Advanced search
Publication Cover
Expert Opinion on Investigational Drugs Volume 12, 2003 - Issue 3
Submit an article Journal homepage
63
Views
40
CrossRef citations to date
0
Altmetric
Review

The potential of nitric oxide therapeutics in stroke

MR Willmot Division of Stroke Medicine, Clinical Sciences Building, University of Nottingham, Nottingham NG5 1PB, UK
&
PMW Bath Division of Stroke Medicine, Clinical Sciences Building, University of Nottingham, Nottingham NG5 1PB, UK
Pages 455-470 | Published online: 02 Mar 2005

Citations (40)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Michelle P Lin, Nerses Sanossian & David S Liebeskind. (2015) Imaging of prehospital stroke therapeutics. Expert Review of Cardiovascular Therapy 13:9, pages 1001-1015.
Read now

Articles from other publishers (39)

George J. Dugbartey. (2023) Nitric oxide in kidney transplantation. Biomedicine & Pharmacotherapy 167, pages 115530.
Crossref
Binhao Chen & Weifeng Jin. (2023) A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine. Frontiers in Neuroscience 17.
Crossref
Beng Leong Lim, Wei Feng Lee, Wei Ming Ng, Wangmin Situ, Kee Vooi Loo, Carmen Jia Man Goh & Wui Ling Chan. (2021) Benefits and safety of transdermal glyceryl trinitrate in acute stroke: A systematic review and meta‐analysis of randomized trials. Academic Emergency Medicine 29:6, pages 772-788.
Crossref
Shiying Zeng, Shisheng Li, Qinglai Tang, Ayinuer Tuerdi, Xinying Tong, Xiaojun Tang, Danhui Yin, Mengmeng Li & Qian Yang. (2022) Association of matrix metalloproteinase‐9 and nitric oxide with hypertension in obstructive sleep apnea. Laryngoscope Investigative Otolaryngology 7:3, pages 885-893.
Crossref
Thompson G Robinson, Jatinder S Minhas & Joseph Miller. (2021) Review of major trials of acute blood pressure management in stroke. Journal of Cerebral Blood Flow & Metabolism 42:3, pages 404-410.
Crossref
Ting Li, Ting Xu, Jin Zhao, Hao Gao & Wenguang Xie. (2022) Depletion of iNOS-positive inflammatory cells decelerates neuronal degeneration and alleviates cerebral ischemic damage by suppressing the inflammatory response. Free Radical Biology and Medicine 181, pages 209-220.
Crossref
Paulina Cieślik, Leszek Kalinowski & Joanna M. Wierońska. (2022) Procognitive activity of nitric oxide inhibitors and donors in animal models. Nitric Oxide 119, pages 29-40.
Crossref
Dearbhla M Kelly & Peter M Rothwell. (2020) Impact of multimorbidity on risk and outcome of stroke: Lessons from chronic kidney disease. International Journal of Stroke 16:7, pages 758-770.
Crossref
Beng Leong Lim, Wei Feng Lee, Wei Ming Ng, Wei Ling Tay & Wui Ling Chan. (2021) Benefits and safety of transdermal glyceryl trinitrate in acute stroke: a systematic review and meta-analysis of randomised trials (protocol). BMJ Open 11:1, pages e043591.
Crossref
Kearsley M. Dillon, Ryan J. Carrazzone, John B. Matson & Khosrow Kashfi. (2020) The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications. Biochemical Pharmacology 176, pages 113931.
Crossref
Shinghung Mak, Zheng Liu, Liangmiao Wu, Baojian Guo, Fangcheng Luo, Ziyan Liu, Shengquan Hu, Jiajun Wang, Guozhen Cui, Yewei Sun, Yuqiang Wang, Gaoxiao Zhang, Yifan Han & Zaijun Zhang. (2020) Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo . ACS Chemical Neuroscience 11:3, pages 314-327.
Crossref
