistry 49:9, pages 2750-2757.
Crossref
Wei Han, Xiangjun Jiang, Zilun Hu, Zelda R. Wasserman & Carl P. Decicco. (2005) Investigation of glycine α-ketoamide HCV NS3 protease inhibitors: Effect of carboxylic acid isosteres. Bioorganic & Medicinal Chemistry Letters 15:15, pages 3487-3490.
Crossref
Joanne E. Tomassini, Krista Getty, Mark W. Stahlhut, Sung Shim, Balkrishen Bhat, Anne B. Eldrup, Thazha P. Prakash, Steven S. Carroll, Osvaldo Flores, Malcolm MacCoss, Daniel R. McMasters, Giovanni Migliaccio & David B. Olsen. (2005) Inhibitory Effect of 2′-Substituted Nucleosides on Hepatitis C Virus Replication Correlates with Metabolic Properties in Replicon Cells. Antimicrobial Agents and Chemotherapy 49:5, pages 2050-2058.
Crossref
Victoria Chung, Anthony R. Carroll, Norman M. Gray, Nigel R. Parry, Pia A. Thommes, K. Claire Viner & Eric A. D'Souza. (2005) Development of Cell-Based Assays for In Vitro Characterization of Hepatitis C Virus NS3/4A Protease Inhibitors. Antimicrobial Agents and Chemotherapy 49:4, pages 1381-1390.
Crossref
Montse Llinàs-Brunet, Murray D. Bailey, Elise Ghiro, Vida Gorys, Ted Halmos, Martin Poirier, Jean Rancourt & Nathalie Goudreau. (2004) A Systematic Approach to the Optimization of Substrate-Based Inhibitors of the Hepatitis C Virus NS3 Protease:  Discovery of Potent and Specific Tripeptide Inhibitors. Journal of Medicinal Chemistry 47:26, pages 6584-6594.
Crossref
Savina Malancona, Stefania Colarusso, Jesus M Ontoria, Antonella Marchetti, Marco Poma, Ian Stansfield, Ralph Laufer, Annalise Di Marco, Marina Taliani, Maria Verdirame, Odalys Gonzalez-Paz, Victor G Matassa & Frank Narjes. (2004) SAR and pharmacokinetic studies on phenethylamide inhibitors of the hepatitis C virus NS3/NS4A serine protease. Bioorganic & Medicinal Chemistry Letters 14:17, pages 4575-4579.
Crossref
Laura Pacini, Linda Bartholomew, Alessandra Vitelli & Giovanni Migliaccio. (2004) Reporter substrates for assessing the activity of the hepatitis C virus NS3-4A serine protease in living cells. Analytical Biochemistry 331:1, pages 46-59.
Crossref
Liangjun Lu, Tami J. Pilot-Matias, Kent D. Stewart, John T. Randolph, Ron Pithawalla, Wenping He, Peggy P. Huang, Larry L. Klein, Hongmei Mo & Akhteruzzaman Molla. (2004) Mutations Conferring Resistance to a Potent Hepatitis C Virus Serine Protease Inhibitor In Vitro. Antimicrobial Agents and Chemotherapy 48:6, pages 2260-2266.
Crossref
Emanuela Nizi, Uwe Koch, Jesus M Ontoria, Antonella Marchetti, Frank Narjes, Savina Malancona, Victor G Matassa & Cristina Gardelli. (2004) Capped dipeptide phenethylamide inhibitors of the HCV NS3 protease. Bioorganic & Medicinal Chemistry Letters 14:9, pages 2151-2154.
Crossref
Robert B Perni, Luc J Farmer, Kevin M Cottrell, John J Court, Lawrence F Courtney, David D Deininger, Cynthia A Gates, Scott L Harbeson, Joseph L Kim, Chao Lin, Kai Lin, Yu-Ping Luong, John P Maxwell, Mark A Murcko, Janos Pitlik, B.Govinda Rao, Wayne C Schairer, Roger D Tung, John H Van Drie, Keith Wilson & John A Thomson. (2004) Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P2 proline variants. Bioorganic & Medicinal Chemistry Letters 14:8, pages 1939-1942.
Crossref
Anton Poliakov, Anja Johansson, Eva Åkerblom, Karin Oscarsson, Bertil Samuelsson, Anders Hallberg & U.Helena Danielson. (2004) Structure–activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors. Biochimica et Biophysica Acta (BBA) - General Subjects 1672:1, pages 51-59.
Crossref
Martin J. Richer, Luiz Juliano, Carl Hashimoto & François Jean. (2004) Serpin Mechanism of Hepatitis C Virus Nonstructural 3 (NS3) Protease Inhibition. Journal of Biological Chemistry 279:11, pages 10222-10227.
Crossref
Robert B. Perni, Janos Pitlik, Shawn D. Britt, John J. Court, Lawrence F. Courtney, David D. Deininger, Luc J. Farmer, Cynthia A. Gates, Scott L. Harbeson, Rhonda B. Levin, Chao Lin, Kai Lin, Young-Choon Moon, Yu-Ping Luong, Ethan T. O'Malley, B.Govinda Rao, John A. Thomson, Roger D. Tung, John H. Van Drie & Yunyi Wei. (2004) Inhibitors of hepatitis C virus NS3·4A protease 2. Warhead SAR and optimization. Bioorganic & Medicinal Chemistry Letters 14:6, pages 1441-1446.
Crossref
Angela M.I. Lam, David Keeney & David N. Frick. (2003) Two Novel Conserved Motifs in the Hepatitis C Virus NS3 Protein Critical for Helicase Action. Journal of Biological Chemistry 278:45, pages 44514-44524.
Crossref
Robert B. Perni, Shawn D. Britt, John C. Court, Lawrence F. Courtney, David D. Deininger, Luc J. Farmer, Cynthia A. Gates, Scott L. Harbeson, Joseph L. Kim, James A. Landro, Rhonda B. Levin, Yu-Ping Luong, Ethan T. O'Malley, Janos Pitlik, B.Govinda Rao, Wayne C. Schairer, John A. Thomson, Roger D. Tung, John H. Van Drie & Yunyi Wei. (2003) Inhibitors of hepatitis C virus NS3·4A protease 1. Non-Charged tetrapeptide variants. Bioorganic & Medicinal Chemistry Letters 13:22, pages 4059-4063.
Crossref
Brett D. Lindenbach & Charles M. Rice. (2003) Evasive maneuvers by hepatitits C virus. Hepatology 38:3, pages 769-771.
Crossref
Nicholas A. Meanwell, Michael H. Serrano-Wu & Lawrence B. Snyder. 2003. 213 228 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.