Amedea B. Seabra, Wallace R. Rolim & Joana C. Pieretti. 2020. Nanomycotoxicology. Nanomycotoxicology 481 501 .
Philip M Bath, Polly Scutt, Jason P Appleton, Mark Dixon, Lisa J Woodhouse, Joanna M Wardlaw & Nikola Sprigg. (2018) Baseline characteristics of the 1149 patients recruited into the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) randomized controlled trial. International Journal of Stroke 14:3, pages 298-305.
Crossref
Jason P Appleton, Polly Scutt, Mark Dixon, Harriet Howard, Lee Haywood, Diane Havard, Trish Hepburn, Tim England, Nikola Sprigg, Lisa J Woodhouse, Joanna M Wardlaw, Alan A Montgomery, Stuart Pocock & Philip M Bath. (2017) Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: Rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053). International Journal of Stroke 14:2, pages 191-206.
Crossref
Kathleen Fontana, Leslie Ventimiglia & Bulent Mutus. (2018) Nitric oxide generating copper-chitosan particles for wound healing applications. Journal of Chemical Technology & Biotechnology 93:8, pages 2093-2101.
Crossref
Polly Scutt, Jason P Appleton, Mark Dixon, Lisa J Woodhouse, Nikola Sprigg, Joanna M Wardlaw, Alan A Montgomery, Stuart Pocock & Philip M Bath. (2018) Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’. European Stroke Journal 3:2, pages 193-196.
Crossref
Amedea B. Seabra & Nelson Durán. (2018) Nitric oxide donors for prostate and bladder cancers: Current state and challenges. European Journal of Pharmacology 826, pages 158-168.
Crossref
Kathleen Fontana & Bulent Mutus. 2017. Nitric Oxide Donors. Nitric Oxide Donors 55 74 .
Lisa WoodhousePolly ScuttKailash KrishnanEivind BergeJohn GommansGeorge NtaiosJoanna WardlawNikola SpriggPhilip M. Bath. (2015) Effect of Hyperacute Administration (Within 6 Hours) of Transdermal Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome After Stroke. Stroke 46:11, pages 3194-3201.
Crossref
. (2015) Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. The Lancet 385:9968, pages 617-628.
Crossref
Philip M. W. Bath. (2014) Baseline Characteristics of the 4011 Patients Recruited into the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) Trial. International Journal of Stroke 9:6, pages 711-720.
Crossref
Marisol Godínez-Rubí, Argelia E. Rojas-Mayorquín & Daniel Ortuño-Sahagún. (2013) Nitric Oxide Donors as Neuroprotective Agents after an Ischemic Stroke-Related Inflammatory Reaction. Oxidative Medicine and Cellular Longevity 2013, pages 1-16.
Crossref
Marcio Wilker Soares Campelo, Reinaldo Barreto Oriá, Luiz Gonzaga de França Lopes, Gerly Anne de Castro Brito, Armenio Aguiar dos Santos, Raquel Cavalcante de Vasconcelos, Francisco Ordelei Nascimento da Silva, Beatrice Nuto Nobrega, Moisés Tolentino Bento-Silva & Paulo Roberto Leitão de Vasconcelos. (2011) Preconditioning with a Novel Metallopharmaceutical NO Donor in Anesthetized Rats Subjected to Brain Ischemia/Reperfusion. Neurochemical Research 37:4, pages 749-758.
Crossref
Kristofer F. Nilsson, Michael Lundgren, Per Agvald, L. Christofer Adding, Dag Linnarsson & Lars E. Gustafsson. (2011) Formation of new bioactive organic nitrites and their identification with gas chromatography–mass spectrometry and liquid chromatography coupled to nitrite reduction. Biochemical Pharmacology 82:3, pages 248-259.
Crossref
Donald J. AbrahamPhilippe G. Nantermet, Evan F. Shalen, Shankar Venkatraman, Hong Zhu & Robert J. Mark. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 447 828 .
Tze-Fun Lee, Corinne N Tymafichuk, David L Bigam & Po-Yin Cheung. (2008) Effects of Postresuscitation N-Acetylcysteine on Cerebral Free Radical Production and Perfusion During Reoxygenation of Hypoxic Newborn Piglets. Pediatric Research 64:3, pages 256-261.
Crossref
Mushfiquddin Khan, Chinnasamy Elango, Mubeen A. Ansari, Inderjit Singh & Avtar K. Singh. (2007) Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia. Journal of Neurochemistry 102:2, pages 365-377.
Crossref
Zinaida S. Vexler, Xian Nan Tang & Midori A. Yenari. (2006) Inflammation in adult and neonatal stroke. Clinical Neuroscience Research 6:5, pages 293-313.
Crossref
. (2016) Glyceryl Trinitrate vs. Control, and Continuing vs. Stopping Temporarily Prior Antihypertensive Therapy, in Acute Stroke: Rationale and Design of the Efficacy of Nitric Oxide in Stroke (ENOS) Trial (ISRCTN99414122). International Journal of Stroke 1:4, pages 245-249.
Crossref
Laura J. Gray, Nikola Sprigg, Parveen A. Rashid, Mark R. Willmot & Philip M.W. Bath. (2006) Effect of Nitric Oxide Donors on Blood Pressure and Pulse Pressure in Acute and Subacute Stroke. Journal of Stroke and Cerebrovascular Diseases 15:6, pages 245-249.
Crossref
Mushfiquddin Khan, Manu Jatana, Chinnasamy Elango, Ajaib Singh Paintlia, Avtar K. Singh & Inderjit Singh. (2006) Cerebrovascular protection by various nitric oxide donors in rats after experimental stroke. Nitric Oxide 15:2, pages 114-124.
Crossref
Mark WillmotAndrew GhadamiBeverly WhysallWim ClarkeJoanna WardlawPhilip M.W. Bath. (2006) Transdermal Glyceryl Trinitrate Lowers Blood Pressure and Maintains Cerebral Blood Flow in Recent Stroke. Hypertension 47:6, pages 1209-1215.
Crossref
Andra Dingman, Sarah Y. Lee, Nikita Derugin, Michael F. Wendland & Zinaida S. Vexler. (2006) Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient cerebral ischemia. Journal of Neurochemistry 96:5, pages 1467-1479.
Crossref
S. Murphy & T. Coughlan. 2006. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology 223 247 .
Claire L. Gibson, Teresa C. Coughlan & Sean P. Murphy. (2005) Glial nitric oxide and ischemia. Glia 50:4, pages 417-426.
Crossref
Mark Willmot, Laura Gray, Claire Gibson, Sean Murphy & Philip M.W. Bath. (2005) A systematic review of nitric oxide donors and l-arginine in experimental stroke; effects on infarct size and cerebral blood flow. Nitric Oxide 12:3, pages 141-149.
Crossref
Mushfiquddin Khan, Bipanjeet Sekhon, Shailendra Giri, Manu Jatana, Anne G Gilg, Kamesh Ayasolla, Chinnasamy Elango, Avtar K Singh & Inderjit Singh. (2005) S -Nitrosoglutathione Reduces Inflammation and Protects Brain against Focal Cerebral Ischemia in a Rat Model of Experimental Stroke . Journal of Cerebral Blood Flow & Metabolism 25:2, pages 177-192.
Crossref
Göran E. Nilsson & Gillian M. C. Renshaw. (2004) Hypoxic survival strategies in two fishes: extreme anoxia tolerance in the North European crucian carp and natural hypoxic preconditioning in a coral-reef shark. Journal of Experimental Biology 207:18, pages 3131-3139.
Crossref
G?ran E. Nilsson & Peter L. Lutz. (2016) Anoxia Tolerant Brains. Journal of Cerebral Blood Flow & Metabolism 24:5, pages 475-486.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.